Matthew Christopher Zimmerman Current Position · City, Iowa; Dr. Larry Oberley mentor Academic Appointments 2007 – 2012 ... “Human Gross Anatomy”, Department of Anatomy and

Zimmerman, M.C. January 2019

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CURRICULUM VITAE

Matthew Christopher Zimmerman Professional Address: University of Nebraska Medical Center

Department of Cellular and Integrative Physiology Durham Research Center 985850 Nebraska Medical Center

Omaha, NE 68198-5850 Telephone: (402) 559-7842 Email: [email protected]

Current Position

July 2012 – Present: Associate Professor with Tenure, Department of Cellular & Integrative Physiology, University of Nebraska Medical Center (UNMC), Omaha, Nebraska

Education and Training

1995 – 1999: B.S. with Honors, Biology, Marian College, Fond du Lac, Wisconsin; Graduated Summa cum laude

1999 – 2004: Ph.D., Anatomy and Cell Biology, The University of Iowa, Iowa City, Iowa; Dr. Robin L. Davisson mentor

2004 – 2007: Postdoctoral Trainee, The University of Iowa Carver College of Medicine, Iowa City, Iowa; Dr. Larry Oberley mentor

Academic Appointments

2007 – 2012: Assistant Professor, Department of Cellular & Integrative Physiology,

University of Nebraska Medical Center, Omaha, NE 2012 – Present: Associate Professor with Tenure, Department of Cellular & Integrative

Physiology, University of Nebraska Medical Center (UNMC), Omaha, Nebraska

2016 – Present Vice-Chair, Department of Cellular & Integrative Physiology, UNMC

Other Academic Appointments 2007 – Present: Member of Redox Biology Center, University of Nebraska – Lincoln 2007 – Present: Member of Center for Drug Delivery and Nanomedicine, UNMC 2012 – Present: Director, Free Radicals in Medicine Program, UNMC 2015 – Present: Chair, Integrative Physiology & Molecular Medicine Doctoral Program, UNMC 2016 – 2017: Vice Chair of the Faculty Council and General Faculty, UNMC

Academic Honors and Awards

1995: Marian College Presidential Scholarship 1996: Marian College Department of Math and Natural Science Scholarship 1999: Marian College National Scholastic Honor Society-Delta Epsilon Sigma 2001: Caroline tum Suden/Frances A. Hellebrandt Professional Opportunity Award, American

Physiological Society

mailto:[email protected]


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2001: Merck New Investigator Award, American Heart Association Council for High Blood Pressure Research

2002: Caroline tum Suden/Frances A. Hellebrandt Professional Opportunity Award, American Physiological Society

2002: Trainee Travel Award, FASEB Summer Research Conference 2003: Teaching Assistant of the Year Award, University of Iowa, Department of Anatomy and

Cell Biology 2003: Procter & Gamble Professional Opportunity Award, Neural Control & Autonomic

Regulation Section, American Physiological Society 2003: New Investigator Award for U.S. Fellows, supported by Aventis Pharma, American Heart

Association Council for High Blood Pressure Research 2004: Procter & Gamble Professional Opportunity Award, Neural Control & Autonomic

Regulation Section, American Physiological Society 2004: Trainee Travel Award, FASEB Summer Research Conference 2004: New Investigator Award for U.S. Fellows, supported by CV Therapeutics, American

Heart Association Council for High Blood Pressure Research 2005: University of Iowa Graduate Deans’ Distinguished Dissertation Award 2005: Young Investigator Award, Society for Free Radical Biology and Medicine 2009: Distinguished Alumni Merit Award, Marian University (formerly Marian College) 2009: Young Investigator, Nebraska Physiological Society 2010: Harry Goldblatt New Investigator Award, American Heart Association Council for High

Blood Pressure Research 2011: Outstanding Achievement, University of Nebraska Medical Center 2011: Joseph P. Gilmore Distinguished New Investigator Award, University of Nebraska

Medical Center 2011: Neural Control & Autonomic Regulation (NCAR) New Investigator Award, American

Physiological Society 2011: New Investigator Award, University of Nebraska Medical Center 2011: Nominee, Popular Science Brilliant Ten 2012: Nominee, UNMC Faculty Senate’s Outstanding Mentor for Graduate Students Award 2013: Chairperson, American Heart Association Midwest Affiliate Research Committee 2014: Member, NIH Special Emphasis Panel Study Section (10 ZRG1 VH-C (02) M) 2014: Special Achievement, University of Nebraska Medical Center 2014: Excellence in Mentoring, Postdoctoral Education Office, University of Nebraska Medical

Center 2015: Member, NIH Special Emphasis Panel/Scientific Review Group (2015/10 HLBP 1) 2015: Member, American Heart Association Midwest Affiliate Board of Directors 2016: Member, NIH Special Emphasis Panel/Scientific Review Group (2016/05 HLBP 1) 2017: President, Nebraska Physiological Society 2018: Member, American Heart Association, Vascular Biology & Blood Pressure Study Section 2018: Member ad hoc, NIH Scientific Review Group (2019/01 ASG)

Memberships in National Professional Societies

American Heart Association (AHA)

American Physiological Society (APS)

Nebraska Physiological Society (NPS)

Society for Redox Biology and Medicine (SfRBM)


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Committee Memberships in National Professional Societies 2011: AHA – Council for High Blood Pressure Research Harry Goldblatt Award

Committee 2011 – 2014: APS – Animal Care and Experimentation (ACE) Committee 2011 – 2014: NPS Councilor 2011 – 2014: SFRBM – Internal Marketing Committee 2011 – 2015: AHA – Midwest Affiliate Research Committee 2011 – 2017: AHA – Council of Hypertension Leadership Committee 2012 – Present: AHA Local Affiliate (Omaha) – Board of Directors Member 2013 – 2015: AHA – Council for High Blood Pressure Research Leadership Committee,

Vice-Chair of the Trainee Advocacy Committee 2013 – 2015: Chairperson, AHA Midwest Affiliate Research Committee 2015 – Present: AHA – Member of Midwest Affiliate Board of Directors 2017, 2018: SFRBM Annual Meeting Program Committee Member

Institutional Service and Committee Membership

2007 – 2008: Thesis Committee member for graduate student, Sheng Wu 2007 – 2015: Graduate Program Committee, Department of Cellular and Integrative

Physiology, UNMC 2008: Summer Undergraduate Research Program (SURP) lecture 2008 – 2009: Thesis Committee member for graduate student, Tess Eidem 2008 – 2010: Thesis Committee member for graduate student, Xiang Yi 2008 – 2011: Seminar Series Coordinator, Department of Cellular and Integrative

Physiology, UNMC 2008 – 2012: Thesis Committee member for graduate student, Liang Xiao 2008 – 2012: Reviewer and judge for Midwest Student Biomedical Research Forum 2008 – 2014: UNMC Research and Development Committee 2008 – 2015: UNMC Graduate Student Fellowship Review Committee Member 2008 – Present: Durham Research Center Building Committee, UNMC 2009 – 2011: Thesis Committee member for graduate student, Marc Ueda 2009 – 2012: UNMC IACUC Review Committee 2009 – 2013: Thesis Committee member for graduate student, Jing Tong 2009 – 2014: UNMC Medical Student Summer Research Application Review Committee 2010: “Tech Talk” presentation made to Dept of Comparative Medicine, UNMC 2010 – 2013: Thesis Committee member for graduate student, Poornima Suresh 2010 – 2014: “Nanomedicine for Diagnosis and Therapy” Certificate Program Advisory

Committee 2010 – Present: Faculty Council of the College of Medicine, UNMC; member 2010 – Present: Nanomaterial Characterization Core Committee 2011: Host/organizer of the annual Redox Biology Center Retreat held in Nebraska

City, NE 2011: Department of Cellular and Integrative Physiology Outstanding Performance

Committee 2011 – 2012: Member, Faculty Search Committee for Department of Cellular & Integrative

Physiology 2012 – 2014: Thesis Committee member for graduate student, Juan Xiong 2012 – 2015: Thesis Committee member for graduate student, Bryan Becker 2012 – 2016: Thesis Committee member for graduate student, Peter Pellegrino 2012 – 2016: Thesis Committee member for graduate student, Duy Ha 2012 – Present: Director, UNMC Free Radicals in Medicine Program


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2012 – Present: Director, Electron Paramagnetic Resonance (EPR) Spectroscopy Core 2013: Host/organizer of the 11th Annual UNL Redox Biology Center Symposium 2014: Co-organizer, 10th Anniversary of the Center for Drug Delivery and

Nanomedicine Workshop 2014 – Present: UNMC Confocal Microscopy Core Advisory Committee 2014 – Present: Thesis Committee member for graduate student, Michael Price 2014 – 2015: Chair; Faculty Search Committee, Department of Cellular and Integrative

Physiology 2014 – 2016: Chair, A. Ross McIntyre Cardio-Renal Seminar Series Selection Committee,

Department of Cellular and Integrative Physiology 2014 – 2017: Thesis Committee member for graduate student, Brendan Ottemann 2015 – Present: Thesis Committee member for graduate student, Mohannad Almikhlafi 2015 – Present: Chair, Integrative Physiology & Molecular Medicine (IPMM) Doctoral Program 2016: Member of a Graduate Council sub-committee to complete the 5-year review

of the Health Promotion and Disease Prevention Research (HPRO) Graduate Program

2016 – 2017: Vice Chair of the Faculty Council and General Faculty, UNMC 2016 – Present: Thesis Committee member for graduate student, Dannah Miller 2016 – Present: Thesis Committee member for graduate student, Anyun Ma 2016 – Present: Thesis Committee member for graduate student, Ahmed Wafi 2016 – Present: Vice Chair, Department of Cellular & Integrative Physiology, UNMC 2016 – Present: Chair, UNMC Graduate Student Fellowship Review Committee 2016 – Present: Member, Center for Patient, Family, and Community Engagement in Chronic

Care Management (CENTRIC) Scientific Advancement Committee, UNMC 2017 – Present: Mentoring Committee for CTR-Mentors Scholar Program Student, Dr. Tammy

