Editorials Prognosis in Familial Atrial Fibrillation Laurent Fauchier, Arnaud Bisson, and Nicolas Clementy e004905 doi: 10.1161/JAHA.116.004905

Anemia and Acute Coronary Syndrome: Time for Intervention Studies Serdar Farhan, Usman Baber, and Roxana Mehran e004908 doi: 10.1161/JAHA.116.004908

Caution is Needed in Designing Pharmacy Coverage Steven A. Farmer and William B. Borden e004466 doi: 10.1161/JAHA.116.004466

Original Research Arrhythmia and Electrophysiology

Contrasting Nav1.8 Activity in Scn10a −/− Ventricular Myocytes and the Intact Heart Dina Myers Stroud, Tao Yang, Kevin Bersell, Dymtro O. Kryshtal, Satomi Nagao, Christian Shaffer, Laura Short, Lynn Hall, Thomas C. Atack, Wei Zhang, Bjorn C. Knollmann, Franz Baudenbacher, and Dan M. Roden e002946 doi: 10.1161/JAHA.115.002946

Neuronal Na v 1.8 Channels as a Novel Therapeutic Target of Acute Atrial Fibrillation Prevention XiaoMeng Chen, LiLei Yu, ShaoBo Shi, Hong Jiang, CongXin Huang, Mayurika Desai, YiGang Li, Hector Barajas-Martinez, and Dan Hu e004050 doi: 10.1161/JAHA.116.004050

Histological Findings and Predictors of Cerebral Debris From Transcatheter Aortic Valve Replacement: The ALSTER Experience Tobias Schmidt, Ozan Akdag, Peter Wohlmuth, Thomas Thielsen, Dimitry Schewel, Jury Schewel, Hannes Alessandrini, Felix Kreidel, Ralf Bader, Maria Romero, Elena Ladich, Renu Virmani, Ulrich Schäfer, Karl-Heinz Kuck, and Christian Frerker e004399 doi: 10.1161/JAHA.116.004399

Simultaneous Non-Invasive Epicardial and Endocardial Mapping in Patients With Brugada Syndrome: New Insights Into Arrhythmia Mechanisms Boris Rudic, Maria Chaykovskaya, Alexey Tsyganov, Vitaly Kalinin, Erol Tülümen, Theano Papavassiliu, Christina Dösch, Volker Liebe, Jürgen Kuschyk, Susanne Röger, Ibrahim El-Battrawy, Ibrahim Akin, Marina Yakovleva, Elena Zaklyazminskaya, Anna Shestak, Stanislav Kim, Mikhail Chmelevsky, and Martin Borggrefe e004095 doi: 10.1161/JAHA.116.004095

Outcomes Associated With Familial Versus Nonfamilial Atrial Fibrillation: A Matched Nationwide Cohort Study Anna Gundlund, Jonas Bjerring Olesen, Laila Staerk, Christina Lee, Jonathan P. Piccini, Eric D. Peterson, Lars Køber, Christian Torp-Pedersen, Gunnar H. Gislason, and Emil Loldrup Fosbøl e003836 doi: 10.1161/JAHA.116.003836

Congenital Heart Disease Electrophysiology Study for Complex Supraventricular Tachycardia in Congenital Heart Disease Patients With Single-Ventricle Physiology Shuenn-Nan Chiu, Jou-Kou Wang, Chun-Wei Lu, Kun-Lang Wu, Wei-Chieh Tseng, and Mei-Hwan Wu e004504 doi: 10.1161/JAHA.116.004504

JAHA: Journal of the American Heart AssociationVolume 5, Issue 11

November 2016

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Phosphodiesterase Inhibitor-Based Vasodilation Improves Oxygen Delivery and Clinical Outcomes Following Stage 1 Palliation Kimberly I. Mills, Aditya K. Kaza, Brian K. Walsh, Hilary C. Bond, Mackenzie Ford, David Wypij, Ravi R. Thiagarajan, Melvin C. Almodovar, Luis G. Quinonez, Christopher W. Baird, Sitaram E. Emani, Frank A. Pigula, James A. DiNardo, and John N. Kheir e003554 doi: 10.1161/JAHA.116.003554

