Intra-University Pharmaceutical Technology &

Education Workshop

Dauch Alumni Center, Purdue University April 19th , 2006

Pharmaceutical TechnologyDesign, development & manufacture of all components of drug products &

pharmaceutical devices

• Active Pharmaceutical Ingredients

– Organic molecules (small molecules)

– Proteins & other biologics (large molecules)

• Scalable drug delivery platforms: oral, injectable, inhalable,transdermal

DiscoveryAPI ProcessDevelopment

& Design

Drug FormDevelopment &Process Design

Manufacturing

Pharmaceutical Materials Science

Clinical Trials

Pharmaceutical Product Pipeline

Small Molecule API ProcessProduce Product

Chemical Synthesis

Dry Dry ProductProduct

Mill Product

Isolate / Purify Product

•Crystallization•Extraction•Chromatography

Produce Product

Large Molecule API Process

•Fermentation•Cell Culture

Physically Isolate Product

•Centrifugation•Filtration

Purify & Polish Product

Isolate API in stable

form

•Homogenization

•Chromatography•Ultrafiltration

•Lyophilization•Crystallization

Drug Delivery Platforms

Solid Form

LiquidForm

PolymerMatrix

Solid Dosage Drug Product ManufactureAPI

Crystallization

Filtration /drying

Oven Drying

Fl. beddrying

Blending

Granulation

Milling

CompressionCoating

Lubrication

Finished Tablet

Compression

Intra-University Pharmaceutical Technology & Education Workshop April 19th , 2006, Dauch Alumni Center, Purdue University

8:00 a.m. Introduction and Opening RemarksGintaras Reklaitis, Chemical EngineeringCharles Rutledge, Vice President for Research

8:20 a.m. Overview of Pharmaceutical Technology & EducationStephen Byrn, Industrial and Physical Pharmacy

8:40 a.m. National Institute for Pharmaceutical Technology & EducationPrabir Basu, Managing Director

9:00 a.m. NSF ERC on Structured Organic CompositesGintaras Reklaitis, Chemical Engineering

9:20 a.m. Institute for Advanced Pharmaceutical Technology, 21st Century R&TVenkat Venkatasubramanian, Chemical Engineering

9:40 a.m. Chao CenterCraig Davis, Industrial and Physical Pharmacy

10:00 a.m. Break

Intra-University Pharmaceutical Technology & Education Workshop

10:20 a.m. NSF IUCRC for Pharmaceutical Processing ResearchRodolfo Pinal, Industrial and Physical Pharmacy

10:40 a.m. Consortium for the Advanced Manufacturing of Pharmaceuticals / Particle Technology and Crystallization ConsortiaStephen Byrn, Industrial and Physical Pharmacy

11:00 a.m. NIST Physical Properties WorkshopKen Morris, Industrial and Physical Pharmacy

11:20 a.m. Poster Session and Lunch

Intra-University Pharmaceutical Technology & Education Workshop

1:20 p.m. Controlled Drug ReleaseKinam Park, Industrial and Physical Pharmacy and Biomedical Engineering

1:40 p.m. BioprocessingMichael Ladisch, Agricultural and Biological Engineering

2:00 p.m. BioseparationsLinda Wang, Chemical Engineering

2:20 p.m. Vaccine TechnologyStanley Hem, Industrial and Physical Pharmacy

2:40 p.m. Product Pipeline ManagementJoseph Pekny, e-Enterprise Center & Chemical Engineering

Intra-University Pharmaceutical Technology & Education Workshop

3:00 p.m. MS Reg Compliance & CGMPNancy Davis, Regulatory Education Program

3:20 p.m. MS in Pharmaceutical Engineering

Carl Wassgren, Mechanical Engineering

3:40 p.m. Training in BioprocessingKari Clase, Industrial Technology

4:00 p.m. Panel Discussion: Future Directions for Pharmaceutical Technology and Education at Purdue

5:00 p.m. Adjournment