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1
National Capital Area Chapter
Society of Toxicology Newsletter
Electronic Edition
March 2017 Issue No. 41
Gertrude-Emilia Costin, Editor
CHAPTER MISSION STATEMENT 2
MESSAGES FROM THE NCAC-SOT EXECUTIVE BOARD MEMBERS 2
The President, Tracy Chen 2
The Student Liaison, Elena Braithwaite 3
The Graduate Student Representatives, Georgina Harris and Kristin Noell 4
The Post-Doctoral Representative, Shelby Skoog 5
The Website Coordinator, Lorraine Twerdok 6
The Newsletter Editor, Gertrude-Emilia Costin 7
TREASURER’S REPORT, Nancy Beck 8
NCAC-SOT MEMBERSHIP 8
Details 8
Membership Application 9
Current NCAC-SOT members 10
NCAC-SOT EXECUTIVE BOARD MEMBERS CONTACT LIST 14
Election results – Meet the New Board Members 15
NCAC-SOT ACTIVITIES UPDATE 16
Meetings of Interest 16
Workshop: Advances in Causal Understanding for Risk Based Decision Making
(6-7 March 2017) 16
Metabolic Syndrome and Associated Diseases: From Bench to the Clinic
(11 March 2017) 17
Water: Tame or Toxic (11 March 2017) 17
Society of Toxicology Annual Meeting (12-16 March 2017) 18
Letter from the President of SOT 18
NCAC-SOT and Johns Hopkins University Joint Reception/Mixer 19
NCAC-SOT Presenter List at SOT 20
NCAC-SOT Spring Symposium: Safety Assessment of Over-the-Counter 22
Botanicals and Nutraceuticals: Update and Challenges (19 April 2017)
Outreach Activities 24
Update from the Chairs 24
NCAC-SOT Outreach Program Survey 24
WHAT’S NEW IN TOXICOLOGY? Grants for Alternatives Research by Sue Leary 25
MEMBERS ACCOMPLISHMENTS CORNER (September, 2016 through March 2017) 26
Publications and Presentations 26
2
CHAPTER MISSION STATEMENT
The National Capital Area Chapter of the Society of Toxicology (NCAC-SOT) was established to provide a
regional focus for scientists of all disciplines interested in toxicology. The Chapter acts to:
Sponsor and co-sponsor symposia on current issues in toxicology
Provide annual awards to an outstanding student and post-doc in toxicology to assist in attending the
annual meeting of the SOT
Maintain communication with the National SOT regarding current toxicology and regulatory concerns
Sponsor Regional Chapter events at the SOT Annual Meetings
- // -
MESSAGES FROM THE NCAC-SOT EXECUTIVE BOARD MEMBERS
President’s Message
Dear NCAC-SOT members,
As you may recall, there have been quite a few changes since our last newsletter issued. I assumed the NCAC-
SOT Presidency due to Erik’s resignation in October, 2016. Our Secretary, Kelly Brant, also resigned in
October due to an inevitable reason. Things happen in life and we understand and appreciate both Erik’s and
Kelly’s service to the NCAC-SOT community. Since this occurred mid-term of their service, the Executive
Board decided to continue functioning with fewer Officers. Although it was about the time for the Board to start
working on details for NCAC and SOT events, we as a team collaborated very well to learn, discuss, and plan
how to better serve our NCAC community. That being said, on behalf of the whole NCAC-SOT community, I
wanted to THANK our Officers (Drs. Nancy Beck, Elena Braithwaite, Gertrude-Emilia Costin, Pedro Del
Valle, Shelby Skoog, Lorraine Twerdok, Ms. Georgina Harris, and Ms. Kristin Noell) for their support and
commitment especially under this special circumstance.
From this newsletter, you will learn about the upcoming activities around the SOT 56th
Annual Meeting held in
Baltimore, just within our region! I hope that many of you will be able to attend the meeting to learn about
toxicology updates, interact with scientists from all over the world, explore potential opportunities, etc. During
the meeting, NCAC-SOT will have a joint reception/mixer with Johns Hopkins University on March 14th
from
6:30 to 9:00 PM at the Pratt Street Ale House. The 2017 NCAC Bern Schwetz Travel Awards will also be
presented during the reception. I hope you are able to join us!
Additionally, I would like to share with you our upcoming NCAC-SOT Spring Symposium, which will be held
on April 19th
at Lister Hill Center auditorium on the NIH main campus, Bethesda. The theme is “Safety
Assessment of Over-the-Counter Botanicals and Nutraceuticals: Update and Challenges”. I wanted to thank Dr.
Jinhui Dou, our NCAC member and an expert in the field, for his great support. During the symposium, we will
also hold a mentoring luncheon, which is led by Dr. Nancy Beck. You will hear more about the symposium in
our future community emails.
Once again, our involvement in Regional Science Fairs (RSFs) has begun. It’s a great opportunity to show our
support in local STEM activities. I wanted to especially thank our NCAC Education and Outreach Committee
(Drs. Pedro Del Valle, Gopala Krishna, and Gladys Erives) for their hard work to coordinate NCAC’s
participation in these meaningful events. Your volunteer service as a RSF judge is much appreciated.
Recently I shared our Officer Election results with you. Let’s congratulate and welcome them to the Board: Dr.
Margaret Whittaker (Vice President/President-Elect), Dr. Xinrong Chen (Secretary), Dr. Charlie Thompson
3
(Treasurer), Dr. Laura Savery (Postdoctoral Representative), and Ms. Dana Freeman (Graduate Student Vice
Representative). The new Board term will start on May 1st, 2017. I would also like to take this opportunity to
THANK our Board members who are completing their term for their leadership, dedication and contributions to
NCAC-SOT:
Dr. Nancy Beck served as Treasurer.