Premature Cardiac Aging in South Asian Compared to Afro-Caribbean Subjects in a Community-Based Screening Study Eduard Shantsila, Alena Shantsila, Paramjit S. Gill, and Gregory Y.H. Lip e004110 doi: 10.1161/JAHA.116.004110

Coronary Heart Disease Lipid-Free Apolipoprotein A-I Reduces Progression of Atherosclerosis by Mobilizing Microdomain Cholesterol and Attenuating the Number of CD 131 Expressing Cells: Monitoring Cholesterol Homeostasis Using the Cellular Ester to Total Cholesterol Ratio Sushma Kaul, Hao Xu, Manal Zabalawi, Elisa Maruko, Brian E. Fulp, Theresa Bluemn, Kristina L. Brzoza-Lewis, Mark Gerelus, Ranjuna Weerasekera, Rachel Kallinger, Roland James, Yi (Sherry) Zhang, Michael J. Thomas, and Mary G. Sorci-Thomas e004401 doi: 10.1161/JAHA.116.004401

Comparison of Drug-Eluting and Bare Metal Stents in Patients With Chronic Kidney Disease: An Updated Systematic Review and Meta-Analysis Renjie Lu, Fenglei Tang, Yan Zhang, Xishan Zhu, Shanmei Zhu, Ganlin Wang, Yinfeng Jiang, and Zhengda Fan e003990 doi: 10.1161/JAHA.116.003990

Effect of High (200 μg/kg per Minute) Adenosine Dose Infusion on Fractional Flow Reserve Variability Dimitrios Alexopoulos, Ioanna Xanthopoulou, Grigorios Tsigkas, Nikolaos Koutsogiannis, Paraskevi Salata, Stylianos Armylagos, Athanasios Moulias, and Periklis Davlouros e004323 doi: 10.1161/JAHA.116.004323

Hydrogen Peroxide-Responsive Nanoparticle Reduces Myocardial Ischemia/Reperfusion Injury Soochan Bae, Minhyung Park, Changsun Kang, Serkan Dilmen, Tae Hi Kang, Dong Goo Kang, Qingen Ke, Seung Uk Lee, Dongwon Lee, and Peter M. Kang e003697 doi: 10.1161/JAHA.116.003697

Bimodal Pattern of Coronary Microvascular Involvement in Diabetes Mellitus Murat Sezer, Mehmet Kocaaga, Emre Aslanger, Adem Atici, Ahmet Demirkiran, Zehra Bugra, Sabahattin Umman, and Berrin Umman e003995 doi: 10.1161/JAHA.116.003995

Effects of the P-Selectin Antagonist Inclacumab on Myocardial Damage After Percutaneous Coronary Intervention According to Timing of Infusion: Insights From the SELECT - ACS Trial Barbara E. Stähli, Catherine Gebhard, Valérie Duchatelle, Daniel Cournoyer, Thibaut Petroni, Jean-François Tanguay, Stephen Robb, Jessica Mann, Marie-Claude Guertin, R. Scott Wright, Philippe L. L’Allier, and Jean-Claude Tardif e004255 doi: 10.1161/JAHA.116.004255

Relationship Between β-Blocker Therapy at Discharge and Clinical Outcomes in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention Chenze Li, Yang Sun, Xiaoqing Shen, Ting Yu, Qing Li, Guoran Ruan, Lina Zhang, Qiang Huang, Hang Zhuang, Jingqiu Huang, Li Ni, Luyun Wang, Jiangang Jiang, Yan Wang, and Dao Wen Wang e004190 doi: 10.1161/JAHA.116.004190

