Upload
khuong
View
38
Download
1
Tags:
Embed Size (px)
DESCRIPTION
Interstitial nephritis associated with PostInfectious GN. PRAET MARLEEN , MD, PhD UNIVERSITY HOSPITAL GHENT. Clinical History: Background. Man 53 year Ethyl ++ , smoking 10-12 cigars/day 1994: T3N0M0 Spinocellular Carcinoma of the glottis - PowerPoint PPT Presentation
Citation preview
Interstitial nephritis associated with PostInfectious GN
PRAET MARLEEN , MD, PhD UNIVERSITY HOSPITAL GHENT
Clinical History: Background Man 53 year Ethyl ++ , smoking 10-12 cigars/day 1994: T3N0M0 Spinocellular Carcinoma of the glottis 2007-2010: recurrent hemoptoe presenting a cystic
lesion at the Right Upper Lobe of the Lung.
Clinical History: Recent 04/10/2011: lobectomie Histology: Pachypleuritis met underlying scar of the pulmonary
parenchyma. Bronchiectasy and chronic inflammation. No malignancy.
Follow up: hydropneumothorax with infection: crp 15 mg/dL, WBC 19000 10^3/µL, fever 39°C, sputum: H.Influenza
Admission in Emergency 3 weeks after lobectomy Acute renal failure: - Creatinin 4,21 mg/dl
- Proteinuria 4.3g/L - Macroscopic hematuria - Oliguria
- WBC: 21700 10^3/µL- CRP 10.6 mg/dl
Normal temperature, normal BP Renal biopsy.
AgMethanamine x 4
Kidney biopsy containing 30 glomeruli: 4 glomeruli are completely sclerosed. 7 glomeruli undergo proliferative changes with crescent formation surrounding the glomeruli segmentally or globally. Glomeruli, tubuli and interstitium are infiltrated by neutrophils. No vasculitis
AG Methanamine x10
CONGORED x25
CONGORED X 10
PAS x40
Differential Diagnosis (Focal) crescentic glomerulonephritis post infection
(PIGN). Microangiopathic vasculitis with crescentic
glomerulonephritis: ANCA-associated systemic vasculitides (Wegener, microscopic polyangitis, Churg- Strauss)
Sepsis with combined interstitial and glomerular changes.
Immunofluorescence Findings Ig G, Ig A, Ig M, C1Q: negative IF findings Kappa, Lambda: negative IF findings C3: strong granular staining at capillary
wall 3+
SUGGESTED DIAGNOSIS: Post infectious glomerulonephritis with crescent formation in < 50% of the glomeruli. IF findings consistent with previous infection.
C3 Deposition at capillary wall
ORIGIN OF INFECTION 2 possibilities:
- Hydropneumothorax with infectious agent: H. Influenzae was found in the sputum.
- Bronchiectasy with ulcerative inflammation and presence of germs: however no infectious agent was cultivated
Treatment of the patientOriginal clinical diagnosis: vasculitis:
plasmapheresis, cyclophosphamide, high dosed steroids. Creat levels up tot 6. 65 mg/dl. However: ANCA: negative, anti GBM: negative
Switch of treatment after IF findings: stop plasmapheresis, stop cyclophosphamide:
Instead: intravenous AB, steroids, dialysis.
Creat level is decreasing with recovery of the patient.
DiscussionGlomerulonephritis and infection - is primarily a childhood disease occuring after
upper respiratory infection(5-10 %) or impetigo (25%) (Streptococcus A, beta – hemolytic, serotypes 12, 49)
- in older patients: less well known Male/female ratio 2.8:1 Immunocompromised background is present in 61 %,
most often diabetes or malignancy Infectious agent most often found: staphylococcus
(46%), streptococcus (16%) and unusual gram- negative organisms.
Discussion Glomerulonephritis and infection:
IF findings in PIGN: IgG and C3, or C3 only IgA dominant PIGN: strong association with
staphylococcal infections of the skin with diabetes as a major risk. This variant of APIGN should be distinguished from the classic IgA nephropathy (Haas M Human Pathology 2008, 39, 1309-1316, Nasr S, D’Agati Nephron Clin Pract 2011, 119, 18-26)
EM findings: classical PIGN: large subepithelial deposits (humps). APIGN: often no subepithelial deposits with varied findings (subendothelial, mesangial). Our patient: NO glomeruli in EM material.
DISCUSSION Glomerulonephritis and infection in
our patient: no definite infectious agent revealed
But “immunocompromised”: alcoholism
NASR. ET AL.: Acute Postinfectious Glomerulonephritis in the Modern Era. Medicine, 87:21-32, 2008
NASR. ET AL.: Acute Postinfectious Glomerulonephritis in the Modern Era. Medicine, 87:21-32, 2008
‘In Western Europe, alcoholism had become the most important risk factor for Acute Postinfectious Glomerulonephritis’
Upper respiratory tract > skin > lung > endocarditis > teeth
56% complete remission 4-17% requiring renal replacement therapy ‘Evidence supporting the use of steroid therapy for
postinfectious crescentic GN is largely anecdotal’