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    K thut v thit b siu(Ultrasound diagnostics)

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    K thut siu m (Ultrasounddiagnostics)

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    OutlineI. Physical properties of ultrasound and acoustic parameters of mediumII. Ultrasonography (Chn on hnh nh bng siu m)

    Impulse reflection method

    A-mode one-dimensional B-mode two-dimensional M-mode Basic characteristics of US images Interventional sonography Echocontrast agents Harmonic imaging

    Principle of 3D imagingIII. Doppler flow measurement

    Principle of Doppler effect Principle of blood flow measurement CW Doppler system Systems with pulsed wave PW Doppler Duplex and Triplex methods

    Power Doppler method Tissue Doppler Imaging (TDI)

    Ultrasonic densitometryIV. Advantages Patient Safety: reducing Ultrasound Doses

    4

    History Ultrasound has been used as a navigational and detection aid by the

    bat for millions of years. It was not until the second world war, however,that man started extensive use of ultrasound for the same purpose.With the enormous potential of military research programs, ultrasoundtechnology rapidly developed.

    Although ultrasound had already been used in the therapy (cha bnh)and was proposed by S.Y. Sokolov for diagnostic use (mc ch iutr) in 1937, no successful attempt to apply the ultrasound echo-sounder principle to medical diagnosis was made until the early 1950s.

    Most of the equipment used at that time were industrial-type ultrasounddevices for detecting flows in metal, but soon ultrasonic devicesgenerally known as ultrasonoscopes specifically intended for medicaldiagnostics were developed. The major advantages of these devicesare the non-invasive and non-ionizing nature of the examination andtheir relatively low cost when compared to X-Ray, MagneticResonance (MR), CT and Isotopic Scanning techniques.

    Over the last decade, the diagnostic usefulness of the equipment hasbeen vastly improved, as better instruments were developed and moreclinical experience gained, and in several diagnostic fields, ultrasoundtechnique has shown to be superior to other methods.

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    Siemens P10 handheldultrasound machine

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    Contrast media sensitivities in imagingonly nuclear imaging has the sensitivity

    10-5MRS

    10-5MRI

    10-9 - 10-12PET

    10-9 - 10-12Nuc Med

    10-3CT

    10-3Sono

    Contrast media concentration(mol/kg BW)

    Imaging method

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    Ultrasound diagnostics

    K thut chun on siu m (ultrasound diagnostics) c pht trin u

    nhng nm 50 ca th k 20. K thut cho phpthu c cc nh ct lp

    (cross-sectional images) ca c th con ngi vi ccthng tin v sinh l

    (physiology) v bnh l (pathology).

    Nguyn l chung: da trnhin tngphn x (reflection) ca sng siu

    m ti c c b mt tip gipm hc (acoustical interfaces)

    Mt s ni dung k thut chnh v siu m:

    Ultrasonography (A, B and M mode, 3D and 4D imaging)

    Doppler flow measurement, including Duplex and Triplex methods

    (Duplex, Colour, Triplex, Power)

    Tissue Doppler imaging

    Ultrasound densitometry

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    I. Physical properties (cc tnh cht Vt l) casng siu m

    Questions: what is ultrasound and what are the main acousticalproperties of medium ?

    Sound is a periodic disturbance (vibrations) that in fluids density,propagates as longitudinal waves (Mechanical vibration or wave).

    Ultrasound is sound with a frequency over 20,000 Hz, which isabout the upper limit of human hearing.

    Obeys the same physical laws as wave.

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    Basic Principles of Sound

    Sound is produced by a vibrating body and travels in the form

    of a wave.

    Sound waves travel through materials by vibrating the

    particles that make up

    the material.

    The pitch ( cao/mc )of the sound is determined

    by the frequency of the wave

    (vibrations or cyclescompleted in a certain

    period of time).

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    Sound spectra

    Diagnostic

    Imaging

    0 20 Hz 20 kHz 1 MHz 30 MHz

    Infrared Audible NDTSound Sound Cleaning

    Sng sium(US) l cc daong c hc (mechanical oscillations)vi tn s > 20 kHz lan truyn trong mt mi t rng n hi (elasticmedium). For medical diagnosis, typically ranging from 1 to 30 MHz.

    Trong c ht lng v kh, US lan truyn nh mt sng dc

    (longitudinal waves). Trong cht rn, US lan truyn nh mt sngngang (transversal waves).