Clinical Outcomes of Vasospastic Angina Patients Presenting With Acute Coronary Syndrome Sung Woo Cho, Taek Kyu Park, Hye Bin Gwag, A. Young Lim, Min Seok Oh, Da Hyon Lee, Choong Sil Seong, Jeong Hoon Yang, Young Bin Song, Joo-Yong Hahn, Jin-Ho Choi, Sang Hoon Lee, Hyeon-Cheol Gwon, and Seung-Hyuk Choi e004336 doi: 10.1161/JAHA.116.004336

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Relationship Between Anemia and Mortality Outcomes in a National Acute Coronary Syndrome Cohort: Insights From the UK Myocardial Ischemia National Audit Project Registry Mamas A. Mamas, Chun Shing Kwok, Evangelos Kontopantelis, Anthony A. Fryer, Iain Buchan, Max O. Bachmann, M. Justin Zaman, and Phyo K. Myint e003348 doi: 10.1161/JAHA.116.003348

Epidemiology Relative Contributions of Arterial Stiffness and Hypertension to Cardiovascular Disease: The Framingham Heart Study Teemu J. Niiranen, Bindu Kalesan, Naomi M. Hamburg, Emelia J. Benjamin, Gary F. Mitchell, and Ramachandran S. Vasan e004271 doi: 10.1161/JAHA.116.004271

Prognostic Importance of C-Reactive Protein in High Cardiovascular Risk Patients With Type 2 Diabetes Mellitus: The Rio de Janeiro Type 2 Diabetes Cohort Study Claudia R. L. Cardoso, Nathalie C. Leite, and Gil F. Salles e004554 doi: 10.1161/JAHA.116.004554

Clopidogrel Improves Skin Microcirculatory Endothelial Function in Persons With Heightened Platelet Aggregation Shabnam Salimi, Joshua P. Lewis, Laura M. Yerges-Armstrong, Braxton D. Mitchell, Faisal Saeed, Jeffry R. O’Connell, James A. Perry, Kathleen A. Ryan, Alan R. Shuldiner, and Afshin Parsa e003751 doi: 10.1161/JAHA.116.003751

Hypertensive Disorders of Pregnancy and Offspring Cardiac Structure and Function in Adolescence Simon Timpka, Corrie Macdonald-Wallis, Alun D. Hughes, Nishi Chaturvedi, Paul W. Franks, Debbie A. Lawlor, and Abigail Fraser e003906 doi: 10.1161/JAHA.116.003906

Bicycling to Work and Primordial Prevention of Cardiovascular Risk: A Cohort Study Among Swedish Men and Women Anders Grøntved, Robert W. Koivula, Ingegerd Johansson, Patrik Wennberg, Lars Østergaard, Göran Hallmans, Frida Renström, and Paul W. Franks e004413 doi: 10.1161/JAHA.116.004413

Short-Term Risk of Bleeding During Heparin Bridging at Initiation of Vitamin K Antagonist Therapy in More Than 90 000 Patients With Nonvalvular Atrial Fibrillation Managed in Outpatient Care Kim Bouillon, Marion Bertrand, Lotfi Boudali, Pierre Ducimetière, Rosemary Dray-Spira, and Mahmoud Zureik e004065 doi: 10.1161/JAHA.116.004065

YKL-40 Level and Hypertension Incidence: A Population-Based Nested Case-Control Study in China Tian Xu, Chongke Zhong, Aili Wang, Zhirong Guo, Xiaoqing Bu, Yipeng Zhou, Yunfan Tian, Xinfeng HuangFu, Zhengbao Zhu, and Yonghong Zhang e004534 doi: 10.1161/JAHA.116.004534

Length of Residence in the United States is Associated With a Higher Prevalence of Cardiometabolic Risk Factors in Immigrants: A Contemporary Analysis of the National Health Interview Survey Yvonne Commodore-Mensah, Nwakaego Ukonu, Olawunmi Obisesan, Jonathan Kumi Aboagye, Charles Agyemang, Carolyn M. Reilly, Sandra B. Dunbar, and Ike S. Okosun e004059 doi: 10.1161/JAHA.116.004059