Wichman 2017 – Present: Thesis Committee member for graduate student, Upasana Niyogi 2017 – 2018: Member, Search Committee for Cellular & Integrative Physiology Chairperson

and Director of Cardiovascular Research Center 2018 – 2019: Member, Search Committee for Division Chief of Cardiovascular Medicine 2018 – Present: Thesis Committee member for graduate student, Chunbo He

National and International Grant Review Service

2008: Reviewer for Research Grants Council of Hong Kong 2014: Member, NIH Special Emphasis Panel Study Section (10 ZRG1 VH-C (02) M) 2015: Member, NIH Special Emphasis Panel/Scientific Review Group (2015/10

HLBP 1) 2016: Member, NIH Special Emphasis Panel/Scientific Review Group (2016/05

HLBP 1) 2018: Member, American Heart Association, Vascular Biology & Blood Pressure –

Basic Science Study Section 2018: Member, NIH Special Emphasis Panel/Scientific Review Group (2019/01

ASG)

Teaching Experience 2000, 2002: Graduate Teaching Assistant, “Human Gross Anatomy”, Department of

Anatomy and Cell Biology, University of Iowa Carver College of Medicine 2008, 2012: Summer Undergraduate Research Program (SURP) lecture, UNMC 2008 – 2011: Course Director, Cellular and Integrative Physiology Graduate Student

Seminar Course (CIP 970), UNMC


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2008 – 2016: “Signaling by Reactive Oxygen Species” lecture in Biomedical Research Training Program (BRTP 824) Cell Signaling graduate course, UNMC

2009: “Central Control of the Cardiovascular System” lecture in CIP 916: Cardio-pulmonary Function in Health & Disease, UNMC

2009 – Present: “Mitochondrial-Produced Reactive Oxygen Species” lecture in Biochemistry 998: Redox Regulation, Oxidative Stress and Selenoproteins, University of Nebraska – Lincoln (UNL). This is a joint course with the Karolinska Institute in Stockholm, Sweden.

2010: Creation of a new advanced physiology course entitled “Redox Biology in Human Disease” (CIP 922). Approved by Graduate College.

2010 – Present: Course Director of CIP 922: Redox Biology in Human Disease, UNMC 2010 – Present: Lecturer in CIP 922: Redox Biology in Human Disease, UNMC 2011 – Present: “Neuronal Membrane Potential”, “Action Potential”, “Synapses”, “Synaptic

Transmission”, “Neurotransmitters” and “Excitotoxicity” lectures to 1st year medical students in Core 4 – Neuroscience, College of Medicine, UNMC

2011: Faculty Moderator for an undergraduate course entitled “Biology of Human Disease” taught at the University of Nebraska – Omaha by UNMC graduate students

2011: “Redox Signaling in the Central Nervous System” lecture in CIP 916: Cardio-pulmonary Function in Health & Disease, UNMC

2013: “Oxidative Stress in the CNS: Implications for Cardiovascular Disease” lecture in CIP 916: Cardio-pulmonary Function in Health & Disease, UNMC

2015: “Redox Biology of Hypertension” lecture in CIP 916: Cardio-pulmonary Function in Health & Disease, UNMC

2015 – 2016: Neurology Residents Basic Neuroscience Lectures: “Membrane & Action Potential” and “Neurotransmitters and Excitotoxicity”, UNMC

2016 – 2017: Member of the Neuroscience/Psychiatry Block Design Team for the new COM curriculum – Training the Physicians of Tomorrow (TPT), UNMC

2017: “Redox Biology of Hypertension” lecture in CIP 916: Cardio-pulmonary Function in Health & Disease, UNMC

2018: Lecturer in BIOC 848: Redox Biochemistry, University of Nebraska – Lincoln

Students and Postdoctoral Fellows Mentored

2008: Alex Renshaw, UNMC undergraduate summer research 2008: James Roat, UNMC medical student summer research 2008: Shervin Razavian, UNMC medical student summer research 2008 – 2009: Andrew Gard, UNMC medical student research honors thesis 2008 – 2010: Rui-Fang Yang, postdoctoral fellow 2008 – 2010: Shumin Li, research associate 2009 – 2013: Erin Rosenbaugh, UNMC PhD graduate student thesis research 2009: Ruth Steadman, UNMC graduate student 2009: Brandon Mizner, UNMC INBRE undergraduate summer research 2009, 2010: Anfei Li, UNMC undergraduate summer research 2010: Jesse Ratzsch, UNMC INBRE undergraduate summer research 2010 – 2011: Sapna Thakur, postdoctoral fellow 2011 – 2013: Saleena Alikunju, postdoctoral fellow 2011 – 2014: Krupa Savalia, UNMC MD/PhD student thesis research 2011 – 2015: Urmi Basu, UNMC PhD graduate student thesis research 2011 – 2016: Jun Tian, research associate 2012 – 2015: Adam Case, postdoctoral fellow 2013 – 2014: Daniel Agraz, UNMC medical student summer research


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2015: Colton Roessner, UNMC undergraduate summer research 2015, 2016: Cleofes Sarmiento, UNMC INBRE undergraduate summer research 2017 – 2018: Juliana Bezerra Medeiros de Lima, visiting graduate student scholar from

Ribeirao Preto Medical School, University of Sao Paulo, Brazil 2018 – Present: Sarah Schlichte, UNMC PhD graduate student thesis research

Junior Faculty Mentored

2013 – 2017: Tiffany Moore, Ph.D., Assistant Professor, College of Nursing, UNMC;

supported by NIH K01 Award (K01NR014474-01) and UNMC Edna Ittner Pediatric Research Support Grant

2015 – 2016: Adam Case, Ph.D., Instructor, Department of Cellular and Integrative Physiology, College of Medicine, UNMC: supported by NIH K99 (K99HL123471-01A1)

2017 – Present: Tammy Wichman, M.D., Associate Professor, Division of Pulmonary, Critical Care, Sleep & Allergy, Department of Internal Medicine

Editorial Boards and Activities

2011 – Present: Editorial Board - American Journal of Physiology (AJP): Heart and Circulatory

Physiology 2011: Invited co-editor of “Cardiovascular & Renal Issue” for Current Opinion in

Pharmacology (Editor: Dr. Irving Zucker) 2012: Invited editor of “Angiotensin Issue” for Antioxidants & Redox Signaling 2012 – Present: Review Editorial Board – Frontiers in Oxidant Physiology 2014 – 2016: Editorial Board – Oxidative Medicine and Cellular Longevity 2018 – 2019: Invited editor of “Redox Biology in Physiology and Disease” for Redox

Biology

Peer Reviewer for Journals

American Journal of Pathology; American Journal of Physiology (AJP): Heart and Circulatory Physiology; American Journal of Physiology (AJP): Regulatory, Integrative, and Comparative Physiology; Antioxidants and Redox Signaling; Biomaterials; Brain Research; Cellular and Molecular Neurobiology; Circulation Research; Current Opinion in Pharmacology; Experimental Physiology; Free Radical Biology and Medicine; Frontiers in Physiology; Heart and Vessels; Histochemistry and Cell Biology; Hypertension; International Journal of Molecular Sciences; International Journal of Nanomedicine; Journal of Applied Physiology; Journal of Cardiac Failure; Journal of Hypertension; Journal of Pharmacology and Experimental Therapeutics; Journal of Vascular Research; Molecular Pharmacology; Nanomedicine; Nature Medicine; PLOS ONE; Regulatory Peptides; Toxicology; Therapeutic Delivery

Community Service/Community Outreach

2011: Presented seminar, “Oxidants, Antioxidants, and Hypertension: It’s All in Your

Head”, to members of the Osher Lifelong Learning Institute, University of Nebraska – Lincoln

2012 – Present: AHA Local Affiliate (Omaha) – Board of Directors Member 2013: Present “lunch and learn” seminar at Gallup Organization entitled:

“Cardiovascular Disease Research” 2013 – 2014: Executive Leadership Team (ELT) Member of the Omaha AHA Heart Walk


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2013 – Present: Team Captain of the Cellular and Integrative Physiology AHA Heart Walk Team

2014: Presented “Nanomedicine and Cardiovascular Disease” at the Omaha Science Café.

2014: Participated in an all-day APS PhUn Week event at Rohwer Elementary School

2014 – Present: Company Leader of the UNMC AHA Heart Walk Teams 2015 – Present: AHA Midwest Affiliate – Board of Directors Member

Bibliography

Peer-Reviewed Published Manuscripts: 1) Ahluwalia J.P., Topp J.D., Weirather K., Zimmerman M.C. and Stamnes M. A role for

calcium in stabilizing transport vesicle coats. J. Biol. Chem. 2001; 276:34148-55. PMID: 11435443.

2) Zimmerman M.C., Lazartigues E., Lang J.A., Sinnayah P., Ahmad I.M., Spitz D.R. and Davisson R.L. Superoxide mediates the actions of angiotensin II in the central nervous system. Circ. Res. 2002; 91:1038-1045. PMID: 12456490.

3) Zimmerman M.C., Davisson R.L. Redox signaling in central neural regulation of cardiovascular function. Prog. Biophys. Mol. Biol. 2004; 84:125-149. PMID: 14769433.

4) Zimmerman M.C., Lazartigues E., Sharma R.V., Davisson R.L. Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system. Circ. Res. 2004; 95:210-216. PMID: 15192025.

5) Zimmerman M.C., Lazartigues E., Dunlay R.P., Sharma R.V., Davisson R.L. Requirement for Rac1-dependent NADPH oxidase in the cardiovascular and dipsogenic actions of angiotensin in the brain. Circ. Res. 2004; 95:532-539. PMID: 15271858.

6) Zimmerman M.C., Sharma R.V., Davisson R.L. Superoxide mediates angiotensin II-induced influx of extracellular calcium in neural cells. Hypertension. 2005; 45(4):717-723. PMID: 15699459.

7) Roghair R.D., Segar J.L., Sharma R.V., Zimmerman M.C., Jagadeesha D.K., Segar E.M., Scholz T.D., Lamb F.S. Newborn lamb coronary artery reactivity is programmed by early gestation dexamethasone prior to the onset of systemic hypertension. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005; 289(4):R1169-R1176. PMID: 15961529.

