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U N I V E R S I T Y O F C O P E N H A G E N
3D printing in a pharmaceutical setting
Johan Peter Bøtker
Pharmaceutical Technology and Engineering Section
Department of Pharmacy
University of Copenhagen
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N
Possibilities with the 3D printing techniques
D E P A R T M E N T O F P H A R M A C Y
3D printing is applied in industries such as food, aerospace,
automotive, jewelry, military, medical and dental.
It is often used for rapid prototyping but within the aerospace
industry it is used for actual production of final parts.
The possibility to modify the design of a given part at will is a huge
benefit for production.
Within the pharmaceutical industry the ability to play with e.g.
surface area and shape in general may provide interesting
possibilities.
Slide 2
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N
Possibilities with the 3D printing techniques
D E P A R T M E N T O F P H A R M A C Y
3D printing aka solid free-form technology (SFF), rapid prototyping
(RP) and additive manufacturing (AM).
1986 Charles Hull field first stereolitographic patent alongside
starting the company “3D systems” and developing the .STL file
format.
1990 Fused deposition modeling (FDM) was developed by Scott
Crump at Stratasys.
1993 MIT Professors Emanuel Sachs and Michael Cima patented
first device named ”3D printer” that could print plastic, metal and
ceramic parts.
3D printing enables more flexible manufacturing. Thus may also
enable more flexible manufacturing of pharmaceuticals. Aprecia
Pharmaceuticals have recently received FDA approval for a 3D
printed orally disintegrating tablet and have started production.
Gross et al., 2014. Anal. Chem. 86: 3240-3253Slide 3
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N
Introduction to 3D printing techniques
D E P A R T M E N T O F P H A R M A C Y
Gross et al., 2014. Anal. Chem. 86: 3240-3253
3D printing can be achieved using various techniques such as:
Stereolitography (SLA)
Inkjet printing
Slide 4
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N
Introduction to 3D printing techniques
D E P A R T M E N T O F P H A R M A C Y
Gross et al., 2014. Anal. Chem. 86: 3240-3253
Selective laser sintering (SLS)
Fused Deposition modeling (FDM)
Slide 5
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N
Possibilities with the 3D printing techniques
D E P A R T M E N T O F P H A R M A C Y
Katstra et al., 2000. J. Control. Release 66: 11-17
Slide 6
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N
Possibilities with the 3D printing techniques
D E P A R T M E N T O F P H A R M A C Y
The 3D printing technique can facilitate the production of highly
complex formulations.
Rowe et al., 2000. J. Control. Release 66: 11-17Slide 7
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N
Possibilities with the 3D printing techniques
D E P A R T M E N T O F P H A R M A C Y
Thus the 3D printing technique can facilitate the production of
highly complex formulations that has a unique dissolution profile.
Rowe et al., 2000. J. Control. Release 66: 11-17Slide 8
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N
Possibilities with the 3D printing techniques
D E P A R T M E N T O F P H A R M A C Y
Sun et al., 2015. Adv. Mater. 27: 7847-7853Slide 9
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N
Possibilities with the 3D printing techniques
D E P A R T M E N T O F P H A R M A C Y
Sun et al., 2015. Adv. Mater. 27: 7847-7853Slide 10
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N
Possibilities with the 3D printing techniques
D E P A R T M E N T O F P H A R M A C Y
Sun et al., 2015. Adv. Mater. 27: 7847-7853Slide 11
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N
Possibilities with the 3D printing techniques
D E P A R T M E N T O F P H A R M A C Y
Sun et al., 2015. Adv. Mater. 27: 7847-7853Slide 12
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y
Activities within 3D printing
Water et al., . J. Pharm. Sci. 104: 1099-1107
3D printed implants containing NF, HA and PLA.
Slide 13
http://www.drug-dev.com/Main/Back-Issues/HOT-MELT-EXTRUSION-OptiMelt-Hot-Melt-Extrusion-Tec-983.aspx
https://3dprint.com/65361/fusion3-discounts/
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y
Activities within 3D printing
Water et al., . J. Pharm. Sci. 104: 1099-1107
3D printed implants containing NF, HA and PLA.
Slide 14
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y
Activities within 3D printing
Water et al., . J. Pharm. Sci. 104: 1099-1107
3D printed implants containing NF, HA and PLA.
Slide 15
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y
Activities within 3D printing
Markl et al., submitted manuscript
3D printed oral formulations.
Slide 16
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y
3D printing two compartment shell
Markl et al., submitted manuscript Slide 17
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y
Activities within 3D printing
Markl et al., submitted manuscript
3D printed oral formulations.
Slide 18
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y
3D printing of PLA shell
Markl et al., submitted manuscript Slide 19
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y
3D printing PVA shell
Markl et al., submitted manuscript Slide 20
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y
3D printing PVA shell
Markl et al., submitted manuscript
3D printed oral powder formulations.
Slide 21
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y
3D printing two compartment shell
Markl et al., submitted manuscript
3D printed oral SNEDDS formulations.
Slide 22
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y
3D printing two compartment shell
Markl et al., submitted manuscript Slide 23
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y
3D printing two compartment shell
Markl et al., submitted manuscript
3D printed oral SNEDDS formulations.
Slide 24
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y
3D printing two compartment shell
Markl et al., submitted manuscript
3D printed oral SNEDDS formulations.
https://www.capsuline.com
Slide 25
U N I V E R S I T Y O F C O P E N H A G E NU N I V E R S I T Y O F C O P E N H A G E N D E P A R T M E N T O F P H A R M A C Y
Credits
Cecilie Rasch, Maria Høtoft Michaelsen, Anette Müllertz, Jukka
Rantanen and Thomas Rades, University of Copenhagen
Slide 26
Daniel Markl and Axel Zeitler, University of Cambridge