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    In medical US, images representing human organs (b phn c th) areformed by transmitting sound waves into the body and receiving back and

    processing the resultant echoes from the tissues.

    To accomplish this, medical ultrasound uses a process very similar to anocean-going vessels depth sounding equipment or oceanic surveyequipment. All of these systems make use of sound waves and their

    reflections.

    Sea

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    Several wave modes ofvibration are used in

    ultrasonic inspection.

    The most common arelongitudinal, shear, and

    Rayleigh (surface)

    waves

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    Ultrasound generation

    High frequency ultrasound is generated with a transducer.

    The transducer is capable of bothtransmitting and receiving soundenergy.

    A piezoelectric element in thetransducer converts electricalenergy into mechanicalvibrations (sound), and viceversa.

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    Tng tc ca US vi m (tissue) Phn x (reflection): xy r a vi c c mt phn cch ngnht, nhn, c

    kch thc > b rng chm tia (smooth homogeneous interfaces of sizegreater than beam width), VD: cc phn t hu c (organ outlines)

    Tn x Rayleigh (Rayleigh scatter): xy r a vi cc kchthc phn hi mnh (small reflector sizes), VD cc t bo mu trongmt mi t rng khngngnht.

    Khc x (refraction): xy r a vi cc mi trng khng cht, c (lessdense to denser medium), khc vi nh sng ikhi to r a s bin dng(distortion)

    Hp th (absorption) (sng m chuyn thnh nhit - sound to heat) Hin tng tngtheo tn s f, ngc vi t ia X Hp th mnh trong phi (lungs), gim dn trong xng (bone) v cc

    m mm (soft tissue), ngc vi t ia X.

    Giao thoa (interference): Cc vn hoa (speckles) trn nhUS l do sgiao thoa gia cc sng tn x Rayleigh.

    Nhiu x (diffraction)

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    Reflection

    Medium 1 Medium 2

    Transmitted waveIncident wave

    Reflected wave

    - One of the basic principles of medical ultrasound diagnosis.

    - Occurs at areas of acoustic impedance mismatch.

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    Refraction

    Medium 1

    Medium 2

    i ncident wave Ref lected wave

    Transmitted wave

    When a propagating ultrasoundwave encounters a interface at anoblique angle, it is Refracted inthe same way that light is refractedthrough a lens. The portion of the

    wave that is not reflectedcontinues into the second medium.It is dependent on the velocities ofthe two medium. If the velocitiesare equal, There would be no

    refraction occurred and the beamgoes straight into the secondmedium. For the velocities ofthe different tissues in the human

    body are quite close, refraction'scan be ignored.

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    Diffraction

    DiffractingObject

    If an ultrasound beam passes

    an obstacle within a distanceof 1 or 2 wavelengths, itsdirection of propagation is

    deflected by diffraction asshown in the figure. Thecloser the beam is to the

    diffracting object, the greaterthe deflection is.

    1 or 2 wavelengths

    Deflecting beam

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    Scattering

    Spherical Scatter-waveOccurs when small particlesabsorb part of the ultrasound

    energy and re-radiate it in alldirections as a spherical field.This means that the transducer

    can be positioned at any angleto the ultrasound beam and

    still receive echoes back.Scattering allows reflectionsfrom objects even smaller than

    the wavelength. Manybiological interfaces haveirregular surfaces, tending to

    give scatter-like reflection,which is quite useful, as it will

    give at least some echoes eventhough the beam is not directlyperpendicular to the reflectinginterface.

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    Backscatter

    Backscatter or Rayleigh scattering occurs

    with structures smaller than the transmittedwavelength. Reflected energy is very low,but contributes to the texture of the image.

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    CCCCcccc thngthngthngthng ssss ssssngngngng mmmm ((((acoustic parameters)))) ccccaaaamimimimi trtrtrtrngngngng

    Tng tc ca USvi mi t rng phn x, tn xngc (back-scattering), khc

    x, suy gim(attenuation: dotnx v hp th)

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    Cc thng s sng m

    Tc truyn sng (speed) of US cph thuc vo tnh n hi vmt (elasticity and density r) ca mi t rng. K- modulnn(modulus of compression).

