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Ali Al-Ibrahim

MFM Fellow

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G1P0 of Japanese descent, 35+5 weeks of gestation

First seen at the low risk clinics

Healthy, no comorbidities Married, partner of Chinese descent

Hepatits B negative, VDRL negative, Rubella immune,Blood group A Rh +ve.

No smoking, no alcohol, no radiation exposure

Prenatal vitamins and Diclectin throughout pregnancy

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At 11+6, NT 1.2

IPS negative, adjusted risk of T21 = 1:1730

Anatomy ultrasound at 19 weeks normal Routine ultrasound done at 34+5 on March 27, 2012

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In Summary G1P0, 35+5

Infra-tentorial mass (tumor) with obstructivehydrocephalus

Normal BPD and HC

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MRI on March 29th

, 2012

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Congenital Intracranial Tumors

Differential Diagnosis and Outcome

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Brain tumors occur less often in the first year of lifethan in the older child and adolescent

The peak age incidence in children is between 5 and 8years

Central nervous system neoplasms are the leadingsolid tumor in children and adolescents and are

surpassed only by leukemia and lymphoma infrequency

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During the perinatal period brain tumors arediagnosed less often than teratomas, neuroblastoma,and leukemia. However they cause over 10% of the

deaths due to neoplasms in this age period Two thirds of brain tumors in the fetus and infant

occur above the tentorium, the reverse is true for theolder child.

Some brain tumors occur in association with certainrenal tumors in infants and children, for example,cerebral primitive neuroectodermal tumor (PNET)and Wilms tumor and rhabdoid tumor

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Clin Neuropathol. 2001 Sep-Oct;20(5):181-9. Neonatal tumors of the CNS: a report of9 cases and a review.Ortega-Aznar A, Romero-Vidal FJ, de la Torre J, Castellvi J, Nogues P

Abstract

Neonatal central nervous system (CNS) tumors are an uncommon and histologicallyheterogeneous group of neoplasms with different clinical and biological features fromthose arising in childhood. We report 9 cases in which a diagnosis of CNS tumor wasconfirmed by biopsy or autopsy during the years 1982-1997 in the Vall d'HebrnChildren's Hospital, Barcelona. Two cases were fetal tumors detected by fetal sonography,3 patients were symptomatic in the first days after birth and 4 patients presented initialclinical signs in the first weeks or months of life. Eight lesions were supratentorial and 1was located in the spinal cord. According to histologic types, there were 2

glioneuronal tumors, 1 anaplastic astrocytoma, 1 choroid plexus carcinoma, 1 immatureteratoma, 1 craniopharyngioma, 1 hemangioblastoma, 1 astroblastoma and 1hemangioendothelioma. Extensive review of the literature indicates that our cases ofhemangioblastoma, astroblastoma and hemangioendothelioma are exceptional and onemore of the very rare and isolated previously published cases.

http://www.ncbi.nlm.nih.gov.myaccess.library.utoronto.ca/pubmed/11594502http://www.ncbi.nlm.nih.gov.myaccess.library.utoronto.ca/pubmed/11594502http://www.ncbi.nlm.nih.gov.myaccess.library.utoronto.ca/pubmed/11594502http://www.ncbi.nlm.nih.gov.myaccess.library.utoronto.ca/pubmed/11594502http://www.ncbi.nlm.nih.gov.myaccess.library.utoronto.ca/pubmed/11594502

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