M O R G R I D G E I N S T I T U T E f o r R E S E A R C H

C O M M I T M E N T

T O D I S C O V E R Y

"We hope to extend the Wisconsin Idea by leveraging the research expertise of UW-Madison and the scienti�c capabilities of the Midwest to spur new discovery, new innovation and new knowledge.”JOHN AND TASHIA MORGRIDGE

Co-Founders

B R A D S C H WA RT ZC E O

�e Morgridge Institute for Research is committed to discovery, in many shapes and forms.

We research fundamental questions in biology that will help solve major health challenges of our time. We’re on the leading frontiers of research in regenerative biology, virology, medical engineering and metabolism, while using computation and bioinformatics to address the most complex questions. And we bring Wisconsin science to life for thousands of visitors each year.

�e Morgridge Institute originated from the remarkable vision of University of Wisconsin-Madison alumni John and Tashia Morgridge. �e Morgridges recognized that an independent research institute could leverage UW-Madison’s formidable strengths in the biosciences and add an element of well-advised risk to move quickly into promising butunproven areas.

We’re committed to the long view of scienti�c research — and to connecting science and society in new and powerful ways.

150

By the Numbers

N E W C E R V I C A L

C A N C E R C A S E S

A N N U A L L Y , 5 0 %

O F W H I C H W I L L

B E F A T A L

E X P E C T E D N E W B R E A S T C A N C E R C A S E S A N N U A L L Y

I N T H E U . S .

P E O P L E W O R L D W I D E W H O H A V E

D I A B E T E S

16%

38,000,000

P E R C E N T A G E O F U . S . H I G H

S C H O O L S E N I O R S W H O A R E

P R O F I C I E N T I N M A T H A N D

I N T E R E S T E D I N A S C I E N C E

A N D T E C H N O L O G Y C A R E E R

41

19 I N D U S T R I A L I Z E D N A T I O N S

W H O S E H I G H S C H O O L

S T U D E N T S O U T P E R F O R M U . S .

S T U D E N T S I N S C I E N C E

3,000,000

A LOOK AT THE CHALLENGES THAT MOTIVATE MORGRIDGE SCIENTISTS

K N O W N D I S E A S E S

C O N N E C T E D T O

M E T A B O L I C D I S O R D E R S ,

I N C L U D I N G H E A R T

D I S E A S E & A L Z H E I M E R ' S

500,000

1,200,000

347,000,000

C O U N T R I E S T H A T D O

N O T H A V E A T L E A S T

O N E L I F E - S A V I N G C T

I M A G I N G M A C H I N E P E R

1 M I L L I O N R E S I D E N T S

230,000 A M E R I C A N S O V E R 4 0

E X P E R I E N C I N G V I S I O N L O S S

395,000 C O R O N A R Y B Y P A S S

O P E R A T I O N S

P E R F O R M E D I N T H E

U . S . E A C H Y E A RO R G A N T R A N S P L A N T S

P E R F O R M E D I N 2 0 1 4

29,532

E X P E C T E D S H O R T A G E O F H I G H - S K I L L E D W O R K E R S I N S T E M

F I E L D S B Y 2 0 1 8

P E O P L E I N T H E U . S . L I V I N G W I T H

H I V I N F E C T I O N

O U RR E S E A R C HA R E A S

O U RR E S E A R C HA R E A S

R E G E N E R A T I V E

B I O L O G Y

E N G I N E E R I N G B L O O D V E S S E L S F O R

C A R D I O V A S C U L A R D I S E A S E

Diseases of blood vessels kill more people worldwide than any other single cause. Although bypass operations for heart disease and peripheral artery disease can be

e�ective, patients o�en lack healthy vessels for transplantation. Human pluripotent stem cells can produce each of the cellular components of the artery.

We study how to derive the cellular components of an artery, and how to assemble them into a functional artery suitable for transplantation.

I N V E S T I G A T I N G D E V E L O P M E N T A L C L O C K S

Nobody knows exactly why mice take 21 days to develop and humans take nine months. Unfortunately, human stem cells repeat this timing in a culture dish, so

making some types of cells can take several months, making therapeutics based on these cells very di�cult. We study the control of developmental timing to

generate therapeutically relevant cell types in a more reasonable time frame.