    - trong nc v m mm c= 1500 - 1600 m.s-1

    - in bone c ~ 3600 m.s-1

    Ph thuc c nhit (temperature) mi trng

    Velocity (c) = Frequency (f) Wavelength ()

    [ ]1. = smKc

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    S suy gim (attenuation) of US th hin qua vic bin snggim dn trong qu trnh truyn (decrease of wave amplitudealong its trajectory). Suy gim ny ph thuc vo tn s:

    Ix = Io e-2ax = .f2

    Ix final intensity, Io initial intensity, 2x medium layer thickness

    (reflected wave travels to and fro), - linear attenuation

    coefficient (increases with frequency).

    V: =log10(I0/IX)/2x

    nn n v ca l dB/cm.

    Ti f = 1 MHz = 1.2 vi c bp (muscle), 0.5 (gan - liver), 0.9 (no- brain), 2.5 (connective tissue - m ni), 8.0 (xng - bone)

    Cc thng s sng m

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    Attenuation

    Attenuation of ultrasound wave occurs when it is propagating

    through the medium. Loss of propagating energy will be in the

    form of heat absorbed by the tissue, approximately 1 dB/cm/MHz,

    or caused by wavefront dispersion (s phn tn) or wavescattering.

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    Cc thng s sng m

    Attenuation ofAttenuation ofAttenuation ofAttenuation of

    ultrasoundultrasoundultrasoundultrasound

    When expressing intensity of

    ultrasound in decibels, we can

    see the amplitudes of echoes(ting vng) to decreaselinearly.

    xk

    I

    Ix

    I

    Ie

    I

    Ixxxx ,

    00

    2

    0

    log2ln ===

    depth[cm]

    I or P

    [dB]attenuation

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    Acoustic impedance (tr khng): product of US speedcand medium density

    Z = . c (Pa.s/m)

    Z.10-6: muscles 1.7, liver 1.65, brain 1.56, bone 6.1,

    water 1.48

    Acoustic parameters of medium

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    We suppose perpendicular incidence of US on an interface betweentwo media with different Z - a portion of waves will pass through and aportion will be reflected (the larger the difference in Z, the higherreflection).

    Acoustic parameters of medium: USreflection and transmission on interfaces

    P1 Z 2 - Z 1R = ------- = ---------------

    P Z2 + Z1

    P2 2 Z 1D = ------- = ---------------

    P Z2 + Z1

    Z

    P P2

    1P

    Z1 2

    Coefficient of reflection R ratio of acoustic pressures (p sut mthanh) of reflected and incident waves

    Coefficient of transmission D ratio of acoustic pressures oftransmitted and incident waves

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    Near field (Fresnel area) this part of US beam is cylindrical thereare big pressure differences in beam axis

    Far field (Fraunhofer area) US beam is divergent (phn k, lchng) pressure distribution is more homogeneous

    Increase of frequency of US or smaller probe diameter causeshortening of near field - divergence of far field increases

    Acoustic parameters of medium: Near field andfar field (trng gn v xa)

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    II. Ultrasonography (Chn on hnh nh bng siu m)

    Passive US low intensity waves which cannot cause substantial

    changes of medium.

    In US diagnostics (ultrasonography = sonography = echography) -

    frequencies used are 2 - 40 MHz with (temporal average, spatial peak)

    intensity of about 1 kW/m2

    Impulse reflection method (phn x xung in): a probe with one

    transducer (b chuyn i) which is source (b pht sng US) as well

    as detector (u thunhn tnhi u) of US impulses. A portion of emitted

    (pht ra) US energy is reflectedon the acoustic interfaces and the

    same probe then receives reflected signal. After processing, the signal

    is displayed on a screen.

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    Transducer

    The transducer is the component which, when connected to

    the ultrasound equipment, transmits the ultrasound andreceives its reflections or echoes from tissues.

    Transducer is one of the most important component of theultrasound system. For more detail information, please referto System Components.

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    Transducer is one of the most important component of the ultrasound system.The transducer is the component which, when connected to the ultrasound

    equipment, transmits the ultrasound and receives its reflections or echoesfrom tissues.

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    Matching Layer

    Transducer

    Crystal

    Tissue

    Impedance Matching

    TransducerCase

    -To transmit as much power as possible from transducer to the tissue.