Dr. Shelby Skoog served as Postdoctoral Representative.
Ms. Georgina Harris served as Graduate Student Representative.
To build a great community, members are the key. Please don’t forget to renew your membership and spread
the word to your associates to consider joining NCAC! By extending our membership and recruiting new active
members, we will be able to promote more impactful activities in our local Chapter.
Lastly, it’s my goal to keep our community informed with toxicology related news and upcoming events. If you
have topics of interest for future NCAC activities (seminar, webinar, symposium, etc.), please let us know. You
can contact our Board members (here) to share your ideas and comments! We are looking forward to hearing
from you!
Kind regards,
Tracy Chen
NCAC-SOT President
- // -
Student Liaison’s Message
Bern Schwetz is a nationally recognized expert in reproductive and developmental toxicology and has extensive
experience working with industry, academia, and government agencies. Some of his most notable
accomplishments include adjunct professor at the University of Arkansas for Medical Science, member of the
National Academy of Science’s Institute of Medicine, Director of the National Center for Toxicological
Research (NCTR), Acting Director of the Environmental Toxicological Program (National Institutes of Health’s
National Institute of Environmental Health Sciences), and Deputy Commissioner of the Food and Drug
Administration. In Dr. Schwetz’s honor, each year the National Capital Area Chapter (NCAC) of the Society of
Toxicology provides travel awards to help promising early career researchers attend scientific conferences.
Six outstanding applications were submitted for consideration this year. The applications featured important
research in a wide variety of fields and disciplines including risk assessment, biomarker development, and
materials science. Each application was blindly evaluated by five different judges based on the clarity of the
abstract and the quality of the studies performed. Thank you to Nancy Beck, Gertrude-Emilia Costin, Georgina
Harris, Elaine Knight, and Kristin Noell for serving as judges and for their commitment to impartial
adjudication of the award.
Without further ado, the NCAC is delighted to announce the winners of the Bern Schwetz Travel Award.
Congratulations go to:
Bern Schwetz Graduate Student Travel Award
Bernadette Ezeabikwa was awarded first place for her abstract entitled
“Low Grade and High Grade Bladder Cancer Cells Differentially Express
Lewis x Glycan Epitopes”.
4
Bern Schwetz Postdoctoral Scholar Travel Award
Peter Petrochenko was awarded first place for his abstract entitled
“Pulsed Laser Deposited Composite PMMA and Nanosilver Thin Film
Device Coating Optimized to Prevent Bacterial Colonization and Support
Bone Stem Cell Growth”.
Teresa Palacios-Hernandez was awarded second place for her abstract entitled
“In vitro Toxicological Evaluation of Ultrasmall Superparamagnetic Iron Oxide
Nanoparticles on Human Coronary Artery Endothelial Cells”.
Laura C. Savery will be recognized with an Honorable Mention Certificate for her abstract
entitled “Deriving a Provisional Tolerable Intake for Intravenous Exposure to Silver
Nanoparticles Released from Medical Devices”.
Ekaterina Mostovenko will be recognized with an Honorable Mention Certificate for her abstract entitled
“Mass Spectrometry Development of Occupational Nanomaterial Exposure”.
Pretal Muldoon will be recognized with an Honorable Mention Certificate for her abstract entitled “Biomarkers
of Behavioral Deficits for Juvenile Environmental Tobacco Smoke Exposure Health Assessment”.
Please join me in congratulating all our winners. Thank you again to all who applied, served as judges and
helped spread the word about the Bern Schwetz travel award. NCAC greatly appreciates all your efforts and
support.
Elena Braithwaite
NCAC-SOT Student Liaison
- // -
Graduate Student Representatives’ Message
To the future of Toxicology, NCAC-SOT Students!!
We hope to meet many of you at the 56th
SOT Annual Meeting and ToxExpo. The Student/Postdoctoral Mixer
is a fun event where you can visit our poster and learn more about the Chapter as well as specialty sections. If
you have not yet signed up for the “Chat with an expert” program, you can still do so if there are spots
available. This offers casual meetups with experienced bench scientists, journal editors, scientific councilors
and executives to name a few. We highly recommend you take advantage of this opportunity.
5
Visit http://www.toxicology.org/events/am/AM2017/program.asp#SP for more information on events and
activities for graduate students. If you are looking for networking opportunities, contact any of our officers.
NCAC-SOT invites you to network with professionals from academia, government and industry. As you can
see throughout our newsletter, we are involved in multiple year-round outreach programs and any help is
appreciated.
At the national meeting, the NCAC-SOT will hold a joint reception with Johns Hopkins University. This will be
held 6:30-9 PM on Tuesday, March 14th
. This is your opportunity to meet the different members of this Chapter,
please join us! In addition, we will be hosting an information table March 13th
-15th
in the SOT Pavilion. Help us
increase the number of student members, inform other graduate students of this Chapter so that we can engage
with more scientists in our region.
Baltimore Maryland has a lot of interesting historic and fun things for you to explore, visit
http://baltimore.org/guides-interests for more information.
See you in Baltimore!
Student representative, Georgina Harris ([email protected])
Vice-student representative, Kristin Noell ([email protected])
- // -
Postdoctoral Representative’s Message
Dear NCAC SOT Postdoctoral Scholars,
We are looking forward to seeing all of you at the 56th
SOT Annual Meeting and ToxExpo in Baltimore, MD in
a few weeks. The meeting will be a great opportunity for you to share your work and network with other
toxicologists.
