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2000 Annual Report Helping and Healing Children for 60 Years 2000 Annual Report 60th Anniversary Edition

Jacksonville, Florida 32207 Helping and

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Page 1: Jacksonville, Florida 32207 Helping and

1650 Prudential Drive, Suite 300Jacksonville, Florida 32207

The Alfred I. duPont Hospital for ChildrenP.O. Box 269

Wilmington, Delaware 19899

The Nemours Health Clinic1801 Rockland Road

Wilmington, Delaware 19899

The Nemours Children’s ClinicsJacksonville

P.O. Box 5720Jacksonville, Florida 32247

OrlandoP.O. Box 568908

Orlando, Florida 32856-8908

Pensacola5225 Carmel Heights

Pensacola, Florida 32504

WilmingtonP.O. Box 269

Wilmington, Delaware 19899

Nemours Cardiac CenterThe Alfred I. duPont Hospital for Children

1600 Rockland RoadWilmington, Delaware 19803

Nemours Cardiac CenterThe Arnold Palmer Hospital for Children and Women

92 W. Miller StreetOrlando, Florida 32806

The Nemours Mansion & Gardens1600 Rockland Road

P.O. Box 109Wilmington, Delaware 19899

Nemours Center of Health Mediawww.KidsHealth.org

2000 Annual Report

Helping and Healing Childrenfor 60 Years

2000 Annual Report60th Anniversary Edition

Page 2: Jacksonville, Florida 32207 Helping and

NEMOURS…Helping and healing children for 60 years with advances in medical skill and technology and

constancy in caring.

Creative Director Paula Foster

Editor Margaret Coupe

WritersKaren BengstonSusan BrownPaddy DietzPatricia M. DucaRobert HopkinsRobert Kettrick, MDCortney TaylorJohn Walsh

PhotographersCindy BrodowayLawrence BrodowayBill CaglePam KleinsasserAlicia Komins-MorrisJoe ManlovePeter OlsonJim Peirce, Jr.Karen Zalewski

Cover PhotoPam Kleinsasser

DesignJennifer HollandHolland Creative Services

Color SeparationThe Laser’s Edge, Inc.

PrintingPritchard & Company

*Actual names of patients and their family members have been changed out of respect for the patients’ privacy.

Page 3: Jacksonville, Florida 32207 Helping and

CONTENTSReport from the Chairman and the President 3About Nemours 5The duPont Legacy 6Alfred I. duPont Hospital for Children 14Nemours Health Clinic 18Nemours Children’s Clinics

Wilmington 20Jacksonville 24Orlando 28Pensacola 32

Nemours Cardiac Center 36Nemours Center for Children’s Health Media 40Nemours by the Numbers 44Nemours Mansion & Gardens 46Nemours Staff Listings 48Publications by Nemours Professionals 56Jacob C. Belin Memorial 64

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REPORT OF THE CHAIRMAN AND THE PRESIDENT OF NEMOURS

Sixty Years. Two generations. Could Mrs. duPont or Mr. Ballpossibly have envisioned the scope, size, and depth of theorganization they established in 1940, following the 1935Will of Mr. duPont? In particular, could they have fathomed

during those dark years of the War that their stewardship, tenacity,and dedication would have resulted in a foundation which:

• had operations extending along the East Coast of the US, • treated over 200,000 patients a year,• provided the most medically sophisticated treatment possible

to the most seriously crippled children, and• employed over 350 doctors and over 1,000 care givers?

It is unlikely that they would have been so immodest.Nevertheless, that is exactly what Nemours celebrated during2000. The investments approved by the Board of Directors to elevate the level of care from high quality—but mainstream—to the highest clinical acuity, with solid organ and stem cell transplants and reconstructive heart surgery, catapulted Nemoursinto an elite group. And though these have been expensive andtumultuous to implement, they are programs that go to the soul of the Nemours Mission—the most acutely and chronically ill children.

In two generations Nemours has come from providing modest palliative care tochildren crippled by polio to alleviating many profoundly crippling conditions anddiseases. During that time Nemours has also become more efficient. Management iscommitted to furthering that efficiency, so new structures and modes of organizingand delivering care will be examined during the coming years.

The Board of Directors and the management of Nemours are proud of meetingthe Mission and providing ever-increasing quality and quantity of care in an intricateand labyrinthine industry. We continue to set our sights forward five to ten years,projecting the needs of children suffering from complex illnesses and the potentialadvances that will help us better address those needs.

The 60th year of the Nemours’ work in the Delaware Valley and 20th year inFlorida coincided with public celebration of the generosity of its benefactors. AlfredI. duPont and Edward Ball were individually honored by the state as Great Floridiansin recognition of their significant contributions to the state’s development, theirextraordinary bequests, and their impact on the lives of children in Florida.

The year also marked the passing of an era with the death of J. C. Belin. Duringhis many years as Chairman of the Board of the Nemours Foundation and a Trusteeof the A. I. duPont Testamentary Trust, he was instrumental in effecting changesthat allowed Nemours to become what it is today. His life was one of industrialinitiative and philanthropic stewardship, and we will miss his insight and perspective.

This annual report is dedicated to the more than 3,000 current employees ofNemours, and the thousands who preceded them, in gratitude for their untiringwork and effort in behalf of the children we serve. We hope that the reader willshare this appreciation for the gifted, skilled, and dedicated people of Nemours—the caregivers and those who support their efforts.

W. Jeff Wadsworth, President and CEO and W. T. Thompson, III, Chairman of the Board

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MISSION STATEMENT

Mr. Alfred I. duPont and Mr. Edward Ball instructed their Trustees to

provide care and treatment for crippled and handicapped, but not

incurable, children, as well as for the elderly. To this end, the mission of

The Nemours Foundation is to provide institutions and services to restore,

and improve, the health of acutely and chronically ill children and the elderly

through care and programs not readily available, with one high standard

of quality and distinction regardless of the recipient’s financial status.

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THE NEMOURS FOUNDATION“It has been my firm conviction throughout life that it is the duty of everyone in the world to do what iswithin his power to alleviate human suffering.”

With these words, recorded in his will, Alfred I. duPont provided for the establishment ofNemours.

Mr. duPont died in 1935 and The NemoursFoundation was incorporated the following year.This charitable institution that duPont described in his will was to provide care and treatment forcrippled, but curable children and care for the elderly, in both instances priority given to residents of Delaware, the state where he was born. Since1936, Nemours has received earnings annually fromthe Alfred I. duPont Testamentary Trust.

One of the original Trustees, Edward Ball,duPont’s loyal associate and brother-in-law, spentmost of his life building the assets of the Trust. Whenhe died in 1981, Mr. Ball left the greatest portion ofhis own estate to Nemours for the care ofhandicapped children in Florida.

Mr. Alfred I. duPont and Mr. Edward Ballinstructed their Trustees to provide care and treatmentfor crippled and handicapped children, as well as forthe elderly. To this end, the mission of Nemours is toprovide institutions and services to restore, andimprove, the health of acutely and chronically illchildren and the elderly through care and programsnot readily available, with one high standard ofquality and distinction regardless of the recipient’sfinancial status.

These institutions and services are:• Alfred I. duPont Hospital for Children in

Wilmington, Delaware.• Nemours Children’s Clinics, outpatient pediatric

subspecialty centers in Wilmington, Delaware at the Alfred I. duPont Hospital for Children, and in Jacksonville, Orlando and Pensacola, Florida.

• Nemours Health Clinic, an outpatient center for the elderly in Wilmington, Delaware.

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T H E N N O W

The Alfred I. duPont Hospital for Children was founded

in 1940 through a bequest in the will of Alfred I. duPont, upon whose estate, Nemours, the hospital now stands.

In his will, Mr. duPont said that he wanted part of his wealth to be used to “alleviate human suffering,”

especially that of children and the elderly. Shortly after his death in 1935, The Nemours Foundation was

established to carry out his wishes. Nemours is headquartered in Jacksonville, Florida, where Mr. duPont

and his wife, Jessie Ball duPont, maintained a winter residence.

6 0 Y E A R S I N D E L AWA R E

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1940s & 1950s1940 — The Alfred I. duPont Institute opens its doors.

1950 — In the 1950’s the average stay atthe duPont Institute was 73 days.

1959 — The duPont Institute adds a newoutpatient clinic and additionalresearch laboratories.

O R T H O P A E D I C B E G I N N I N G S

Mrs. duPont appointed Alfred R. Shands, Jr., MD,as the first medical director, and the Alfred I. duPontInstitute opened its doors to treat “crippled children”on July 1, 1940. A young mother carried the firstpatient into the hospital, a two-and-a-half-year-old girl with congenital dislocation of the hip. After recovering from surgery performed by Dr. Shands, the girl walked out of the hospital.

L E A D E R S H I P O V E R T H E Y E A R S

Alfred Shands, MD, “wrote the book.” In the 1930she wrote The Handbook of Orthopaedic Surgery, atext that was reprinted often and that has guided thecareers of many physicians in training. In 1937 hecame to Wilmington, Delaware, and served as medicaldirector of the Alfred I. duPont Institute for 22 years.

G. Dean MacEwen, MD, took over the direction ofthe hospital in 1958 and stayed until 1984. His uniquecombination of skill, vision and charisma led the hospitalinto the forefront of pediatric orthopaedic practice. In1960, under his direction, duPont became one of thefirst hospitals in the country to perform spinal fusionsurgery with an internal fixation device, fusing a thinsteel rod to the patient’s spine to straighten it permanently.Thanks to Dr. MacEwen, Delaware became the firststate to perform school screenings for scoliosis. Dr.

MacEwen also focused on education and training:more than 20 percent of U.S. orthopaedic surgeons inpositions of clinical and administrative leadership todayreceived training at duPont. By the mid 1970s, Dr.MacEwen had done his job so well that the hospitalwas overcrowded. He oversaw the planning for a new,million-square-foot facility, which opened in 1984.

From 1986 until 1999, Robert Doughty, MD, PhD,served as medical director. He was the hospital’s firstpediatrician-in-chief, and its first non-surgeon medicaldirector. Dr. Doughty helped to establish an academicalliance with Thomas Jefferson University and bringJefferson’s pediatric residency program to Wilmington.By assembling an impressive group of physicians andsurgeons to head new and developing programs, Dr.Doughty oversaw the hospital’s transformation to afull-service children’s medical center. He is now VicePresident for Nemours Physician Practices, with abroader focus for the multiple clinical sites, north and south, of the unified physician group.

T H E E M E R G E N C E O F A W O R L D - C L A S SFA C I L I T Y

Today the Alfred I. duPont Hospital for Childrenserves thousands of families in the Delaware Valley region.In addition, our magnet programs in orthopaedics, oncology,cardiology, cardiac surgery, and organ transplantationattract patients from across the country and around the

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T H E D U P O N T L E G A C Y: H I S T O R I C A L P E R S P E C T I V E

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1960s & 1970s 1968 — The duPont Institute, along with Wilmington Medical Center, creates a program to detect andtreat congenital hip dislocation in infants.

1970 — The average stay at the duPontInstitute is 47 days.

1975 — The duPont Institute starts a rehabilitation program for childrenand teens with brain and spinalcord injuries.

world. In 1999, the duPont Hospital performed morethan 12,000 surgical procedures and logged more than300,000 visits at its various locations throughoutDelaware, Pennsylvania and New Jersey.

T O D AY ’ S L E A D E R S

Roy Proujansky, MD, took over the medical leader-ship of the hospital in 1999, managing the clinical,education and research programs conducted by theemployed medical staff of the duPont Hospital forChildren, which numbers more than 180 physicians.Dr. Proujansky is also Robert L. Brent Professor of

Pediatrics and chairman of that department at JeffersonMedical College. He had been chief of the Division ofGastroenterology since 1989. Thomas P. Ferry has beenat the administrative helm of the hospital since 1979.Under his leadership, more than 20 medical and surgicalprograms have been added and the clinical volume ofthe hospital has increased twenty-fold. Mr. Ferry waspromoted to Vice President of Hospital Operations forThe Nemours Foundation in 1999.

N U R S I N G R E F L E C T I O N S

“When I started working here at the hospital, ourpatients convalesced for months,” says Maryke Cottman,RN, who joined the staff in 1969. In the 1970s, childrenundergoing spinal fusion for scoliosis would be hospital-ized for two weeks in traction before surgery and up tosix months in a chin-to-hip body cast. “Now, kids arein and out in a few days. It’s hard to believe I’ve beenhere 30 years—and how much things have changed.”Kay Upp, RN, who has been on staff for more than 20years, has similar recollections. “Each summer, the wardswere full of young girls getting fusion. It was how theyspent their summer vacation.” Now fusion patients arewalking two days after surgery. Most don’t need a castand most go home within a week. “I feel I’ve witnesseda lifetime’s worth of change,” adds Marilyn Boos, RN,advanced practice nurse for the cerebral palsy program.Since her arrival on staff 28 years ago, she has seen morefamily involvement and better collaboration between

T H E D U P O N T L E G A C Y: H I S T O R I C A L P E R S P E C T I V E

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Page 11: Jacksonville, Florida 32207 Helping and

1980s & 1990s1986 — Robert Doughty, MD, is appointedmedical director, the first non-surgeon to head the hospital.

1998 — The Nemours Cardiac Center opensat the duPont Hospital for Children.

doctors and nurses. “We’ve gone from a relatively slow-paced facility to doing open-heart surgery and organtransplants. Even though I’ve lived and worked throughit all, I’m still amazed,” says Upp. “The nursing unitsare different, the diagnoses are different. But for thoseof us with a passion for pediatrics, we’re taking care of kids, and that’s what we love to do.”

P O T E N T I A L F O R F U T U R E C A R E

From its inception, the mission of the Alfred I.duPont Hospital for Children has included a significantcomponent for research. Thomas R. Brown, MD, whowas the first Chairman of the Medical Advisory Boardbeginning in 1937, was charged with planning a programof basic research related to problems of the “crippledchildren” served here.

The three-fold mission of patient care, educationand research has always been at the core of the workdone under the auspices of Nemours Research Programs.When the mission was updated to include a vision andvalues statement for the organization, research wasimportant, as always. One core value notes: “We arecommitted to scholarly and scientific inquiry directedtoward the health of children.”

How do you mend a broken heart? The researchteam working in the Tissue Engineering & RegenerativeMedicine (TERM) Lab headed by Robert Akins, PhD,

has an unexpected answer: biosynthetic implants.Researchers in the TERM lab are working to developimplant materials that surgeons can use in the treatmentof congenital and acquired heart diseases. The centralidea is to salvage pieces of tissue that are removed duringsurgery and break the tissue down into individual cells inthe lab. These cells are then rearranged to form a new pieceof tissue that can potentially be used to augment heartfunction in another patient. So far, the team has beenremarkably successful in producing small implants thathave many of the functional features of the intact heart.

Prospects for the use of this type of technology arevery exciting. The goal of the research team is to producebiosynthetic implants within the next decade. Withstrong and consistent teamwork, they look forward to bringing cardiac tissue engineering into a surgicalsetting to help many children with heart diseases.

Despite its longstanding history, the hospital is stilla dynamic organization—standing ready to changewith the times. Just as the hospital has evolved from anorthopaedic institution to a full service children’s hospital,so too has the nature and scope of research performedthere changed. Research is an organization-wide endeavor,spanning all operating divisions of Nemours. Clearly,research and education make it possible for Nemoursto brighten the lives and health of many more childrenthan can be accommodated even within the walls ofthe expanded system.