Using developmental biology to advance medicine at a cellular level

V I R U S – H O S T I N T E R A C T I O N SViruses not only block host defense genes, but actively exploit many

other host gene functions to replicate. We are de�ning these interactions to shed light on infection and to develop

broad-spectrum antivirals.

V I R U S E S A N D C A N C E RRoughly 15 percent of human cancers are caused by speci�c tumor

viruses. We are deciphering how such tumor viruses infect and drive tumor development, and how to prevent or treat these cancers.

S Y S T E M S B I O L O G YBiology can’t be understood by studying single genes any more than

a novel could be understood by studying single words. We use systematic, genome-wide analyses to build higher understanding of

virus infection and control.

Understanding and controlling virus and host biology

V I R O L O G Y

M E D I C A L

E N G I N E E R I N G

M U L T I S C A L E I M A G I N GOur imaging technologies bridge from micro- to macro-resolution and provide

novel insights at the interface of microscopy and medical imaging. �ese methods are used to study the role of collagen alignment and metabolism in cancer.

I M A G I N G I N S T R U M E N T A T I O NOur instrumentation has applications in detectors, light sources and analysis

so�ware. We are redesigning computed tomography (CT) — one of the most widely used medical devices — for faster imaging, dose reduction, and improved

image quality.

M E D I C A L D E V I C E SWe’re building better tools for doctors, ranging from emergency room solutions and

radiology to pathology and the surgical suite. A novel switch lighting system is being developed that provides full light in the operating room, with �uorescence,

tumor-speci�c views to the surgeon.

Creating technologies to better diagnose, treat and prevent disease

T U N I N G C E L L U L A R E N E R G E T I C SDysfunction of mitochondria, the “powerhouses” of cells, contributes to over 150 diseases, including cancer and diabetes. We are discovering

ways to modulate mitochondria as a therapeutic strategy.

C O E N Z Y M E Q I N H E A L T H A N D D I S E A S ECoenzyme Q is essential for energy production, and its de�ciency

underlies a wide range of disorders including Parkinson’s and many other neurodegenerative diseases. We are de�ning the pathways that

produce this essential molecule.

D I S C O V E R I N G F U N C T I O N S F O R M E T A B O L I C G E N E SDespite decades of work, nearly one-third of genes important for

mitochondrial function have never been studied. We’re dedicated to understanding the importance of these genes to human health.

Studying the chemistry of life and its disruption in human disease

M E T A B O L I S M

CCT provides the human expertise to help researchers leverage computing technology to answer transformational questions ranging from

neuroscience and cancer to medical records. �e team facilitates hundreds of UW-Madison scientists annually in putting 300 million compute hours to work for novel data-intensive and high-throughput research methods. As a pioneer in distributed computing, the team focuses on the data and

security aspects of large scale research computing.

C O R E

C O M P U T A T I O N A L

T E C H N O L O G Y

Leveraging the power of computing to expand the frontiers of biology

Discovery Outreach o�ers a wide range of innovative programs that connect with more than 30,000 visitors

annually. From the massive Wisconsin Science Festival to small-group, hands-on lab experiences, the Morgridge

Institute sparks public interest in and appreciation of science for all ages.

D I S C O V E R Y

O U T R E A C H

Generating public excitement for science

P A U L A H L Q U I S T , Director of Virology, is a fellow of the prestigious Howard Hughes Medical Institute, who has made key contributions to understanding of cancer-causing viruses and of virus-host interactions. His work focuses on HIV, human papillomavirus (HPV), in�uenza and Epstein-Barr virus.

J A M E S T H O M S O N , Director of Regenerative Biology, is one of the world’s leading stem cell scientists. His discoveries have rede�ned biomedicine, �rst with the isolation and culturing of human embryonic stem cells in 1998; then in the development of human pluripotent stem cells from adult skin cells in 2007.  �e discoveries led to two “Breakthrough of the Year” honors from the journal Science.