8) Zimmerman M.C., Oberley L.W., Flanagan S.W. Mutant SOD1-induced neuronal toxicity is mediated by increased mitochondrial superoxide levels. J Neurochem. 2007; 102(3): 609-618. PMID: 17394531.

9) Erickson J.R., Joiner M.A., Guan X., Kutschke W., Yang J., Oddis C.V., Bartlett R.K., Lowe J.S., O’Donnell S.E., Aykin-Burns N., Zimmerman M.C., Zimmerman K., Ham A.J.L., Weiss R.M., Spitz D.R., Shea M.A., Colbran R.J., Mohler P.J., Anderson M.E. A dynamic pathway for calcium independent activation of CaMKII by methionine oxidation. Cell. 2008; 133:462-474. PMCID: PMC2435269.

10) Zimmerman M.C., Zucker I.H. Mitochondrial dysfunction and mitochondrial-produced reactive oxygen species: New targets for neurogenic hypertension? Hypertension. 2009; 53(2):112-4. PMCID: PMC2692314.

11) Ding Y., Li Y.L., Zimmerman M.C., Davisson R.L., Schultz H.D. Role of CuZn superoxide dismutase on carotid body function in heart failure rabbits. Cardiovasc Res. 2009; 81(4):678-85. PMCID: PMC2642603.

12) Zheng M.Q., Tang K., Zimmerman M.C., Liu L., Xie B., Rozanski G. Role of -glutamyl transpeptidase in redox regulation of K+ channel remodeling in post-myocardial infarction rat hearts. Am J Physiol Cell Physiol. 2009; 297(2):C253-62. PMCID: PMC2724099.

13) Ding Y., Li Y.L., Zimmerman M.C., Schultz H.D. Elevated mitochondrial superoxide contributes to enhanced chemoreflex in heart failure rabbits. Am J Physiol Integr Comp


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Physiol. Am J Physiol Regul Integr Comp Physiol. 2010; 298(2):R303-11. PMCID: PMC2828171.

14) Davisson R.L., Zimmerman M.C. Angiotensin-II, oxidant signaling, and hypertension: Down to a T? Hypertension. 2010; 55(2):228-30. PMCID: PMC2811261.

15) Yin J.X., Yang R.F., Li S., Renshaw A.O., Li Y.L., Schultz H.D., Zimmerman M.C. Mitochondria-produced superoxide mediates angiotensin II-induced inhibition of neuronal potassium current. Am J Physiol Cell Physiol. 2010; 298(4):C857-65. PMCID: PMC3115892. *Highlighted in April 2010 issue of Physiology.

16) Wang H.J., Pan Y.X., Wang W.Z., Gao L., Zimmerman M.C., Zucker I.H., Wang W. Exercise training prevents the exaggerated exercise pressor reflex in rats with chronic heart failure. J Appl Physiol. 2010; 108(5):1365-75. PMCID: PMC2867544.

17) Rosenbaugh E.G, Roat J.W., Gao L., Yang R.F., Manickam D.S., Yin J.X., Schultz H.D., Bronich T.K., Batrakova E.V., Kabanov A.V., Zucker I.H., Zimmerman M.C. The attenuation of central angiotensin II-dependent pressor response and intra-neuronal signaling by intracarotid injection of nanoformulated copper/zinc superoxide dismutase. Biomaterials. 2010; 31(19):5218-26. PMCID: PMC2860066.

18) Yi X., Zimmerman M.C., Yang R.F., Vinogradov S., Kabanov A.V. Pluronic-modified superoxide dismutase 1 (SOD1) attenuates angiotensin II-induced increase in intracellular superoxide in neurons. Free Radical Biol Med. 2010; 49(4):548-58. PMCID: PMC2998907.

19) Rump T.J., Muneer P.M., Szlachetka A., Lamb A., Haorei C., Alikunju S., Xiong H., Keblesh J., Liu J., Zimmerman M.C., Jones J., Donahue T.M., Persidsky Y., Haorah J. Acetyl-L-carnitine protects neuronal function from alcohol-induced oxidative damage in the brain. Free Radical Biol Med. 2010; 49(10):1494-504. PMCID: PMC3022478.

20) Yang R.F., Yin J.X., Li Y.L., Zimmerman M.C.*, Schultz H.D.* Angiotensin-(1-7) increases neuronal potassium current via a nitric oxide-dependent mechanism. Am J Physiol Cell Physiol. 2011; 300(1):C58-64. PMCID: PMC3023184. *Contributed equally as corresponding author.

21) Zhao Y., Haney M.J., Klyachko N.L., Li S., Booth S.L., Higginbotham S.M, Jones J., Zimmerman M.C., Mosley R.L., Kabanov A.V., Gendelman H.E., Batrakova E.V. Polyelectrolyte complex optimization for macrophage delivery of redox enzyme nanoparticles. Nanomedicine. 2011; 6(1):25-42. PMCID: PMC3037278.

22) Zimmerman M.C. Angiotensin II and angiotensin-1-7 redox signaling in the central nervous system. Curr Opin Pharmacol. 2011; 11(2):138-43. PMCID: PMC3075313.

23) Wang H.J., Li Y.L., Zhang L.B., Zucker I.H., Gao L., Zimmerman M.C., Wang W. Endogenous reactive oxygen species modulates voltage-gated sodium channels in dorsal root ganglia of rats. J Appl Physiol. 2011; 110(5):1439-47. PMCID: PMC3098663.

24) Tong J., Zimmerman M.C., Li S., Yi X., Luxenhofer R., Jordan R., Kabanov A.V. Neuronal uptake and intracellular superoxide scavenging of a fullerene (C(60))-poly(2-oxazoline)s nanoformulation. Biomaterials. 2011; 32(14):3654-65. PMCID: PMC3085347.

25) Zucker I.H., Zimmerman M.C. The renin-angiotensin system in 2011: new avenues for translational research. Curr Opin Pharmacol. 2011; 11(2):101-4. PMCID: PMC3700569.

26) Zimmerman M.C., Takapoo M., Jagadeesha D.K., Stanic B., Banfi B., Bhalla R.C., Miller F.J. Activation of NADPH oxidase 1 increases intracellular calcium and migration of smooth muscle cells. Hypertension. 2011; 58(3):446-53. PMCID: PMC3160712.

27) Deo S.H., Fisher J.P., Vianna L.C., Kim A., Chockalingam A., Zimmerman M.C., Zucker I.H., Fadel P.J. Statin therapy lowers muscle sympathetic nerve activity and oxidative stress in patients with heart failure. Am J Physiol Heart Circ Physiol. 2012; 303(3):H377-85. PMCID: PMC3423160.

28) Natarajan S.K., Zhu W., Liang X., Zhang L., Demers A.J., Zimmerman M.C., Simpson M.A., Becker D.F. Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death. Free Radic Biol Med. 2012; 53(5):1181-91. PMCID: PMC3432146.

http://www.ncbi.nlm.nih.gov/pubmed/20185628







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29) Tong J., Yi X., Luxenhofer R., Banks W.A., Jordan R., Zimmerman M.C., Kabanov A.V. Conjugates of superoxide dismutase 1 with amphiphilic poly(2-oxazoline) block copolymers for enhanced brain delivery: synthesis, characterization, and evaluation in vitro and in vivo. Mol Pharm. 2013; 10(1):360-77. PMCID: PMC3570234.

30) Allen-Gipson D.S., Zimmerman M.C., Zhang H., Castellanos G., O’Malley J.K., Alvarez-Ramirez H., Kharbanda K, Sisson J.H., Wyatt T.A. Smoke extract impairs adenosine wound healing: Implications of smoke-generated reactive oxygen species. Am J Respir Cell Mol Biol. 2013; 48(5):665-73. PMCID: PMC3707376.

31) Abdul-Muneer P.M., Schuetz H., Wang F., Skotak M., Jones J., Gorantla S., Zimmerman M.C., Chandra N., Haorah J. Induction of oxidative and nitrosative damage leads to cerebrovascular inflammation in animal model of mild traumatic brain injury induced by primary blast. Free Radic Biol Med. 2013; 60:282-91. PMCID :PMC4007171.

32) Rosenbaugh E.G., Savalia K.K., Manickam D.S., Zimmerman M.C. Antioxidant-based therapies for angiotensin II-associated cardiovascular diseases. Am J Physiol Regul Integr Comp Physiol. 2013; 304(11):R917-28. PMCID: PMC3680755.

33) Case A.J., Li S., Basu U., Tian J., Zimmerman M.C. Mitochondrial-localized NADPH oxidase 4 is a source of superoxide in angiotensin II-stimulated neurons. Am J Physiol Heart Circ Physiol. 2013; 305(1):H19-28. PMCID: PMC3727106.

34) Li S., Case A.J., Yang R.F., Schultz H.D., Zimmerman M.C. Over-expressed copper/zinc superoxide dismutase localizes to mitochondria in neurons inhibiting the angiotensin II-mediated increase in mitochondrial superoxide. Redox Biol. 2013; 2:8-14. PMCID: PMC3863132.

35) Rodriguez-Rocha H., Garcia-Garcia A., Pickett C., Sumin L., Jones J., Chen H., Webb B., Choi J., Zhou Y., Zimmerman M.C., Franco R. Compartmentalized oxidative stress in dopaminergic cell death induced by pesticides and complex I inhibitors: Distinct roles of superoxide anion and superoxide dismutases. Free Radic Biol Med. 2013; 61C:370-383. PMCID: PMC3883883.

36) Thomas V.C., Kinkead L.C., Janssen A., Schaeffer C.R., Woods K.M., Lindgren J.K., Peaster J.M., Chaudhari S.S., Sadykov M., Jones J., Mohamadi Abdelghani S.M., Zimmerman M.C., Bayles K.W., Somerville G.A., Fey P.D. A dysfunctional tricarboxylic acid cycle enhances fitness of staphylococcus epidermidis during β-lactam stress. MBio. 2013; 4(4). pii: e00437-13. PMCID: PMC3747581.

37) Harrison-Findik D.D., Lu S., Zmijewski E.M., Jones J., Zimmerman M.C. Effect of alcohol exposure on hepatic superoxide generation and hepcidin expression. World J Biol Chem. 2013; 4(4):119-30. PMCID: PMC3856307.