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T H E N N O W

As Nemours in Delaware observes the 60th anniversary

of dedication to advancing children’s health needs as defined by the Foundation’s Board, Nemours in Florida

celebrates twenty years of progress toward expanding the realization of that mission. From modest beginnings,

the Florida-based system for subspecialty pediatric care is rapidly evolving to become comparable in quality

and scope to Nemours programs and services established in Delaware.

2 0 Y E A R S I N F L O R I D A

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1980s 1981 — The Nemours Foundation acquiredthe Hope Haven Children’s Hospital.

1982 — Wood W. Lovell, MD, appointed medical director.

1985 — The Pediatric Surgical Associatesjoin Nemours.

H O P E H AV E N C H I L D R E N ’ S H O S P I TA LB E C O M E S N E M O U R S

Jacksonville had been the winter home of Alfred I.duPont and his wife Jessie Ball duPont. After their deathit was the operational headquarters for the duPontTestamentary Trust and a good share of Edward Ball’sbusiness enterprise. So in 1980 when the Trustees soughtthe right combination of factors to hasten success of theirFlorida venture to improve the health of children, it wasfitting that the first part of the answer was found inJacksonville. On February 1, 1981, the former HopeHaven Hospital, founded at the end of the 19th centuryin Jacksonville, was purchased by Nemours and becameThe Nemours Children’s Hospital. The historic communityresource—which had benefited from the largesse of JessieBall duPont and other civic-minded leaders—held promiseto more than meet the desires of the directors as theylooked in Florida to benefit crippled but curable children.Hope Haven, which continues to this day as a separateorganization dedicated to serving children with speechand learning disabilities, also provided the seed forconception and development of a unique medicaldelivery model: the Nemours Children’s Clinic.

Hope Haven had previously emphasized orthopaedics,repair of congenital anomalies such as cleft palate, andrehabilitative programs similar to services provided atthe hospital in Wilmington. Like the duPont Hospitalfor Children in Delaware, the newly acquired NemoursChildren’s Hospital in Jacksonville was also redirected

to encompass a broad array of children’s illnesses.New services were added to the hospital, and essentiallya new medical staff—a Medical Panel created to carefor the children. Nemours Children’s Hospital uniquelyaccepted Medicaid and Children’s Medical Servicepatients without question; Nemours paid the doctors and absorbed the hospital component of care. The first year, these services exceeded $2 million.

A consultant was retained to help with plans for thefuture of Nemours and its now dual geographic focus(Delaware and Florida); his report recommended somecentral management of programs to implement themission, and a general manager was appointed to provideleadership to the operational programs of Nemours.The Foundation, now with central management for its children’s health initiatives, began to envision the potential of matching the Nemours mission andresources with the needs of children whose physicallimitations and illness might be improved or cured.

A P L A N F O R S U P E R S P E C I A LT Y C A R E—F O R K I D S

In 1984 the Trustees directed its management tofashion a long-range plan for Nemours: a vision forchildren’s care in Florida and Delaware, using hospitalsand physicians to provide treatment toward a “cure”for a range of pediatric scourges, involving the bestskill and talent available for such conditions. It alsocalled for research and teaching: medical education

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T H E D U P O N T L E G A C Y: H I S T O R I C A L P E R S P E C T I V E

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1980s & 1990s 1988 — Albert H. Wilkinson, Jr., MD appointed interim medical director.

1990 — Moved into new Nemours Children’sClinic building in Jacksonville.

1996 — Robert G. Kettrick appointed new medical director.

for future pediatric specialists and health education for children and families. What better way to spreadthe duPont legacy “in perpetuity”?

Physicians in Jacksonville had become sold on theconcept of a centralized system of care for children. Localhospitals and physicians had consolidated pediatric careto a degree at Baptist and its Wolfson Children’s Hospital,so it was natural that the primary hospital partner forNemours in Jacksonville has been Wolfson. Other alliances—with Mayo and various universities and medical schools—have been created for purposes of education andresearch. Foundation directors were convinced that thegreatest unmet need for children in Jacksonville wasimproved pediatric specialty physician services and notmore hospital beds. The Nemours Children’s Hospitalwas transformed into the first Nemours Children’sClinic: a “Mayo-like” facility for children that wouldwork with its chief inpatient affiliate in close allianceto present a continuum of children’s services.

The Nemours team lost little time in putting togetherthe core of what would become one of the most respectedmedical teams in Florida. From offices in the HowardBuilding on the Wolfson campus, physicians with creden-tials, reputations, and respected skill were assembled tocome to Jacksonville and build a new venture based ontrust and vision. The first recruits in July 1985 includedthe practice of Drs. Wilkinson and Webb—PediatricSurgical Associates. Warner Webb, MD, had beenChief of Staff at Hope Haven and saw the need for

children in northern Florida to have this opportunity.(He now says unequivocally that the current localstandard of excellence can be directly credited to Nemours, its resources, and its visionary leadership.)

The facility that houses the first Florida NemoursChildren’s Clinic—NCC-J—was completed and occupiedin fall of 1990. Linked as it is to the affiliated Wolfsoninpatient pediatric program by a high-level walkwaythat straddles a major interstate highway, it is animposing eleven stories high. More impressive are thephysicians and staff who raised the expectations forpediatric care in northern Florida. Among the medicalleaders who contributed to this record of advancementwere Wood Lovell, MD, the first medical director ofNemours Children’s Hospital, Albert Wilkinson, MD, thefounding medical director of Nemours Children’s Clinic,and Morey Haymond, MD, the first medical director.

Others in Florida looked to Jacksonville for adviceand involvement. After repeated visits to Orlando forconsultation on developing children’s services at theArnold Palmer Hospital and related medical practices,Nemours was invited to establish a practice similar to the one in Jacksonville. An Orlando presence wasestablished in 1996. Similarly, hospital leaders atSacred Heart in Pensacola invited Nemours to becomeinvolved in children’s medical care in the Panhandleand northwestern part of Florida; that was begun in1998. By now, the same Nemours Children’s Clinicmodel begun at Jacksonville—collaborating with local

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1990s & 20001998 — Nemours Children’s Clinic openedin Pensacola.

2000 — John Cheatham, M.D., an interven-tional cardiologist, broadened theoptions for children at the NemoursCardiac Center site in Orlando.

providers to optimize children’s care—was representedin newer locations in Florida.

What’s past may be prologue. More than a millionclinic visits have been provided to Florida’s children byNemours specialists—physicians who set the standardin their field in children’s heart disease, orthopaedics,cerebral palsy and other birth-related conditions, diabetes, cancer and pulmonary medicine. Under way in Orlando is the second phase of development for theNemours Cardiac Center, which brings world leadersin cardiac services to children in Florida at the Orlandocampus. The future of Nemours and its mission werestrengthened in 1999 by the creation of a more corporatestructure for planning and executing its operationalprograms.

H I S T O R I C C H A N G E I N J A C K S O N V I L L E —A C A S E S T U D Y

In recalling the scope of his practice in his earlyJacksonville days, Jay Cummings, MD, one of the firstorthopaedic surgeons recruited to practice with Nemours,described the treatment to relieve some of the mostdebilitating and painful aspects of cerebral palsy,uneven limb development, spina bifida, congenital hip and foot anomalies, and scoliosis—conditionsrequiring prolonged periods of uncomfortable, some-times painful treatment. Patients, families, health professionals and the community can rejoice at thechange in a relatively short time.

In Jacksonville in mid 2000, Cheryl was referredby her physician to Dr. Cummings at NCC-J for treatment of her scoliosis that was progressing despite the use of bracing. He offered her and her mother the possibility of an endoscopic instrumentation andfusion or the traditional posterior fusion through anopen incision. Their choice was for the minimally invasive technique. The procedure performed by Dr.Cummings and his associate, Eric Loveless, MD, was the first such procedure performed in this area. Throughfour small incisions, the discs between the curved vertebrae were removed. Screws were then inserted into the vertebrae. The screws were then connected to a straight steel rod, thereby straightening her spine. This procedure will prevent increasing deformity and potential problems with back pain and lung function. More importantly for a teenager, it will allow her to look more like her peers. Her hospital stay was measured in days and her prognosis is excellent.

Warner Webb, MD, one of the early Nemours-in-Florida medical leaders, recently described Nemours as “the best thing that happened for children’s health in this area.” Now, twenty years after unprecedentedadvancement in children’s pediatric care in north and central Florida, Nemours is poised to continue to answer the challenge offered by the Foundation’sbenefactors: to provide institutions and services torestore, and improve, the health of acutely and chronically ill children.

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1996 — Expansion to Orlando.

Ian Nathanson, MD, appointed new medical director.

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This year the duPont Hospital for Children added two programs of national

stature to complement its range of exceptional services. The Division of Solid

Organ Transplantation, headed by Stephen Dunn, MD, was developed to add

liver transplantation to the hospital’s existing program in kidney transplantation.

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ALFRED I. DUPONTHOSPITAL FOR CHILDREN

Wilmington, Delaware

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In July, Dr. Dunn essentially moved his renownedteam and program of 13 years from St. Christopher’sHospital for Children to the duPont Hospital. It is one of the nation’s most active organ transplantprograms for children, with the expectation ofdoing 20 or more transplants annually. As ofDecember, Dr. Dunn and his team had successfullyperformed six liver transplants and one kidneytransplant. (Kristina’s story as duPont’s first livertransplant case is told on page 17.)

Secondly, construction and furnishing of theBlood and Bone Marrow Transplantation Unit wascompleted in 2000. The unit, headed by nationallyrenowned transplant surgeon Michael Trigg, MD,was planned to open for patients early in 2001. An open house was held inOctober to give hospital staff and visitors an opportunity to tour the spaciousand comfortable 10-bed unit. In addition to the patient rooms, which includesleeping accommodations for parents, the unit offers a playroom with exerciseequipment; child life activity space; classroom for educational activities; familylounge; and many more features that support effective staff interaction withpatients and families. Following the opening, the unit was closed for ongoingextensive environmental testing to ensure that it is clean and safe prior to itsofficial opening in January.

Phases I and II of the hospital’s surgical expansion project were completed in 2000. New operating rooms and an endoscopy suite were opened to accommodate the increasing demand for surgical services. In addition, the new Ophthalmology and Dental Care Centers were finished and ready for business by year’s end. These cheerful, eye-catching areas are not only appealing but are designed to promote efficiency and comfort for both patients and staff. The new Post Anesthesia Care Unit is nearly completed and construction begins early in 2001 on a new outpatient care center tohouse Urology and Urodynamics, among other services. In addition, patient care units are getting a facelift to assure consistent thematic design with newer hospital programs. Attractive new wallcoverings, furniture, flooring,lighting and other aesthetic touches are being added while the units remain fully operational.

At the annual meeting of the medical staff in November, Administrator/CEOTom Ferry named Rita Meek, MD, to the position of hospital Medical Director,effective January 1, 2001. In this role, Dr. Meek is responsible for coordinating the medical functions of the hospital (as distinguished from the practice),including quality of care, program planning, hospital medical staff management,credentialing and accreditation.

She will work closely with hospital and practice administration whilemaintaining her clinical practice in hematology/oncology. Dr. Meek, who was the state’s first board-certified pediatric hematologist/oncologist when she arrived in Delaware in 1984, established the children’s cancer program at the duPont Hospital in 1994.

Thomas P. FerryAdministrator/Chief Executive

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KristinaParlin, New Jersey

When Kristina’s parents took her home from the hospital, she was, likemany newborns, a tad yellow. Hyperbilirubinemia, or newborn jaundice,affects nearly half of all infants in the first few days after birth. Parents are typically advised to take the baby home and expose her to sunlight toreduce the jaundice. In Kristina’s case, it didn’t work. In fact, the baby’s yellow discoloration only got worse. By the time her doctor realized Kristina’snewborn jaundice was something much more serious, there was no time to lose.

Biliary atresia, a condition which causes the liver to fail rapidly, meantthat Kristina’s only real hope was a liver transplant. At that point, the familywas referred to Stephen Dunn, MD, one of the country’s most renowned livertransplant surgeons. Kristina’s mother, Michele, was able to donate a portion of her liver to Kristina, thanks to living related donor techniques pioneeredand perfected by Dr. Dunn and colleagues in the division of solid organ transplantation. Mother and daughter were the first liver donor/liver transplant patients at the duPont Hospital for Children and made a happily successful debut. Kristina is now home in Parlin, New Jersey, and comes to the hospital for regular check-ups. She is plump and thriving.

In July 2000, the new Division of Solid Organ Transplantation under Dr.Dunn’s leadership initiated a liver transplantation program at the duPontHospital for Children, in addition to augmenting the hospital’s existing programin kidney transplantation. Dr. Dunn, an internationally renowned transplantsurgeon, was previously director of the liver and kidney transplant program at St. Christopher’s Hospital for Children in Philadelphia for 13 years. Hisparticular expertise is in the area of living related donor procedures, whichallow living relatives to donate a segment of liver for transplantation. Thistechnique makes it possible for more children to receive liver transplants in a timely manner. In addition, Dr. Dunn hopes to develop programs of smallintestinal transplantation and pancreas transplantation for patients with diabetes at the hospital.

Roy Proujansky, MD, Chief Executive of the Practice and Chairman,Department of Pediatrics, said: “We are thrilled with Dr. Dunn’s decision to move his program to the duPont Hospital for Children. Dr. Dunn’s skills,enthusiasm and vision perfectly complement our future growth and directionas a major provider of pediatric specialty care in the region.”

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To offer quality health services to the elderly and bring comfort to them

is a rewarding profession of those who work for Nemours Health Clinic

in Wilmington, Delaware. Here is the story of a lady who greatly benefited

from these services and wanted others to know her story.

NEMOURSHEALTH CLINIC

Wilmington, Delaware

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BlancheWilmington, Delaware

Blanche came to Nemours HealthClinic in 1993 after hearing fromneighbors and acquaintances about the “wonderful” place to receivehealthcare services for seniors inDelaware. Physical changes at 79 in her overall health had necessitated hertaking daily prescription medications —for high blood pressure, cholesterolreduction, colitis and pain. None werecovered by either Medicare or hersecondary insurance carrier. The costof these medications seriously cut intoher modest income. At Nemours, shewas elated to learn that she could gether prescriptions discounted, whichwould give her significant savings. Withher enrollment at NHC she would alsogain access to any dental, eye andhearing needs at the same location.

Blanche had multiple medicalproblems that were also causing her discomfort, and when she presented for an initial exam at the dental clinic,these were also discussed. She had sought help without remedy for jaw pain inthe lower arch and was experiencing dry mouth syndrome. The dentist indicatedthat her jaw pain might stem from a vitamin deficiency brought on by her colitis;a daily multi-vitamin was prescribed to alleviate the condition. Her dry mouthcould be remedied by drinking small sips of water throughout the day.

When Blanche returned in two weeks to begin her dental treatment, shewas excited to report that both her immediate problems of jaw pain and drymouth were greatly reduced after following the dentist’s suggestions.

Barbara, Blanche’s daughter and primary caregiver, says that delivery ofservices is excellent in all aspects at NHC. “Each area has staff members whoreally care not only about the patient, but who also show kindness to those whoare the caregivers. The pharmacists take the time to explain the medications,their usage and also the interactions with both prescription and over-the-counter drugs. My mother had suffered with her oral problems of jaw painand dry mouth for years, and Nemours helped her get a positive resolution to both. Nemours staff tends to the whole patient, recognizing her relationshipwith family members. The entire staff is there in time of need to just give a hug, when you are having a rough time of caring for a senior parent. Both mother and I are so very grateful for the excellent services provided by Nemours.”