P I L A R O S S O R I O , Morgridge Bioethicist in Residence, is an international expert on emerging bioethical issues, including stem cell research, the human genome project, healthcare data and privacy, gene editing and synthetic biology. She served on President Clinton’s program on Ethical, Legal and Social Implications of Human Genomics.

M I R O N L I V N Y , Chief Technology O�cer, is an international leader in the �eld of high-throughput computing. His innovations are used by thousands of scientists globally to harness data from massive research challenges, including the search for the Higgs boson and cosmic neutrinos, mapping the human genome and harnessing healthcare data.

D A V E P A G L I A R I N I , Director of Metabolism, is a national leader in research on the composition and function of mitochondria. He is driven to discover the underpinnings of mitochondrial dysfunction, which plays a role in more than 150 human diseases. Pagliarini is a UW-Madison associate professor of biochemistry.

K E V I N E L I C E I R I , Interim Director of Medical Engineering, is an internationally known expert in advanced light microscopy. He also is principal investigator of the UW-Madison Laboratory for Optical and Computational Instrumentation (LOCI). Eliceiri leads Morgridge e�orts in advanced biofabrication and multi-scale imaging.

E X C E L L E N C E I N B I O M E D I C A L R E S E A R C H

Our lead investigators bring prestigious research accomplishments to the Morgridge Institute

M O R G R I D G E B O A R D O F T R U S T E E S

CARL GULBRANDSEN, managing director, Wisconsin Alumni Research Foundation; JAMES DAHLBERG, professor emeritus, biomolecular chemistry; DR . HARVEY COHEN, professor of pediatrics, Stanford University School of Medicine; TASHIA MORGRIDGE, author and retired educator; THOMAS PYLE, chairman, �e Pyle Group LLC; PATRICIA LIPTON, retired executive director, State of Wisconsin Investment Board; JOHN MORGRIDGE, chairman emeritus, Cisco Systems; JOHN BURRIS, president, Burroughs Wellcome Fund; CAROL

SKORNICKA, retired senior vice president, Midwest Airlines; DR . JAMES

BERBEE, clinical assistant professor, UW-Madison emergency medicine; Board Chairman DR . FRED ROBERTSON, venture partner, Baird Capital; and DR . BRAD SCHWARTZ, Morgridge CEO. Not pictured: DR . THOMAS KRUMMEL, Emile Holman Professor and Chair Emeritus of Surgery, Co-Director of Stanford Biodesign, Stanford University; TERRI POTTER , retired CEO, Meriter Health Services.

F R O M L E F T :

Your gi� kickstarts biomedical research projects that explore truly

big questions in health care and disease. Your support will help ignite new partnerships and discoveries for researchers and scientists conducting

experiments that matter.

You can provide start-up resources such as scholarships and fellowships to talented undergraduate, graduate and postdoctoral students, and early

stage researchers pursuing scienti�c passions.

S P A R K F U N D Y O U N G I N V E S T I G A T O R

F U N D

Your gi� provides discretionary dollars that advance biomedical

research in partnership with UW-Madison. Your support helps improve human health by enabling

and translating innovative and interdisciplinary research.

M O R G R I D G E I N S T I T U T E

F U N D

You can inspire the public’s curiosity in science and technology.

�e Inspire Fund supports Morgridge outreach programs that attract more than 30,000 science enthusiasts of all ages each year.

I N S P I R E F U N D

G I V E O N L I N E N O W : MO R G R I D G E . O R G / G I V E

�e nonpro�t Morgridge Institute for Research is governed by a board of trustees as a private, independent, 501(c)3 Medical Research Organization. Your contribution is tax deductible to the full extent provided by law.T

EA

R H

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E

G I V E O N L I N E N O W

MO R G R I D G E . O R G / G I V E

�e Morgridge Institute seeks to improve human health through innovative, interdisciplinary biomedical research, in partnership with a great public research university.

We can match your passion to the areas of greatest promise in research and discovery. To learn more about making a gi�, please contact Bill Swisher, Chief Development O�cer at 608-316-4364, bswisher@morgridge.org

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