M. Vokrojova MD, M. Vokrojova MD, D. Sivekova MD, L. Wagnerova MD D. Sivekova MD, L. Wagnerova MD Prof. P. Kuchynka MD, PhDProf. P. Kuchynka MD, PhD

The authors have no financial interest in the presentation materialThe authors have no financial interest in the presentation material

COMPARISON OF POST-LASIK OUTCOMES WITH COMPARISON OF POST-LASIK OUTCOMES WITH STANDARD EXCIMER PROCEDURE AND STANDARD EXCIMER PROCEDURE AND

CUSTOM VUE PHOTOABLATION WITH IRIS CUSTOM VUE PHOTOABLATION WITH IRIS REGISTRATIONREGISTRATION

PURPOSE, OBJECTIVEPURPOSE, OBJECTIVE

To evaluate the difference in clinical outcomes To evaluate the difference in clinical outcomes between LASIK (VISX S4, AMO) patients treated between LASIK (VISX S4, AMO) patients treated with standard (conventional) excimer procedure with standard (conventional) excimer procedure and wavefront - guided procedure CustomVue and wavefront - guided procedure CustomVue with IRIS registration.with IRIS registration.

Endpoints includedEndpoints included

PPre- and postoperative complete ophthalmic examination re- and postoperative complete ophthalmic examination was done including UCVA, BCVA, manifest refraction, was done including UCVA, BCVA, manifest refraction, corneal topography, pachymetry (Pentacam, Oculus) corneal topography, pachymetry (Pentacam, Oculus) and wavefront analysis (VISX WaveScan, AMO).and wavefront analysis (VISX WaveScan, AMO).

MATERIALS, METHODSMATERIALS, METHODS

Group A: 84 eyesGroup A: 84 eyes Average Age : 24,7 y.Average Age : 24,7 y. Preop UNCA: 0,08 (0,01-Preop UNCA: 0,08 (0,01-

0,2)0,2) Preop BSCVA: 1,0Preop BSCVA: 1,0 Preop MRSE: -4,10 Preop MRSE: -4,10 ±±1,951,95

Surgical techniqueSurgical technique Moria M2 microkeratomMoria M2 microkeratom

(130 (130 μμm)m) Suction rings according Suction rings according

keratometry nomogramskeratometry nomograms Excimer laser: VISX S4 Excimer laser: VISX S4

conventional procedureconventional procedure

Group B: 40 eyesGroup B: 40 eyes Average Age : 25,6 y.Average Age : 25,6 y. Preop UNCA: 0,03 (0,01-Preop UNCA: 0,03 (0,01-

0,2)0,2) Preop BSCVA: 1,0Preop BSCVA: 1,0 Preop MRSE: -4,55 Preop MRSE: -4,55 ±± 1,69 1,69

Surgical techniqueSurgical technique Moria M2 microkeratomMoria M2 microkeratom

(130 (130 μμm)m) Suction rings according Suction rings according

keratometry nomogramskeratometry nomograms Excimer laser: VISX S4 Excimer laser: VISX S4

Custom Vue with IRIS Custom Vue with IRIS registartion procedureregistartion procedure

MATERIALS, METHODSMATERIALS, METHODS

RESULTSRESULTSUNCVA/BCVA, Efficacy indexUNCVA/BCVA, Efficacy index

0

10

20

30

40

50

60

70

80

0,63 0,8 1 1,25

UNCVABCVA

Group A (n=84)

0

5

10

15

20

25

30

0,63 0,8 1 1,25

UNCVABCVA

Efficacy index: post.UCVA/preop.BCVA

1,05 ± 0,17 Efficacy index: post.UCVA/preop.BCVA

1,06 ± 0,18

Group B (n=40)

RMS error preopRMS error preop RMS error postopRMS error postop

Standard LASIKStandard LASIK

(n=84)(n=84)0,33 0,33 μμmm

±± 0,135 SD 0,135 SD0,51 0,51 μμmm

±± 0,193 SD 0,193 SD

CustomVue LASIK CustomVue LASIK with IRIS with IRIS registration registration

(n=40)(n=40)

0,36 0,36 μμmm

±± 0,149 SD 0,149 SD0,42 0,42 μμmm

±± 0,146 SD 0,146 SD

RESULTSRESULTSWavefront analysis

p= 0,012

Pupil size : 6 mm

MRSEMRSE SDSD

Standard LASIKStandard LASIK

(n=84)(n=84)-0,120-0,120 ±± 0,392 0,392

CustomVue LASIK CustomVue LASIK with IRIS with IRIS registration registration

(n=40)(n=40)

-0,086-0,086 ±± 0,393 0,393

RESULTSRESULTSMRSE 6 month postop

p= 0,360,36

RESULTSRESULTSPredictabilityPredictability

scattergrams of attamted vs. achieved scattergrams of attamted vs. achieved refraction, refraction,

6 month postop6 month postop

1,2

9,5

30,9

52,4

4,81,2

5,010,0

27,5

50,0

7,5

0,00

10

20

30

40

50

60

70

80

90

100

-1,75 to -1,26

-1,25 to -0,76

-0,75 to -0,26

-0,25 to+0,25

0,26 to 0,75 0,76 to 1,25

MRSE (Dpt)

%

Standard LASIK

CustomVue LASIK with IRISregistration

RESULTSRESULTSRefractive outcome (MRSE)

6 month postop

-5,00

-4,00

-3,00

-2,00

-1,00

0,00

1,00

0 1 month postop 9 month postop

MR

SE

(D

pt)

standard LASIK

Custom Vue LASIK withIR registration

RESULTSRESULTS Stability of Stability of

refractionrefraction

CONCLUSIONCONCLUSION Our results show that the Wavefront - guided Our results show that the Wavefront - guided

procedure doesprocedure does nnoot treat the current HOAs, but t treat the current HOAs, but reduces the HOAs induced by reduces the HOAs induced by eexcimer laser. xcimer laser.

Results of Wavefront analysis show that the Results of Wavefront analysis show that the differences in postoperative HOAs in both differences in postoperative HOAs in both groups is statistically significant (p=0,012).groups is statistically significant (p=0,012).

The difference in the mean postoperative The difference in the mean postoperative MRMRSE SE

in both groups is not statistically significant in both groups is not statistically significant (p=0,36).(p=0,36).