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Simulating Disease States with the Living Heart Human Model
Dassault Systmes
Twitter: @BaillargeonBP
Enric Estruch Traveria Jiang Yao
Tom Battisti Karl DSouza
Brian P. Baillargeon
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The Living Heart Project
Mission: Advance the development of safe & effective cardiovascular products and treatments by uniting engineering, scientific, & biomedical experts to deliver validated models and translate simulation technology into improved patient care
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Modeling a Living Heart Multiphysics
Multiscale Tissue Cellular Protein Molecular
Mechanical
Fluid
Electrical
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Building the Living Heart Model (LHM)
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New Tissue Models
Detailed Fiber Orientations
Coupled Multi-physics
Geometry from Scan Data
Valves, Fluid Pressure,
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Electrical Results
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Mechanical Results
Mitral Valve
Motion with the Ventricles Removed
Heart Disease - diagnosis & treatments
Bio-treatments
Medical Image Enhancement
Data Analytics
3DPrinting Medical Devices
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LHM Initial Hemodynamics
Initial model tuning efforts were performed using the 3D model
However, despite efforts, the hemodynamic response of the LHM still exhibited some non-physiological behavior
We needed a new approach to correct this Focusing on the hemodynamics also could
be leveraged as these conditions are altered for disease states Downward slope
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The Challenge Simulating Disease
How can we efficiently adapt the model to simulate a more accurate healthy state and disease states? 3D modeling was too expensive There are many model parameters Many cardiac cycles (10+) may be required to achieve a
steady-state response for diseased states
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Hemodynamic Workflow For Alternate States
Design-of-Experiments Improved Shape of LV chosen from DOE database
LPM taught from 3D Model
Final LV PV Loop (5 Cardic Cycles)
LPM Model Run Iteratively
Original profile
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LHM DOE Database SQL database including 296 entries varying
Material parameters (10 parameters, a, b, t0, m, b etc)
Viscous resistance for fluid exchanges (7 parameters)
Elasticity for compliances (3 parameters)
Extracted key model measurements
Systolic and diastolic blood pressure and volume for all 7 compartments
Cardiac output, stoke volume/work, ejection fraction
Systemic and pulmonary vascular resistances
Very detailed queries can be made following the SQL language
e.g. Give me the 10 jobs with the highest ejection fraction and tell me the material parameters for the LV
Show me the PV loop of the last beat of all runs that have a minimum pressure in LA of 5mmHg
Data structure Hemodynamic Material Pressure-Volume
Hemodynamic Data for each run
X-Y Plot
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Database Verification Disease States (1/2)
Left Ventricle Right Ventricle
Impact of changing the afterload (e.g. Hypertension)
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Database Verification Disease States (2/2)
Impact on Left Ventricle with Varying Valve Resistance (e.g. Mitral Valve Stenosis)
Impact on Left Ventricle due to Loss (e.g. lack of oxygen or excess CO2) or Increase (e.g. due to a drug) in Contractility
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Improved Hemodynamic Results for the LHM
LV PV Loops (5 Cardic Cycles)
Pressure vs Time for LV (red), LA (blue) and Arterial System (black)
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Summary
The LHM is a 3D, high fidelity multi-physics simulator An efficient hemodynamics-based methodology was developed to rapidly bring
the LHM to alternate cardiac states This methodology will be utilized to tune the model for other specific diseases
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www.3ds.com/heart
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Simulating Disease States with the Living Heart Human ModelThe Living Heart ProjectSlide Number 3Building the Living Heart Model (LHM)Electrical ResultsMechanical ResultsSlide Number 7LHM Initial HemodynamicsSimulating DiseaseHemodynamic Workflow For Alternate StatesLHM DOE DatabaseDatabase Verification Disease States (1/2)Database Verification Disease States (2/2)Improved Hemodynamic Results for the LHMSummarySlide Number 18Slide Number 19