I hope you all have registered for the postdoc-specific activities at the meeting, including:
Student/Postdoctoral Scholar Mixer: Sunday, March 12, 7:30 pm to 9:00 pm
o Hilton Baltimore Holiday Ballroom 4 (Ticket required)
In Vitro Toxicology Lecture and Luncheon - Monday, March 13, 11:30 am to 1:00 pm
o Lecture: “Human Organs-on-Chips Testing – Strengths and Challenges” by Anthony Bahinski,
GlaxoSmithKline
o Hilton Baltimore Holiday Ballroom 4 (Ticket required)
Postdoctoral Assembly Luncheon - Tuesday, March 14, 12:00 pm to 1:15 pm
o CC Room 324 (Ticket required)
We also hope to see you at the NCAC and Johns Hopkins University Joint Reception/Mixer at the Pratt Street
Ale House on Tuesday, March 14, from 6:30 pm to 9:00 pm. This will be a fun event to get to know your
colleagues in the area!
Thank you to all of the NCAC postdocs who submitted abstracts for SOT as well as those who applied for the
NCAC Bern Schwartz Travel Award! Congratulations to the Bern Schwartz award winners as well as the
postdocs who received other awards including national SOT, Regional Chapter, Specialty Section, and Special
Interest Group awards. The postdoctoral awardees will be recognized at the PDA Luncheon at the Annual
Meeting.
6
Finally, congratulations to the newly elected NCAC-SOT officers! Laura Savery will be the new Postdoctoral
Representative, and we are looking forward to her enthusiasm and leadership on the Board.
For more information and resources for postdoctoral scholars, please feel free to contact me
Sincerely,
Shelby Skoog
NCAC-SOT Postdoctoral Representative
- // -
Website Coordinator’s Message
Dear NCAC-SOT Members,
The NCAC-SOT leadership team is updating the NCAC-SOT website, which can be accessed from the SOT
website or directly at http://www.toxicology.org/groups/rc/ncac/index.asp. During this process, we are
conducting a major review and update to make the website more useful for our Chapter members as well as
visitors, including potential new Chapter members. While we are conducting updates and revisions, the best
places for you to find up-to-date chapter information are at the following locations:
Announcements of upcoming events, deadlines, and news items; Announcements appear on the right
side of every page of the website
For General Chapter Information see the following web pages which appear on the left side of every
page of the website:
o Home – provides the Chapter mission statement
o Bylaws – provides the nuts and bolts of how our Chapter is organized to conduct business for
our members
o Membership – provides the benefits of being a Chapter member, and forms to join
For Chapter Activity Information see the following web pages which also appear on the left side of
every page of the website:
o Newsletters – provides the most extensive news on Chapter activities; contains links to recent
and archived newsletters back to 2004
o Annual Reports – provides Chapter reports to National SOT Leadership (check out just how
much your Chapter accomplishes each year – you might be surprised!)
o Awards and Opportunities – provides information on current Chapter scholarly and travel
awards, as well as acknowledging our Bern Schwetz Award winners for travel assistance to
recent SOT meetings. Opportunities to participate in community activities are also listed here
The website update process is time-intensive, and requires input from many sources, including our NCAC
Members. Please visit the website and see if there is anything YOU would like to see on the website. This could
be Chapter-related activities, or upcoming activities sponsored by other Chapters or organizations that you think
would be of interest to fellow Chapter members. Please contact me ([email protected]) with website
questions, ideas, or posting suggestions.
Warm Regards,
Lorraine Twerdok
NCAC-SOT Website Coordinator
7
Newsletter Editor’s Message
Dear NCAC-SOT Members,
It seems that 2017 is a very fast-paced year, not entirely surprising given that we are in the Chinese Rooster
year. With that in mind, January flew by in no time and by the time of me writing this letter, half of February is
already accounted for. Needless to say, March is around the corner and so is SOT. You have by now read all the
enthusiastic updates from our Executive Board members who look forward to a busy, high quality meeting in
Baltimore. As my fellow Board members, I encourage you to attend the meeting, network, connect and
exchange research ideas at the best venue for the toxicologists to gather and brainstorm.
The direction of my letter is geared towards the concept of team building and communication. I have worked in
multiple and diverse teams over the years, I learned from each experience and carried it to the next scientific or
personal endeavor. During the last part of 2016 and into 2017, I had the opportunity to be part of our Board
team that came together in an extraordinary cohesive way to carry on the mission of the Chapter. As our
President, Tracy Chen, shared, the team found the energy and the generosity to dedicate its time and continue
the ongoing activities after unforeseen circumstances prevented key members of the Board to be available. It is
a rewarding and inspirational experience to be part of such a team and I encourage members of the NCAC-SOT
Chapter to run for elections, become part of the team if elected and encourage others to join the Chapter. It is an
amazing group activity to which you can contribute and learn from. I would like to thank all my fellow board
members for being such a great team and also for helping me tremendously for the preparation of the
newsletters. I look forward to working together with the newly elected members of our Executive Board,
starting with 1 May 2017.
If in Baltimore, visit us at the Chapter’s poster or presentation table and ask us about becoming an active
member of the Chapter or to share your ideas.
Thank you,
Gertrude-Emilia Costin
NCAC-SOT Newsletter Editor
- // -
8
TREASURER’S REPORT
NCAC-SOT Treasurer's Report – Jan 27, 2017 by
Nancy Beck, Treasurer
Account activity since last report (Winter 2016 Newsletter)
July 31, 2016 (Balance) $10,594.30
Debits
9/9/16 Student Award (Loudon County) $50.00
9/26/16 Student Award (Loudon County) $50.00
Total Debits $100.00
Credits
9/12/16 Dues (Renewals and New Members)
$25.00 10/24/16 $25.00 12/19/16 $645.00 12/19/16 Donation to NCAC $250.00
Total Credits $945.00
Balance $10594.30
December 31, 2016* (Closing balance) *Most recent bank statement in our possession.