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Nemours Children’s Clinic—Wilmington experienced unprecedented

growth in 2000, not only at the main hospital campus but at practice

sites throughout the Delaware Valley.

Positions of leadership were filled as Marc S. Keller, MD, and

NEMOURSCHILDREN’S CLINIC

Wilmington, Delaware

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Stephen Dunn, MD, joined the practice in the rolesof Chairman, Medical Imaging, and Chief, Divisionof Solid Organ Transplantation, respectively.

Dr. Keller was previously Director of PediatricDiagnostic Imaging and Professor of Radiology andPediatrics at Yale-New Haven Children’s Hospital.Dr. Dunn was previously Director of the Liver andKidney Transplant Program at St. Christopher’sHospital for Children and Associate Professor ofSurgery at the Medical College of Pennsylvania/Hahnemann University. Dr. Dunn’s team manages one of the country’s most active programs in pediatric liver transplantation.

In the year 2000 the pediatrics staff of Thomas Jefferson Universitybecame employees of the NCC—Wilmington practice. This group of more than 100 physicians, nurses and support staff includes general pediatricians,neonatologists and hospitalists at Jefferson and its health system affiliate, Bryn Mawr Hospital.

The Practice has responded vigorously and successfully in one of the nation’smost competitive markets as new specialty pediatric partnerships continue tobe forged with other health systems. The most recent addition: Virtua Health,a five-hospital network in southern New Jersey. This partnership holds muchpromise, both in terms of geographic reach and the fact that more than 7,000children are born at Virtua hospitals each year. As part of our long-term growthand commitment to the Atlantic City Medical Center, a new 15,000-square-footspecialty center was officially opened at the AtlantiCare Healthpark in the falland is now the centerpiece of our partnership there.

Our primary care network, duPont Pediatrics, also experienced considerablegrowth in 2000. Two offices were consolidated into one expanded site at St.Francis Hospital in downtown Wilmington. The result has been increasing efficiency coupled with increasing patient satisfaction. In the growing communities of Bear and Milford, Delaware, duPont Pediatrics moved into more spacious offices to accommodate new patient volume. In Dover, the practice has also outgrown its original site and plans are underway for expansion later this year. duPont Pediatrics primary care offices continue to earn praise for service, quality and patient satisfaction.

Many strategic prerogatives have been taken away from health providersin this marketplace. That the A. I. duPont Hospital and NCC-W continue tosee increasing demand for both primary and specialty pediatric services makesthe past year all the more remarkable. The Hospital and the Clinic have longrealized the most important resource of any organization is the human resource,and that fact continues to drive what’s done and how it’s done in Wilmington.Under the leadership of Roy Proujansky, MD, the Clinic continues to providenational leadership in the delivery of health care to children.

Roy Proujansky, MDChief Executive of the Practice

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AiryelElkton, Maryland

“It wasn’t a day I would want to relive,” said Elkton, Maryland, resident Angela. She had noticed that her 10-month-old daughter Airyel had some swelling and discoloration around her eyes, so she brought her to the pediatrician for the baby’s first sick visit. The pediatrician suspectedneuroblastoma with orbital involvement and ordered a CT scan and abdominalultrasound, which confirmed his suspicions. He immediately sent Airyel to the duPont Hospital for Children. “They started running tests to see howadvanced the cancer was. It was at stage IV. The tumor had spread throughout her body—into her bones and behind her left eye, pushing it forward,” Angela recalled.

After two days of imaging studies and laboratory tests, Airyel had surgery to remove the primary tumor from her adrenal gland. “I was imagining theworst. They had to pry her out of my arms,” Angela remembered. After Airyelrecovered from surgery, she began treatment with chemotherapy under thewatchful care of the physicians at NCC-W.

The support of the social workers, nurses and physicians made all the difference to Angela. When Airyel had her surgery, Lee Lucas, oncology socialworker, was by Angela’s side. Oncologist Gregory Griffin, MD, explained things in a way that made it easy for Angela to understand what was happening.“They adapted to all of our needs. I stayed in the hospital with Airyel. When my family couldn’t come, they were all of the support I had. They helped me with insurance and catered to Airyel’s sister, too.”

Now Airyel’s cancer is in remission and she is into everything. She is runningaround and getting into things, doing her best to annoy her sister. Angela speaksconfidently: “If we get through this okay, I will be the world’s proudest mother.I know Airyel will be able to do anything she chooses to do.”

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At Nemours Children’s Clinic in Jacksonville, the year 2000 was one targeted to

cut costs while continuing to advance the quality of services. The Nemours

Children's Clinic in Jacksonville confronted these challenges and will enter

the year 2001 having effected economies in the delivery system while at

NEMOURSCHILDREN’S CLINIC

Jacksonville, Florida

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the same time advancing, strengthening, and refining existing programs.

In the Department of Anesthesiology, Richard Helffrich, MD, turned the chairmanship over to Sal Goodwin, MD. Before coming toNemours, Dr. Goodwin was a Professor ofPediatrics, Anesthesiology and Critical Care at the University of Florida in Gainesville. He is a nationally recognized leader in the field of pediatric anesthesiology and critical care. Inaddition, Karen Ott, MD, Marjorie Lewis, MD, and Jane Goodwin, MD, joined the department. The addition of these exceptionally bright and well-educated individuals gives additional strength to our efforts in pain care for children.

The pediatric endocrinology service in Jacksonville represents one of the strongest programs in the country. Nelly Mauras, MD, continues to lead an exceptional service, education and research effort. The Northeast FloridaPediatric Diabetic Center, a partnership with the Wolfson Children’s Hospital and the Nemours Children’s Clinic led by Larry Fox, MD, is increasingly influential in northeast Florida. The Diabetes and Me newsletter edited by Dr. Fox is distributed throughout the Nemours practices. Priscilla Gagliardi,MD, joined the practice this year following training at the University HospitalBrasilia, as well as the University of Kentucky and the Children’s Hospital of Cincinnati.

In Radiology we added Christopher Zaleski, MD, who comes to us from the University of Miami where he was an Associate Professor. Dr. Zaleski has quickly established himself with referring physicians as an outstandingradiologist and with residents as an outstanding educator.

Samir Midani, MD, formerly of the University of Florida, has joined us full time as our Division Chief of Infectious Diseases. As a superb clinician and educator, Dr. Midani establishes an independent Nemours practice ininfectious diseases.

Dan Mollitt, MD, formerly a Professor of Surgery at the University ofFlorida in Jacksonville, has joined Nemours as Chief of the Division of General Surgery. Dr. Mollitt joins a clinically talented group that includes Warner Webb, MD, James Borger, MD, Maryanne Dokler, MD, and JohnNoseworthy, MD. We look to Dr. Mollitt to expand both the clinical and academic agenda in the area of pediatric general surgery at Nemours.

ENT emerges as a revitalized and stronger division. Daniel Wohl, MD,from the Medical College of Virginia, and Gary Josephson, MD, from theUniversity of Miami, team up to bring the practice a level of expertise and sophistication that bodes well for the future of the department as an integral part of the Nemours Children’s Clinic in Jacksonville.

Robert G. Kettrick, MDChief Executive of the Practice

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ChrissyMiddleburg, Florida

In April of 1985 Chrissy was diagnosed with type 1 diabetes when she was just 14 months old. She doesn’t remember what life was like without having to poke her finger and take shots. Always an active child, her lifestylehas become even more hectic as a popular teenager—complicating control ofher diabetes and making its management more difficult. The oldest sibling in a family of five, her day starts at 6 a.m. and often doesn’t end until 10 p.m.Trying to maintain a consistent eating pattern between her Middleburg HighSchool schedule, church and community activities was next to impossible. Shewas taking up to five injections of insulin a day in an effort to maintain good control.

Chrissy finally started using an insulin pump a year and a half ago, just after she turned 14. Since then, her blood sugar control has improveddespite the demanding schedule she keeps. Chrissy has never considered diabetes to be a problem in her life; in fact, she even feels it has taught her to accept responsibility at a young age. Her efforts to maintain good bloodsugar control have easily extended to other aspects of her life where self-discipline and commitment pay off. As a child with diabetes, Chrissy attendedCamp JADA, the local diabetes day camp sponsored by the American DiabetesAssociation. Today Chrissy is a counselor at Camp JADA and setting an example for other youngsters with diabetes. By sharing her story of CampJADA and her life with diabetes, Chrissy was recently notified that she wasselected to represent her school statewide in the Prudential Community Service scholarship competition.

Chrissy is a leader. She excels in band, where her responsibility for the clarinet section has contributed to the marching and concert bands’ outstanding performance in competition. She stands out academically, where she belongs to the National Beta Club and was recently inducted into the National Honor Society. She sets a fine example in generosity, sharing her talents—she tutors other students, which she really enjoys. She is a class officer, on the planning committee for this year’s prom, and is a member of SWAT—Students Working Against Tobacco. Chrissy is active in her church youth group and tours with them as far away as New York, Texas and Jamaica to give musical performances, participate in Bible study and witness for her faith.

Chrissy is not shy or slowed down by the fact that she has diabetes. She is considering a career in the ministry and has started to apply for college scholarship monies. Picture a young woman in charge of her life! No chronic illness is going to slow Chrissy down and prevent her from enjoying life or from her accomplishing all she chooses to do!

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Nemours Children’s Clinic—Orlando has realized and is planning for major

advances at the start of the new millennium. The size, scope, and geographic reach

of the practice are growing, bringing greatly improved access to subspecialty

pediatric medical care for children and families in Central Florida. From a clinical

NEMOURSCHILDREN’S CLINIC

Orlando, Florida

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perspective, there is both an increased demand for services, and NCC—Orlando physicians are delivering care to an increasingly medically complex population. Technological advances such as introduction of the electronic medical record(EMR) promise mid- to long-term enhancements to the quality and cost-effectiveness of patient care delivery.

Complementing the work of NCC—Orlandowill be the presence in Orlando of the Florida operational site of the Nemours Cardiac Center,with a world-renowned faculty that other Nemoursstaff welcome in a collaborative embrace. Thisrecent addition of physicians and surgeons fromaround the world has enhanced what was already a superior group of subspecialists and has added a link to the A. I. duPont Hospital for Children,home to the original Nemours Children’s Cardiac Center site.

The Nemours Children’s Clinic—Orlando continues to build relationshipswith community physicians to strengthen the quality and continuity of care.For example, local pediatricians have been receptive to the introduction of thehospitalist group, which is comprised of doctors who assume care for childrenduring their stay at Arnold Palmer Hospital for Children & Women. The child’sprimary care doctor is fully apprised of the patient’s medical treatment during thehospitalization, relieving the referring physician of difficult time and geographicalcommitments that often interfere with other patient care. For those doctorsaffected by the dilemma of trying to be in two places simultaneously, the hospitalist program has been a great support.

The Central Florida community served by Nemours has also expanded to include the Daytona Beach area and Melbourne, where offices now providespace for doctors who visit on a weekly basis. As a result of a commitment to the East Central Coast of Florida, services of this outstanding group of subspecialists can be extended to an additional population of one million.

In October, Nemours physicians began treating critically ill children inDaytona Beach at Halifax Medical Center’s new pediatric intensive care unit— Speediatrics. A similar exclusive agreement is being developed with HolmesRegional Medical Center in Melbourne. Their new unit is expected to be openin the spring of 2001.

The response to NCC—Orlando in Central Florida has been enthusiastic,as families realize the benefits that come with access to the highest caliber of physicians and surgeons. For those children who have multiple medicalissues, the convenience of physical proximity of the doctors has been an addedadvantage. The commitment to the local community is an integral part ofwhat makes Nemours a good neighbor, and what has made success of NCC—Orlando so complete. Civic leaders have joined relieved parents and caregiversin welcoming this group to Central Florida.

Ian Nathanson, MDChief Executive of the Practice

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BeckyMelbourne, Florida

In July of 2000, Becky’s family set out for a much-anticipated family adventure. After camping for a week in the mountains of North Carolina, they proceeded to Virginia and then on to Washington, D.C. On the Fridaybefore they were to return home, the ten-year-old began complaining ofheadache and fever. Her mother, Anna, figured that the cold her son had been fighting had finally caught up with Becky. Later that day, on a train ride, Becky laid her head down in her mother’s lap. Anna then noticed a tick on Becky’s ear and promptly removed it. Two day’s later, while travelingthrough South Carolina, Becky’s mother discovered that not only had Becky not improved, she had now begun to develop a rash on her face, neck, and abdomen.

The parents began treating Becky with Benadryl to help the rash. BySunday they had made it home, but their child was apparently getting worse.They took her to the doctor the following morning. The doctor diagnosed herwith strep throat and possibly scarlet fever. He prescribed penicillin for Becky;but by the following Saturday she had lost her appetite, had become less alert,and was having trouble doing the smallest of tasks.

On Saturday, the doctor’s office instructed the family to take Becky directly to the hospital. By 6:45 that evening, she had slipped into a coma. She testedpositive for meningitis and was immediately transferred to Arnold PalmerHospital for Children & Women for more specialized care. She was met at the hospital by Robert Pettignano, MD, Nemours’ newest addition to theCritical Care team. He quickly assessed her situation and suspected that Becky was in grave danger. Her tiny body was not responding to the prescribedantibiotics and her rash was not symptomatic of scarlet fever. Dr. Pettignanothen decided to call in Michael Muszynksi, MD, a Nemours infectious diseasespecialist, to confirm his speculation that Becky may have contracted RockyMountain Spotted Fever on her recent camping trip. Having seen numerouscases of Rocky Mountain Spotted Fever during his fellowship training atOklahoma Children’s Hospital, Dr. Muszynski concluded that this was indeed the case.

Becky was given a regimen of tetracycline and slowly but surely began torespond to the drug. After two and a half weeks at Arnold Palmer Hospital, shewas finally ready to go back to her local hospital in Melbourne. She continued to improve during another three weeks of rehabilitation and two weeks of outpatient care.

Becky is now back in school with her fellow fifth-grade friends. Her lovefor bike riding and skating has motivated her to get back to her old scheduleand regain her mobility.

The family is grateful for the expertise and teamwork of two fine physicianswho recognized the urgency of Becky’s grave situation in time to save her life.

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Nemours Children’s Clinic—Pensacola (NCC-P) has greatly expanded in the

Year 2000, starting with a smooth transition into its new six-story building

where construction began in the early months of 1999. Many new programs

have been great successes for the clinic this year.

NEMOURSCHILDREN’S CLINIC

Pensacola, Florida

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New physicians such as Cynthia Reyes, MD,pediatric surgeon, Alan Sacks, MD, pediatric gastroenterologist, and Anthony Hughes, MD, pediatric otolaryngologist joined NCC-P to offertheir particular expertise to the children of theFlorida Panhandle.

The establishment of the ENT Clinic in the third quarter expanded the range of clinical services available at NCC-P. For the first time, children in the referral area will have easy access to a pediatric otolaryngologist with state-of-the-art diagnostic and therapeutic equipment in theoutpatient setting. In addition, the Division ofPulmonology had formal recognition and financialsupport of the satellite Cystic Fibrosis Center by the Cystic Fibrosis Foundation this year.

