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MCQs of Liposomes
1. Liposomes are spherical structures, usually
between_________in diameter:a) 80nm-100nm
b) 60nm-100nm
c ) 55nm-1000nm
d) 15nm-1000nm
2. Liposomes consists of a bilayer of__________a) hydrophilic
molecules
b) hydrophobic molecules
c) both a and b
d) None
3. Liposomes have _________half-lifea) longer
b) Shorter
c) Intermediate
d) Both a and b
4. Liposomes have _______solubilitya) lower
b) higher
c) both a and b
d) None
5. Liposome phospholipid undergoes _________a) oxidation
b) hydrolysis
c) acetylation
d) both a and b
6. The diameter of Small unilamellar vesicles
is_________a)20-100nm
b)20-1000nm
c)10-100nm
d)100nm-400nm
7. Intermediate sized unilamellar vesicles are prepared
by__________a) sonication
b) high pressure extrusion technique
c) detergent dialysis
d) both b and c
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8. Tranfersome belongs to the classification according to
_________a) composition
b)application
c)function
d)none of the above9. Liposomes with _______number of lamella
are called as pauci-lamellar liposomes
a) lower
b)higher
c)single
d)none of the above
10.Loading of the entrapped agents before/during the manufacture
procedure is known as______
a) active loading
b) passive loadingc)both a and b
d)none of the above
11.Passive Loading Technique includes__________a)
Lyophilization
b)proliposomes
c) solvent dispersion
d) both a and b
12.Drawback of Lipid hydration method is ___________a) low
internal volume
b) high encapsulation efficiency
c)size distribution is homogenous
d) none of the above
13.Tip of sonicator is directly engrossed into liposome
dispersion in _________a) bath sonication
b) probe sonication
c)none of the above
14.The resulting liposomes from French pressure cell extrusion
are__________thansonicated SUVs
a)smaller
b)equal
c)larger
15.To produce a microemulsion of small vesicles at least
___________circulations arerequired
a)at least 20 circulation but not greater than 200
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b)10 circulations
c)at least 200 circulation but not greater than 2000
d) at least 2 circulations but not greater than 10
16.Dried reconstituted vesicles method is performed
in____________a)solvent dispersionb)mechanical dispersion
c)both a and b
17.Solvent vaporization is also known as__________a) ether
injection
b) ethanol injection
c) double emulsification
d) reverse-phase evaporation
18.Amphotericin B liposomes are given______________a) lungs
b)oral
c)transdermal
d) Intravenous
19.Ketoconazole liposomes are given by_____________a) lungs
b)oral
c)transdermal
d)Intravenous
20.Temperature used for Ether Injection method is __________or
under reduced pressurea)15-25
o
Cb)55-65
oC
c)55-85oC
d)none of the above