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    Ultrasonography

    Impulse reflection method

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    Ultrasonography

    Impulse reflection method

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    Ultrasonography

    Impulse reflection method

    Main parts of the US apparatus (thitb):

    Common to diagnostics and therapy

    probe with electroacoustic transducer

    (transducers)generator of electric oscillations

    (continuous, pulsed)

    Special parts of diagnostic apparatus

    electronic circuits for processing ofreflected signal

    display unit

    recording unit

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    Ultrasonography

    A-mode one-dimensional

    Distances between reflecting interfaces and the probe are

    shown (cho bit khong cch gia cc mt phn x tipgip)

    Reflections from individual interfaces (boundaries of

    media with different acoustic impedances) are representedby vertical deflections( lchng lch theophng tr c y) of base line, i.e. the echoes.

    - Echo amplitude is proportional to the intensity of reflected

    waves (amplitude modulation)

    - Distance between echoes shown on the screen is

    proportional to real distance between tissue interfaces.Today used mainly in ophthalmology (nhn khoa).

    48

    Ultrasonography

    A-mode one-dimensional

    IH1

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    Slide 48

    IH1 olej se ji dvno nepouv, doporuuji opravit na gel filmIvo Hrazdira, 11/15/2008

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    A tomogram (phng php chp ri) is depicted basedon the following principle:

    - Brightness of points on the screen represents intensityof reflected US waves (brightness modulation).

    - Static B-scan: a cross-section (ct ngang) image ofexamined area in the plane given by the beam axis anddirection of manualmovement (di chuyn bng tay) ofthe probe on body surface. The method was used in 50

    and 60 of 20th century

    Ultrasonography

    B-mode two-dimensional

    50

    Ultrasonography

    B-mode two-dimensional - static

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    Ultrasonography M-mode

    One-dimensional static B-scan shows movement of reflecting

    tissues. The second dimension is time in this method.

    Static probe detects reflectionsfrom moving structures. The bright

    pointsmove verticallyon the screen, horizontal shiftingof the record

    is given by slow time-base.

    Displayed curves represent movementof tissue structures

    chest wallchest wallchest wallchest wall

    ((((llllngngngngngngngngcccc))))

    LungsLungsLungsLungs((((phphphphiiii))))

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    Ultrasonography

    Comparison of A-, B- and M-mode principle

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    Repetitive formation (s hnh thnh/sp xp lp li) ofB-mode images of examined area by fast deflection( lch nhanh) of US beam mechanically (in the past)or electronically in real time today.

    Electronic probes consist of many piezoelectrictransducers which are gradually activated (s dngtng bc mt).

    Ultrasonography

    B-mode - dynamic

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    Ultrasound probes for dynamic B-mode: electronic and

    mechanical (history), sector (hnh qut) and linear (tuyn tnh).

    Ultrasonography B-mode - dynamic

    Abdominal cavity (khongt rng, l hngtrongbng) isoftenexamined byconvex probe (u d li) a combinationof a sector and linearprobe.

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    Modern ultrasonography - digital processing of image

    Analogue part detection system

    Analogue-digital converters (ADC)

    Digital processing of signal possibility ofprogramming (preprocessing, postprocesssing), image storage

    (floppy discs, CD, flash cards etc.)

    Ultrasonography B-mode - dynamic

    MEMORY

    MEMORY

    MEMORY

    MEMORY

    samplingsamplingsamplingsampling

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    Ultrasonography B-mode - dynamic

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    Degree of reflectivity (mc phn x) echogenity( vng). The images of cystic (nang/u nang, liquid-filled)and solid structures are different. According to the intensityof reflection we can distinguish structures:

    - hyperechogenic, izoechogenic, hypoechogenic,anechogenic.

    Solid structures acoustic shadow (vng ti m)(caused by absorption and reflection of US)

    Air bubbles and other strongly reflecting interfacescause repeating reflections (reverberation s di m,comet tail ui sao chi).

    Ultrasonography

    Basic characteristics of US images

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    Acoustic shadow caused byabsorption and reflection of US

    by a kidney stone (si thn,see the arrow)

    Hyperechogenic area below acyst (nang/u nang) (lowattenuation of US duringpassage through the cystcompared with the surroundingtissues see the arrow)

    Ultrasonography

    Si thn

    Nang thn

    IH3

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    Limitation! absorption of US increases with frequency ofultrasound = smaller penetration depth

    Ultrasonography

    Spatial (v khng gian)resolution of US imagingsystem is determined bythe wavelength of theUS. When the objectdimension is smaller thanthis wavelength only

    scattering occurs.Hence higher spatialresolution requires higherfrequencies

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    Higher frequency ultrasound gives better resolution, but attenuationin the tissue also increases with increased frequency. Therefore, acompromise has to be made between resolution andpenetration depth.