Ischemic Stroke and Risk of Venous Thromboembolism in the General Population: The Tromsø Study Ludvig B. Rinde, Birgit Småbrekke, Ellisiv B. Mathiesen, Maja-Lisa Løchen, Inger Njølstad, Erin M. Hald, Tom Wilsgaard, Sigrid K. Brækkan, and John-Bjarne Hansen e004311 doi: 10.1161/JAHA.116.004311

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Ectopic Fat Depots and Coronary Artery Calcium in South Asians Compared With Other Racial/Ethnic Groups Sachin K. Garg, Feng Lin, Namratha Kandula, Jingzhong Ding, Jeffrey Carr, Matthew Allison, Kiang Liu, David Herrington, Dhananjay Vaidya, Eric Vittinghoff, and Alka M. Kanaya e004257 doi: 10.1161/JAHA.116.004257

Genetics Ventricular-Vascular Coupling in Marfan and Non-Marfan Aortopathies Farina Loeper, Jantine Oosterhof, Mark van den Dorpel, Denise van der Linde, Yaxin Lu, Elizabeth Robertson, Brett Hambly, and Richmond Jeremy e003705 doi: 10.1161/JAHA.116.003705

Health Services and Outcomes Research Impact of Cost Sharing on Therapeutic Substitution: The Story of Statins in 2006 Pengxiang Li, J. Sanford Schwartz, and Jalpa A. Doshi e003377 doi: 10.1161/JAHA.116.003377

Impact of Insurance Status on Outcomes and Use of Rehabilitation Services in Acute Ischemic Stroke: Findings From Get With The Guidelines-Stroke Laura N. Medford-Davis, Gregg C. Fonarow, Deepak L. Bhatt, Haolin Xu, Eric E. Smith, Robert Suter, Eric D. Peterson, Ying Xian, Roland A. Matsouaka, and Lee H. Schwamm e004282 doi: 10.1161/JAHA.116.004282

Heart Failure Smad Nuclear Interacting Protein 1 Acts as a Protective Regulator of Pressure Overload-Induced Pathological Cardiac Hypertrophy Yu-yan Lu, Da-chun Xu, Yi-fan Zhao, Guo-fu Zhu, Meng-yun Zhu, Wei-jing Liu, Xue-jing Yu, Wei Chen, Zheng Liu, and Ya-wei Xu e003943 doi: 10.1161/JAHA.116.003943

MiR-590 Promotes Transdifferentiation of Porcine and Human Fibroblasts Toward a Cardiomyocyte-Like Fate by Directly Repressing Specificity Protein 1 Vivek P. Singh, Megumi Mathison, Vivekkumar Patel, Deepthi Sanagasetti, Brian W. Gibson, Jianchang Yang, and Todd K. Rosengart e003922 doi: 10.1161/JAHA.116.003922

Myocardial Immunocompetent Cells and Macrophage Phenotypes as Histopathological Surrogates for Diagnosis of Cardiac Sarcoidosis in Japanese Yasuyuki Honda, Toshiyuki Nagai, Yoshihiko Ikeda, Mamoru Sakakibara, Naoya Asakawa, Nobutaka Nagano, Michikazu Nakai, Kunihiro Nishimura, Yasuo Sugano, Keiko Ohta-Ogo, Yasuhide Asaumi, Takeshi Aiba, Hideaki Kanzaki, Kengo Kusano, Teruo Noguchi, Satoshi Yasuda, Hiroyuki Tsutsui, Hatsue Ishibashi-Ueda, and Toshihisa Anzai e004019 doi: 10.1161/JAHA.116.004019

Hypertension Clinical Adverse Effects of Endothelin Receptor Antagonists: Insights From the Meta-Analysis of 4894 Patients From 24 Randomized Double-Blind Placebo-Controlled Clinical Trials Anhua Wei, Zhichun Gu, Juan Li, Xiaoyan Liu, Xiaofan Wu, Yi Han, and Jun Pu e003896 doi: 10.1161/JAHA.116.003896