The Division of Pediatric Cardiology initiated a new outpatient echocardio-graphy service, which has improved both access and quality for our patients.Also, in conjunction with Pulmonology, outpatient stress testing is now available.Outpatient IV therapy services have been greatly expanded to include not onlyHematology/Oncology but also Nephrology, Rheumatology and Endocrinology.This provides chemotherapy services as well as diagnostic testing for the childrenbeing evaluated and treated in these divisions.

Relations with NCC-P’s affiliate hospital continue to mature. NCC-Pphysicians are now the Director of the Pediatric Residency program andMedical Director of the Children’s Hospital. NCC-P Pediatric Surgery hasestablished a surgical procedure area in the Neonatal Intensive Care Unit that has improved morbidity and mortality of neonates undergoing operativeprocedures.

In November, 2000, the Pediatric Surgery and Pediatric Gastroenterologydivisions initiated a new diagnostic service, electrogastrography. This non-invasive tool helps evaluate gastric motility disturbances. This is the only service of its kind in the Nemours system. As part of the introduction of this service, a national conference on intestinal dysmotility hosted by NCC-P inDecember was attended by the recognized national leaders in this field.

The Orthopaedics Division has recruited a physician’s assistant and isusing a new bone density machine (CubaClinical) to aid in the diagnosis ofchildren who are prone to stress fractures and osteoporosis.

With the new building, physicians and programs, NCC-P has a solid foundation to offer the best health care to the community of Pensacola andNorthwest Florida.

David Bailey, MD, MBAChief Executive of the Practice

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JohnPensacola, Florida

Digestion of food is often troublesome for infants and toddlers. Most outgrowthis problem and move on to table foods and other delicacies like pizza. John’sdifficulty with digestion became apparent at fourteen months old. He beganvomiting and having frequent upper respiratory tract infections. The problemworsened as he got older. At age eight, he developed trouble swallowing. Foodwould get stuck in his chest during meals and create severe chest pain. Hewould retch to bring the food back up to relieve the pain. Meals were not very enjoyable as he wrestled his food down or forced food back up to relievediscomfort. It was at this time that he was diagnosed with achalasia. Achalasia is an abnormality of the distal esophagus where the muscle does not relax. The result is an extreme narrowing of the distal esophagus that does not allow the food to pass into the stomach.

John battled with achalasia until thirteen years old, when he was referred toRobert Dillard, MD, a pediatric gastroenterologist at Nemours Children’sClinic —Pensacola. Dr. Dillard performed an endoscopic balloon dilation of thedistal esophagus with some success. John was relieved of symptoms and wasable to eat solid foods for the first time in many years. Unfortunately, hissymptoms returned a month later and he had to return to a very soft diet.

Dr. Dillard referred John to Cynthia Reyes, MD, a pediatric surgeon atNemours Children’s Clinic in Pensacola, for a surgical esophagomyotomy. In this surgery, the muscle of the narrow distal esophagus is split to relieve the obstruction. Instead of making one large incision in the chest or abdomen,Dr. Reyes chose to perform laparoscopic surgery. In this minimally invasivesurgery, 5mm incisions are created to pass a camera lens and instruments intothe abdomen. The procedure is viewed on a large television monitor in theoperating room while surgery is done through these tiny openings. Dr. Dillardperformed endoscopy at the same time of surgery to light up the esophagus for Dr. Reyes to clearly see where to split the muscle. The inside of the esophagus was televised on another monitor to watch the esophagus dilate as the esophagomyotomy was performed. A Thal fundoplication was also performed to minimize the risk of gastroesophageal reflux and to keep theesophagomyotomy open.

John was able to recover quickly after surgery because of the small incisions.He was sent home in two days and returned to school five days after surgery.The hospital stay would have been one week and his recovery time at homeone month with the traditional large incision. His diet was gradually advancedto solid foods. He no longer has to force his food down and his chest pain isalmost gone. John and his parents are very pleased with the outcome of thesurgery and with Drs. Reyes and Dillard. Life is so much more enjoyable,including the pizza on the menu again!

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The Nemours Foundation established a cardiac program in 1997 uniquely

structured along programmatic lines, both organizationally and financially.

Any program of this scope might take at least 7 to 10 years to mature. In the

case of the Nemours design, with its plan for parallel operational entities in

NEMOURSCARDIAC CENTER

Wilmington, Delaware • Orlando, Florida

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the Delaware and Florida service areas, progresshas been rapid indeed.

In Wilmington as of year-end 2000, more thana hundred people are devoted to the Cardiac Centerincluding physicians, nurses, and technical andadministrative staff. There is a newly constructedoutpatient facility including a cardiopulmonaryexercise testing area. The inpatient facility consistsof 13 family-friendly private rooms, 3 swing bedsand a 7-bed cardiac intensive care unit. Facilitiesin Orlando are very similar in design.

Clinical activity in Wilmington is increasing asprojected; in the first two quarters of year 2000activity in all areas has exceeded 1999 performance by 10 per cent. Outreachefforts are currently under way to extend access for children to more than 30hospitals and clinics in nearby states. Because of the competitive nature of the northern site, hospitals will benefit from personalized service by Nemourscardiologists to influence referral patterns and draw patients into activity atduPont Hospital for Children.

All physicians, nurses and staff of both Cardiac Center sites—linkedthrough a common mission—are solely dedicated to the management of pediatric heart disease. This non-traditional but highly effective structureeliminates conflicts of interest and divided loyalties, so a multi-specialty focus can produce the highest quality outcomes efficiently. This reduces mortality and morbidity, as well as length of stay and cost—an appealingcombination to families and payers.

During the past year a complete faculty and staff have been recruited in Orlando. Extensive renovations have accomplished facilities equivalent tothose in Wilmington. Clinical activity at Arnold Palmer Hospital began to bephased in by February 2000 and became fully operational in April. A workingrelationship has been established with Nemours pediatricians and surgical specialists at NCC-O, as well as with privately practicing cardiologists.

The outpatient volume of activity at the Nemours Cardiac Center inOrlando has gradually ascended. Cardiology activity will extend to targetedcommunities and linkage of all Nemours sites will be completed for referrals.

Thus, as envisioned by the plan for a world-class pediatric cardiac program, services will be provided to children on two campuses. Throughtelecommunication, exchange of physicians and patients, and integrated training strategies, a central goal will be achieved. The amalgamated Cardiac Center will be a powerful, resonating, seamless system for cardiac disease management in children; it will develop treatment strategies, educate professionals, and perform basic and clinical research. The Nemours Cardiac Center, Wilmington and Orlando, will not merely employ the latest advances in treatment of children’s hearts, but will participate significantly in developing them.

William I. Norwood, MD, PhDDirector

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WinfieldWilmington, Delaware

Within hours of baby Winfield’sbirth near Baltimore, he was rushedby ambulance to the NemoursCardiac Center in Wilmington. Win,as he’s known, had been whiskedaway from the delivery room anddiagnosed with hypoplastic leftheart syndrome (HLHS), leavinghis parents in a state of panic. “Iwas expecting a healthy baby,” said Win’s mother, Melissa. “And he looked bigand healthy.” But an astute delivery team picked up the sometimes subtle signsof the serious cardiac defect.

When Win and his father, Winfield, Sr., arrived at the duPont Hospital, theywere met by pediatric cardiologist Gina Baffa, MD, who explained everythingthat was about to happen. Before Win was 24 hours old, he was out of surgerywith his father at his bedside in the cardiac intensive care unit. Win’s surgeon,William Norwood, MD, led the team that performed the surgery on December 23.

By the time Melissa was able to make the trip to Wilmington, Win wasrecovering nicely and the staff encouraged her to “take charge of mothering.”Despite his condition and the surgery he had just been through, “Win neverseemed terribly fragile,” Melissa recalled. “The staff was phenomenal. They madesure I knew I was competent to care for him.” Melissa also felt very supportedby the “family atmosphere” of the inpatient cardiac unit. “Everyone got to knowus and we got to know all the doctors and nurses and the other families. We feltas though we were part of a mini-community. It was wonderful.” On New Year’sEve, the Norrisville, MD, family was able to take Win home.

Babies who undergo the Norwood procedure for correction of HLHS musthave three operations done at staged intervals during the first year of life. Win’sfirst surgery, on his first day of life, went like clockwork. During a routine cardiaccatheterization prior to the second procedure, Win’s left pulmonary artery wasfound to be smaller than normal. In order to obtain more balanced blood flowbetween the two lungs, a stent was then placed in the left pulmonary artery inorder to enlarge it. “The stent doesn’t always work (to encourage lung develop-ment), and they told us that,” said Melissa. “But I was just so convinced Winwould recover. He was eating well and completely on target developmentally. Iprayed for a miracle and I got it.” Prior to Win’s third surgery, Melissa recallsanesthesiologist/intensivist Ellen Spurrier, MD, running toward her waving anX-ray—and beaming. It showed Win’s left lung had developed fully. His stage 3 procedure went smoothly, “like a song,” smiled Melissa.

“Win is normal in every way,” said Melissa with pride. “All the things Iworried about—cognitive and motor skills deficits, developmental delays—he has defied. He is healthy and robust, smart, verbal and a great tormenter of his sisters.” It doesn’t get much better—or more normal—than that.

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JavierOrlando, Florida

Eva and Frank couldn’t have known that when their son, Javier, was diagnosed with a congenital heart disease, he would eventually make medicalhistory in Central Florida. In 1999 at one year of age, Javier was being seen for a routine check-up when his doctor heard a strange noise during examinationof his heart. Javier was diagnosed with an atrial septal defect (ASD), a holebetween the upper two chambers of the heart. If left untreated, ASD causesother medical problems and decreased life expectancy.

Eva and Frank investigated the treatment options available for Javier’scondition. They wanted to find an alternative to open heart surgery and weretold that such technology currently was not available. “We thought we wouldhave to wait until Javier was 4 years old for new procedures to be applicable,”said Eva. Only a year passed, however, when Frank and Eva were told that anon-surgical option was available to correct Javier’s ASD. The parents likedwhat they heard about the potential of the new procedure and the effect itmight have on Javier’s cardiac and general health. They took their little boy to the Arnold Palmer Hospital Children’s Heart Institute, a joint effort with theNemours Cardiac Center, the only hospital in Florida that had the technologyand the medical expertise to perform the non-surgical procedure.

Javier became the first patientin Central Florida to undergo thenew procedure, which uses a devicethat is delivered to the heart via acatheter inserted through a smallopening in the groin vein. Once inplace, the device fills the hole betweenthe atria and holds the heart tissuetogether. The procedure was per-formed by John P. Cheatham, MD,an internationally known pediatriccardiology interventionalist recruitedby the Nemours Cardiac Center. Theentire non-surgical treatment took alittle more than two hours and Javierwas ready to go home the next day.“He was up and running around inno time,” Eva said.

“We really didn’t want Javier tohave open heart surgery, so we werevery thankful to have the non-surgicaloption,” said Eva. “We couldn’thave asked for a better experienceand everyone—the doctors, thenurses—took wonderful care of our son.”

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In October of 2000 the Nemours Center for Children’s Health Media was recognized as a

separate operating division of Nemours in acknowledgment of its past accomplishments,

its potential, and its unique mission. That was terrific, but the Center’s pace does not

allow time to rest on its “laurels.”

NEMOURS CENTERFOR CHILDREN’S HEALTH MEDIA

Wilmington, Delaware

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In the online world there is a commonly usedphrase: “moving at Web speed.” For the Center forChildren’s Health Media—developers of theFoundation’s family-oriented KidsHealth Website—moving rapidly and flexibly is a necessity inthe fast-changing, competitive online environment.It’s a world in which incredible change involvestechnology, medical information, business strate-gies, staffing, the competitive landscape, and justabout every aspect of day-to-day existence.

The Center’s fundamental mission, however,remains unchanged: to create effective media forfamilies to learn about and improve the health ofchildren. What has changed this past year is thedevelopment of new Center strategies that will allow us to expand our capabilitiesand outreach while preserving and contributing to the assets of Nemours.

Where are we now? Health on the Web has continued to “heat up” thisyear as both families and businesses seek better ways to find information andconduct health-related transactions. We live in a world that is more information-driven. Parents, particularly, have a strong need for reliable information asthey advocate for their children. Yet we know from what they tell researchersnationwide, parents often feel inadequately listened to, insufficiently informed,and excessively rushed through care.

KidsHealth addresses thesecustomer-driven needs by supplyingfamilies with dependable, engaging,and up-to-date online informationwith a simple goal: improving thehealth of children. This year, increas-ing numbers of families have becomecomfortable using the Web. Almost70 percent of young families are con-nected to the Web, and two thirds of those are using the Web to find health informa-tion and resources. Children and teens are particularly comfortable with these newtechnologies, and well over 90 percent of schools in the country are connected to theWeb. Because almost anyone can post information—including health information—on the Web, accuracy is a major concern. KidsHealth has established Nemours as aclear national leader in effective family education regarding children’s health.

This year KidsHealth continues as the most visited, most linked-to site on the Web concerning children’s health, with about 8,000,000 annual users(and growing still). More than 14,000 Web sites link to Nemours’ KidsHealth.Given the thousands of health Web sites out there and the intensity of thecompetition, that’s a significant accomplishment. The site continues to garner a number of top, juried awards for its design and content and remains still one of the few sites with specific information for kids and for teens. KidsHealthcontinues to generate much national press and is generally recognized as oneof the leaders in online education concerning children’s health.

Neil Izenberg, MDChief Executive

“I would like to thank you for not only the information, but also for the waythe text was presented. I do not have a medical background, so it was niceto be able to read your article and understand it … at least now I willunderstand half of what the doctor is saying … again, I thank you andplease keep up the excellent work.”

—Thomas, age 44

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The Center for Children’s Health Media goals have stretched from simplyproviding the most useful, recognized, and highest quality health information invarious media to include generation of income with which to fund continueddevelopment. Thus growth can be enhanced while allowing expanded reach ofthe Nemours brand and service mission. To accomplish this, the Center over

the last year has developed itsown proprietary Web-publishingsoftware that improves the efficiencyand effectiveness of the Center’stalented editorial staff. The entire18-step editorial process is nowcompletely Web-based, eliminatingpaperwork while permitting bettertracking and organization of work.

With regard to our business goals, our new leading-edge capabilities allow theCenter to serve out its KidsHealth Web content to other sites. As of November2000, KidsHealth articles, images, and animations created and owned by Nemourscan appear on other sites under license from Nemours. Now families previously“limited” to seeing KidsHealth content only on our Web site will be able to accessour information from dozens of other Web sites worldwide. Initial licensees includetop children’s hospitals, widely known family-friendly corporations, and prominentmedia companies. A number of other strategic initiatives are in the works: our“flagship” KidsHealth Web site does not “stand alone.” Our site is part of a larger,more comprehensive strategy by the Center to develop our educational message inmultiple media (Web, video/TV, and print) which reinforce and support each other.

In January 2000, the Center created the multi-volume reference encyclopedia,Human Diseases and Conditions (Charles Scribner’s Sons) and later begannational distribution to libraries and schools. The reception for this work, thefirst of its kind aimed at the teen-and-above audience, has resulted in sales andorders far beyond projections. As a result of the success of this series, the Centerhas been asked to develop annual supplemental volumes. The first additionalvolume, Behavioral Health and Conditions, is underway. Human Diseases andConditions not only carries out our mission of educating children about health,

but also substantiallysupportsNemours’ goal of branddevelopment.