38) Thomas V.C., Sadykov M.R., Chaudhari S.S., Jones J., Endres J.L., Widhelm T.J., Ahn J.S., Jawa R.S., Zimmerman M.C., Bayles K.W. A central role for carbon-overflow pathways in the modulation of bacterial cell death. PLoS Pathog. 2014; 10(6):e1004205. PMCID: PMC4063974

39) Lindgren J.K., Thomas V.C., Olson M.E., Chaudhari S.S., Nuxoll A.S., Schaeffer C.R., Lindgren K.E., Jones J., Zimmerman M.C., Dunman P.M., Bayles K.W., Fey P.D. Arginine deiminase in Staphylococcus epidermidis functions to augment biofilm maturation through pH homeostasis. J Bacteriol. 2014. 196(12):2277-2289. PMCID: PMC4054176.

40) Savalia K., Manickam D.S., Rosenbaugh E.G., Tian J., Ahmad I.M., Kabanov A.V., Zimmerman M.C. Neuronal uptake of nanoformulated superoxide dismutase and attenuation of angiotensin II-dependent hypertension following central administration. Free Radic Biol Med. 2014; 73:299-307. PMCID: PMC4116739.

41) Collister J.P., Bellrichard M., Drebes D., Nahey D., Tian J., Zimmerman M.C. Overexpression of copper/zinc superoxide dismutase in the median preoptic nucleus attenuates chronic angiotensin II-induced hypertension in the rat. Int J Mol Sci. 2014; 15(12):22203-22213; doi:10.3390/ijms151222203. PMCID: PMC4284703.


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42) Basu U., Seravalli J., Madayiputhiya N., Adamec J., Case A.J., Zimmerman M.C. Rapid metabolism of exogenous angiotensin II by catecholaminergic neuronal cells in culture media. Physiol Rep. 2015; 3(2): e12287, doi: 10.14814/phy2.12287. PMCID: PMC4393196

43) Case A.J. and Zimmerman M.C. Redox-regulated suppression of splenic T-lymphocyte activation in a model of sympathoexcitation. Hypertension. 2015; 65(4):916-923. PMCID: PMC4359089.

44) Vianna L.C., Deo S.H., Jensen A.K., Holwerda S.W., Zimmerman M.C., Fadel P.J. Impaired dynamic cerebral autoregulation at rest and during isometric exercise in type 2 diabetes patients. Am J Physiol Heart Circ Physiol. 2015; 308(7):H681-7. PMCID: PMC4385994.

45) Thomas V.C., Chaudhari S.S., Jones J., Zimmerman M.C., Bayles K.W. Electron paramagnetic resonance (EPR) spectroscopy to detect reactive oxygen species in Staphylococcus aureus. Bio-protocol. 2015; 5(17): pii: e1586. PMCID: PMC4863951.

46) Case A.J., Agraz D., Ahmad I.M., Zimmerman M.C. Low-dose Aronia melanocarpa concentrate attenuates paraquat-induced neurotoxicity. Oxid Med Cell Longev. 2016; 2016:5296271. doi:10.1155/2016/5296271. PMCID: PMC4684878.

47) Collister J.P., Taylor-Smith H., Drebes D., Nahey D., Tian J., Zimmerman M.C. Angiotensin II-induced hypertension is attenuated by overexpressing copper/zinc superoxide dismutase in the brain organum vasculosum of the lamina terminalis. Oxid Med Cell Longev. 2016; 2016:3959087. doi:10.1155/2016/3959087. PMCID: PMC4736576.

48) Saraswathi V., Ganesan M., Perriotte-Olson C., Manickam D.S., Westwood R.A., Zimmerman M.C., Ahmad I.M., Desouza C.V., Kabanov A.V. Nanoformulated copper/zinc superoxide dismutase attenuates vascular cell activation and aortic inflammation in obesity. Biochem Biophys Res Commun. 2016; 469(3):495-500. doi: 10.1016/j.bbrc.2015.12.027.

49) Case A.J. and Zimmerman M.C. Sympathetic-mediated activation versus suppression of the immune system: Consequences for Hypertension. J Physiol. 2016; 594(3):527-36. doi: 10.1113/JP271516. PMCID: PMC4930069.

50) Jouett N.P., Moralez G., White D.W., Eubank W.L., Chen S., Tian J., Smith M.L., Zimmerman M.C., Raven P.B. N-Acetylcysteine reduces hyper-acute intermittent hypoxia induced sympathoexcitation in human subjects. Exp Physiol. 2016; 101(3)387-96. PMCID: PMC4817372.

51) Ahmad I.M., Temme J.B., Abdalla M.Y., Zimmerman M.C. Redox status in workers occupationally exposed to long term low levels of ionizing radiation: A pilot study. Redox Report. 2016; 21(3):139-45. doi: 10.1080/13510002.2015.1101891. PMCID: PMC5011313.

52) Chaudhari S.S., Thomas V.C., Sadykov M.R., Bose J.L., Ahn D.J., Zimmerman M.C., Bayles K.W. The LysR-type transcriptional regulator, CidR, regulates stationary phase cell death in Staphylococcus aureus. Mol Microbiol. 2016; 101(6):942-953. DOI: 10.1111/mmi.13433. PMCID: PMC5014633.

53) Collister J.P., Hartnett C., Mayerhofer T., Nahey D., Stauthammer C., Kruger M., Tobias A., O’Sullivan G., Parker J., Tian J., Case A.J., Zimmerman M.C. Overexpression of copper/zinc superoxide dismutase in the median preoptic nucleus improves cardiac function after myocardial infarction in the rat. Clin Exp Pharmacol Physiol. 2016; 43(10):960-6. DOI: 10.1111/1440-1681.12607. PMCID: PMC5008989.

54) Case A.J., Roessner C.T., Tian J., Zimmerman M.C. Mitochondrial superoxide signaling contributes to norepinephrine-mediated T-lymphocyte cytokine profiles. PLoS One. 2016; 11(10):e0164609. doi: 10.1371/journal.pone.0164609. PMCID: PMC5058488.


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55) Vaz G.C., Sharma N.M., Zheng H., Zimmerman M.C., Santo R.S., Frezard F., Fontes M.A., Patel K.P. Liposome-entrapped GABA modulates the expression of nNOS in NG108-15 cells. J Neurosci Methods. 2016; 273:55-63. PMCID: PMC5074414.

56) Case A.J., Tian J., Zimmerman M.C. Increased mitochondrial superoxide in the brain, but not periphery, sensitizes mice to angiotensin II-mediated hypertension. Redox Biol. 2017; 11:82-90. DOI: 10.1016/j.redox.2016.11.011. PMCID: PMC5124355

57) Gao L., Zimmerman M.C., Biswal S., Zucker I.H. Selective Nrf2 gene deletion in the rostral ventrolateral medulla evokes hypertension and sympathoexcitation in mice. Hypertension. 2017; 69(6):1198-1206. PMCID: PMC5452971.

58) Chaudhari S.S., Kim M., Lei S., Razvi F. Alqarzaee A.A., Hutfless E.H., Powers R., Zimmerman M.C., Fey P.D., Thomas V.C. Nitrite derived from endogenous bacterial nitric oxide synthase activity promotes aerobic respiration. MBio. 2017; 8(4): e00887-17. doi: 10.1128/mBio.00887-17. PMCID: PMC5539425

59) Zimmerman M.C., Clemens D.L., Duryee M.J., Sarmiento C., Chiou A., Hunter C.D., Tian J., Klassen L.W., O’Dell J.R., Thiele G.M., Mikuls T.R., Anderson D.R. Direct antioxidant properties of methotrexate: Inhibition of malondialdehyde-acetaldehyde-protein adduct formation and superoxide scavenging. Redox Biol. 2017; 13:588-93. PMCID: PMC5552384.

60) Natarajan G., Perriotte-Olson C., Bhinderwala F., Powers R., Zimmerman M.C., Desouza C.V., Talmon G.A., Yuhang J., Kabanov A.V., Saraswathi V. Nanoformulated copper/zinc superoxide dismutase exerts differential effects on glucose versus lipid homeostasis depending on the diet composition possibly via altered AMPK signaling. Transl Res. 2017; 188:10-26. PMCID: PMC5819896.

61) Mikuls T.R., Duryee M.J., Rahman R., Anderson D.R., Sayles H.R., Hollins A., Michaud K., Wolfe F., Thiele G.E., Sokolove J., Robinson W.H., Lingampalli N., Nicholas A.P., Talmon G.A., Su K., Zimmerman M.C., Klassen L.W., Thiele G.M. Enrichment of malondialdehyde-acetaldehyde antibody in the rheumatoid arthritis joint. Rheumatology (Oxford). 2017; 26(10):1794-1803. PMCID: PMC5850833.

62) Dickinson J.D., Sweeter J.M., Warren K.J., Ahmad I.M., DeDeken X., Zimmerman M.C., Brody S.L. Autophagy regulates DUOX1 localization and superoxide production in airway epithelial cells during chronic IL-13 stimulation. Redox Biol. 2017; 14:272-284. PMCID: PMC5635347.

63) Tian C., Gao L., Zimmerman M.C., Zucker I.H. Myocardial infarction-induced microRNA-enriched exosomes contribute to cardiac Nrf2 dysregulation in chronic heart failure. Am J Physiol Heart Circ Physiol. 2018; 314(5):H928-939. PMCID: PMC6008149.

64) Moralez G., Jouett N.P., Tian J., Zimmerman M.C., Bhella P.A., Raven P.B. Effect of centrally acting angiotensin converting enzyme inhibitor on the exercise-induced increases in muscle sympathetic nerve activity. J Physiol. 2018; 596(12):2315-2332. doi: 10.1113/JP274697. PMCID: PMC6002210.

65) Price M.E., Case A.J., Pavlik J.A., DeVasure J.M., Wyatt T.A., Zimmerman M.C., Sisson J.H. S-nitrosation of protein phosphatase 1 mediates alcohol-induced ciliary dysfunction. Sci Rep. 2018 Jun 26;8(1):9701. doi: 10.1038/s41598-018-27924-x. PMCID: PMC6018795.