$11,439.30
- // -
NCAC-SOT MEMBERSHIP
Details
Did you remember to renew both your SOT and NCAC memberships this year? Annual membership fees for
NCAC-SOT remain unchanged this year and are only $25 for regular memberships and $10 for full-time
students. These negligible fees are used to fund our symposium each year and to support a myriad of student
activities, including student awards, travel supplements, and K-12 outreach.
If you have not yet renewed your regional Chapter membership, please do so today! You can do that online at
http://www.toxicology.org/script/loginredirect2.asp?page=dues, or just fill out and mail in the membership
application form on the next page.
- // -
9
Membership Application
MEMBERSHIP APPLICATION
Name: ______________________________________________________
Affiliation: ______________________________________________________
Address
______________________________________________________
______________________________________________________
City: __________________________________________
State: _____ Zip Code: ____________
Area Code: ______ Phone: _________________FAX:____________________
E-mail: ______________________________________________________
Membership Type ______ Full Member ($25) ______ Student ($10)
Please check the most appropriate responses:
SOT Member
_____ Yes
_____ No
Highest Degree Attained
_____ A.S. _____ M.P.H.
_____ B.A. _____ M.S.
_____ B.S. _____ M.A.
_____ D.V.M. _____ Ph.D.
_____ D.V.M./Ph.D. _____ Sc.D.
_____ M.D. _____ V.M.D.
_____ M.D./Ph.D. _____ V.M.D./Ph.D.
Type of Affiliation
_____ Academia
_____ Consulting
_____ Contract Lab
_____ Government
_____ Industry- Chemical/Petroleum
_____ Industry- Pharmaceutical
_____ Industry- Other
_____ Other- _____________
Please complete the information above and send with a check, money order or credit card (payable to National Capital Area
Chapter SOT, no POs) to the address below. The NCAC SOT will review your application, and you will be notified within 30
days. Those not accepted will receive a full refund. Current RC members: please do not use this form since your renewal dues are
billed annually through SOT.
Payment Type: Money Order______ Check ______ Credit Card ______
Credit Card # _______________________________________ Exp date ________
Name on Card ______________________________________
Signature
Please send form as a pdf to: If paying by check, please send to:
D. Charles Thompson, Treasurer Society of Toxicology, ATTN: Ashley Black
[email protected] 1821 Michael Faraday Drive, Suite 300,
Reston, VA 20190
National
Capital Area
10
Current NCAC-SOT Members
Dear NCAC-SOT members,
The NCAC-SOT Executive Board considers useful to publish the membership roster in each newsletter. As of March 2017, the Chapter members are
listed below (First NameLast NameInstitution):
Valerie Adams US Army-Public Health Center
Lauren Amable National Institute on Minority Health and
Health Disparities
Jay Ansell Personal Care Products Council
Sarah Attreed Johns Hopkins University
Michael Babich US Consumer Product Safety Commission
Sainath Babu Hampton University
Christopher Bates Exponent Inc
Ilona Bebenek US FDA
Nancy Beck American Chemistry Council
Richard Becker American Chemistry Council
Tracy Behrsing US FDA
Eric Beier US FDA-CTP
Rosonald Bell Indivior
Joseph Betz NIH
Melanie Biggs Consumer Product Safety Commission
Norman Birchfield US EPA-ORD
Adrienne Black 3E Company
Uni Blake American Petroleum Institute
Michael Bolger US FDA
Gary Bond US FDA-CDER
Ivan Boyer Cosmetic Ingredient Review
Steven Bradbury Steven P Bradbury & Associates LLC
Elena Braithwaite US FDA
Kelly Brant US FDA
Chad Brocker National Cancer Institute
Deborah Burgin CDC-ATSDR
Gary Burin Technology Sciences Group Inc
John Burns
Jon Cammack MedImmune Inc
Connie Chen ILSI Health and Environmental Sciences
Institute
Tracy Chen US FDA
Xinrong Chen U S Consumer Product Safety Commission
Weihsueh Chiu Texas A&M University
Makena Clive Johns Hopkins Bloomberg School of Public
Health
Chrissy Cochran US FDA
Joseph Contrera Computational Toxicology Services LLC
Erdem Coskun National Institute of Standards and
Technology
Gertrude-Emilia Costin Institute for In Vitro Sciences
Rodger Curren Institute for In Vitro Sciences
Irina Dahms DSM Nutritional Products Ltd
Pedro Del Valle US FDA-CDER
Marcus Delatte US FDA-CDER
Jose Delgado-Jimenez National Cancer Institute, NIH
Christopher DeMerlis Colorcon Inc
John DeSesso Exponent Inc
Dhanraj Deshmukh University of Maryland Baltimore
Kshama Doshi University of Maryland
Jinhui Dou FDA
Kimberly Ehman WuXi AppTec
Marion Ehrich Virginia-Maryland College of Veterinary
Medicine
Michelle Embry ILSI Health and Environmental Sciences
Institute
11
Neeraja Erraguntla American Chemistry Council
Bernadette Ezeabikwa University of Maryland Eastern Shore
Marc Fariss ToxSynergy
Michael Feasel US Army-ECBC
Louan Fisher Toxicology Regulatory Services (TRS)
Suzanne Fitzpatrick US FDA
Jennifer Fleischer ToxServices LLC
Thomas Flynn US FDA-CFSAN
Bruce Fowler
Dana Freeman Johns Hopkins University
Jason Fritz US EPA-NCEA
Shayne Gad Gad Consulting Services
Sanket Gadhia National Center for Advancing
Translational Sciences
Kevin Gaido US FDA
Joan Garey Reproductive Toxicology Center