Knockdown of Inhibitory Guanine Nucleotide Binding Protein Giα-2 by Antisense Oligodeoxynucleotides Attenuates the Development of Hypertension and Tachycardia in Spontaneously Hypertensive Rats Yousra Ali El-Basyuni, Yuan Li, and Madhu B. Anand-Srivastava e004594 doi: 10.1161/JAHA.116.004594

Irisin Lowers Blood Pressure by Improvement of Endothelial Dysfunction via AMPK -Akt- eNOS - NO Pathway in the Spontaneously Hypertensive Rat Jinjuan Fu, Yu Han, Jialiang Wang, Yukai Liu, Shuo Zheng, Lin Zhou, Pedro A. Jose, and Chunyu Zeng e003433 doi: 10.1161/JAHA.116.003433

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Long-Term Visit-to-Visit Blood Pressure Variability and Renal Function Decline in Patients With Hypertension Over 15 Years Yook Chin Chia, Hooi Min Lim, and Siew Mooi Ching e003825 doi: 10.1161/JAHA.116.003825

Interventional Cardiology Neurological Injury in Intermediate-Risk Transcatheter Aortic Valve Implantation Jonathon P. Fanning, Allan J. Wesley, Darren L. Walters, Eamonn M. Eeles, Adrian G. Barnett, David G. Platts, Andrew J. Clarke, Andrew A. Wong, Wendy E. Strugnell, Cliona O’Sullivan, Oystein Tronstad, and John F. Fraser e004203 doi: 10.1161/JAHA.116.004203

Kidney in Cardiovascular Disease Development and Validation of a Risk Score for Prediction of Acute Kidney Injury in Patients With Acute Decompensated Heart Failure: A Prospective Cohort Study in China Li Zhi Zhou, Xiao Bing Yang, Ying Guan, Xing Xu, Ming T. Tan, Fan Fan Hou, and Ping Yan Chen e004035 doi: 10.1161/JAHA.116.004035

Preventive Cardiology Low Body Mass Index, Serum Creatinine, and Cause of Death in Patients Undergoing Percutaneous Coronary Intervention Kashish Goel, Rajiv Gulati, Guy S. Reeder, Ryan J. Lennon, Bradley R. Lewis, Atta Behfar, Gurpreet S. Sandhu, Charanjit S. Rihal, and Mandeep Singh e003633 doi: 10.1161/JAHA.116.003633

Effects of Statin on Arrhythmia and Heart Rate Variability in Healthy Persons With 48-Hour Sleep Deprivation Wei Ren Chen, Hong Bin Liu, Yuan Sha, Yang Shi, Hao Wang, Da Wei Yin, Yun Dai Chen, and Xiang Min Shi e003833 doi: 10.1161/JAHA.116.003833

25-Hydroxyvitamin D Levels and Markers of Subclinical Myocardial Damage and Wall Stress: The Atherosclerosis Risk in Communities Study Erin D. Michos, Elizabeth Selvin, Jeffrey R. Misialek, John W. McEvoy, Chiadi E. Ndumele, Aaron R. Folsom, Christie M. Ballantyne, and Pamela L. Lutsey e003575 doi: 10.1161/JAHA.116.003575

Stroke Coronary Artery Calcium Score Improves the Prediction of Occult Coronary Artery Stenosis in Ischemic Stroke Patients Ysoline Beigneux, Jean-Louis Sablayrolles, Olivier Varenne, Jean-Louis Mas, and David Calvet e003770 doi: 10.1161/JAHA.116.003770

Valvular Heart Disease Role for Galectin-3 in Calcific Aortic Valve Stenosis J. Rafael Sádaba, Ernesto Martínez-Martínez, Vanessa Arrieta, Virginia Álvarez, Amaya Fernández-Celis, Jaime Ibarrola, Amaia Melero, Patrick Rossignol, Victoria Cachofeiro, and Natalia López-Andrés e004360 doi: 10.1161/JAHA.116.004360