66) Moore T.A., Ahmad I., Zimmerman M.C. Oxidative stress and preterm birth: An integrative review. Biol Res Nurs. 2018; 20(5):497-512. doi: 10.1177/1099800418791028. PMCID: In process.

67) Price M.E., Gerald C.L., Pavlik J.A., Schlichte S.L., Zimmerman M.C., Devasure J.M., Wyatt T.A., Sisson J.H. Loss of cAMP-dependent stimulation of isolated cilia motility by alcohol exposure is oxidant dependent. Alcohol. 2018 Oct 3; pii: S0741-8329(18)30170-8. doi: 10.1016/j.alcohol.2018.09.010. PMCID: in process.

68) Clemens D.L., Duryee M.J., Sarmiento C., Chiou A., McGowan J.D., Hunter C.D., Schlichte S.L., Tian J., Klassen L.W., O’Dell J.R., Thiele G.M., Mikuls T.R., Zimmerman

https://dx.doi.org/10.1016/j.redox.2016.11.011


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M.C.*, Anderson D.R*. Novel antioxidant properties of doxycycline. Int J Mol Sci. 2018; 19(12), 4078; doi:10.3390/ijms19124078. PMCID: in process. * Contributed equally as corresponding author.

69) Moore T.A., Case A.J., Mathews T.L., Epstein C.M., Kaiser K.L., Zimmerman M.C. IL-17A and chronic stress in pregnant women at 24-28 weeks gestation. Nurs Res. 2018. doi: 10.1097/NNR.0000000000000334. [Epub ahead of print]. PMCID: in process.

70) Moore T.A., Ahmad I.M., Schmid K.K., Berger A.M., Ruiz R.J., Pickler R.H., Zimmerman M.C. Oxidative stress levels throughout pregnancy, at birth, and in the neonate. Biol Res Nurs. 2018. [In-press]. PMCID: in process.

71) Ahmad I.M., Abdalla M.Y., Moore T.A., Bartenhagen L., Case A.J., Zimmerman M.C. Healthcare workers occupationally exposed to ionizing radiation exhibit altered levels of inflammatory cytokines and redox parameters. Antioxidants. 2019. 8(1): 12. doi:10.3390/antiox8010012. PMCID: in process.

Manuscripts submitted or in preparation: 1) Rosenbaugh E.G, Manickam D.S., Batrakova E.V., Kabanov A.V., Zimmerman M.C.

Neuronal uptake and subcellular localization of functional nanoformulated copper/zinc superoxide dismutase. (in preparation).

2) Rosenbaugh E.G, Manickam D.S., Tian J., Ahmad I.M., Kabanov A.V., Zimmerman M.C. Central administration of nanoformulated copper/zinc superoxide dismutase inhibits the angiotensin II-mediated pressor response. (in preparation).

3) Yang R.F., Yin J.X., Li Y.L., Schultz H.D., Zimmerman M.C. Angiotensin-(1-7) inhibits angiotensin II intra-neuronal signaling. (in preparation).

Abstracts: 1) Zimmerman M.C., Ahluwalia J.P., and Stamnes M. (2000). Role of divalent cations in

transport vesicle formation. University of Iowa College of Medicine Research Week. 2) Ahluwalia J.P., Topp J.D., Weirather K., Zimmerman M.C., and Stamnes M. (2000). A role

for calcium in stabilizing the coat on Golgi-derived transport vesicles. Molecular Biology of Cell. 11:278a.

3) Zimmerman M.C., Haskell R.E., Davidson, B.L. and Davisson R.L. (2000). Targeted gene ablation in cardiovascular control regions of brain. FASEB J. 14:A66.

4) Zimmerman M.C., Lazartigues E. and Davisson R.L. (2001). Central angiotensin II-induced cardiovascular responses involve reactive oxygen species signaling. FASEB J. 15:A784.

5) Zimmerman M.C., Lang J.A., Lazartigues E., Sinnayah P., Davisson R.L. (2001). A novel angiotensin II signaling mechanism in central cardiovascular regulation: a role for reactive oxygen species. Hypertension. 38:485.

6) Zimmerman M.C., Dunlay R.P., Wise M.E., Zhang Y., Yan Z., Engelhardt J.F., Davisson, R.L. (2002). Rac1-activated NAD(P)H oxidase mediates central angiotensin II-induced blood pressure and dipsogenic effects. FASEB J. 16:A791.

7) Zimmerman M.C., Dunlay R.P., Wise M.E., Zhang Y., Yan Z., Engelhardt J.F., Davisson R.L. (2002). Rac1-activated NAD(P)H oxidase-dependent reactive oxygen species production mediates central angiotensin II-induced cardiovascular responses. FASEB summer conference, Snowmass, CO.

8) Zimmerman M.C., Dunlay R.P., Zhang Y., Yan Z., Engelhardt J.F., Sharma, R.V., Davisson, R.L. (2003). Central angiotensin II (AngII)-induced cardiovascular responses are mediated by NAD(P)H oxidase-derived superoxide radicals. FASEB J. 17:A885.

9) Zimmerman M.C., Lazartigues E., Sharma R.V., Davisson R.L. (2003). Superoxide in the brain mediates the slow-pressor effects of peripheral angiotensin II infusion in mice. Hypertension. 42:398.


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10) Zimmerman M.C., Lazartigues E., Sharma R.V., Davisson, R.L. (2003). The slow-pressor response of peripheral angiotensin II infusion in mice is mediated by intracellular superoxide production in the central nervous system. Free Radical Biology and Medicine. 35(supplement 1):S162.

11) Zimmerman M.C., Lazartigues E., Sharma R.V., Davisson, R.L. (2004). Increased intracellular superoxide generation in the subfornical organ plays a key role in peripheral angiotensin II-dependent hypertension. FASEB J. 18:A1259.

12) Zimmerman M.C., Sharma R.V., Davisson R.L. (2004). Superoxide mediates angiotensin II-induced influx of extracellular calcium in neural cells. Hypertension. 44:501.

13) Zimmerman M.C., Flanagan S.W., Venkataraman S., Oberley L.W. (2005). Mutant SOD1 increases reactive oxygen species production from mitochondria in a cell culture model of amyotrophic lateral sclerosis. Free Radical Biology and Medicine. 39(supplement 1):S65.

14) Zimmerman M.C., Flanagan S.W., Venkataraman S., Oberley L.W. (2006). Overexpression of MnSOD attenuates aberrant mitochondrial superoxide production and oxygen consumption in mutant SOD1-associated amyotrophic lateral sclerosis. Society for Neuroscience.

15) Zimmerman M.C., Takapoo M., Damahalli J., Stanic B., Banfi B., Miller F., Bhalla R. (2008). Nox1-derived reactive oxygen species (ROS) mediate thrombin-induced influx of calcium in vascular smooth muscle cells (SMC). FASEB J. 22:1181.11

16) Razavian S., Jones J.A., Zimmerman M.C. (2008). Mutant superoxide dismutase 1 (SOD1) expression in glial cells induced neuronal toxicity in a cell culture model of amyotrophic lateral sclerosis (ALS). Nebraska Physiological Society.

17) Yin J.X., Li Y.L., Xiao L., Schultz H.D., Zimmerman M.C. (2008). Cytoplasmic and mitochondrial-produced superoxide mediates angiotensin II (AngII)-induced inhibition of K+ current in CATH.a neurons. FASEB J. 22:lb150.

18) Yi X., Zimmerman M.C., Vinogradov S., Kabanov A.V. (2008) Intracellular delivery of superoxide dismutase (SOD) by pluronic block copolymer modification. Gordon Research Conference: Drug Carriers in Medicine and Biology.

19) Renshaw A.O., Yin J.X., Li Y.L., Schultz H.D., Zimmerman M.C. (2008). Overexpression of mitochondria-targeted superoxide dismutase (MnSOD) modulates angiotensin II signaling in neurons. American Heart Association, High Blood Pressure Council.

20) Yin J.X., Li Y.L., Schultz H.D., Zimmerman M.C. (2008). Angiotensin II-induced increase in mitochondria-localized superoxide modulates K+ current in neurons. Mitochondrial Biology in Cardiovascular Health & Diseases Conference, National Institutes of Health.

21) Zimmerman M.C., Li S., Yang R. (2008). NOX4 in neuron mitochondria: A possible source of angiotensin II-induced mitochondrial-localized superoxide production. 15th Annual Society for Free Radical Biology and Medicine Conference.

22) Gard A.P., Zimmerman M.C. (2009). Measuring extracellular and intracellular superoxide in angiotensin II-stimulated neurons using electron paramagnetic resonance. 12th Annual Cardiovascular Research Symposium, University of Nebraska Medical Center.

23) Roat J.W., Batrakova E.V., Kabanov A.V., Zimmerman M.C. (2009). Nanomedicine-driven delivery of copper/zinc superoxide dismutase to angiotensin II-sensitive neurons. Midwest Student Biomedical Research Forum.

24) Mizner B., Li S., Zimmerman M.C. (2009). Nox4 in mitochondria: A possible link between NADPH oxidase and mitochondria in angiotensin II intraneuronal signaling. Proceedings of the 8th Annual Nebraska INBRE Conference. (Awarded 2nd place)

25) Rosenbaugh E., Roat J.W., Yang R., Batrakova E.V., Kabanov A.V., Zimmerman M.C. (2009). Nanotechnology-driven delivery of active CuZnSOD to neurons. Proceedings of the 8th Annual Nebraska INBRE Conference.

26) Li S., Yang R., Yin J.X., Schultz H.D., Zimmerman M.C. (2009). Increasing mitochondrial levels of CuZnSOD in CATH.a neurons via adenovirus-mediated gene transfer inhibits


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angiotensin II-dependent intra-neuronal signaling. 12th Annual Nebraska Physiological Society Meeting.

27) Steadman R., Zimmerman M.C. (2009). Improving H2O2 detection methods with electron paramagnetic resonance spectroscopy. 12th Annual Nebraska Physiological Society Meeting.