Chandramallika
(Molly) Ghosh US FDA-CDRH
Peter Goering US FDA
Julia Gohlke Virginia Tech
Emily Golden ToxServices LLC
Gopakumar Gopalakrishnan Supernus Pharmaceuticals Inc
Thomas Gray
Sidney Green
James Griffiths Council for Responsible Nutrition CRN
Rupa Guha University of Maryland Baltimore
Maureen Gwinn US EPA/Office of Research and
Development
Karen Hamernik US EPA
Georgina Harris Center for Alternatives to Animal Testing
Wafa Harrouk US FDA-CDER
Kristina Hatlelid US Consumer Product Safety Commission
Tala Henry US EPA-OPPTS
James Hobson US FDA-CTP
Colette Hodes US EPA-OLEM
Alan Hood US Food & Drug Administration
Eric Hooker US Consumer Product Safety Commission
Keith Hostetler Toxicology Regulatory Services (TRS)
Terry Hrubec Via College of Osteopathic Medicine
Virginia Campus
Chia-Wen Hsu US FDA
Annette Iannucci Occupational Safety and Health
Administration
Jon Inglefield Emergent BioSolutions Inc
William Irwin Regulatory
Nikolai Ivanov Philip Morris International
David Jackson US Army Center for Environmental Health
Research
David Jacobson Kram ToxRox Consultancy, LLC
Devaraya Jagannath Toxicology Consulting Services
Samantha Jones US EPA-NCEA
Bernard Jortner Virginia-Maryland College of Veterinary
Medicine, Virginia Tech
Athena Keene Afton Chemical Corporation
Raju Khatri University of Maryland Baltimore
Do Hyung Kim Henry M. Jackson Foundation
James Kim EOP Office of Management and Budget
Elaine Knight NIH-NCI
Charles Kokoski US FDA
Andrew Kraft US EPA-NCEA
Gopala Krishna Supernus Pharmaceuticals Inc
Francis Kruszewski American Cleaning Institute
James Lamb Exponent Inc
Cindy Landgren Defense Threat Reduction Agency
Amy Lavin Williams Exponent Inc
Jonathan Leshin United States Public Health Service
Nastassja Lewinski Virginia Commonwealth University
Cissy Li US FDA-CFSAN
Anne Loccisano Exponent Inc
Linda Loretz Personal Care Products Council
12
James MacGregor Toxicology Consulting Services
Judith MacGregor Toxicology Consulting Services
Michael Madejczyk US Army CEHR
Susan Makris US EPA-ORD
Wimolnut Manheng US FDA-CDER
Nikki Maples-
Reynolds Waterborne Environmental Inc.
Suzanne Martos Johns Hopkins University
Joanna Matheson US Consumer Product Safety Commission
Kathleen McCoy Virginia Commonwealth University
Timothy McGovern US FDA
Marie McKeon MilliporeSigma (BioReliance/EMD
Millipore)
William Mendez ICF International
Donna Mendrick US FDA-NCTR
Beth Mileson Technology Sciences Group Inc
Michael Morrow JPEO Medical Countermeasure Systems
Janet Moser Dept of Homeland Security
Ekaterina Mostovenko Virginia Commonwealth University
Frederic Moulin US FDA
Pretal Muldoon Virginia Commonwealth University
Jorge Muñiz Ortiz US Environmental Protection Agency
Caitlin Murphy Smithers Avanza
Laine Myers US FDA
Alexander Nguyen North Carolina State University
Simone Nicholson MedImmune Inc
Andrey Nikiforov Toxicology Regulatory Services (TRS)
Kristin Noell University of Maryland Eastern Shore
Ofelia Olivero NIH-NCI
Robert Osterberg Osterberg Pharm-Tox Consulting
Andrew Ottens Virginia Commonwealth University
Teresa Palacios-
Hernandez US Food and Drug Administration
Geoffrey Patton US FDA
Leslie Patton Technology Sciences Group Inc
Peter Petrochenko US FDA
Jennifer Pierson ILSI Health and Environmental Sciences
Institute
Anne Pilaro US FDA-CBER
Caroline Pinto US EPA-ORISE
Karen Porter PointCross Life Sciences
Resha Putzrath Navy and Marine Corps Public Health
Center
Kathleen Raffaele US EPA-OSWER
Jennifer Rayner SRC
Gunda Reddy Army Public Health Center
Emily Reinke US Army Public Health Center
Sharon Reutter-Christy Edgewood Chemical Biological Center
Paul Roney BARDA
Leah Rosenfeld US FDA
Laurie Roszell Army Public Health Center
Shakil Saghir Smithers
Laura Savery US FDA
Louis Scarano US EPA
Anthony Scialli Scialli Consulting LLC
Pankaj Sethi University of Georgia
Jennifer Shing FDA
Shelby Skoog US FDA
Deborah Smegal US FDA
Martin Stephens Johns Hopkins Bloomberg School of Public
Health
Stephan Stern Cancer Research Technology Program
Leidos Biomedical Research Inc
Dale Strother ToxSolve LLC
Evi Struble US FDA
Richard Thomas Intercet Ltd
D Charles Thompson US FDA-CDER
Scott Thurmond US FDA-CFSAN
Richard Troast Troast Environmental Consulting
Lorraine Twerdok TWERDOK CONSULTING, LLC
13
Vipin Tyagi University College of Medical Sciences and
GTB Hospital (University of Delhi)
René Viñas Grocery Manufacturers Association
Zhengxi Wei University of Rhode Island
Kimberly White
Margaret Whittaker ToxServices LLC
Paddy Wiesenfeld US FDA-CFSAN
Jessica Wignall ICF International
Gary Wolfe Gary Wolfe Toxicology LLC
Linnzi Wright US Army Edgewood Chemical Biological
Center
James Yager Johns Hopkins Bloomberg School of Public
Health
Tracey Zoetis SciLucent LLC
Joanne Zurlo Johns Hopkins Bloomberg School of Public
Health
- // -
14
NCAC-SOT EXECUTIVE BOARD MEMBERS CONTACT LIST
President: Tracy Chen (2017-2018)
U.S. Food and Drug Administration
301-796-3597
Past President: Pedro L. Del Valle (2017-2018)
U.S. Food and Drug Administration
301-796-2111
Treasurer: Nancy Beck (2014-2017)
American Chemistry Council
202-249-6417
Secretary: Open until May 1st, 2017
Councilors: Gertrude-Emilia Costin (2015-2018)
Newsletter Editor
Institute for In Vitro Sciences, Inc.