    Compromise frequency3-5 MHz penetration in depth of about20 cm

    Frequency Low High

    Resolution Better

    Penetration Better

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    Slide 58

    IH3 doplnny ipkyIvo Hrazdira, 11/15/2008

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    Axial (theo trc) spatial resolution - it is given by the shortestdistance of two distinguishable structures lying in the beam axis

    it depends mainly on frequency (at 3.5 MHz about 0.5 mm)

    Lateral (bn/ bn) spatial resolution - it is given by the shortestdistance of two distinguishable structures perpendicularly to the

    beam axis depends on the beam width Elevation (mt/mt chiu) resolution ability to distinguish two

    planes (sections) lying behind or in front of the depicted tomographic(chp ri) plane it depends on frequency and beam geometry

    Ultrasonography Spatial Resolution

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    The best resolving power (kh nng phn gii caonht) can be found in the narrowest part (phn hpnht) of the US beam profile.

    Focusing US beam is converged (hi t) at theexamined structure by means of acoustic lenses (shapesof the layer covering the transducer) or electronically.

    The probes can be universal or specially designedfor different purposes with different focuses.

    The position of focus can be changed in most sectorprobes.

    Ultrasonography Spatial Resolution

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    Typical acoustic lens with logarithmic profile

    By changing the lens shape, the beam diameter and length of focal zonecan be controlled.

    A transducer with an axially symmetric logarithmic acoustic lens will form anarrow axially symmetric weakly diverging US beam. A transducer with acylindrical logarithmic lens will create a "knife-like" ultrasonic beam: narrow

    and weakly diverging in one direction but wide and uniform in theperpendicular direction. If the logarithmic surface of the lens is attached to the piezoelement and the

    front (radiating) surface is flat the probe can be used as both an immersionand a contact transducer.

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    Ultrasonography

    Interventional sonography (chn on c can thip)

    Interventional sonography is used mainly for guidingpunctures (chch/chch l):

    - diagnostic (chn on) thin needle (kim tim)punctures to take tissue samples for histology (tin s cam)

    - therapeutic (cha bnh) for aspiration (ht) of a cyst(nang) or an abscess (p-xe) content or an exudate (chtdch), etc.

    Puncture can be done by free hand the probe is next tothe puncture site or the puncture needle is guided by aspecial probe attachment.

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    UltrasonographyUltrasonographyUltrasonographyUltrasonography

    Echocontrast agents (Cc cht tng tng phn)

    - increase echogenity ( vng) of streaming blood, gasmicrobubbles(mainly air or volatile

    hydrocarbons)

    - free- enclosed inbiopolymer

    envelope

    A SEM micrograph ofencapsulatedechocontrast agent

    66

    UltrasonographyUltrasonographyUltrasonographyUltrasonography

    Echocontrast agents - application

    Enhanced demarcation (ranh gii) of heart ventricle (tmtht) after application of the echocontrast agent

    67

    An impulse (xung in) with basic frequencyf0 is emitted into the tissue. The receiver,however, does not detect the reflected USwith this same frequency but with the secondharmonic frequency 2f0. Its source is tissue

    itself (advantage in patients ). The method isalso used with echocontrast agents sourceof the second harmonic are oscillatingbubbles. Advantageous when displayingblood supply of some lesions (vt thng).

    Conventional (left) and

    harmonic (right) images of akidney with a stone.

    Ultrasonography

    Harmonic imaging (to nh iu ha)

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    - The probe is linearly shifted, tilted or rotated.The data about reflected signals in individual planes are stored inmemory of a powerful PC which consequently performs mathematicalreconstruction of the image.

    - Disadvantages of some 3D imaging systems: relatively long timeneeded for mathematical processing, price.

    Ultrasonography

    Principle of three-dimensional (3D) imaging

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    Four-dimensional (4D) imageThe fourth dimension is time

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    III. Doppler flow measurement(o dngchy Doppler)

    Hiu ng Doppler:- The Doppler effect: frequency shift of waves formed or reflected ata moving object.