28) Rosenbaugh E*., Roat J.W., Yang R., Batrakova E.V., Kabanov A.V., Zimmerman M.C. (2009). Nanotechnology-driven delivery of active copper/zinc superoxide dismutase to neurons. 12th Annual Nebraska Physiological Society Meeting. (*Awarded 2nd place)

29) Yang R*., Yin J.X., Li Y.L., Ding Y., Zimmerman M.C., Schultz H.D. (2009). Interplay between angiotensin-(1-7) and angiotensin II signaling in neurons. 12th Annual Nebraska Physiological Society Meeting. (*Awarded 1st place, tie)

30) Roat J.W., Gao L., Rosenbaugh E., Yang R., Yin J.X., Schultz H.D., Batrakova E.V., Kabanov A.V., Zucker I.H., Zimmerman M.C. (2009). Nanoformulated copper/zinc superoxide dismutase (CuZnSOD) attenuates angiotensin II signaling in neurons and in intact animals. 63rd American Heart Association High Blood Pressure Research Conference. Hypertension.54:e26-e127.

31) Rosenbaugh E., Roat J.W., Yang R., Yin J.X., Schultz H.D., Gao L., Zucker I.H., Bronich T.K., Batrakova E.V., Kabanov A.V., Zimmerman M.C. (2009). Nanotechnology-driven delivery of active copper/zinc superoxide dismutase to neurons inhibits angiotensin II-induced increase in superoxide. 16th Annual Society for Free Radical Biology and Medicine Conference. Free Radic Biol Med. 47:S67.

32) Rosenbaugh E., Roat J.W., Gao L., Yang R.F, Manickam D.S., Yin J.X., Schultz H.D., , Bronich T.K., Batrakova E.V., Kabanov A.V., Zucker I.H., Zimmerman M.C. (2010). Nanotechnology-driven delivery of active copper/zinc superoxide dismutase to neurons inhibits angiotensin II intra-neuronal signaling. Midwest Student Biomedical Research Forum.

33) Yang R.F., Yin J.X., Li Y.L., Zimmerman M.C., Schultz H.D. (2010). Angiotensin-(1-7) increases neuronal potassium current via a nitric oxide-dependent mechanism. Experimental Biology Conference. FASEB J. 24:809.19

34) Yang R.F., Yin J.X., Li Y.L., Schultz H.D., Zimmerman M.C. (2010). Angiotensin-(1-7) inhibits angiotensin II intra-neuronal signaling. Experimental Biology Conference. FASEB J. 24:1051.12.

35) Li S., Yang R.F., Yin J.X., Schultz H.D., Zimmerman M.C. (2010). Increase mitochondrial expression of copper/zinc superoxide dismutase (SOD1) following adenovirus mediated gene transfer inhibits angiotensin II (AngII) intra-neuronal signaling. Experimental Biology Conference. FASEB J. 24:1018.1.

36) Rosenbaugh E., Roat J.W., Gao L., Yang R.F, Manickam D.S., Yin J.X., Schultz H.D., Bronich T.K., Batrakova E.V., Kabanov A.V., Zucker I.H., Zimmerman M.C. (2010). Nanoformulated superoxide dismutase 1 (SOD1): Implications for angiotensin II (AngII) and brain-related cardiovascular diseases. Experimental Biology Conference. FASEB J. 24:402.2.

37) Razavian S., Jones J.A., Zimmerman M.C. (2010). Mutant superoxide dismutase 1 expression in glial cells induces neuronal toxicity in a cell culture model of amyotrophic lateral sclerosis. American College of Physicians – Internal Medicine Conference.

38) Yi X., Gao L., Farr S.A., Price T.O., Yang R.F., Batrakova E., Vinogradov S., Zimmerman M.C., Zucker I.H., Banks W.A., Kabanov A.V. (2010). Beyond PEGylation - Protein Modification with Block Copolymers for CNS Delivery. 37th Annual Meeting of the Controlled Release Society.

39) Rosenbaugh E*., Gao L., Manickam D.S., Bronich T.K., Batrakova E.V., Kabanov A.V., Zucker I.H., Zimmerman M.C. (2010). Neuronal uptake of nanoformulated copper/zinc superoxide dismutase inhibits central angiotensin II-dependent hypertension and intra-


15

neuronal signaling. 8th International Nanomedicine and Drug Delivery Symposium (NanoDDS’10). (*Awarded 3rd place for presentation).

40) Zimmerman M.C. and Li S. (2010). Intra-neuronal signaling of angiotensin II: Involvement of mitochondrial-localized Nox4 and mitochondrial superoxide. 64th American Heart Association High Blood Pressure Research Conference. (*Awarded Harry Goldblatt New Investigator Award). Hypertension. 56(5):e58.

41) Zimmerman M.C. and Li S. (2010). Intra-neuronal signaling of angiotensin II: Involvement of mitochondrial-localized Nox4 and mitochondrial superoxide. American Heart Association Scientific Sessions “Best of AHA Specialty Conferences Poster Session”.

42) Rosenbaugh E., Manickam D.S., Batrakova E.V., Kabanov A.V., Zucker I.H., Zimmerman M.C. (2010). Nanoformulated copper/zinc superoxide dismutase increases neuronal uptake via active endocytosis. 17th Annual Society for Free Radical Biology and Medicine Conference. Free Radic Biol Med. 49:S195-6.

43) Rosenbaugh E., Manickam D.S., Batrakova E.V., Kabanov A.V., Zimmerman M.C. (2011). Neuronal uptake of nanoformulated copper/zinc superoxide dismutase (SOD1) via clathrin-mediated endocytosis. Experimental Biology Conference. FASEB J. 25:651.8.

44) Rosenbaugh E., Manickam D.S., Batrakova E.V., Kabanov A.V., Zimmerman M.C. (2011). Neuronal uptake and subcellular localization of nanoformulated copper/zinc superoxide dismutase (SOD1). Central Region IDeA Conference.

45) Zimmerman M.C. (2011). Oxidants and antioxidants in angiotensin II intra-neuronal signaling and neurogenic hypertension. Central Region IDeA Conference.

46) Thakur S. and Zimmerman M.C. (2011). Angiotensin II decreases extracellular superoxide levels in a brain microvascular endothelial cell culture model. American Heart Association High Blood Pressure Research Conference. Hypertension. 58(5):e130.

47) Zimmerman M.C. and Li S. (2011). Nox4 in neuron mitochondria: A source of superoxide in angiotensin II stimulated neurons. Australian High Blood Pressure Research Conference.

48) Rosenbaugh E., Manickam D.S., Batrakova E.V., Kabanov A.V., Zimmerman M.C. (2012). Neuronal uptake and subcellular localization of functional nanoformulated copper/zinc superoxide dismutase (SOD nano). Experimental Biology Conference. (Selected for Oral Presentation). FASEB J. 26:893.2.

49) Savalia K.K., Manickam D.S., Rosenbaugh E., Kabanov A.V., Zimmerman M.C. (2012). Neuronal toxicity & uptake of cross-linked copper/zinc superoxide dismutase nanozyme (cl-SOD1 nano). Experimental Biology Conference. FASEB J. 26:904.3.

50) Basu U., Alikunju S., Zimmerman M.C. (2012). Angiotensin II (AngII) regulates activity of kinases and phosphatases in neurons. Experimental Biology Conference. FASEB J. 26:904.7.

51) Deo S.H., Zimmerman M.C., Fadel P.J. (2012). Elevated reactive oxygen species and increased mononuclear NADPH oxidase expression in type 2 diabetes patients. Experimental Biology Conference. FASEB J. 26:1137.6.

52) Deo S.H., Vianna L.C., Kim A., Zimmerman M.C., Fadel P.J. (2012). Impaired dynamic cerebral autoregulation in type 2 diabetes patients is associated with elevated oxidative stress. Experimental Biology Conference. FASEB J. 26:685.8.

53) Zimmerman M.C., Rosenbaugh E.G., Manickam D.S., Kabanov A.V. (2012) Nanoformulated antioxidants: Delivery to central neurons and modulation of angiotensin II intra-neuronal signaling. American Physiological Society Conference: Autonomic Regulation of Cardiovascular Function in Health and Disease, Omaha, NE. The Physiologist. 55(6):264.

54) Rosenbaugh E.G., Tian J., Manickam D.S., Batrakova E.V., Kabanov A.V, Zimmerman

M.C. (2012) Utilization of nanoformulated copper/zinc superoxide dismutase to attenuate the central angiotensin II-induced pressor response. American Heart Association High Blood Pressure Meeting, Washington D.C. Hypertension. 60:A185.


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55) Rosenbaugh E.*, Tian J., Manickam D.S., Kabanov A.V., Zimmerman M.C. (2012). Nanoformulated copper/zinc superoxide dismutase (CuZnSOD) inhibits the central angiotensin II (AngII)-induced pressor response. 19th Annual Society for Free Radical Biology and Medicine Conference. Free Radic Biol Med. 53(2):S173-4. *Received Young Investigator Award.

56) Basu U. and Zimmerman M.C. (2012). Overexpression of manganese superoxide dismutase (MnSOD) attenuates angiotensin (AngII)-induced inhibition of protein phosphatase 2A (PP2A) activity in central neurons. 19th Annual Society for Free Radical Biology and Medicine Conference. Free Radic Biol Med. 53(2):S155-6.

57) Case A.J., Franco Cruz R., Zimmerman M.C. (2013). Hydrogen peroxide (H2O2) is not increased in angiotensin II (AngII)-stimulated neurons overexpressing superoxide dismutase (SOD). FASEB J. 27:1143.15.

58) Basu U., Madayiputhiya N., Zimmerman M.C. (2013). Angiotensin II (AngII) is rapidly metabolized in neuronal cell culture media as determined by liquid chromatography-tandem mass spectrometry (LC MS/MS). FASEB J. 27:927.6.

59) Collister J., Cristina H., Nahey D., Stauthammer C., Kruger M., O’Sullivan G., Parker J., Tian J., Zimmerman M.C. (2013). Overexpression of CuZnSOD in median preoptic nucleus improves cardiac function after myocardial infarction in the rat. FASEB J. 27:919.6.

60) Savalia K.K., Manickam D., Rosenbaugh E.G., Tian J., Ahmad I., Kabanov A.V., Zimmerman M.C. (2013). Nanoformulated copper/zinc superoxide dismutase: Alternative therapeutic strategy for angiotensin II-dependent neurogenic hypertension. Hypertension. 62:A73.