The Centerhas just finished

KidsHealth Guide for Parents: Birth to Age 5. The guide is an 800-page softbound trade book that comprehensively addresses a variety of parentingissues for new parents. The book will be distributed in the fall of 2001.McGraw-Hill has committed significant resources to promoting the work.KidsHealth Guide for Parents: Birth to Age 5 can serve as just the first of a series of comprehensive guides for parents—and, again, promotes

“This is the best Web site I have seen that relates to this kind of stuff.While reading through some of the Teen articles, I could put myself intosome of the situations. It makes me glad to know I’m not alone. Thank youfor boosting my confidence and my self-esteem. You really made my day.Keep up the good work.”

-Emily, age 13

“Thank you so much! Your site answered so many of my questions and morethat I was afraid to ask someone I knew. This site helped me understandthings that I was really confused about because most of the facts I haveheard were mixed with the wrong ideas. I really appreciate your site’s honesty and directness.”

—Brian, age 13

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Nemours’ aims of education, improvement of children’s health, and branddevelopment.

With regard to video, the Center created Financial Management During Crisis.This project, initiated by the Kelly Ann Dolan Memorial Fund and partiallysupported by the Independence Foundation, gives guidance to families strugglingwith chronically and terminally ill children. The program is being distributednationally in significant numbers. Favorable press articles concerning the videohave appeared in 27 states. Thevideo received the Gold Award from the HESCA Media Festival.

The online, print, and videoworks created by the Center canpowerfully cross-promote each otheras well as the work of Nemours and its other operating divisions. The opportunitiesfor Nemours to remain the best-recognized source of online (and other) mediafor families about health are tremendous and exciting. The next years are criticalfor us in this evolving arena, and the challenges are formidable, but the rewardsare considerable. We remain optimistic that, as an organization, we are capableof anticipating demand at “Web speed.”

“I just wanted to let you know that I think this is a really great site. It has so many answers to questions that I know teenagers are afraid to ask.”

—Mara, age 17

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NEMOURSBY THE NUMBERS

Nemours Health Clinic

Alfred I. duPont Hospital for Children

Net Revenue Dollar Service Revenue Dollar Service Expense Dollar

Inpatients

Funded byNemours

10%Patient Revenue

89%Daily Paitient

Services18%

SurgicalServices

14%

OutpatientProfessional

Services32%

OtherProfessional

36%

Depreciation andInsurance

12%

Maintenance and Utilities

10%

Education andResearch

5%Administrative

2%

General Expenses10%

Nursing Care/Professional

Care61%

1996

4,925 5,226

6,491 6,713 6,858

1997 1998 1999 2000

Average Length of Stay

1996

5.1 DAYS

4.5 DAYS 4.6 DAYS 4.5 DAYS 4.6 DAYS

1997 1998 1999 2000

Surgical Procedures

1996

8,2649,369

11,11612,583

15,187

1997 1998 1999 2000

Patient Days

1996

24,603 24,155

29,541 30,492 31,224

1997 1998 1999 2000

44

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Nemours Children’s Clinic—Pensacola

Net Revenue Dollar Service Revenue Dollar Service Expense Dollar

ProfessionalServices

100%Depreciation and

Insurance17%

Maintenance, Rentand Utilities

11%

Education andResearch

3%

Administrativeand General

21%

ProfessionalServices

48%

Nemours Children’s Clinic—Orlando

Net Revenue Dollar Service Revenue Dollar Service Expense Dollar

ProfessionalServices

100%Depreciation and

Insurance11%

Maintenance, Rentand Utilities

3%

Education andResearch

7%

Administrativeand General

23%

ProfessionalServices

56%

Nemours Children’s Clinic—Jacksonville

Net Revenue Dollar Service Revenue Dollar Service Expense Dollar Total Practice Visits

AncillaryServices

10%Professional

Services90% Depreciation and

Insurance13%

Maintenance, Rentand Utilities

3%

Education andResearch

12%

Administrativeand General

26%

ProfessionalServices

46%

1996

97,504 93,818 96,257 99,767 97,956

1997 1998 1999 2000

Total Practice Visits

58,927

72,110

87,323

102,292

1997 1998 1999 2000

Total Practice Visits

9,724

17,98420,217

22,491

1997 1998 1999 2000

Nemours Children’s Clinic—Wilmington

Net Revenue Dollar Service Revenue Dollar Service Expense Dollar Total Practice Visits

Patient Revenue

52%

OtherRevenue

15%

Funded byNemours

33%

Patient Revenue

46%

OtherRevenue

9%

Funded byNemours

45%

Patient Revenue

41%

OtherRevenue

3%

Funded byNemours

56%

Patient Revenue

67%

OtherRevenue

8%

Funded byNemours

25%

AncillaryServices

2%Professional

Services98%

Depreciation andInsurance

7%

Maintenance, Rentand Utilities

4%

Education andResearch

15%

Administrativeand General

30%

ProfessionalServices

44%242,094

252,302

324,368

1998 1999 2000

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The duPont family arrived in America on New Year’s Day 1800, so the Year 2000

marked their 200th anniversary in this country. The family held a spectacular

reunion this summer during the week of June 19-25, with approximately 2,000

members in attendance. Public tours of the Nemours Mansion and Gardens were

NEMOURSMANSION & GARDENS

Wilmington, Delaware

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47

suspended for that week to allow conducted tours for more than 550 duPont familymembers participating in the reunion. The visiting relatives were treated to exhibitsassembled for that very special celebration: china and crystal decorated with theduPont family crest; beautiful hand-painted miniatures of duPont family ancestorsin their native France; the framed passports of Eleuthère Irénée, founder of theduPont Company, and his wife, Sophie and their children; and even a silver coffeeand tea service belonging to the patriarch, Pierre Samuel duPont de Nemours.

The Nemours Mansion and original part of the Gardens were designed byCarrère and Hastings of New York City and built for Alfred I. duPont by Smythand Son of Wilmington in 1910. The Gardens are based on those designed byLe Nôtre at Vaux le Vicomte in France; there is also a feel of Versailles. AlfredI. duPont’s only son, Alfred Victor, and Gabriel Massena designed the rest of theGardens, as well as the Carillon Tower and the original Alfred I. duPont Institute.Garden statuary adds to the old world charm and includes Henri Crenier’s“Achievement” dominating the center of the Maze Garden. The Russian Gatesmade by French ironworker Jean Tijou for Catherine the Great’s palace outsideSt. Petersburg, Russia, are an outstanding example of 18th century ornamentalironwork. The gilded wrought-iron gates soar 19'10" high and reveal the birthand death dates of Catherine (1729-1796), Empress of Russia.

Rare pieces of furniture and accessories now on display in the Mansioninclude a Louis XVI Compound Musical Clock made about 1785 by DavidRoentgen and Peter Kintzing for MarieAntoinette. The clock, which plays four different French tunes on dulcimer and pipeorgan on each of three interchangeablecylinders, was recently restored and is inperfect working order. There is also a chairfrom the Coronation of King George VI ofEngland and Queen Elizabeth in 1937, whichJessie Ball duPont may have attended. A late18th Century French chandelier, which is saidto have belonged to the Marquis de Lafayette,hangs from the ceiling of the main staircase; onthe lower landing is a bust of the Marquis byHoudon, dated 1790.

There are numerous paintings byEuropean and American artists. A GilbertStuart work was recently rediscovered wrappedin brown paper in a third-floor closet whennew computers were being installed to allowmore efficient documentation of The NemoursCollection. Rare tapestries and Oriental carpets complement the eclectic collection of decorative arts throughout the Mansion,and the chauffeur’s garage houses severalvintage automobiles and other vehicles,including a pony cart used by the children to drive around the estate.

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STAFF LISTINGBoard of Directors

Hugh M. DurdenJohn S. LordHerbert H. PeytonJohn F. Porter, IIIW. T. Thompson, IIIW. L. Thornton

Board of Managers

J. H. Baumann, Jr.Richard T. ChristopherCharles E. Hughes, Jr.Craig M. McAllaster, EdDKathleen D. Wilhere

The Nemours Foundation

W. Jeff WadsworthPresident and Chief Executive OfficerRobert D. Bridges, CPAVice President of Finance & Chief Financial OfficerRobert A. Doughty, MD, PhDVice President of Physician PracticesFrancis P. Koster, EdD Vice President of Corporate ServicesThomas P. FerryVice President of Hospital OperationsTeresa H. DuPree, CPA Vice President of Audit, Compliance and QualityTerri Mullins YoungVice President of Human ResourcesRonald G. Malloy Treasurer

Nemours Center for Children’s Health Media

Neil Izenberg, MDChief Executive

Nemours ClinicalManagement Programs

Ian Nathanson, MDDirector

Medical Education

Pamela H. Arn, MDManager

Nemours Research Programs

Vicky L. Funanage, PhDResearch Manager

Research AdministrationDelaware

Vicky L. Funanage, PhDDirector of Medical Research Roy Proujansky, MDDirector of Clinical Research Audrey Maxwell, MBA, CHEAssistant Administrator,Nemours Research Edward Jones, MBAAdministrative Director (FL)

Delaware Research Programs

Vinay Nadkarni, MDAnesthesia/Critical CareResearchGeorge R. Dodge, PhDBone and CartilageResearch LabRobert L. Brent, MD, PhD, DSc Clinical & EnvironmentalTeratologyRobert W. Mason, PhDClinical BiochemistryJudith A. Childs, RN, PhDClinical PharmacologyBeth Mineo-Mollica, PhDDelaware AssistiveTechnology InitiativeKaren Oerter Klein, MDEndocrinology Research

William W. Reenstra, PhDEpithelial Cell BiologyRoy Proujansky, MDGastroenterology ResearchSaul Surrey, PhDHematologic Genetic DiseasesSteven E. McKenzie, MD, PhDHematology/OncologyResearchPaul T. Fawcett, PhDImmunology ResearchDevendra Mehta, MDIntestinal & PancreaticDiseasesVicky L. Funanage, PhDMusculoskeletal InheritedDiseaseJ. Richard Bowen, MDOrthopaedic ResearchTariq Rahman, PhDPediatric EngineeringResearch LabMargaret Keller, PhDSickle Cell & ThalassemiaResearchLeslie Krueger, PhDSolid Organ TransplantationResearchH. Timothy Bunnell, PhDSpeech ResearchKirk Dabney, MDSpinal Trauma ResearchMarshall Schwartz, MDSurgery ResearchRobert E. Akins, Jr., PhDMuscle Regeneration Research

Florida Research Programs

John Lima, PharmDDirector of Clinical PediatricPharmacologyJames E. Sylvester, PhDDirector, Cellular andMolecular Medicine LaboratoryPrabhakaran Balagopal, PhDAssociate Director, BiomedicalAnalysis LaboratoryTimothy Wysocki, PhDDirector, Center for PediatricPsychology Research

Nelly Mauras, MDChair, Florida-wide ClinicalResearch Review Committee,Endocrinology andMetabolic Disease ResearchDavid Geller, MDDirector, Pulmonary AerosolLaboratoryEric Sandler, MDHematology/OncologyResearchJohn Mazur, MDOrthopaedic ResearchDesmond Brown, MDOrthopaedic ResearchCharles Price, MDOrthopaedic Research

Alfred I. duPont Hospital For Children

Management Thomas P. FerryAdministrator/Chief Executive

Rita Meek, MDHospital Medical DirectorSteven J. Bachrach, MDAssociate Medical DirectorJ. Mark McLooneChief Operating OfficerWilliam BrittonAssistant Administrator,FinanceFrancis HendrickAssistant AdministratorPatricia Conway, MSN, RNDirector of NursingAnne J.WrightSenior Director, BusinessDevelopment

Nemours Children’s Clinic —Wilmington

ManagementRoy Proujansky, MDChief Executive of the PracticeJ. Richard Bowen, MDSurgeon-in-Chief

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Gina AltieriAdministratorMariane StefanoAssociate Administrator

Department of Anesthesiology & Critical Care Medicine

Stephen T. Lawless, MDActing Chairman

Attending Active StaffLynda R. Arai, MDB. Randall Brenn, MDRobert P. Brislin, DODinesh Choudhry, MDSabina DiCindio, DOEdward J. Cullen, DOPhoebe Fisher, MDJames Hertzog, MDMichael S. Katz, MDHenry H. Khine, MDScott Penfil, MDVinay M. Nadkarni, MDMary D. Theroux, MD

duPont Pediatrics

Kevin Sheahan, MDChief

Attending Active StaffThiele Anthony, MDAguida Atkinson, MDDino Baca, DOHal Byck, MDLinda Caballero-Goehringer,

MDLaurie Cooke, MDMarta Diaz, DODaniel Glasstetter, MDAndrew Henderson, MDNancy Heinz-Sader, MDGeorge Hilty, MDJohn Forest, MDWilliam Houston, MDPatrick Jarvie, MDAnna Kolano, DOJudith Larkin, MDMaurice Liebesman, MDGary Lytle, MDZarela Molle-Rios, MDFrancis Montone, DOLawrence Pradell, MDAnthony Policastro, MDNelson Santos, MD

Jennifer Shrager, MDCarol Squyres, MDCharles Thomas, MDVaruna Tuli, MDDolores Un, MD

Department of Medical Imaging

Marc Keller, MDChairman

Attending Active StaffLeslie E. Grissom, MDSusanne Grasso, MDH. Theodore Harcke, MDMyung S. Lee, MDGerald A. Mandell, MDPauravi Vasavada, MD

Community StaffViroon Donavanik, MDMichael Dzeda, MDMuhammed Haq, MDPeter Hulick, MDStephen Klein, MDJoseph Ravalese, III, MD David Suh, MDDonald Tilton, DO

Department of Orthopaedics

J. Richard Bowen, MDChairman

Attending Active StaffKirk W. Dabney, MDPeter Gabos, MDShanmuga Jayakumar, MDRichard Kruse, DOWilliam Mackenzie, MDDan E. Mason, MDFreeman Miller, MDSuken Shah, MDRobert P. Stanton, MD

Community StaffMichael Axe, MD John Capo, MDChristopher D. Casscells, MDJonathan Contompasis, DPMThomas Edwards, MDJohn Fisher, MDBrian Galinat, MDErrol Ger, MDAli Kalamchi, MD Victor Kalman, DO

Paul Kupcha, MDBong Lee, MDElliott Leitman, MDArmando Mendez, MDCraig Morgan, MDWilliam Newcomb, MDBrent Noyes, MDLeo Raisis, MDBruce Rudin, MDDavid Sowa, MDRobert Steele, MBBSPeter Townsend, MD

Sports Medicine Program

Craig Morgan, MDDirector

Active StaffBrian Galinat, MDMichael J. Axe, MDVictor Kalman, DO

Department of Pathology/Clinical Laboratory

Frederick Meier, MDChairman/Medical Director

Katrina Conard, MDDirector, Surgical Pathology/Associate Medical Director

Community StaffRichard Callery, MD

Department of Pediatrics

Roy Proujansky, MDChairmanSteven J. Bachrach, MDVice Chairman andAssociate Medical DirectorSteven J. Selbst, MDVice Chairman

Division of GeneralPediatrics

Steven J. Bachrach, MDDivision Chief

Attending Active StaffLouis Bartoshesky, MDHal Byck, MDDeborah Consolini, MD

Allan R. DeJong, MDEllen Feingold, MDJohn Gould, MDSandra Hassink, MDPatrice Hyde, MDNeil Izenberg, MDJ. Jeffrey Malatack, MDSteven Selbst, MDDavid West, MDLisa Zaoutis, MD