    - Application: can be used for detection and measurement of bloodflow, as well as, for detection and measurement of movements ofsome acoustical interfaces inside the body (foetal heart tim thai,blood vessel walls vch mch mu)

    Christian. A. Doppler (1803-1853), Austrian physicistand mathematician, formulated his theory in 1842during his stay in Prague.

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    perceived (nhn/thu c)frequency corresponds with

    source frequency in rest (trngthi ngh)

    perceived frequency is higher

    when approaching (vt chuynng li gn ngun thu)

    perceived frequency is lowerwhen moving away (di chuynra xa)

    Doppler flow measurement

    Principle of Doppler effect

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    When something moves toward you, radiation emited from it has anapparently shorter wavelength, and for away moving, longerwavelength:

    = change in wavelength

    = wavelength

    v= relative velocity (speed)

    c= speed of radiation

    (in this case, light)

    Doppler flow measurement

    Principle of Doppler effect

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    Application of Doppler effect

    in blood flow velocitymeasurement

    Moving reflector (backscatterer) = erythrocytes

    (erythrocyte)

    Doppler flow measurement

    Principle of Doppler effect

    (hng cu)

    74

    US Doppler blood flow-meters (my o lu lng mu):are based on the difference between the frequency ofultrasound (US) waves emitted by the probe and those

    reflected (back-scattered) by moving erythrocytes.

    The frequency of reflected waves is (in comparison withthe emitted waves):

    - higher in forward blood flow (towards the probe)

    - lower in back blood flow (away from the probe)

    The difference between the frequencies of emitted andreflected US waves is proportional to blood flow velocity.

    Doppler flow measurement

    Principle of blood flow measurement

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    Doppler flow measurement

    General principle of blood flow measurement

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    1) Calculation of Doppler frequency change fd2) Calculation of reflector (erythrocytes) velocity v

    1) 2)

    fv- frequency of emitted US waves

    - angle made by axis of emitted US beam and the velocityvector of the reflector

    c US speed in the given medium (about 1540 m/s in blood)

    c

    vff

    vd

    cos2 = cos2

    = v

    d

    f

    cf

    v

    Doppler flow measurement

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    Dependence of velocityoverestimation on theincidence angle (if thedevice is adjusted fora = 0, i.e. cosa = 1)

    a - angle made by axis of emitted

    US beam and the velocity vector of

    the reflector

    Doppler flow measurement

    Angle alpha

    78

    1) Systems with continuous wave CW. They are used for measurement onsuperficial (trn b mt) blood vessels. High velocities of flow can bemeasured, but without depth resolution. Used only occasionally.

    2) Systems with pulsed wave - PW. It is possible to measure blood flow withaccurate depth localisation (v trchnh xc). Measurement of high velocitiesin depths is limited.

    Doppler flow measurement

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    The probe has only one transducer which acts alternately asemitter and receiver.

    The measurement of velocity and direction of blood flow in the

    vessel is evaluated in the so-called sampling volume withadjustable size and depth.

    The pulse duration defines the size of the sampling volume

    (this volume should involve the whole diameter of the examinedblood vessel).

    Doppler flow measurement

    Systems with pulsed wave - PW

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    Aliasing (s mo tn hiu) at high repetition frequencyof pulses the upper part of the spectral curve can appearin negative velocity range

    - at velocity above 4m/s aliasing cannot be removed

    NyquistNyquistNyquistNyquist limitlimitlimitlimit

    Doppler methods

    Pulse wave (PW) systems

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    DUPLEX method

    is a combination

    of dynamic B-mode imaging (the morphology ofexamined area with blood vessels is depicted)

    and the PW Doppler system (measurement of velocityspectrum of blood flow).

    It allows to examine blood flow inside heart or in deep blood

    vessels (flow velocity, direction and character)

    Doppler methods

    82

    Doppler methods

    Scheme: sector imagewith sampling volume

    DUPLEX method

    Image of carotid (ng mch) withspectral analysis of blood flow velocity

    83

    Doppler methods DUPLEX method

    Placement of sampling volume (left) and the record of blood flow

    velocity spectrum in stenotic (hp) a. carotis communis(ngmch/tnh mch chung) (right)

    84

    Doppler methods

    Colour Doppler imaging (nh Doppler mu)

    Principle:- The image consists of black-white and colour part.- The black-white part contains information about reflectivityand structure of tissues.

