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CaltechExplorer
Guoan Zheng ([email protected])
PhD candidate, Electrical Engineering, Caltech
Samuel Yang ([email protected])
Undergraduate (’11), Business Economics & Management and Electrical Engineering , Caltech
Seung Ah Lee ([email protected])
PhD student, Electrical Engineering, Caltech
Team: CaltechExplorer
Low-cost On-chip Microscope for Point-of-Care Diagnostics
CaltechExplorer
CaltechExplorer
Product :
Lensless on-chip microscope
drop-and-flow
Simple
1.5cm x 1.5cm
On-chip and portable
Compact
0.75um
20x~40x objective
High-resolution
less than $10
Low-cost
CaltechExplorer
Market pain • Traditional microscopes expensive
– No means for portable imaging device
• Lack of affordable healthcare diagnostics in developing countries
– 250 million cases of malaria/year
– Lack of instrument and professionals on site
– Misdiagnosis and misuse of drugs
CaltechExplorer
Target Market
Field diagnostics
Blood-borne parasite
diagnostics (Malaria)
Water-borne parasite
diagnostics
Aid organizations,
Government
Military
Conventional microscope
Antigen test kits
Point-of-care
medical devices
Complete blood counting
Blood-borne parasite diagnostics
Semen monitoring
Telemedicine devices
Hospitals,
Research centers,
Consumer products
Conventional microscope
Flow cytometer,
FACS machine
Medical
Applications
Customers
Competing
technologies
CaltechExplorer
Point-of-care diagnostics market
• Many organizations on malaria : $2 billion/year (NIH 2007)
• US $45 billion global in vitro diagnostics market (Medscape 2008)
• Global telemedicine market $18 Billion by 2015 (GIA 2009)
• Market barriers
– Government regulation and safety
– Accuracy and reliability
– Cost
CaltechExplorer
Technology:
Sub-pixel resolving optofluidic microscope
• Flow the sample on top of a CMOS image sensor
• Capture a sequence of low resolution images
• Reconstruct the high resolution image by super resolution
algorithm
A sequence of low resolution images
CaltechExplorer
Device structure
• Microfluidic channel on top of the image sensor
• Reconstruction demo
Device scheme Microfluidic channel (top view)
Red blood cell flowing (with background removed) Low
resolution
sequence
Reconstructed
high
resolution
image
CaltechExplorer
Smart phone application
Software optimization
Telemedicine
Product Status
Prototype in the lab
One microfluidic channel
PDMS based
Multiple microfluidic channels
Silicon based
Massive
Production in
Semiconductor
foundry
Start-up and
Collaboration
IP
Further
Development
2 provisional patents filed
Visualyze Technologies, Inc.
Tek4Dev (First customer, Non-profit group)
Wafer level production
CaltechExplorer
• MIT technology review: cover feature
• The New York Times
• LE FIGARO (Franch): news feature
• 科技周刊 (Chinese): news feature
• Vision system design: news feature
. . .
Media coverage
“Using a $1.50 digital camera sensor, scientists at Caltech have created the simplest and cheapest microscope yet. Such a device could be used to diagnose disease such as Malaria in the developing world.” ---- MIT technology review (Oct. 25/2010)
CaltechExplorer
Malaria diagnostics with on-chip microscope
• Suitable for telemedicine approach –Automated image recognition
• Simple and fast imaging – Faster preparation step
– Microscope specialist not required on cite
– Data acquisition rate : 2000 cells/min
• Low-power portable device – Imaging with sunlight
– Access to rural areas
CaltechExplorer
Malaria diagnostics with on-chip microscope
• Color imaging for parasite
detection
• Applicable to blood counting
devices for health monitoring
• Collaboration with NYU
Langone Medical Center
• Support from the Gates
Foundation
• Clinical trials with Tek4Dev
CaltechExplorer
Time line
'10 '11 '12 '13
Malaria field
testing
Blood counting
clinical trials
Foundry
fabrication
Smartphone
application
development
FDA approval and
commercialization
Imaging system
commercialization
CaltechExplorer CaltechExplorer
References 1. Guoan Zheng, Seung Ah Lee, Samuel Yang and Changhuei Yang, “Sub-pixel resolving optofluidic microscope for on-chip cell imaging”, , Advance Article, Lab on a Chip, DOI: 10.1039/C0LC00213E (2010). 2. Seung Ah Lee, Guoan Zheng, Samuel Yang and Changhuei Yang, “Malaria infected blood cell diagnosis based on sub-pixel resolving optofluidic microscope”, submitted (2010).
3. Guoan Zheng, Samuel Yang, Seung Ah Lee and Changhuei Yang, “Super resolution Optofluidic Microscopy”, CIT-5567-P, 2010.
4. Guoan Zheng, Samuel Yang, Seung Ah Lee and Changhuei Yang, “Projective microscopy imaging on a chip”, CIT-5578-P, 2010.
Online video (1500 views in last week)
http://www.youtube.com/watch?v=CFR1kctjHj8
Questions?
CaltechExplorer
Portable microscope for
field diagnostics
Low-cost medical device
for home diagnostics
Blood-borne parasite
diagnostics
Water-borne parasite
diagnostics
Complete blood counting
Blood-borne parasite
diagnostics
Aid organizations,
Military
Hospitals,
Research centers,
Consumer products
Conventional microscope
Antigen test kits
Conventional microscope
Flow cytometer,
FACS machine
Medical
Applications
Customers
Competing
technologies
Target Market
Markets
CaltechExplorer
Portable
microscope for
field diagnostics
Low-cost medical
device for
hospitals and
home-diagnostics
Blood-borne parasite
diagnostics (malaria)
Water-borne parasite
diagnostics
Complete blood
counting
Blood-bourne
parasite diagnostics
Aid organizations
Military
Hospitals,
Research centers.
Consumers
Conventional
microscope,
Antigen test kits
Conventional
microscope,
Flow cytometer,
FACS machine
Market
CaltechExplorer
Market
Portable microscope for
field diagnostics
Blood-borne parasite
diagnostics
Water-borne parasite
diagnostics
Aid organizations,
Military
Conventional microscope
Antigen test kits
Low-cost medical device
for home diagnostics
Complete blood counting
Blood-borne parasite
diagnostics
Hospitals,
Research centers,
Consumer products
Conventional microscope
Flow cytometer,
FACS machine
Medical
Applications
Customers
Competing
technologies
Markets
CaltechExplorer
Target Market
Field diagnostics
Blood-borne parasite
diagnostics (Malaria)
Water-borne parasite
diagnostics
Aid organizations,
Military
Conventional microscope
Antigen test kits
Point-of-care
medical devices
Complete blood counting
Blood-borne parasite
diagnostics
Hospitals,
Research centers,
Consumer products
Conventional microscope
Flow cytometer,
FACS machine
Medical
Applications
Customers
Competing
technologies