301-947-6524
Lorraine Twerdok (2016-2019)
Website Coordinator
TWERDOK CONSULTING, LLC
Elena Braithwaite (2016-2019)
Student Liaison
U.S. Food and Drug Administration
240-402-4540
Postdoctoral Shelby Skoog (2015-2017)
Representative: U.S. Food and Drug Administration
301-796-2800
Graduate Georgina Harris (2015-2017)
Student John Hopkins University
Representative: 410-614-4916
Graduate Kristin Moneque Noell (2016-2017)
Student University of Maryland Eastern
Vice- Shore
Representative: [email protected]
15
Election Results – Meet the New Board Members New elected Board Members will join the Board on May 1
st, 2017.
Dr. Margaret Whittaker – Vice President/President-Elect
Dr. Xinrong Chen – Secretary
Dr. Charlie Thompson – Treasurer
Dr. Whittaker is the Managing Director and Chief Toxicologist of ToxServices LLC. She
manages ToxServices projects for the United States EPA’s Safer Choice Program, Clean
Production Action’s GreenScreen for Safer Chemicals, and Cradle to Cradle Certified
Program. As project manager and technical lead, Dr. Whittaker has contributed to and/or
managed the development of hundreds of human health risk assessments, chemical hazard
assessments, exposure assessments, as well as hundreds of product-specific toxicology
evaluations. Dr. Whittaker is one of the pioneers in the field of chemicals alternatives
assessments and drinking water risk assessment methods, and is a key contributor to
advancing these methods around the world. Dr. Whittaker is a Diplomate of the American
Board of Toxicology who earned a Ph.D. in Toxicology from The University of Maryland,
Baltimore and an M.P.H. in Environmental Health from The University of Michigan. Dr.
Whittaker is a U.K./EuroTox Registered Toxicologist, as well as a Chartered Biologist and
Fellow of the U.K. Royal Society of Biology.
American board-certified toxicologist (DABT) with over 7 years’ experience in toxicological
evaluation and risk assessment for products regulated by the Food and Drug Administration
(FDA), Environmental Protection Agency (EPA), and the Consumer Product Safety
Commission (CPSC). Currently works as a regulatory toxicologist at CPSC and is actively
involved in several working groups sponsored by ICCVAM, ISO, and ASTM. Functions as
an agency coordinator for CPSC and EPA quarterly chemical hazard meeting. Years of
experience in drug metabolism, genetic toxicology, reproductive and developmental
toxicology, liver toxicology, in vitro alternative assay, and regulatory toxicology; capable of
presenting and explaining scientific concepts in an easy to understand way; strong at problem
solving, communication, leadership and decision making; active member of Society of
Toxicological (SOT), Society of Risk Assessment (SRA), and Society of Teratology for
many years.
Donald Charles (Charlie) Thompson earned a B.S. in Pharmacy and a Ph.D. in Toxicology
from the University of North Carolina at Chapel Hill. He is a diplomate of the American
Board of Toxicology (D.A.B.T.). Prior to undertaking his doctoral work, he practiced
pharmacy for a brief stent in the retail, hospital, and pharmaceutical industry sectors. His
doctoral research at UNC was conducted under the tutelage of Dr. Steve Chaney (Department
of Biochemistry and Biophysics, School of Medicine and Curriculum in Toxicology),
investigating the biochemical toxicology of platinum-based anti-neoplastic agents. Since
earning the doctorate, he has worked at Procter & Gamble (Human & Environmental Safety,
Laundry & Cleaning Products) in Cincinnati, OH, USFDA/Center for Food Safety and
Applied Nutrition/Office of Food Additive Safety, Burdock Group Consultants (food,
beverage, dietary supplements, pet food, animal feed, and cosmetics), USEPA/Office of
Research and Development/Integrated Risk Information System Program, and most recently,
USFDA/Center for Drug Evaluation and Research/Office of New Drugs. His current
responsibilities include pharmacology/toxicology oversight of the nonprescription (OTC)
drug products. In addition to his work, Charlie is currently serving as President of the
Association of Government Toxicologists (AGT).
16
Dr. Laura Savery – Postdoctoral Representative
Ms. Dana Freeman – Graduate Student Vice Representative
- // -
NCAC-SOT ACTIVITIES UPDATE
Meetings of Interest
Workshop: Advances in Causal Understanding for Risk Based Decision Making
Workshop Date: March 6-7, 2017
Workshop location: Washington, D.C., and via webcast
Workshop Description: New molecular and informatics approaches have advanced understanding of how molecular pathways are
affected by exposure and the molecular networks involved in disease. However, these advances are often not yet
deemed sufficient to establish causality for public health risk assessments; regulators still rely primarily on
traditional apical endpoints, such as those endpoints observed in animal studies.