    - The colour part informs about movements in the examinedsection. (The colour is derived from average velocity of flow.)

    The apparatus depicts distribution and direction of flowing bloodas a two-dimensional image:

    - BART rule blue away, red towards. The flow away from theprobe is coded by blue colour, the flow towards the probe iscoded by red colour. The brightness is proportional to the velocity,

    turbulences (s hn lon) are depicted by green patterns.

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    Doppler methods

    Colour Doppler imaging

    Carotid bifurcation(chia/r nhnh ngmch)

    86

    Doppler methods TRIPLEX method

    A combination of duplex method (B-mode imaging withPW Doppler) and color flow mapping

    Normal finding of blood flow in a. carotis communis(left) andabout 90%-stenosis (hp) of a. carotis interna(right)

    IH6

    87

    Doppler methods TRIPLEX method

    stenosis

    of

    a. carotis

    88

    Doppler methodsPOWER DOPPLER method

    - the whole energy of the Doppler signal is utilised

    - mere (phn/on) detection of blood flow only l ittle dependson the so-called Doppler incidence angle- imaging of even very slow flows (blood perfusion of tissuesand organs)- flow direction is not shown

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    Slide 86

    IH6 opravena chybn formulaceIvo Hrazdira, 11/19/2008

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    Tissue Doppler Imaging (TDI)

    Colour coding of information about velocity and direction of

    movements of tissues

    Velocities 1-10 mm/s

    are depicted.

    TDI of a. carotis

    communisduringsystole (tm thu)

    90

    Ultrasonic densitometry (o ttrng bng siu m)It is based on both the measurement of speed of ultrasound in bone

    and the estimation of ultrasound attenuation in bone. In contrast to X-raymethods, ultrasound densitometry also provides information on thestructure of bone and its elastic properties:

    The speed of ultrasound depends on the density and elasticity of the

    measured medium. The anterior ( pha trc) area of the tibia (xngchy/xng ng chn) and the posterior ( pha sau) area of the

    calcaneus (xng gt) are frequently used as places of measurement.The speed of ultrasound is given by the quotient of measured distanceand the transmission time.

    Ultrasound attenuation depends on the physical properties of the givenmedium and the frequency of the ultrasound applied. For the frequencyrange 0.1 - 1 MHz the frequency dependence is nearly linear.

    Attenuation is currently expressed in dB/MHz/cm.

    Clinical importance: diagnostics of osteoporosis (chng long xng)

    91

    Ultrasonic densitometry

    Ultrasound measurements usedto assessbone density at the calcaneus

    US advantages/disadvantages

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    Advantages

    By comparison with X-ray, CT, MR and other diagnostic methods,Ultrasound diagnosis, especially for soft tissues and moving organ

    like heart and blood flow, has shown great advantages as following:

    * Real Time Imaging (except MR)

    * Non-invasive (except MR)

    * Non-ionizing Radiation (except MR)

    * Relatively Low Cost

    * Wide Applications

    * Mobility

    * Flexible Imaging

    * Biopsy (sinh thit)

    94

    Limitations

    Surface must be accessible to transmit ultrasound.

    Skill and training is more extensive than with some other methods.

    Normally requires a coupling medium to promote transfer of sound

    energy into test specimen.

    Materials that are rough, irregular in shape, very small, exceptionally

    thin or not homogeneous are difficult to inspect. Cast iron and other coarse grained materials are difficult to inspect

    due to low sound transmission and high signal noise.

    Linear defects oriented parallel to the sound beam may go

    undetected.

    Reference standards are required for both equipment calibration,and characterization of flaws.

    Patient Safety: reducing UltrasoundDoses

    96

    Prudent use of Ultrasound

    US is non-ionising BUT since many bioeffects ofultrasound have not yet been studied fully, prudent

    (cn trng) use is recommended

    ALARA as low as reasonably achievable (exposure)

    In practice prudent = justification (cn chnh) +optimisation (ti u)

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    Biological Effects

    Possible bioeffects: inactivation of enzymes, altered (bin i) cellmorphology, internal haemorrhage (chy mu/xut huyt trong), freeradical formation

    Mechanisms of bioeffects:

    Mechanical effects

    Displacement and acceleration of biomolecules

    Gas bubble cavitation (to l hng) (stable and transient vnhvin v tm thi)

    Elevated tissue temperatures (absorption of ultrasound andtherefore increase in temperature high in lungs, less in bone, leastin soft tissue)

    All bioeffects are deterministic with a threshold (cavitation) or withoutit (heating).