Repositionable Versus Balloon-Expandable Devices for Transcatheter Aortic Valve Implantation in Patients With Aortic Stenosis Thomas Pilgrim, Stefan Stortecky, Fabian Nietlispach, Dik Heg, David Tueller, Stefan Toggweiler, Enrico Ferrari, Stéphane Noble, Francesco Maisano, Raban Jeger, Marco Roffi, Jürg Grünenfelder, Christoph Huber, Peter Wenaweser, and Stephan Windecker e004088 doi: 10.1161/JAHA.116.004088

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Vascular Medicine Relationship of Platelet Reactivity With Bleeding Outcomes During Long-Term Treatment With Dual Antiplatelet Therapy for Medically Managed Patients With Non- ST -Segment Elevation Acute Coronary Syndromes Jan H. Cornel, E. Magnus Ohman, Benjamin Neely, Joseph A. Jakubowski, Deepak L. Bhatt, Harvey D. White, Diego Ardissino, Keith A.A. Fox, Dorairaj Prabhakaran, Paul W. Armstrong, David Erlinge, Udaya S. Tantry, Paul A. Gurbel, and Matthew T. Roe e003977 doi: 10.1161/JAHA.116.003977

Toll-Like Receptor ( TLR )4 and MyD88 are Essential for Atheroprotection by Peritoneal B1a B Cells Hamid Hosseini, Yi Li, Peter Kanellakis, Christopher Tay, Anh Cao, Edgar Liu, Karlheinz Peter, Peter Tipping, Ban-Hock Toh, Alex Bobik, and Tin Kyaw e002947 doi: 10.1161/JAHA.115.002947

Special Reports International Collaborative Partnership for the Study of Atrial Fibrillation ( INTERAF ): Rationale, Design, and Initial Descriptives Jonathan C. Hsu, Masaharu Akao, Mitsuru Abe, Karen L. Anderson, Alvaro Avezum, Nathan Glusenkamp, Shun Kohsaka, Deirdre A. Lane, Gregory Y. H. Lip, Chang-Sheng Ma, Frederick A. Masoudi, Tatjana S. Potpara, Teo Wee Siong, Mintu P. Turakhia, Hung-Fat Tse, John S. Rumsfeld, and Thomas M. Maddox e004037 doi: 10.1161/JAHA.116.004037

“Small Blood Vessels: Big Health Problems?”: Scientific Recommendations of the National Institutes of Health Workshop Francesca Bosetti, Zorina S. Galis, Margaret S. Bynoe, Marc Charette, Marilyn J. Cipolla, Gregory J. del Zoppo, Douglas Gould, Thomas S. Hatsukami, Teresa L. Z. Jones, James I. Koenig, Gerard A. Lutty, Christine Maric-Bilkan, Troy Stevens, H. Eser Tolunay, Walter Koroshetz, on behalf of the “Small Blood Vessels: Big Health Problems” Workshop Participants e004389 doi: 10.1161/JAHA.116.004389

Contemporary Reviews Databases for Congenital Heart Defect Public Health Studies Across the Lifespan Tiffany J. Riehle-Colarusso, Lisa Bergersen, Craig S. Broberg, Cynthia H. Cassell, Darryl T. Gray, Scott D. Grosse, Jeffrey P. Jacobs, Marshall L. Jacobs, Russell S. Kirby, Lazaros Kochilas, Asha Krishnaswamy, Arianne Marelli, Sara K. Pasquali, Thalia Wood, Matthew E. Oster, for the Congenital Heart Public Health Consortium e004148 doi: 10.1161/JAHA.116.004148

Early Denervation and Later Reinnervation of the Heart Following Cardiac Transplantation: A Review Morcos Awad, Lawrence S. C. Czer, Margaret Hou, Sarah S. Golshani, Michael Goltche, Michele De Robertis, Michelle Kittleson, Jignesh Patel, Babak Azarbal, Evan Kransdorf, Fardad Esmailian, Alfredo Trento, and Jon A. Kobashigawa e004070 doi: 10.1161/JAHA.116.004070

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5 (11)

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