Join a workshop on March 6-7, 2017, hosted by the Standing Committee on Emerging Science for
Environmental Health Decisions, to discuss the current thinking surrounding causal models, how novel
approaches and tools are relevant for environmental health, and how they can be incorporated into the decision
making process.
Held in Washington, DC and webcast, this free, 2-day workshop will bring together leading environmental
health experts, toxicologists, statisticians, sociologists, epidemiologists, regulators and experts from other fields
that utilize different data streams for establishing causality in complex systems. Please register today!
Please visit the workshop website to register to attend and for more information, including the preliminary
agenda: http://nas-sites.org/emergingscience/.
Dr. Savery is an ORISE postdoctoral fellow at the FDA in the Center for Devices and
Radiological Health, where she is currently developing a safety assessment approach for the
release of silver nanomaterials associated with medical devices. She received her doctorate in
Biochemistry and Molecular Biology from the University of Maine in 2013. She has been
awarded funding including an ORISE postdoctoral fellowship, USEPA STAR Fellowship
(graduate), SMART program internship at Baylor College of Medicine (undergraduate) and a
Coastal Bend Health Education Center Research Grant (undergraduate). She has authored six
peer-reviewed publications and thirty poster or oral presentations at national and international
conferences. She has been a member of the SOT since 2005 and has served the SOT in the
following capacities: Student Representative of the Metals Specialty Section (2012-2014) and
the Northeast Regional Chapter (2006-2007).
Dana Freeman is a predoctoral student in Toxicology at the Johns Hopkins Bloomberg
School of Public Health. She moved to Baltimore, MD from Atlanta, GA where she received
her bachelor’s degree in Biochemistry at the Georgia Institute of Technology. She became
interested in a career in toxicology during her ORISE fellowship at the US Centers for
Disease Control. She is pursuing research that explores mechanisms behind gene-
environment interactions in the brain. She recently joined the laboratory of Dr. Zhibin Wang
to study human environmental epigenomes. She is active in the Environmental Health &
Engineering student organization (EHESO) and serves as the student representative in her
department’s research retreat planning committee. She is a new member of SOT and
interested to become more involved in the organization and in the promotion of toxicological
research across the National Capital Area.
17
Metabolic Syndrome and Associated Diseases: From Bench to Clinic
Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic, an SOT 56th
Annual Meeting
Satellite, will address a major public health concern. The overarching objectives of this conference include
defining knowledge gaps, identifying research needs, protecting public health, and empowering product
development.
Location: Baltimore, Maryland, immediately before SOT 56th
Annual Meeting
Date: Saturday, March 11, 2017
What knowledge will you gain:
Greater understanding of developmental aspects and challenges in therapeutic strategies for associated
diseases;
Enhanced appreciation for the mechanisms (e.g., microbiome, inflammation, mitochondrial dysfunction)
that underlie these pathologies as well as the effects of drugs and environmental agents;
Increased awareness of the pathways and risk factors leading to disease and how these pathways can be
perturbed to develop drugs for disease interventions; creating a unique combination likely to lead to new
thought processes; and
Additional opportunities for scientific collaborations.
To register and submit an abstract so you can participate in our extended poster session, visit the conference
website. This conference is organized under the auspices of the SOT Contemporary Concepts in Toxicology
(CCT) Conferences Committee.
- // -
Water: Tame or Toxic?
Time: 2-4 PM, 3/11/2017, Saturday
Location: Institute of Marine and Environmental Technology (IMET), 701 E Pratt Street, Baltimore, Maryland
21202
Event Website: http://imet.usmd.edu/water
Description: Water is a precious resource. We drink it, bathe in it, play in it, and are over 50% composed of it. It is necessary
for life as we know it. As harmless and as welcome as it can be, in certain circumstances water and the aquatic
environment can pose a threat to our health. As the Society of Toxicology prepares to meet in Baltimore for its
annual conference beginning March 12, please join the Toxicology Education Foundation and the Institute of
Marine and Environmental Technology for this free program to learn more about the safety and hazards of
water. Presentations will cover principles of toxicology, water pollution, drinking water contamination, toxic and
poisonous marine organisms, water overdose, seafood contamination, and more.
Agenda: Introduction and Overview – Philip Wexler, National Library of Medicine (10 minutes)
Welcome to IMET – Russell Hill, Institute of Marine and Environmental Technology (10 minutes)
The Hitchhiker’s Guide to Toxicology (What Makes a Poison?) – Toni Hayes, Alynylam
Pharmaceuticals (20 minutes)
Food Poisoning, Seriously – Potentially Dangerous Seafood-related Poisoning – Hong Kim,
Maryland Poison Center (20 minutes)
All the Thinking About What You’re Drinking – Virunya Bhat, NSF International (20 minutes)
Is the Green Water Safe? And can it be made Clear? – Al Place, Institute of Marine and
Environmental Technology (20 minutes)
DNA markers can help pinpoint sources of sewage in Baltimore’s harbor – Eric Schott, Institute of
Marine and Environmental Technology (20 minutes)
18
Annual Society of Toxicology Meeting
Dear Colleagues,
On behalf of SOT Council, the SOT Committees, Regional Chapters, Special Interest Groups, Specialty
Sections, SOT Supporters, exhibitors, and other partners, I invite you to join us in Baltimore, Maryland, March
12–16, 2017, for the SOT 56th
Annual Meeting and ToxExpo.
Approximately 6,500 toxicologists from more than 50 countries are expected to share their research and
expertise during the 160+ Scientific Sessions, featuring nearly 2,500 abstracts. This makes the SOT Annual
Meeting an ideal place to expand your scientific knowledge, find new collaborators, and catch up on the latest
techniques and initiatives.
