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KEYSTONE SYMPOSIA Connecting the Scientific Community Keystone Symposia is a 501(c)3 nonprofit directed and supported by the scientific community. Conferences provide an opportunity for debate, exchange and learning combined with leisure activities in world-class settings. Biomarker Discovery, Validation and Applications February 3-8, 2008 Granlibakken Conference Center and Lodge, Lake Tahoe, California To register or for more information on this and 50+ other conferences, please visit www.keystonesymposia.org/8B1 or call 800-253-0685. Organizers: Mark S. Boguski and Jean-Jacques Garaud Topics Include: New Strategies for Biomarker Discovery and Use Biomarker Qualification Imaging Biomarkers Genomic Strategies Multiplex Biomarkers and System Response Profiles New Technologies Translational Medicine and the Critical Path Slide 2 Preliminary analysis of TLAs* at the 2008 Keystone Biomarker Conference Dr. Mark Boguski www.markboguski.net February 8, 2008 *Three-Letter Acronyms Slide 3 BUN CSF FDR HIV LPS MRS PET SDA CAD DNA FHF HPV MDA NAC PLA SIV CEA ESI GBM HTG MEF NIH PSA SSC CIR FDA GSH IFX MRI OOB RCC TIA CRC FDG HDG LDA MRM PCR RNA TMA TLAs used in oral presentations or abstracts Slide 4 BUN CSF FDR HIV LPS MRS PET SDA CAD DNA FHF HPV MDA NAC PLA SIV CEA ESI GBM HTG MEF NIH PSA SSC CIR FDA GSH IFX MRI OOB RCC TIA CRC FDG HDG LDA MRM PCR RNA TMA Supervised clustering shows 6 categories Slide 5 BUN CSF FDR HIV LPS MRS PET SDA CAD DNA FHF HPV MDA NAC PLA SIV CEA ESI GBM HTG MEF NIH PSA SSC CIR FDA GSH IFX MRI OOB RCC TIA CRC FDG HDG LDA MRM PCR RNA TMA Work is being done on a variety of diseases Slide 6 BUN CSF FDR HIV LPS MRS PET SDA CAD DNA FHF HPV MDA NAC PLA SIV CEA ESI GBM HTG MEF NIH PSA SSC CIR FDA GSH IFX MRI OOB RCC TIA CRC FDG HDG LDA MRM PCR RNA TMA The number of validated biomarkers is small Slide 7 BUN CSF FDR HIV LPS MRS PET SDA CAD DNA FHF HPV MDA NAC PLA SIV CEA ESI GBM HTG MEF NIH PSA SSC CIR FDA GSH IFX OOB RCC TIA CRC FDG HDG LDA MRM PCR RNA TMA A variety of research methods are being used Experimental Methods MRI Slide 8 BUN CSF FDR HIV LPS MRS PET SDA CAD DNA FHF HPV MDA NAC PLA SIV CEA ESI GBM HTG MEF NIH PSA SSC CIR FDA GSH IFX Imaging Methods OOB RCC TIA CRC FDG HDG LDA MRM PCR RNA TMA A variety of research methods are being used MRI Slide 9 BUN CSF FDR HIV LPS MRS PET SDA CAD DNA FHF HPV MDA NAC PLA SIV CEA ESI GBM HTG MEF NIH PSA SSC CIR FDA GSH IFX OOB RCC TIA CRC FDG HDG LDA MRM PCR RNA TMA A variety of research methods are being used Mathematical Methods Slide 10 BUN CSF FDR HIV LPS MRS PET SDA CAD DNA FHF HPV MDA NAC PLA SIV CEA ESI GBM HTG MEF NIH PSA SSC CIR FDA GSH IFX MRI OOB RCC TIA CRC FDG HDG LDA MRM PCR RNA TMA A variety of research methods are being used All Methods Slide 11 BUN CSF FDR HIV LPS MRS PET SDA CAD DNA FHF HPV MDA NAC PLA SIV CEA ESI GBM HTG MEF NIH PSA SSC CIR FDA GSH IFX MRI OOB RCC TIA CRC FDG HDG LDA MRM PCR RNA TMA A variety of compounds and reagents are being used Slide 12 BUN CSF FDR HIV LPS MRS PET SDA CAD DNA FHF HPV MDA NAC PLA SIV CEA ESI GBM HTG MEF NIH PSA SSC CIR FDA GSH IFX MRI OOB RCC TIA CRC FDG HDG LDA MRM PCR RNA TMA Only two organizations are interested in or are supporting the work Slide 13 BUN CSF FDR HIV LPS MRS PET SDA CAD DNA FHF HPV MDA NAC PLA SIV CEA ESI GBM HTG MEF NIH PSA SSC CIR FDA GSH IFX MRI OOB RCC TIA CRC FDG HDG LDA MRM PCR RNA TMA Some data remains unclassified Slide 14 BUN CSF FDR HIV LPS MRS PET SDA CAD DNA FHF HPV MDA NAC PLA SIV CEA ESI GBM HTG MEF NIH PSA SSC CIR FDA GSH IFX MRI OOB RCC TIA CRC FDG HDG LDA MRM PCR RNA TMA Some data remains unclassified Out-Of-Bag !? Slide 15 BUN CSF FDR HIV LPS MRS PET SDA CAD DNA FHF HPV MDA NAC PLA SIV CEA ESI GBM HTG MEF NIH PSA SSC CIR FDA GSH IFX MRI OOB RCC TIA CRC FDG HDG LDA MRM PCR RNA TMA Summary and Conclusions Slide 16 BUN CSF FDR HIV LPS MRS PET SDA CAD DNA FHF HPV MDA NAC PLA SIV CEA ESI GBM HTG MEF NIH PSA SSC CIR FDA GSH IFX MRI OOB RCC TIA CRC FDG HDG LDA MRM PCR RNA TMA Summary and Conclusions Slide 17 BUN CSF FDR HIV LPS MRS PET SDA CAD DNA FHF HPV MDA NAC PLA SIV CEA ESI GBM HTG MEF NIH PSA SSC CIR FDA GSH IFX MRI OOB RCC TIA CRC FDG HDG LDA MRM PCR RNA TMA Summary and Conclusions Slide 18 BUN CSF FDR HIV LPS MRS PET SDA CAD DNA FHF HPV MDA NAC PLA SIV CEA ESI GBM HTG MEF NIH PSA SSC CIR FDA GSH IFX MRI OOB RCC TIA CRC FDG HDG LDA MRM PCR RNA TMA Summary and Conclusions Slide 19 Thats all folks. Supplemental Slides Follow Slide 20 TLAs used in oral presentations or abstracts BUNCADCEACIRCRC CSFDNAESIFDAFDG FDRFHFGBMGSHHTG HIVHPVHTGIFXLDA LPSMDAMEFMRIMRM MRSNACNIHOOBPCR PETPLAPSARCCRNA SDASIVSSCTIATMA