Community StaffDongho Baag, MDJudy L. Bailey, MDDavid Bauman, MDRobert Beckman, MDDavid Bercaw, MDHugh Bonner, MDHoward Borin, MDIlene L. Boudreaux, MDPaula Brenn, MD Robert Berley, MDCheryl Bolinger, MDAnthony Brazen, DORobert L. Brent, MD, PhDRichard Brigandi, MDMarie Brislin, MDKim Carpenter, MDRicardo Castro, MDJohn Cellucci, DONeal B. Cohn, MD Jeffrey P. Cramer, MDElizabeth Craven, MDTheresa D’Amato, MDHenry DePhillips, MDDaniel DePietropaolo, MDSteven E. Diamond, DOJanice Dickter, MDKristine Diehl, MDJoseph DiSanto, MD Timothy Dowling, MDMichael Dreyer, MD David Driban, MDMargaret duPont, MDValerie Elener, MD Jerald Eng, MDDavid M. Epstein, MDDavid Estock, MDMarita Fallorina, MDJudith N. Feick, MDBonni S. Field, MDAlfred Fletcher, MD Allen Friedland, MDPasquale Fucci, MDWilliam Funk, MDCynthia A. Gabrielli, DO

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Juan Gadea, MD Yvette Gbemudu, MDEphigenia Giannoukos, MDJames Gill, MDMark A. Glassner, MDP. Michael Glowacki, MDMatthew Gotthold, MDRebecca Grinarml, MDJohn Hocutt, MDSiobhan Irwin, MDElizabeth Jackovic, MDHoratio Jones, MD Henry Karsch, DOEdwin C. Katzman, MDVenita Kaul, MDKaren Kelly, MD Bernard King, MDKerry Kirifides, MDGershon A. Klein, MDShirley Klein, MDNirmala Kothari, MDRenee Kottenhahn, MDJames Knox, MDMary Kobak, MDHal Kramer, MDJanet P. Kramer, MDDavid M. Krasner, DOStephen Kushner, DONeil Lattin, MDJoseph Leiberman, MDVictoria A. Levin, MDSusan Livesay, MDCheryl Lowe, MDMarilyn K. Lynam, MDA. Radford MacFarlane, MD Stephanie Malleus, MDLawrence Markman, MDCarol Marsh, MDNeftali Martinez, MDBrian McDonough, MDEdward McReynolds, MDM. Diana Metzger, MDSangita Modi, MDJohn Murphy III, MDAntonio C. Narvaez, MDQuan C. Nguyen, MDRobert Olivieri, MDRobert Olympia, MDSuguna Patibanda, MBBSCharles Pohl, MDMargaret Proctor, MDCraig Quigley, MD Kevin Roberts, MDRoger Ruckman, MDKent Sallee, MD

Scott Schaeffer, MDVicky Scheid, MDEric Schwartz, DOPatricia Scott, MDStuart Septimus, MDEric B. Shapiro, DOKristen Shapren, MDDavid Sherwood, MD Regina Simonetti, MDDavid Simpson, MDEdward R. Sobel, DOGeorge Spyropolous, MDJ. Bartley Stewart, MDPamela Stone, MDJ. Jordan Storlazzi, MDIrene Szeto, MDCarla Taylor, MDCharles D. Thomas, MD Caren Thompson, MDChitra Vaidyanathan, MDAnabis Vera-Gonzalez, MD Joann Villamarin, MDJoseph A. Vitale, DO Sarabeth Walker, MDRobert S. Walter, MDDyanne Westerberg, DOJudith C. Wollman, MDVijaya Yezdani, MDFataneh Ziari, MDDebra Zussman, MD

Jefferson Pediatrics

Clara Callahan, MDRosemary Casey, MDGeorge Datto, MDGary Emmett, MDCynthia McIntosh, MDCharles Pohl, MDJudith Turow, MD

Division of Allergy & Immunology

Stephen J. McGeady, MDDivision Chief

Attending Active StaffEjaz Youssef, MD

Community StaffDenise DiPrimio-Kalman, DOWilliam Geimeier, MDRichard Kim, MDGregory Marcotte, MD

Maher Nashed, MDQuan Nyugen, MDAndrew Weinstein, MD

Division of BehavioralHealth

Richard Kingsley, MDDivision Chief

Attending Active StaffOliver Yost, MD

Affiliate StaffJane Crowley, PsyDDeborah L. Miller, PhDJennifer S. Pendley, PhDColleen Sherman, PhDDavid Sheslow, PhDDouglas Tynan, PhD

Community StaffRichard Cruz, MDDiana Terrell, PhDNidia de Yanez, MD

Division of Cardiology(See Nemours Cardiac Center)

Division of Dermatology

Patrice Hyde, MDDivision Chief

Community StaffFanny Berg, MD

Division of DevelopmentalMedicine

Susan B. Stine, MDDivision Chief

Attending Active StaffRhonda Walter, MD

Community StaffRobert Saunderson, MDJ. Jordan Storlazzi, MD

Division of EmergencyMedicine

Kate Cronan, MDDivision Chief

Attending Active StaffMagdy Attia, MDAnn Baldwin Bates, MDFred A. Fow, MDMarla Friedman, MDSusanne Kost, MDJohn Loiselle, MDDeborah Maroko, MDColette Mull, MDKathleen Palmer, MDEileen Quintana, MDSteven Selbst, MDSabina Singh, MDBambi Taylor, MD

Division of Endocrinology

Grafton D. Reeves, MDDivision Chief

Attending Active StaffGary Carpenter, MDAugustine Chikezie, MDSteven Dowshen, MDDaniel Doyle, MDJudith Ross, MD

Division of Gastroenterology & Nutrition

Devendra Mehta, MDDivision Chief

Attending Active StaffSheeja Abraham, MDJ. Fernando del Rosario, MDJoan S. DiPalma, MDRoy Proujansky, MDStephen Shaffer, MDJohn Tung, MD

Community StaffJaime H. Rivera, MDNancy Vinton, MD

Division of GeneticsCharles I. Scott Jr., MDDivision Chief

Attending Active StaffLouis Bartoshesky, MD

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Division ofHematology/Oncology

Rita S. Meek, MDDivision Chief

Attending Active StaffMaureen F. Edelson, MDGregory C. Griffin, MDAndrew Walter, MD

Community StaffPhilip Blatt, MDEric Martin, MD

Division of InfectiousDiseases

Joel D. Klein, MDDivision Chief

Attending Active StaffStephen C. Eppes, MD

Division of Neonatology

John Stefano, MDDivision Chief

Active StaffMichael Antunes, MDCarlos Duran, MDKatherine Esterly, MDRobert Locke, DOEmil Mondoa, MBBSDavid Paul, MDStephen Pearlman, MDMichael Spear, MDDeborah J. Tuttle, MD

Jefferson NeonatologySusan Adeniyi-Jones, MDGerard Cleary, DOHemant Desai, MDShobhana Desai, MDEric Gibson, MDLeonard Goldsmith, DOJay Greenspan, MDStephen Higgins, MDMary Jacquette, MDGlenn Kaplan, MDMichael Kornhauser, MDImran Qayyum, MDRichard Ritterman, MDKolawole Solarin, MD

Robert Stavis, MDSuzanne Touch, MD

Division of Nephrology

Attending Active StaffLaszlo Hopp, MDCharles McKay, MD

Community StaffRobert Cox, MDRobert Dressler, MDJoseph Kuhn, MDLindsay Slater, MDWilliam Miller, MD

Division of Neurology

Attending Active StaffWinslow J. Borkowski, Jr., MDSteven Falchek, MDMichael H. Goodman, MDMena Scavina, MDMarcy Yonker, MD

Community StaffS. Charles Bean, MDCharles Brill, MD Richard Fischer, MDLeonard Graziani, MDHarold Marks, MDDonna Stephenson, MD

Division of PulmonaryMedicine

Raj Padman, MDDivision Chief

Attending Active StaffAaron Chidekel, MDLouis Guernsey, MDLaura S. Inselman, MD

Community StaffJohn J. Goodill, MD

Division of Rehabilitation

Michael Alexander, MDDivision Chief

Attending Active StaffThelma Citta-Pietrolungo, DOMaura McManus, MD

Division of Rheumatology

Carlos D. Rosé, MDDivision Chief

Attending Active StaffBalu H. Athreya, MD

Community StaffDonald Goldsmith, MDJames Newman, MD

Department of Surgery

James S. Reilly, MDChairmanMarshall Schwartz, MDVice Chairman

Division of General Surgery

Philip Wolfson, MDDivision Chief

Attending Active StaffAviva Katz, MDPeter Mattei, MDStephen Murphy, MDMarshall Schwartz, MD

Community StaffRaafat Abdel-Misih, MDDiana Dickson-Witmer, MDLamar Ekbladh, MDGerard J. Fulda, MDDennis Hoelzer, MDMatthew Hoffman, MDPaul Kaminski, MDMichael Mortiz, MDArlene Smalls, MDKatheryn Warren, MDBarry Wasserman, MDDennis Witmer, MD

Division of CardiothoracicSurgery

Community StaffAllen Davies, MDSatoshi Ikeda, MDGerald Lemole, MDKathleen McNicholas, MDD. Bruce Panasuk, MD

Division of Dentistry

Garrett Lyons, Sr., DDSDivision Chief

Community StaffRosemary Clay, DMD Lynn Collins, DDSEugene D’Amico, III, DDSThomas Dougherty, DDSDominic Gioffre, DDSDavid Goodman, DDS James L. Goodwill, DDSEdwin Granite, DMD Joseph Kelly, DDSDavid King, DMDMichael Kremer, DMDGarrett Lyons, Jr., DDSAndrew Malinowski, DDSDebra Pace-Tufano, DMDLouis Rafetto, DDS Francis J. Vaughan, DDS

Division of Gynecology

Community StaffMatthew Hoffman, MDKevin Kelley, MDJeffrey B. Russell. MD

Division of Neurosurgery

Attending Active StaffHugh O’Donnell, MDJoseph Queenan, MD

Community StaffBikash Bose, MD Magdy Boulos, MDAnn-Christine Duhaime, MDMatthew Eppley, MDMartin Gibbs, MD Yakov Koyfman, MDWilliam Kraut, MD Otto Medinilla, MD Michael Sugarman, MDPeter Sun, MDLeslie Sutton, MD

Division of Ophthalmology

Sharon S. Lehman, MDDivision Chief

Attending Active StaffNanette Zale, MD

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Community StaffRobert Abel, Jr., MDJane C. Edmond, MDJohn Ferguson, III, MDNeil Kalin, MDPaula Ko, MDDavid Larned, MDDouglas Mazzuca, DORalph Milner, MDDorothy Moore, MDStefan O’Connor, MDGeorge Popel, MDCharles Rickards, MDRichard Sherry, MDS. Gregory Smith, MDMichael Vincent, MDCharles Wang, MD

Division of Otolaryngology/Head & Neck Surgery

Steven Cook, MDDivision Chief

Attending Active StaffEllen Deutsch, MDJames Reilly, MD

Community StaffPaul Imber, MDJay D. Luft, MDWilliam Medford, MDKenneth Nissim, MDJoseph I. Ramzy, MDMichael Teixido, MDKu W. Suh, MDEmilio Valdes, MDThomas Willcox, Jr., MDRobert L. Witt, MD

Division of Plastic Surgery

Community StaffMehdi Balakhani, MDLawrence D. Chang, MDJohn Danyo, MDPaul Kim, MDAbdollah Malek, MDChristopher Saunders, MDJonathan Saunders, MDDavid Zabel, MD

Division of Urology

T. Ernesto Figueroa, MDDivision Chief

Attending Active StaffJulia S. Barthold, MDR. Bruce Filmer, MBBS

Community StaffBruce Benge, MDStephen Brutscher, DOAndrew Glick, MDHoward M. Snyder, III, MDWilliam Ziegenfus, MD

Thomas Jefferson UniversityPediatric Residency Program

Steven Selbst, MDDirectorLisa Zaoutis, MDAssociate Program Director

Nemours Health Clinic

ManagementThomas P. FerryExecutive DirectorW. Frank Morris, Jr., RPhClinic Manager and Directorof Pharmacy

Dental Clinic Active StaffJeffrey Bright, DMDKaren Carter, DMDRebekah Fedele, DMDDiane Dudderar-Foster, DDSFrancis A. Flomerfelt, DDSJeffrey Foster, DDSGeorge E. Frattali, DDSDann J. Gladnick, DMDDavid A. King, DMDAntonio Kledaras, DDSHammond M. Knox, DDSAlbert Marsilli, DDSDavid E. Mastrota, DMDKelly Walker, DDSWoodrow Wilson, DDSEdward Yalisove, DDS

EndodontistDebra Pace-Tufano, DMD

Oral SurgeonsEugene D’Amico, DMDJames Goodwill, DDSMichael R. Kremer, DMDLouis Rafetto, DDS

Downstate Dental Active StaffLiama V. Anthaney, DMDRobert Blitzer, DDSJeffrey J. Brown, DMDChristopher Burns, DDSMichael Butterworth, DDSJames R. Carmean, DDSThomas E. Conley, DDSDavid R. Deakyne, DDSMario P. DiSabatino, DDSI. Kent Elkington, DDSRobert N. Emory, DDSRonald L. Harpster, DDSJohn H. Hatfield, DDSEdward S. Hendel, DDSArthur W. Henry, DDSBlair Jones, DDSJames W. Kramer, DMDBruce Lauder, DDSWilliam L. Lord, DDSJohn C. Lynch, DDSThomas Marier, DDSThomas W. Mercer, DMDJoseph E. Morgan, DDST. M. Postlethwait, DDSRichard B. Taylor, DDSWayne H. Thomas, DDSRobert Webster, DDSJohn B. Wheeler, IV, DDSJesse R. Williamson, DDSRichard Williamson, DDSBruce B. Wright, DDS

Oral Surgeons DownstateMichael Cahoon, DMDJohn Capodanno, DDSBruce D. Fisher, DDSThomas R. Mullen, DMDNorman Lippman, DDS

Periodontist DownstateSteven D. Nemcic, DDS

Eye Clinic Active StaffG. Richard Bennett, MS, ODPhyllis Chambers-Mobley, ODJohn B. Ferguson, III, MDSarah L. Foster, ODGeorge W. Kledaras, ODH. Martin Moss, ODJean Marie Pagani, ODJane Schweitzer, MDStephen Sinclair, MDKatherine W. Taylor, ODSteven D. Warwick, OD

Milford Satellite FacilityRobert Abel, MDAndrew Barrett, MDPhilip J. Gross, ODJane Schweitzer, MDBryan Sterling, ODKatherine W. Taylor, OD

Nemours Cardiac Center

William I. Norwood, MD, PhDDirector

John T. WalshExecutive Administrator

Wilmington Campus

Active StaffAnesthesiology/Intensive Care

Deborah A. Davis, MDRussell C. Raphaely, MDEllen A. Spurrier, MD

Cardiothoracic Surgery

Richard D. Mainwaring, MDWilliam I. Norwood MD, PhD

Cardiology

Paul C. Anisman, MDJeanne Marie Baffa, MDMajeed A. Bhat, MDWayne H. Franklin, MDCandace L. Gibbin, MDSamuel S. Gidding, MDHenry A. Kane, MDLazaros K. Kochilas, MDKevin O. Maher, MDKenneth A. Murdison, MDJohn D. Murphy, MDFrances R. Zappalla, DO

