Jurnal PK Farida(1)

8/10/2019 Jurnal PK Farida(1)

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Global Journal of Pharmacology 7 (2): 123-132, 2013ISSN 1992-007! I"#SI Publ$ca%$on&, 2013"#I: 10'29$*o&$'g+'2013'7'2'72171

Hepato-Renal and Hematological Effects of Diclofenac Sodium in Rats

1Zeynab Kh. El-Maddawy and 1,2Ibrahim M. El-Ashmawy

1"ar%mn% of Pharmacology, .acul%y of /%r$nary *$c$n, lan*r$a n$4r&$%y, 5gy%

2"ar%mn% of /%r$nary *$c$n, 6a&&$m 4$4r&$%y, ur$*ah, 6a&&$m, 182, Sau*$ rab$a

Abstract: h r&n% &%u*y a& carr$* ou% %o 4alua% %h a*4r& ffc%& of a *a$ly &$ngl $n+c%$on of*$clofnac &o*$um a% *$ffrn% *o&& on &om hma%olog$cal, b$ochm$cal aram%r& an* o$*a%$4 &%r&&';$&%olog$cal chang& $n l$4r an* '7 mg F'

"$clofnac ha& %h caac$%y%o %ra% uncoml$ca%*ur$nary %rac% $nfc%$on&cau&* by E. coli' E7F' I%ha& al&o bn &hon %o bffc%$4 $n %ra%$ngSalmonlla $nfc%$on& $nm$c EF an* $& un*r$n4&%$ga%$on for %h%ra%mn% of

#orresponding Aut$or: ynab

Cham$& 5B-a**ay,

"ar%mn% ofPharmacology,

.acul%y of/%r$nary


2/34


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+c%$on) a%*$ffrn%*o&& on

&omhma%olog$cal,

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;moglob$nconcn%ra%$on a&*%rm$n*

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m%r$callyaf%r %hrac%$on$%h%h$obarb$%ur$c ac$*

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by Placre% al' E23F'@*uc*

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S*lac< an*B$n*&ayE28F' hm%ho* $&

ba&* on %hr*uc%$4cla4ag of

, -*$%h$ob$&- (2-n$%robnLo$cac$*)("N) by&ulfhy*ryl (-

S;) grou %oy$l* ayllocolour $%hma$mumab&orbanca% 812 nm'

128


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E'amination:

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r&n%* a&man& lu&or m$nu& %h&%an*ar*rror' hm$n$muml4l of &$gn$f$canca& &% a% &

0'0'

RES"&

S

Hematologi

cal

,indings:

*m$n$&%ra%$on of *$clofnac&o*$um a% a*o& of >'7mg


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*ioc$emi

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, G',I'S%auffr%,;'S$

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r$marycul%ur&of ra%ha%ocy%&'o$cology, In4$%ro, :->>'

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*, N'@','G'yr&,J'?'"a4$la,@'J';$gh%an*B'@'Pohl,1993'Immunochm$ca

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an*;a%ology,12:282-20'

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buch$, T',S'

Na7->0'

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Jurnal PK Farida(1)