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Johnson & Johnson's Scientific Response to Help Combat COVID-19 We are committed to: Progress Toward a Vaccine for COVID-19 We have been actively engaged in fighting pandemics for over a century. We have done it before, and we will do it again. Paul Stoffels, M.D. Vice Chairman of the Executive Committee and Chief Scientific Officer, Johnson & Johnson Since the early days of the outbreak, Johnson & Johnson has been working with industry partners, governments and health authorities to help end the fast-moving COVID-19 pandemic through the development of a possible preventive vaccine candidate against COVID-19. Our Janssen COVID-19 vaccine program is leveraging Janssen's AdVac ® technology, which provides the ability to rapidly develop new vaccine candidates. Vaccine development initiated January 12, 2020 Commitment to Collaboration Working with partners to screen a library of compounds, and conducting clinical trials to explore potential therapeutics Accelerating the clinical development of our Janssen COVID-19 vaccine candidate and expanding our manufacturing and distribution capabilities Collaborating with regulators, healthcare organizations, institutions and communities worldwide to help ensure our research platforms, existing science and outbreak expertise can be maximized to stem this public health threat Announcement of our lead vaccine candidate, with two backups March 30, 2020 For more information on Johnson & Johnson's multi-pronged approach to help combat COVID-19, visit jnj.com/coronavirus. © Johnson & Johnson Last updated: October 26, 2020 The search for a potential COVID-19 vaccine and COVID-19 treatments is being progressed by partnerships and collaborations, including those between the Janssen Pharmaceutical Companies of Johnson & Johnson and the Biomedical Advanced Research and Development Authority (BARDA), part of the U.S. Department of Health & Human Services, and the Beth Israel Deaconess Medical Center (BIDMC). We are committed to collaborating with multiple stakeholders to ensure any future effective vaccines and/or therapies against COVID-19 will be accessible wherever needed. Initiation of Phase 3 ENSEMBLE clinical trial September 21, 2020 Announcement of interim results from Phase 1/2a clinical study September 2020 Initiation of Phase 1/2a first-in-human clinical trial July 22, 2020 Publication of preclinical data in Nature, demonstrating that our lead vaccine candidate protected against infection with COVID-19 July 30, 2020 Taking an evidence- and science-based, ethics- and values-driven approach to medical safety, putting patient and consumer wellbeing first and foremost in our decision making and actions

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Johnson & Johnson's Scienti�c Response to Help Combat COVID-19

We are committed to:

Progress Toward a Vaccine for COVID-19

We have been actively engaged in �ghting pandemics for over a century. We have done it before, and we will do it again.

Paul Sto�els, M.D.Vice Chairman of the Executive Committee and Chief Scienti�c O�cer, Johnson & Johnson

Since the early days of the outbreak, Johnson & Johnson has been working with industry partners, governments and health authorities to help end the fast-moving COVID-19 pandemic through the development of a possible preventive vaccine candidate against COVID-19.

Our Janssen COVID-19 vaccine program is leveraging Janssen's AdVac® technology, which provides the ability to rapidly develop new vaccine candidates.

Vaccine development initiated

January 12, 2020

Commitment to Collaboration

Working with partners to screen a library of compounds, and conducting clinical trials to explore potential therapeutics

Accelerating the clinical development of our Janssen COVID-19 vaccine candidate and expanding our manufacturing and distribution capabilities

Collaborating with regulators, healthcare organizations, institutions and communities worldwide to help ensure our research platforms, existing science and outbreak expertise can be maximized to stem this public health threat

Announcement of our lead vaccine candidate,

with two backupsMarch 30, 2020

For more information on Johnson & Johnson's multi-pronged approach to help combat COVID-19, visit jnj.com/coronavirus.

© Johnson & JohnsonLast updated: October 26, 2020

The search for a potential COVID-19 vaccine and COVID-19 treatments is being progressed by partnerships and collaborations, including those between the Janssen Pharmaceutical Companies of Johnson & Johnson and the Biomedical Advanced Research and Development Authority (BARDA), part of the U.S. Department of Health & Human Services, and the Beth Israel Deaconess Medical Center (BIDMC). We are committed to collaborating with multiple stakeholders to ensure any future e�ective vaccines and/or therapies against COVID-19 will be accessible wherever needed.

Initiation of Phase 3 ENSEMBLE clinical trial

September 21, 2020

Announcement of interim results from Phase 1/2a

clinical studySeptember 2020

Initiation of Phase 1/2a �rst-in-human clinical trial

July 22, 2020

Publication of preclinical data in Nature, demonstrating

that our lead vaccine candidate protected against

infection with COVID-19July 30, 2020

Taking an evidence- and science-based, ethics- and values-driven approach to medical safety, putting patient and consumer wellbeing �rst and foremost in our decision making and actions