61) Basu U., Case A.J., Madayiputhiya N, Zimmerman M.C. (2013). Development of a chronic angiotensin II (AngII)-stimulated neuronal cell culture model. Hypertension. 62:A152.

62) Case A.J., Liu M., Ding S.J., Zimmerman M.C. (2013). Nitration of the tyrosine in angiotensin II attenuates its biological activity. Free Radic Biol Med. 65:S69.

63) Collister J., Bellrichard M., Nahey D., Tian J., Zimmerman M.C. (2014). Overexpression of copper/zinc superoxide dismutase (SOD1) in the median preoptic nucleus attenuates chronic angiotensin II hypertension in the rat. FASEB J. 28:686.16.

64) Collister J., Hartnett C., Mayerhofer T., Nahey D., Stauthammer C., Kruger M., O’Sullivan G., Parker J., Tian J., Zimmerman M.C. (2014). Overexpression of copper/zinc superoxide dismutase (SOD1) in the median preoptic nucleus improves cardiac function after myocardial infarction in the rat. FASEB J. 28:686.17.

65) Deo S., Zimmerman M.C., Zucker I.H., Fadel P. (2014). Elevated levels of reactive oxygen species in heart failure patients: role for increased mononuclear NADPH oxidase expression. FASEB J. 28:1153.9.

66) Case A.J., Zimmerman M.C. (2014). Redox-regulated suppression of resting splenic T-lymphocyte activation in a model of sympathoexcitation. Free Radic Biol Med. 76(Supplement 1):S42-43.

67) Basu U., Case A.J., Liu J., Li Y.L., Zimmerman M.C. (2014). Overexpression of redox-sensitive calcium/calmodulin-dependent protein kinase II (CaMKII) in central neurons augments angiotensin II (AngII)-induced hypertension. Free Radic Biol Med. 76(Supplement 1):S41.

68) Moore T.A., Ahmad I.M., Jones J., Case A.J., Zimmerman M.C. (2014). Superoxide and superoxide dismutase levels in high-risk pregnant women: A pilot feasibility study. Free Radic Biol Med. 76(Supplement 1):S51.

69) Case A.J., Tian J., Zimmerman M.C. (2015). Increased mitochondrial superoxide in the brain, but not periphery, sensitizes mice to angiotensin II-mediated hypertension. Hypertension. 66:A120.


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70) Moore T.A., Ahmad I.M., Roessner C., Jones J., Zimmerman M.C. (2015). Free radical and antioxidant levels in high-risk pregnant women during the 2nd trimester. Free Radic Biol Med. 87(Supplement 1):S16.

71) Ahmad I.M., Temme J.B., Abdalla M.Y., Zimmerman M.C. (2015). Oxidant-antioxidant status in workers occupationally exposed to long term low levels of ionizing radiation – A pilot study. Free Radic Biol Med. 87(Supplement 1):S13.

72) Case A.J. and Zimmerman M.C. (2015). Inverse regulatory effects of mitochondrial superoxide in resting and activated T-lymphocytes. Free Radic Biol Med. 87(Supplement 1):S39.

Oral Presentations and Chaired Sessions at Local, National, and International Meetings: 2003 Experimental Biology/American Physiological Society (APS) summer conference 2003 Experimental Biology/American Physiological Society annual meeting 2003 American Heart Association High Blood Pressure Research annual meeting 2003 Society for Free Radical Biology and Medicine annual meeting 2004 Experimental Biology/American Physiological Society annual meeting 2004 American Heart Association High Blood Pressure Research annual meeting 2005 Society for Free Radical Biology and Medicine annual meeting 2006 Society for Neuroscience annual meeting 2009 Nebraska Physiological Society annual meeting 2009 American Heart Association High Blood Pressure Research Council annual meeting 2010 American Association of Anatomists (AAA) Annual Meeting at Experimental Biology 2010 Chaired APS-Sponsored “Mitochondrial Oxidants and Antioxidants in Autonomic

Regulation and Cardiovascular Function" Featured Topic at Experimental Biology 2010 Co-Chaired “Nanomedicine Research Report” Session at 8th International Nanomedicine

and Drug Delivery Symposium (NanoDDS’10) 2010 American Heart Association High Blood Pressure Research Council annual meeting 2010 American Heart Association Scientific Sessions 2011 Experimental Biology/American Physiological Society annual meeting 2011 Host/organizer of the annual University of Nebraska – Lincoln Redox Biology Center

Retreat 2011 Central Region Institutional Development Award (IDeA) Conference 2011 Co-Chaired “Oxidative Stress” Session at AHA High Blood Pressure Research Council

annual meeting 2011 Co-Chaired “Harry Goldblatt Award Finalist” Session at AHA High Blood Pressure

Research Council annual meeting 2011 High Blood Pressure Research Council of Australia annual meeting 2012 Angiotensin Gordon Conference 2012 Experimental Biology/American Physiological Society annual meeting 2012 APS Conference: Autonomic Regulation of Cardiovascular Function in Health and

Disease 2012 American Heart Association High Blood Pressure Research Council annual meeting 2013 FASEB Summer Research Conference: “Renal Hemodynamics: Integrating with the

Nephron and Beyond” 2014 American Society of Hypertension Annual Scientific Meeting 2014 Chaired Session – “Oxidative Stress” – American Heart Association Council on

Hypertension annual meeting 2014 Chaired Session – “Oxidative Stress, Inflammation, and Immunity” – International

Society of Hypertension, New Investigator Symposium 2015 Co-Organizer, 3rd Annual Meeting of the International Academy of Cardiovascular

Sciences - North America Section


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2016 FASEB Summer Research Conference: Neural Mechanisms in Cardiovascular Regulation: Novel Research and Disease Treatment Strategies

2016 American Society of Nephrology Annual Conference 2018 Society for Redox Biology and Medicine Annual Conference Invited Presentations: 2001 Marian College Math & Natural Science Honors Banquet, invited keynote speaker. 2006 Emory University, Atlanta GA. “Mitochondrial-produced ROS in CNS-associated

Diseases”. 2008 University of Nebraska, Lincoln, NE. “Angiotensin II Signaling in Neurons: Role of

Mitochondrial versus Cytoplasmic-Produced Reactive Oxygen Species”. 2008 Cornell University, Ithaca, NY. “Mitochondrial-Produced Reactive Oxygen Species:

Signaling Intermediates in Angiotensin II-Stimulated Neurons”. 2008 University of Nebraska Medical Center, Omaha, NE. “Mitochondrial-Produced Reactive

Oxygen Species: Signaling Intermediates in Angiotensin II-Stimulated Neurons”. 2008 Nebraska Wesleyan University, Lincoln, NE. “Dysregulation of Oxidants and

Antioxidants in the Brain and the Pathogenesis of Hypertension”. 2009 Louisiana State University Health Science Center, New Orleans, LA. “Mitochondrial-

Produced Reactive Oxygen Species: Signaling Intermediates in Angiotensin II-Stimulated Neurons”

2009 12th Annual Cardiovascular Research Symposium, University of Nebraska Medical Center, Omaha, NE. “Mitochondrial-Produced Oxidants and Central Cardiovascular Regulation in Hypertension”.

2009 Oberley Memorial Free Radical Symposium, Iowa City, IA. “Role of Mitochondrial-Produced Superoxide in Angiotensin II-Dependent Intra-neuronal Signaling and Neurogenic Hypertension”.

2010 Tech Talk presentation to Dept of Comparative Medicine, UNMC. “Using a Mouse Model of Hypertension to Study the Role of Oxidants and Antioxidants in the Brain in the Pathogenesis of Cardiovascular Disease”.

2010 American Association of Anatomists (AAA) Annual Meeting at Experimental Biology. “Nanoformulated superoxide dismutase 1 (SOD1): Implications for angiotensin II (AngII) and brain-related cardiovascular diseases”.

2010 University of Missouri – Columbia, Columbia, MO. “Mitochondrial-Produced Superoxide in Angiotensin II Intra-Neuronal Signaling and Neurogenic Hypertension”.

2011 University of Pennsylvania School of Medicine, Philadelphia, PA. “Antioxidant Nanozymes: Delivery to the CNS and Modulation of Cardiovascular Function”.

2011 University of Minnesota, Minneapolis, MN: “Oxidants and Antioxidants in Angiotensin II Intra-Neuronal Signaling and Neurogenic Hypertension”.

2011 American Heart Association, Midwest Affiliate, Local Chapter: Presentation given to members of the Youth Market Team. “Oxidants, Antioxidants, and Hypertension: It’s All in Your Head”.

2011 UNMC, College of Pharmacy, Omaha, NE: “Superoxide Dismutase Nanozyme: Delivery to Central Neurons and Inhibition of Angiotensin II Intra-Neuronal Signaling”.

2011 Medical College of Wisconsin, Milwaukee, WI: “Oxidants and Antioxidants in Angiotensin II Intra-Neuronal Signaling and Neurogenic Hypertension”.

2011 Osher Lifelong Learning Institute, University of Nebraska – Lincoln: “Oxidants, Antioxidants, and Hypertension: It’s All in Your Head”.

2012 UNMC Chancellor’s Board of Councilors Meeting, Omaha, NE: “Oxidants, Antioxidants, and Hypertension: It’s All in Your Head”.

2012 University of Mississippi Medical Center, Jackson, MS: “Oxidants and Antioxidants in Angiotensin II Intra-Neuronal Signaling and Neurogenic Hypertension”.


