Lecture 19 – Epigenomics – Plants

BIOL 5190/6190 Cellular & Molecular Singal TransductionPrepared by Bob Locy

Last modified -13F

Epigenetics – Stable, but expression-related changes in gene function

1. Methylation of DNA & Histones is involved in epigenetic transcriptional regulation• Correlation between DNA methylation and histone modification• Correlation between gene expression changes and DNA Methylation

2. Transposable elements are regulated by DNA Methylation• Correlation between DNA Methylation and TE transposition

3. How is DNA methylation mediated?• Enzymology known• Transposable elements part of repeat-associated/heterochromatic DNA in

the genome• Repeat associated DNA methylation controls “transposase” function that

mediates transposition, and thus, epigenetic “inheritance”

Plant Biotic and Abiotic Stress Responses

1. Old time work2. Epigenetic stuff3. State of the Art

Epigenetic Regulation of Transcription and Transposition

Bucher et al., (2012) Current Opinion in Plant Biology 15 (5): 503-510

Stress Regulated Epigenenic Gene Regulation

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

Proposed model for Epigenetic Control of TE-host coevolution

Bucher et al., (2012) Current Opinion in Plant Biology 15 (5): 503-510

Transducers Second Messengers I

J.R., and Pikaard, C.S. 2011. Nature Reviews Molecular Cell Biology 12:483–492.

CSB Fig 02:01 Cell signalling pathways

J.R., and Pikaard, C.S. 2011. Nature Reviews Molecular Cell Biology 12:483–492.