Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 1

Introduction to Bioengineering

Presented to Chabot College ENGR10 • Nov06

Ovijit Chaudhuri

PhD candidate

Department of Bioengineering,

University of California Berkeley

Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 2

What is Bioengineering?

• Applying engineering techniques/analysis and technology to biological and medical problems. – Some areas (biomedical engineering) are

focused on medical applications and using technology for solutions to healthcare problems (traditional).

– Others are focused on using engineering principles and ideas to understand the way biological systems are constructed.

• Bioengineering is very interdisciplinary encompassing various fields.

Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 3

Prosthetics – Hip replacement

Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 4

Medical Imaging

• MRI, PET, CAT, etc …

Cuellar Clinic website

Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 5

Biomechanics

• How stiff does the hip replacement need to be? • What kind of loads will it experience?

Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 6

Biomaterials

• Mechanical properties? • Materials that are easy to

mold?• What kind of materials

are biocompatible?• Wear, tear, corrosion. • Immune Response?

www.machinedesign.com

Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 7

Improving healthcare: Lab on a chip Devices

Whitesides, Nature, 2006 Yager, et al., Nature, 2006

El-Ali, et al., Nature, 2006

Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 8

Drug Delivery

Glucose sensor/ delivery deviceGough lab, UCSD

Microjet injection deviceFletcher lab, UC Berkeley

Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 9

Industry

• Hip replacement• Other prosthetic devices• Cardiac stents (Guidant, Johnson and Johnson)• Other cardiac devices• Drug delivery devices

Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 10

Understanding the “engineering” of biological systems - Computational

Biology

Max Delbrueck Center Berlin-Buch

Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 11

Understanding the “engineering” of biological systems - Synthetic Biology

Keasling lab, UC Berkeley

Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 12

Understanding the “engineering” of biological systems -Tissue Engineering

Engler, et al., Cell, 2006

Nelson, et al., Science, 2006

Kurpinski, et al., Cell, 2006

Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 13

Understanding the “engineering” of biological systems – cell mechanics and

motility

David Rogers, Vanderbilt U.

Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 14

Atomic Force Microscopy

Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 15

Our Atomic Force Microscope

Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 16

Growing actin networks power cell movement and provide rigidity

Svitkina, et al.,JCB, 1999

Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 17

Our studies of actin networks

Parekh, et al., Nat. Cell Bio. 2005

Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 18

Questions?