    98

    Output Power from Transducer

    varies from one machine to another

    Increases as one moves from real-time imaging tocolour flow Doppler

    M-mode output intensity is low but dose to tissue ishigh because beam is stationary

    99

    Risk Indicators

    To avoid potentially dangerous exposures, two indices were

    introduced: TI and MI. Their values (different for different organs)are often displayed on device screens and should not be

    exceeded.

    Thermal Index (TI): TI = possible tissue temperature rise if

    transducer is kept stationary

    TIS: soft tissue path

    TIB: bone near focus of beam

    TIC: Cranium (near surface bone)

    Mechanical Index (MI): measure of possible mechanical bioeffects

    100

    More on the TI and MI

    Thermal index device power divided by the power that wouldincreased the temperature by one degree under conditions ofminimum heat loss (without perfusion).

    Mechanical index (for assessment of cavitation-conditioned

    risk, increased danger when using echocontrast agents):

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    101

    Justification

    No commercial demos on human subjects

    No training on students

    No see baby just for fun or excessive screening inobstetrics

    102

    Optimisation of Dose 1

    Minimise TI and MI and use appropriate index (TIS, TIB,TIC), care in cases when these underestimate

    Check acoustic power outputs on manual

    Use high receiver gain when possible as opposed to hightransmit power

    Start scan with low transmit power and increasegradually

    103

    Optimisation of Dose 2

    Avoid repeat scans and reduce exposure time

    Do not hold transducer stationary

    Greater care when using contrast agents as these increasethe possibility of cavitation

    Exceptional care must be taken in applying pulsed Doppler inobstetrics

    Regular quality control of the ultrasound device

    104

    Other applications

    Some of the applications for which ultrasonic testing may be

    employed include:

    Flaw detection (cracks, inclusions, porosity, etc.)

    Erosion & corrosion thickness gauging

    Assessment of bond integrity in adhesively joined and brazedcomponents

    Estimation of void content in composites and plastics

    Measurement of case hardening depth in steels

    Estimation of grain size in metals

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    Thickness Gauging

    Ultrasonic thickness gauging isroutinely utilized in thepetrochemical and utilityindustries to determine variousdegrees of corrosion/erosion.

    Applications includepiping systems,storage andcontainment facilities,and pressure vessels.

    106

    Flaw Detection De-laminations

    Contact, pulse-echo inspection for delaminations on 36rolled beam.

    107

    Flaw Detection in Welds

    One of the most widely usedmethods of inspecting

    weldments is ultrasonic

    inspection.

    Full penetration groove welds

    lend themselves readily toangle beam shear wave

    examination.

    108

    Applications: Equipment

    Equipment for ultrasonic testing is very diversified. Proper

    selection is important to insure accurate inspection data as

    desired for specific applications.

    In general, there are three basic components that comprisean ultrasonic test system:

    - Instrumentation

    - Transducers

    - Calibration Standards

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    Transducers

    Transducers are manufactured in a variety of forms,shapes and sizes for varying applications.

    Transducers are categorized in a number of ways whichinclude:

    - Contact or immersion

    - Single or dual element

    - Normal or angle beam

    In selecting a transducerfor a given application, itis important to choose thedesired frequency,

    bandwidth, size, and in some cases focusingwhich optimizes the inspection capabilities.

    110

    Instrumentation

    D-meters or digital thicknessgauge instruments provide theuser with a digital (numeric)readout.

    They are designed primarily for

    corrosion/erosion inspectionapplications.

    Some instruments provide the user with both a digital readout anda display of the signal. A distinct advantage of these units is thatthey allow the user to evaluate the signal to ensure that the digitalmeasurements are of the desired features.

    111

    Flaw detectors are instruments

    designed primarily for theinspection of components for

    defects.

    However, the signal can be

    evaluated to obtain other

    information such as materialthickness values.

    Both analog and digital display.

    Offer the user options of gating

    horizontal sweep andamplitude threshold.