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2012 Omaha American Heart Association Board of Directors Meeting: “Oxidants, Antioxidants, and Hypertension: It’s All in Your Head”

2013 Gallup, Omaha, NE: “Cardiovascular Disease Research” 2013 Creighton University, Omaha, NE: “Oxidants, Antioxidants, and Hypertension: It’s All in

Your Head” 2014 Omaha Veterans Affairs Medical Center, Omaha, NE: “Oxidants, Antioxidants, and

Hypertension: It’s All in Your Head” 2014 Omaha Science Café, Omaha, NE: “Nanomedicine and Cardiovascular Disease” 2014 UNMC Cardiology Grand Rounds, Omaha, NE: “Revisiting ‘Oxidative Stress’ in

Cardiovascular Disease”. 2015 SUNY Polytechnic Institute, Colleges of Nanoscale Science and Engineering, Albany,

NY: “Nanoformulated Superoxide Dismutase and Hypertension”. 2015 University of North Carolina, Chapel Hill, NC. “Nanoformulated Superoxide Dismutase

for the Improved Treatment of Hypertension”. 2015 University of Iowa, Iowa City, IA. Oberley Memorial Redox Symposium. “Nanoformulated

Superoxide Dismutase and Hypertension”. 2015 UNMC Research and Innovation Week, Donor Dinner, Omaha, NE: “Antioxidants and

High Blood Pressure: It’s All in Your Head”. 2016 UNMC Regenerative Medicine Program, Omaha, NE: “Role of Redox Signaling and

Antioxidants in the Brain in the Pathogenesis of Hypertension”. 2016 LSU Health – Shreveport, Shreveport, LA: “Redox Signaling in the Brain and

Antioxidant-Based Therapeutics: Consequences for Hypertension”. 2016 University of Nevada School of Medicine, Reno, NV: “Redox Signaling in the Brain and

Antioxidant-Based Therapeutics: Consequences for Hypertension”. 2016 George Washington University, Washington, D.C.: “Redox Signaling in the Brain and

Antioxidant-Based Therapeutics: Consequences for Hypertension”. 2016 University of South Dakota, Vermillion, SD: “Redox Signaling in the Brain and

Antioxidant-Based Therapeutics: Consequences for Hypertension”. 2017 UNMC, Cardiology Grand Rounds: “Redox Signaling and Antioxidant-Based

Therapeutics: A Radical View of Cardiovascular Disease”. 2017 West Virginia University, Morgantown, WV: “Redox Signaling and Antioxidant-Based

Therapeutics: A Radical View of Hypertension”. 2017 University of Texas – Arlington, Arlington, TX: “Redox Signaling in the Brain and

Antioxidant-Based Therapeutics: Consequences for Hypertension”. 2018 University of Nebraska, Lincoln, NE; Nebraska Center for the Prevention of Obesity

Disease: “Redox Signaling in the Brain and Antioxidant-Based Therapeutics: A Radical View of Hypertension”.

2018 University of North Carolina, Chapel Hill, NC: “Redox Signaling in the Brain and Antioxidant-Based Therapeutics: A Radical View of Hypertension”.

Grant/Research Support

Current

NIH, R01HL127071-01A1. “Targeting Sympathetic Overactivity in CKD Patients: Mechanisms & Novel Therapies”, 04/01/16 – 03/31/2020. Role: Co-Investigator (PI: Paul Fadel, University of Texas – Arlington).

NIH, R01CA210439-01A1. “Targeting the Metabolic Basis of Cachexia in Pancreatic Cancer”, 12/16/2016 – 11/30/2021. Role: Co-investigator (PI: Singh).

NIH, R21AA02545-01A1. “The Effectiveness of NanoSOD in Ameliorating Ethanol-Induced Liver Injury in Obesity”, 09/01/2017-08/31/2019. Role: Co-investigator (PI: Viswanathan).

NIH, R01AI125588-01A1. “The Role of Arginine Catabolic Pathways in Modulating Staphylococcal Fitness”, 11/06/2017-10/31/2022. Role: Co-investigator (PI: Thomas).


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NIH, P20GM104320. University of Nebraska Center for the Prevention of Obesity Diseases (NPOD). “Understanding the Bioactivity of the Dietary γ-Glutamyl Peptide (γ-EV) in the Prevention of Obesity and Obesity-Linked Hypertension”. 01/01/2018-12/31/2019. Role: Co-investigator (PI: Majumder).

University of Nebraska - Collaboration Initiative/System Science. “Understanding the

Molecular Mechanism of Dietary -glutamyl Peptides in the Prevention of Low-Grade Inflammation-Induced Chronic Disorders”. 07/07/2018 – 06/30/2020. Role: Co-PI (Multi-PIs: Majumder; Moreau).

NIH, R01HL144146-01. “Potential Therapies to Improve Ventricular Vagal Function in Type 2 Diabetes”. 08/01/2018-07/31/2022. Role: Co-investigator (PI: Li).

NIH, 1R21ES027666-01A1. “Pro-NP Prevention of UV-Induced Skin Cancer”. 08/15/2018 – 07/31/2020. Role: Co-investigator (PI: Hansen)

Previous

NIH, 1P30GM103335-01. University of Nebraska-Lincoln Redox Biology Center. “Core B: Electron Paramagnetic Resonance (EPR) Spectroscopy Core”, 09/01/2012 – 07/31/2018. Role: Core Director.

AHA, 14GRNT20390010. “Brain Delivery of Nanoformulated Superoxide Dismutase for the Improved Treatment of Hypertension”. 07/01/2014 – 06/30/2017. Role: PI.

NIH, 2R01AA008769-20A1. “Ethanol-Mediated Cilia Motility Dysfunction”, 08/20/2012 – 05/31/2017. Role: Co-investigator (PI: Sisson).

University of Nebraska – Lincoln, Redox Biology Center. “VAP-1 and its Role in Sympatho-excitation in Type 1 Diabetes Mellitus”, 06/01/2016 – 05/31/2017. Role: Co-investigator (PI: Bidasee).

NIH, 1R01HL103942-01. “Mitochondrial Redox Systems in Neurogenic Hypertension", 07/01/2010 – 03/31/2017. Role: PI.

NIH, 1K01NR014474-01. “Physiologic Stress During Pregnancy on Maternal and Infant Outcomes”, 04/15/2014 – 03/31/2017. Role: Mentor (PI: Tiffany Moore, assistant professor).

UNMC Edna Ittner Pediatric Research Support. “Oxidative Stress and Inflammation in

Low‐Risk Pregnant Women and Newborn Infants”, 10/15/15 – 10/14/16. Role: Mentor (PI: Tiffany Moore, assistant professor).

NIH, 1K99HL123471-01A1. “Redox Regulation of T-lymphocytes in Sympathoexcitation-associated Hypertension”, 07/03/15 – 08/31/2016. Role: Mentor (PI: Adam Case, instructor).

NIH, 2P20GM103480-06. “Nebraska Center for Nanomedicine”, 09/15/2013 – 05/31/2016. Role: Co-investigator (PI: Bronich).

NIH, R56HL124992-01. “Carotid Body in Pathophysiology of Heart Failure: Afferent-Efferent Mechanisms”, 09/01/14 – 08/31/15. Role: Co-investigator (PI: Schultz).

UNMC Graduate Student Fellowship. “Redox Sensitive Proteins in Brain Angiotensinergic Signaling”, 07/01/2014 – 06/30/2015. Role: Mentor (PI: Urmi Basu, graduate student).

NIH NRSA Postdoctoral Fellowship, 1F32HL122021-01. “Regulation of Mitochondrial Redox Systems in T-lymphocytes During Hypertension”, 07/01/14 – 06/30/15. Role: Mentor (PI: Adam Case, postdoctoral fellow)

AHA Postdoctoral Fellowship, 13POST17060015: “Regulation of Mitochondrial Redox Systems in T-lymphocytes During Hypertension”, 07/01/2013 -06/30/2015. Role: Mentor (PI: Adam Case, postdoctoral fellow).

NIH NRSA Predoctoral Fellowship, 1F31NS073398-01A1: “Brain Delivery of Nanoformulated Superoxide Dismutase”, 07/01/2011 – 06/30/2013. Role: Mentor (PI: Erin Rosenbaugh, graduate student).

NIH, 1P20RR021937-01A2. Center for Biomedical Research Excellence (COBRE), Nebraska Center for Nanomedicine, University of Nebraska Medical Center: “A


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Nanozyme Antioxidant Therapy for the Treatment of Angiotensin II-Dependent Hypertension”, 10/1/2008 – 06/30/2013. Role: Project Leader (Director: Kabanov).

American Heart Association Scientist Development Grant, 0930204N: “Role of Superoxide vs. Hydrogen Peroxide in the Redox Regulation of Angiotensin II-Induced Sympathoexcitation”, (Percentile Rank: 0.65%), 01/01/2009 – 12/31/2012. Role: PI.

Subcontract from the University of Nebraska – Lincoln: “Electron Paramagnetic Resonance (EPR) Spectroscopy Facility”, 06/09/10 – 06/30/12. Role: PI.

NIH, 2P01HL062222-11. “Neuro-Circulatory Function in Chronic Heart Failure”, 07/01/09 – 06/30/2014. Role: Other (PI: Zucker).

NIH, 3R01HL038690-21A1. “Sympathetic Control in Heart Failure: A Role for Statins”, 07/15/2009 – 06/30/2011. Role: Co-investigator (PI: Zucker).

NIH, 2P20RR017675-06. Center for Biomedical Research Excellence (COBRE), Redox Biology Center, University of Nebraska: “Role of mitochondrial-produced reactive oxygen species in neurogenic hypertension”, 07/01/2007 – 06/30/2009. Role: Project Leader (Director: Gladyshev).

Muscular Dystrophy Association (Subcontract from the University of Iowa): “Role of Reactive Oxygen Species in ALS-associated Mutant SOD-1 Toxicity”, 11/01/2007- 12/31/2008. Role: Co-investigator (PI: Flanagan)

National Research Service Award (NCI), The University of Iowa Free Radical and Radiation Biology Program: 01/01/2005-06/30/2007. Role: PI (Director: Oberley).

American Heart Association (Heartland Affiliate) Predoctoral Fellowship: “Oxidant Signaling in Central Neural Control of Cardiovascular Function”, 01/01/2003-06/30/2004. Role: PI (Sponsor: Davisson).

National Research Service Award (NCI), The University of Iowa Free Radical and Radiation Biology Program: “A Novel Angiotensin II Signaling Mechanism in Central Cardiovascular Regulation: A Role for Reactive Oxygen Species”, 01/01/2002-12/31/2002. Role: PI (Director: Oberley).

Documents

Matthew Christopher Zimmerman Current Position · City, Iowa; Dr. Larry Oberley mentor Academic Appointments 2007 – 2012 ... “Human Gross Anatomy”, Department of Anatomy and