Orlando Campus

Active StaffAnesthesiology/Intensive Care

Hamish M. Munro, MDScott R. Schulman, MDH. Kenneth Spalding, MD

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Cardiothoracic Surgery

Christian Pizarro, MDMark Galantowicz, MD

CardiologyJohn P. Cheatham, MDCraig E. Fleishman, MDCharles S. Kleinman, MDRodrigo A. Nehgme, MDArwa S. Saidi, MDDenver Sallee, III, MD

Nemours Children’s Clinic—Jacksonville

ManagementRobert G. Kettrick, MDChief Executive of the PracticeBarry P. SalesAdministratorWilliam A. Cover, Jr.Senior Associate Administrator

Department of Anesthesiology & Critical Care Medicine

Salvatore R. Goodwin, MDChairman

Division of PediatricAnesthesia

Stefanie F. Schrum, MDDivision Chief

Avis S. Chen, MDSteven V. Collins, MDLynn S. Findley, MD Renee Gaver, MDJane A. Goodwin, MDSalvatore R. Goodwin, MDRichard A. Helffrich, Jr., MDRobert G. Kettrick, MDMarjorie A. Lewis, MDKaren D. Ott, MDStefanie F. Schrum, MDPatricia C. Stephens, MDKevin J. Sullivan, MD

Division of Critical Care MedicineKevin J. Sullivan, MD

Department of Orthopaedics

R. Jay Cummings, MD Chairman

Eric A. Loveless, MDDavid M. Mandel, MDJohn M. Mazur, MDShawn C. Standard, MD

Sports Medicine

George A. Hahn, MD

Department of Pediatrics

Paul A. Pitel, MDChairman

Division of Endocrinology& Metabolic Diseases

Nelly Mauras, MDDivision Chief

Larry A. Fox, MDPriscila C. Gagliardi, MDRobert C. Olney, MD

Division of Gastroenterology& Nutrition

Donald E. George, MD Division Chief

Jonathan S. Evans, MD

Division of Genetics

Pamela H. Arn, MD Division Chief

Anthony A. Perszyk, MD

Division of Hematology/Oncology

Eric S. Sandler, MD Division Chief

Cynthia A. Gauger, MDJ. Michael Joyce, MD, PhDPaul A. Pitel, MD

Division of HospitalPediatrics

Clifford B. David, MD Division Chief

Gina Penaflor, MD

Division of InfectiousDiseases/Immunology

Samir Midani, MD Division Chief

Division of Neurology

William R. Turk, MD Division Chief

Harry S. Abram, MDDavid N. Hammond, MDDaniel E. Shanks, MDLaura Lyons Bailet, PhD

Division of Pulmonology/Allergy & Immunology

David A. Schaeffer, MD Division Chief

Bonnie B. Hudak, MDJ. Dale Schrum, MD

Division of Psychologyand Psychiatry

Timothy Wysocki, PhD Division Chief

Michael DeLaHunt, MDLisa M. Buckloh, PhDChristine C. Gray, PhDPeggy Greco, PhDElizabeth M. Schilling, PhD

Department of Radiology

Debbie J. Merinbaum, MD Chairman

W. Gray Mason, Jr., MDChristopher G. Zaleski, MD

Department of Surgery

John Noseworthy, MD Chairman

Division of Ophthalmology

Robert W. Hered, MD Division Chief

Lee R. Hunter, MDAlexander E. Pogrebniak, MD

Division of Otolaryngology

Daniel L. Wohl, MD Division Chief

Gary D. Josephson, MD

Division of PediatricSurgery

Daniel L. Mollitt, MD Division Chief

James A. Borger, MD Maryanne L. Dokler, MDH. Warner Webb, MD

Division of Urology

Michael J. Erhard, MD Division Chief

John Noseworthy, MD

Nemours Children’s Clinic— Orlando

ManagementIan Nathanson, MDChief Executive of the PracticeCharles Price, MDSurgeon-in-ChiefMark Swanson, MDPediatrician-in-ChiefWilliam J. WinderAdministratorRoseann McAnultyAssociate Administrator

Adolescent Medicine

Jonathan Schneider, DODivision Chief

Penny Tokarski, MD

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Behavioral Pediatrics

Stephen Commins, MDDivision Chief

Leslie Gavin, PhD

General AcademicPediatrics

Robert Cooper, MDDivision Chief

Janice Howell, MDJoan Meek, MDSunita Patil, MDDouglas Short, MDLloyd Werk, MD

Pediatric Anesthesiology

Madonna Kelly, MDDivision Chief

Karen Bender, MDLisa Christensen, MDMartine Denn, MDCarol Klim, MDTimothy Roedig, MDRebecca Welch, MDJames Yoachim, MD

Pediatric Critical Care

Mary Farrell, MDDivision Chief

Lindsey Johnson, MDRobert Pettignano, MDLarry Spack, MDMark Swanson, MDJohn Tilelli, MD

Pediatric Endocrinology

Paul Desrosiers, MDDivision Chief

Richard Banks, MDBethel Steindel-Kopp, MD

Pediatric Gastroenterology

Joel Andres, MDDivision Chief

Jeffrey Bornstein, MDNora Erhart, MDDavid Milov, MD

Pediatric Genetics/Metabolism

John McReynolds, MDDivision Chief

Pediatric Hematology/Oncology

Vincent Giusti, MDDivision Chief

Judy Wall, MD

Pediatric Hospitalist

Ira Pinnelas, MDDivision Chief

Pamela D. Andrew, MDMatthew Seibel, MD

Pediatric Infectious DiseaseMichael Muszynski, MDDivision Chief

Catherine Lamprecht, MD

Pediatric NephrologyNorman Pryor, MDDivision Chief

Jorge Ramirez, MD

Pediatric Neurology

Michael Pollack, MDDivision Chief

Charles Dreyer, MD

Pediatric Ophthalmology

Stanley Hand, MDDivision Chief

Louis Blumenfeld, MD

Pediatric Orthopaedics

Charles Price, MDDivision Chief

Raymond Knapp, MDJonathan Phillips, MDMark Sinclair, MD

Pediatric Otolaryngology

David Moser, MDDivision Chief

Cheryl Cotter, MDJames Kosko, MD

Pediatric Pulmonology

Floyd Livingston, MDDivision Chief

Ann-Marie Brooks, MDDavid Geller, MDIan Nathanson, MDMark Weatherly, MD

Pediatric Surgery

Ross Morgan, MDDivision Chief

Marc Levy, MDDavid Miller, MDDonald Plumley, MD

Pediatric Urology

Mark Rich, MDDivision Chief

Michael Keating, MD

Nemours Children’s Clinic— Pensacola

ManagementDavid J. Bailey, MD, MBAChief Executive of the PracticeWilliam B. Blanchard, MDPediatrician-in-ChiefJimmy E. Jones, MD, MPASurgeon-in-Chief

Pediatric Cardiology

William B. Blanchard, MDPediatrician-in-ChiefJoseph P. Davenport, MDDivision Chief

Pediatric Critical Care

Rex L. Northup, MDDivision Chief

Robert F. Patterson, MD

Pediatric Endocrinology

Helen Y. Hsiang, MD, MPHDivision Chief

Pediatric Gastroenterology

Robert P. Dillard, MDDivision Chief

Alan I. Sacks, MD

Pediatric Hematology/Oncology

Thomas G. Jenkins, MDDivision Chief

Pediatric Nephrology

Edward C. Kohaut, MDDivision Chief

Pediatric Orthopaedics

T. Desmond Brown, MDDivision ChiefJ. Marc Cardelia, MD

Pediatric Rheumatology

James M. Lawrence, III, MDDivision Chief

Pediatric Pulmonology

Kevin D. Maupin, MDDivision Chief

Pediatric Surgery

Jimmy E. Jones, MD, MPASurgeon-in-ChiefCynthia Reyes, MDDivision Chief

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Adachi K, Zhao Y, Yamaguchi T, Surrey S.Assembly of gamma- with alpha-globinchains to form human fetal hemoglobin in vitro and in vivo. J Biol Chem. 2000;275:12424-12429.

Akins RE. Prospects for the Use of CellImplantation, Gene Therapy, and Tissue Engineering in the Treatment of MyocardialDisease and Congenital Heart Defects. In:Sames K. ed. Tissue Engineering andRegenerative Medicine. Eco Med Press,Landsberg, Germany. 2000;1-16.

Alavi K, Prasad R, Lundgren K, SchwartzMZ. Interleukin-11 enhances small intestineabsorptive function and mucosal mass afterintestinal adaptation. J Pediatr Surg.2000;35:371-374.

Alavi K, Schwartz MZ, Palazzo JP, PrasadR. Treatment of inflammatory bowel dis-ease in a rodent model with the intestinalgrowth factor glucagon-like peptide–2. JPediatr Surg. 2000;35:847-851.

Alavi K, Schwartz MZ, Prasad R, FunanageVL. Leptin: A new growth factor for the smallintestine. Surg Forum. 2000;50:527-529.

Alexander MA, Molnar GE. eds. Physicalmedicine and rehabilitation: State of the art reviews. Philadelphia, PA: Hanley andBelfus. 2000.

Aquino VM, Herrera L, Sandler ES, BuchananGR. Feasibility of oral ciprofloxacin for the outpatient management of febrile neutropenia in selected children with cancer. Cancer. 2000;88(7):1710-1714.

Attardi DM, Paul DA, Tuttle DJ, GreenspanJS. Premedication for intubation in neonates.Arch Dis Child Fetal Neonatal Ed.2000;83:F161.

Attia M, Quintana E. Neck Masses. In: SelbstSM, Cronan KC. eds. Pediatric EmergencyMedicine Secrets. Hanley and Belfus,Philadelphia. 2000;90-94.

Attia M. Sore Throat. In: Selbst SM, CronanKC. eds. Pediatric Emergency MedicineSecrets. Hanley and Belfus, Philadelphia.2000;109-111.

Attia MW, Russell J. Isolated first rib fracturein a high school lacrosse player. PediatrEmerg Care. 2000;16:31-32.

BBarroso U, Jednak R, Fleming P, Barthold JS,González R. Bladder calculi in children whoperform clean intermittent catheterization.BJU Int. 2000;85:879-884.

Bailet LL, Turk WR. The impact ofchildhood epilepsy on neurocognitive andbehavioral performance: A prospective longitudinal study. Epilepsia. 2000;41(4):426-431.

Barthold JS, Kumasi-Rivers K, Upadhyay J,Shekarriz B, Imperato-McGinley J. Testicularposition in androgen insensitivity syndrome:Implications for the role of androgens intesticular descent. J Urol. 2000;164:497-501.

Beausoleil J, Schwarz R, McGeady SJ. CD40ligand expression in immunodeficiency withhyper IgM and congenital rubella syndrome.Pediatr Asthma Allergy Immunol. 2000;14:225-230.

Belasco JB, Goldwein JW, Simms S, GriffinG, D'Angio G, Lange B. Hypofractionatedmoderate dose radiation, intrathecalchemotherapy, and repetitive reinduction/reconsolidation systemic therapy for centralnervous system relapse of acute lymphoblasticleukemia in children. Med Pediatr Oncol.2000;34:125-131.

Blake KV. Asthma. In: Herfindal ET, GourleyDR. eds. The Textbook of Therapeutics: Drugand Disease Management. 7th ed. LippincottWilliams & Wilkins, Baltimore. 2000;727-764.

Blecker U, Gold BD. Gastritis y úlcera péptica en pediatría. Pediatr Integral.1999;4:86-100.

Bolino A, Levy ER, Muglia M, Conforti FL, LeGuern E, Salih AM, Georgiou DM,Christodoulou RK, Hausmanowa-PetrusewiczI, Mandich P, Gambardella A, Quattrone A,Devoto M, Monaco AP. Genetic refinementand physical mapping of the CMT4B geneon chromosome 11q22. Genomics.2000;63:271-278

Bolino A, Muglia M, Conforti FL, LeGuernE, Salih MAM, Georgiou DM, ChristodoulouRK, Hausmanowa-Petrusewicz I, MandichP, Schenone A, Gambardella A, Bono F,Quattrone A, Devoto M, Monaco AP. Charcot-Marie-Tooth type 4B is caused by mutationin the gene encoding myotubularin-relatedprotein-2. Nat Genet. 2000;25:17-19.

Brent RL, Oakley GP, Mattison DR. Theunnecessary epidemic of folic acid-preventablespina bifida and anencephaly. Pediatrics.2000;106:825-827.

Brent RL. ACSH Phthalate Panel. Letter toeditor. Response to: A scientific evaluationof health effects of two plasticizers used inmedical devices and toys: A report from theAmerican Council on Science and Health.Medscape Gen Med. 2000;May 12:2(el).

Brent RL. Response to: Whelan E. Leadand human health: An update. AmericanCouncil on Science and Health, Pesticidesand Chemicals Forum, August 14, 2000.

Brent RL. The Effect of Embryonic andFetal Exposure to X-rays and Isotopes. In:Barron WM, Lindheimer MD. eds. MedicalDisorders during Pregnancy. 3rd edn. MosbyYear-Book, St. Louis. 2000;586-610.

Bunnell HT, Yarrington D, Polikoff JB. STAR:Articulation Training for Young Children.Proceedings of the Sixth InternationalConference on Spoken Language Processing,October 16-20, 2000;85-88, Beijing, China.

CChidekel A, Steele-Moore L, Padman R,Pellegrino V, Berg D, Klein J. Nasopharyngealcolonization in children with cystic fibrosis:Antibiotic resistance and intrafamilial spread.Inf Dis Clin Pract. 2000;9:333-336.

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Chidekel AS. The respiratory health effectsof passive smoking on children. Del Med J.2000;72:203-207.

Choi IH, Lipton GE, Mackenzie W, BowenJR, Kumar SJ. Wedge-shaped distal tibialepiphysis in the pathogenesis of equinovalgusdeformity of the foot and ankle in tibiallengthening for fibular hemimelia. J PediatrOrthop. 2000;20:428-436.

Christian CW, Lavelle JM, DeJong AR, LoiselleJ, Brenner L, Joffe M. Forensic evidencecollection in prepubertal victims of sexualassault. Pediatrics. 2000;106:100-104.

Clancy RR, McGaurn SA, Wernovsky G,Spray TL, Norwood WI, Jacobs ML, MurphyJD, Gaynor JW, Goin JE. Preoperative riskof death prediction model in heart surgerywith deep hypothermia circulatory arrest in the neonate. J Thorac Cardiovasc Surg.2000;119:347-357.

Coplen DE, Barthold JS. Controversies inthe management of ectopic ureteroceles.Urology. 2000;56:665-668.

Crenshaw S, Herzog R, Castagno P, RichardsJ, Miller F, Michaloski G, Moran E. Theefficacy of tone-reducing features in orthoticson the gait of children with spastic diplegiccerebral palsy. J Pediatr Orthop.2000;20:210-216.

Cronan KC. Bites and Stings. In: Selbst SM, Cronan KC. eds. Pediatric EmergencyMedicine Secrets. Hanley and Belfus,Philadelphia. 2000;363-368.

Crenn P, Thuillier F, Rakatoambinina B,Rongier M, Darmaun D, Messing B. Duodenalvs gastric administration of labeled leucinefor the study of splanchnic metabolism inhumans. J Appl Physiol. 2000;89(2):573-580.

DDarmaun D, Humbert B. Does the fate ofenterally administered glutamine depend on its molecular form? Bound versus freeamino acid. Nutrition. 2000;16(11-12):1101-1102.

Darmaun D. Role of glutamine depletion in severe illness. Diabetes Nutr Metab.2000;13(1):25-30.

DeFilippo RE, Barthold JS, Gonzalez R.The application of magnetic resonanceimaging for the preoperative localization of nonpalpable testis in obese children: An alternative to laparoscopy. J Urol.2000;164:154-155.

Deleon MA, Gidding SS, Gotteiner N, BackerCL, Mavroudis C. Successful palliation ofEbstein’s anomaly on the first day of lifefollowing fetal diagnosis. Cardiol Young.2000;10:384-387.

DeNicola LR, Kissoon N, Duckworth LJ,Blake KV, Murphy SP, Silkoff PE. Exhalednitric oxide as an indicator of severity ofasthmatic inflammation. Pediatr EmergCare. 2000;16(4):290-295.

Doyle D, DiGeorge A. Hormones andPeptides of Calcium Homeostasis and BoneMetabolism. In: Behrman RE, KliegmanRM. eds. Nelson Textbook of Pediatrics.16th edn. WB Saunders Co, Philadelphia.2000;1715.

Doyle D, DiGeorge A. Hyperparathyroidism.In: Behrman RE, Kliegman RM. eds. NelsonTextbook of Pediatrics. 16th edn. WBSaunders Co, Philadelphia. 2000;1716-1717.

Doyle D, DiGeorge A. Pseudohypopara-thyroidism. In: Behrman RE, Kliegman RM.eds. Nelson Textbook of Pediatrics. 16th edn.WB Saunders Co, Philadelphia. 2000;1718.

EEdelson MF, McKenzie SE. Why is thisnewborn bleeding? Contemp Pediatr.2000;17:60-70.

Eppes SC, Nelson DK, Lewis LL, Klein JD.Characterization of Lyme meningitis andcomparison with viral meningitis in children.Pediatrics. 1999;103:957-960.

FFang Q, Sun Y-Y, Cai W, Dodge GR, LotkeP, Williams WV. Cartilage-reactive T cellsin rheumatoid synovium. Int Immunol.2000;12:659-669.

Fawcett LB, Pugarelli JE, Brent RL. Effectsof supplemental methionine on antiserum-induced dysmorphology in rat embryos cultured in vitro. Teratology. 2000;61:332-341.

Filmer B. Megaureter-Congenital. In:Gomella LG. ed. The Five-minute UrologyConsult. Lippincott, Williams, and Wilkins,Philadelphia. 2000;340-341.

Filmer B. Posterior Urethral Valves. In:Gomella LG. ed. The Five-minute UrologyConsult. Lippincott, Williams, and Wilkins,Philadelphia. 2000;396-397.

Flynn JM, Mackenzie WG, Kolstad K,Sandifer E, Jawad AF, Galinat B. Objectiveevaluation of knee laxity in children. JPediatr Orthop. 2000;20:259-263.

Forabosco P, Collins A, Latiano A, AnneseV, Clementi M, Andriulli A, Fortina P, DevotoM, Morton NE. Combined segregation andlinkage analysis of inflammatory bowel disease in the IBD1 region using severity to characterise Crohn’s disease and ulcerativecolitis. Eur J Hum Genet. 2000;8:846-852.

Fortina P, Delgrosso K, Sakazume T,Santacroce R, Mountereaux S, Hung-Ju S,Graves D, McKenzie S, Surrey S. A simpletwo-color, array-based approach for mutationdetection. Eur J Human Genet. 2000;8:884-894.

Fouladi M, Langston J, Mulhern R, JonesD, Xiong X, Yang J, Thompson S, Walter A,Heideman R, Kun L, Gajjar A. Silent lacunarlesions detected by magnetic resonanceimaging of children with brain tumors: Alate sequela of therapy. J Clin Oncol.2000;18:824-831.

Fow F. Neurosurgical Emergencies. In:Selbst SM, Cronan KC. eds. PediatricEmergency Medicine Secrets. Hanley andBelfus, Philadelphia. 2000;271-276.

Fow F. Orthopedic Emergencies. In: SelbstSM, Cronan KC. eds. Pediatric EmergencyMedicine Secrets. Hanley and Belfus,Philadelphia. 2000;281-288.

Friedman O, Chidekel A, Lawless ST, CookSP. Postoperative bilevel positive airwaypressure ventilation after tonsillectomy andadenoidectomy in children-a preliminaryreport. Int J Pediatr Otorhinolaryngol.1999;51:177-180.

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GGabos PG, Miller F, Galban MA, Gupta GG,Dabney K. Prosthetic interposition arthroplastyfor the palliative treatment of end-stagespastic hip disease in nonambulatory patientswith cerebral palsy. J Pediatr Orthop.1999;19:796-804.

Gervasio J, Brown RO, Lima JJ, TabbaaMG, Abell T, Werkman R. Haberer LJ, Hak LJ. Sequential group trial to determinegastrointestinal site of absorption and systemicexposure of azathioprine. Dig Dis Sci. 2000;45:1601-1607.

Goldman FD, Rumelhart SL, de Alacron P,Holida MD, Lee NF, Miller J, Trigg ME,Giller R. Poor outcome in children withrefractory/relapsed leukemia undergoingbone marrow transplantation with mis-matched family member donors. BoneMarrow Transplant. 2000;25:943-948.

Gonzalez J, Heredia E, Rahman T, BarnerK, Arce G. Optimal digital filtering fortremor suppression. IEEE Trans BiomedEngin. 2000;47:663-674.

Gorelick MH, Singh SB. RespiratoryEmergencies. In: Selbst SM, Cronan KC.eds. Pediatric Emergency Medicine Secrets.Hanley and Belfus, Philadelphia.2000;241-252.

Griseri P, Sancandi M, Patrone G, BocciardiR, Hofstra R, Ravazzolo R, Devoto M, Romeo G,Ceccherini I. A single-nucleotide polymorphicvariant of the RET proto-oncogene isunderrepresented in sporadic Hirschsprungdisease. Eur J Hum Genet. 2000;8:721-724.

Grzegorzewski A, Kumar SJ. In situ postero-lateral spine arthrodesis for grades III, IV,and V spondylolithesis in children and adolescents. J Pediatr Orthop. 2000;20:506-511.

HHankard RG, Haymond MW, Darmaun D.Role of glucose in the regulation of glutaminemetabolism in health and in type 1 insulin-dependent diabetes. Am J Physiol EndocrinolMetab. 2000;279(3):E608-E613.

Harcke HT. Medical assistance to theDominican Republic by health professionalsof the Delaware Army National Guard. DelMed J. 1999;71:36-39.

Harris MA, Wysocki T, Sadler M, WilkinsonK, Harvey LM, Buckloh LM, Mauras N,White NH. Validation of a structured interview for the assessment of diabetes self management. Diabetes Care.2000;23:1301-1304.

Herrera L, Farah RA, Pellegnai VA, AquinoDB, Sandler ES, Buchanan GR, Viletta ES.Immunotoxins against CD19 and CD22 are effective in killing precursor-B acutelymphoblastic leukemia cells in vitro.Leukemia. 2000;14(5):853-858.

Hertzog JH, Dalton HJ, Anderson BD, ShadAT, Gootenberg JE, Hauser GJ. Prospectiveevaluation of propofol anesthesia in thepediatric intensive care unit for electiveoncology procedures in ambulatory andhospitalized children. Pediatrics.2000;106:742-747.

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Hobson GM, Davis AP, Stowell NC, KolodnyEH, Sistermans EA, de Coo IFM, FunanageVL, Marks HG. Mutations in non-codingregions of the proteolipid protein gene inPelizaeus-Merzbacher disease. Neurology.2000;55:1089-1096.

IInselman LS. Pediatric pulmonary pearls.Sahn SA, Heffner JE. Series eds. Philadelphia,PA: Hanley and Belfus; 2000.

Izenberg N. ed. Human diseases and conditions. New York, NY. Charles Scribner’sSons. 2000.

JJednak R, Barroso U, Barthold JS, GonzálezR. A simplified technique for upper poleheminephrectomy in duplex kidneys. JUrol. 2000;164:1326-1328.

Jednak R, Schimke CM, Barroso U, BartholdJS, Gonzalez R. Further experience withseromuscular colocystoplasty lined withurothelium. J Urol. 2000;164:2045-2049.

KKatz K, Lawler J, Wax J, O’Connor R,Nadkarni V. Vasopressin pressor effects incritically ill children during evaluation forbrain death and organ recovery. Resuscitation.2000;47:33-40.

Keating MA, Rich MA. Radiology of SpecificNeuromuscular Diseases Affecting theUrinary Tract: Myelomeningocele andRelated Conditions. In Clinical Urography2nd edn. WB Saunders, Philadelphia.2000;2394-2408.

Keenan C, Alexander MA, Sung I-Y, MillerF, Dabney K. Intrathecal Baclofen for theTreatment of Spasticity in Children. In:Alexander MA, Molnar GE. eds. PhysicalMedicine and Rehabilitation: State of theArt Reviews. Hanley and Belfus, Philadelphia.2000;275-284.

Keller MA, Delgrosso K, Surrey S, SchwartzE. Identification of the nucleotide changeresponsible for Hb P-Galveston. Hemoglobin.2000;24:165-167.

Khan TM, Kissoon N, Hasan MY, SaldajenoV, Murphy SP, Lima JJ. Comparison ofplasma levels and pharmacodynamics afterintraosseous and intravenous administrationof fosphenytoin and phenytoin in piglets.Pediatr Crit Care Med. 2000;1:60-64.

Kissoon N, Duckworth LJ, Blake KV,Murphy SP, Taylor CL, Silkoff PE. FE(NO):Relationship to exhalation rates and onlineversus bag collection in healthy adolescents.Am J Respir Crit Care Med.2000;162(2):539-545.

Koczur L, Strine C, Peischl D. CasePresentations: Practical Applications inWheelchair Technology. In: Alexander MA,Molnar GE. eds. Physical Medicine andRehabilitation: State of the Art Reviews.Hanley and Belfus, Philadelphia.2000;323-338.

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Kost S, Taylor B. Limp. In: Selbst SM,Cronan KC. eds. Pediatric EmergencyMedicine Secrets. Hanley and Belfus,Philadelphia. 2000;86-89.

Kost S. Dental/Periodontal Emergencies. In: Selbst SM, Cronan KC. eds. PediatricEmergency Medicine Secrets. Hanley andBelfus, Philadelphia. 2000;253-256.

Kost S. Stridor. In: Selbst SM, Cronan KC.eds. Pediatric Emergency Medicine Secrets.Hanley and Belfus, Philadelphia. 2000;116-118.

Kryger JV, Barthold JS, González R. Surgicalmanagement of urinary incontinence in children with neurogenic sphincteric incompetence. J Urol. 2000;163:256-263.

LLima JJ, Duckworth L, Kissoon N. Ultradianrhythm of exhaled nitric oxide in children.Am J Respir Crit Care Med. 2000;161(3).

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Lima JJ, Nguyen BN, Parker RB, JohnsonJA. Chronopharmacodynamic model of S-verapamil-evoked antihypertensive effects.Clin Pharmacol Ther. 2000;67:125.

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R E S O L U T I O N

A D O P T E D B Y T H E B O A R D O F D I R E C T O R S O F T H E N E M O U R S F O U N D AT I O NA N D T H E A L F R E D I . d u P O N T T E S TA M E N TA R Y T R U S T

WHEREAS, The Directors of The Nemours Foundation and the Trusteesof the Alfred I. duPont Testamentary Trust desire to record their deep sorrowon the passing of Jacob C. Belin on May 31, 2000, and wish to recognize andhonor his long and successful career dedicated to his community, his role withthe St. Joe Paper Company, and his outstanding dedication to the Alfred I.duPont Testamentary Trust and The Nemours Foundation, and

WHEREAS, J. C. Belin contributedgreatly to the growth and beauty of the city of Port St. Joe, serving as its mayor and participating in the civic activities of the community and in the founding of Long Avenue Baptist Church, and

WHEREAS, J. C. Belin served the St. Joe Paper Company for over sixty years from an employee in the testing laboratory to President, Chief ExecutiveOfficer, Director and Chairman of theBoard, and

WHEREAS, In the furtherance of his duties with St. Joe Paper Company, he served as officer and Director of the subsidiary companies, bringing great value to the Company and to the Trust, its principal shareholder, and

WHEREAS, J. C. Belin served in a most excellent and faithful mannerduring more than thirty years of his business career as Trustee of the Alfred I.duPont Testamentary Trust and contributed significantly to the growth, stabilityand advancement of this Organization, and

WHEREAS, In his role as Director of The Nemours Foundation, andChairman of its Board of Directors, Jacob C. Belin made great contributions to the care and treatment of crippled children in Delaware and Florida and forthe elderly in Delaware and tirelessly performed all the duties entrusted to him,

NOW THEREFORE BE IT RESOLVED, That the Trustees of the Alfred I. duPont Trust and the Directors of The Nemours Foundation hereby give formal expression of their grievous loss in the death of Jacob C. Belin and dohereby note in the records the many contributions of a man who was esteemedby his associates, loved by his friends and deeply admired by all.

BE IT FURTHER RESOLVED, That a certified copy of this joint Resolutionbe tendered to his family in expression of our sympathy and great respect.

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NEMOURS…Helping and healing children for 60 years with advances in medical skill and technology and

constancy in caring.

Creative Director Paula Foster

Editor Margaret Coupe

WritersKaren BengstonSusan BrownPaddy DietzPatricia M. DucaRobert HopkinsRobert Kettrick, MDCortney TaylorJohn Walsh

PhotographersCindy BrodowayLawrence BrodowayBill CaglePam KleinsasserAlicia Komins-MorrisJoe ManlovePeter OlsonJim Peirce, Jr.Karen Zalewski

Cover PhotoPam Kleinsasser

DesignJennifer HollandHolland Creative Services

Color SeparationThe Laser’s Edge, Inc.

PrintingPritchard & Company

*Actual names of patients and their family members have been changed out of respect for the patients’ privacy.

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1650 Prudential Drive, Suite 300 Jacksonville, Florida 32207

The Alfred I. duPont Hospital for ChildrenP.O. Box 269

Wilmington, Delaware 19899

The Nemours Health Clinic1801 Rockland Road

Wilmington, Delaware 19899

The Nemours Children’s ClinicsJacksonville

P.O. Box 5720Jacksonville, Florida 32247

OrlandoP.O. Box 568908

Orlando, Florida 32856-8908

Pensacola5225 Carmel Heights

Pensacola, Florida 32504

WilmingtonP.O. Box 269

Wilmington, Delaware 19899

Nemours Cardiac CenterThe Alfred I. duPont Hospital for Children

1600 Rockland RoadWilmington, Delaware 19803

Nemours Cardiac CenterThe Arnold Palmer Hospital for Children and Women

92 W. Miller StreetOrlando, Florida 32806

The Nemours Mansion & Gardens1600 Rockland Road

P.O. Box 109Wilmington, Delaware 19899

Nemours Center of Health Mediawww.KidsHealth.org

2000 Annual Report

Helping and Healing Childrenfor 60 Years

2000 Annual Report60th Anniversary Edition