Every year, networking is a key component of the meeting – from the Welcome Reception to Regional Chapter,
Specialty Interest Group, and Specialty Section Receptions and all of the events in between. At this year’s
meeting, plan to visit ToxExpo from 12:30 pm to 1:20 pm on Tuesday, March 14, for dedicated networking time,
as only a limited number of Scientific Sessions are programmed during this time.
More than 350 exhibitors are expected in this year’s ToxExpo, where you can discover new products and
technology, career and partnership opportunities, and more. ToxExpo is open Monday to Wednesday from 9:15
am to 4:30 pm, and I encourage all attendees to schedule time to visit our exhibitors.
SOT is pleased to be returning to Baltimore, the location of the 2009 Annual Meeting and ToxExpo. The
Convention Center is located in downtown Baltimore, adjacent to the beautiful Inner Harbor and the historic
Little Italy neighborhood. A short walk from the center is the National Aquarium, Port Discovery, the B&O
Railroad Museum, and other attractions. And don’t forget the award-winning restaurants, where you can sample
the famous Chesapeake Bay blue crabs.
I hope you join us in Baltimore for the 56th
Annual Meeting and ToxExpo to help SOT fulfill its mission of
creating a safer and healthier world by advancing the science and increasing the impact of toxicology.
Sincerely,
John B. Morris, PhD
2016–2017 SOT President
19
20
Annual SOT NCAC-SOT Presenter List (presented by day/date, time, alphabetical order – author’s last name)
Date Time Session Title Abstract ID/
Poster Board
Author(s)
Presentation Title Institution First (initial). Last
Name
3/13/2017 11:45 AM to
12:15 PM
Regional Chapter, Special Interest
Group, and Specialty Section Poster
Sessions - Representative Attended
NCAC-SOT
Poster
NCAC-SOT
Representatives
Creating local networks between toxicologists in
Maryland, Virginia, and the District of
Columbia
NCAC-SOT
3/13/2017 2:00 PM to
4:45 PM
Workshop Session: Bispecific
Molecules: Nonclinical and Clinical
Development Challenges
1562
(2:00 PM) P. Del Valle
Chairperson
Historical Perspectives of Bispecific
Antibodies
US FDA –
CDER
3/14/2017 9:30 AM to
12:45 PM
Neurotoxicology: General
Neurotoxicity 1748/P233 G. Harris
Toxicity and Resilience Mechanisms in Luhmes
3D Model Exposed to Rotenone
Johns Hopkins
University,
Bloomberg
School of
Public Health
3/14/2017 9:30 AM to
12:45 PM
Exposure Assessment and
Biomonitoring 1911/P535 E. Mostovenko
Mass Spectrometry Development of
Occupational Nanomaterial Exposure
Biomarkers
Virginia
Commonwealth
University
3/14/2017 9:30 AM to
12:45 PM Tobacco Products 1928/P554 P. Muldoon
Biomarkers of Behavioral Deficits for Juvenile
Environmental Tobacco Smoke Exposure Health
Assessment
Virginia
Commonwealth
University
3/14/2017 1:15 to 4:30
PM Metals III 2129/P347 L. Amable
Single Cell Cisplatin and Other Metal
Measurements by ICP-MS NIMHD/NIH
3/14/2017 1:15 to 4:30
PM Genetic Toxicity 2278/P636 G.E. Costin
The 3D Human Reconstructed Skin
Micronucleus Assay (RSMN) Using the
Epiderm™ Tissue: Validation and Application
to the Safety Assessment of Cosmetics
Ingredients
IIVS
3/14/2017 1:15 to 4:30
PM Biomarkers 2030/P136 B. Ezeabikwa
Low Grade and High Grade Bladder Cancer
Cells Differentially Express Lewis X Glycan
Epitope
University of
Maryland
Eastern Shore
3/14/2017 1:15 to 4:30
PM Medical Devices 2140/P404 P. Petrochenko
Pulsed Laser Deposited Composite PMMA and
Nanosilver Thin Film Device Coating
Optimized to Prevent Bacterial Colonization and
Support Bone Stem Cell Growth
US FDA
3/14/2017 1:15 to 4:30
PM Metals III 2130/P348
E. Shide
L. Amable
Characterization of the Ovarian Cancer Whole
Cell and Mito-Metallome NIMHD/NIH
3/15/2017 9:30 AM to
12:15 PM
Workshop Session: Challenges and
Novel Approaches
Evaluating Developmental and
Reproductive Toxicity of
Biotherapeutics
2359
(11:30 AM) P. Del Valle
Thinking Beyond DART Studies for Risk
Assessment of Biotherapeutics
US FDA –
CDER
21
Date Time Session Title Abstract ID/
Poster Board
Author(s)
Presentation Title Institution First (initial). Last
Name
3/15/2017 12:30 PM to
1:50 PM
Informational Session:
Communicating Toxicology
to the Public
2730
(12:48 PM) N. Beck Communicating Information on Chemical Safety
American
Chemistry
Council
3/15/2017 1:15 to 4:30
PM
Alternatives to Mammalian Models I:
Liver, Ocular, and Skin Alternatives 2745/P113 G.E. Costin
Addressing the Assignment of US EPA Hazard
Categories for Dermal Safety by a Revised
Prediction Model of the Validated In Vitro Skin
Irritation Test (OECD TG 439)
IIVS
3/15/2017 1:15 to 4:30
PM Nanotoxicology: General 2902/P364 L. Savery
Deriving a Provisional Tolerable Intake for
Intravenous Exposure to Silver Nanoparticles
Released from Medical Devices
US FDA
3/16/2017 8:30 AM to
11:45 AM Late-Breaking Poster Session 6 3561/P536 G. Krishna
Genotoxicity Assessment of Viloxazine (spn-
812), a Norepinephrine Reuptake Inhibitor, as a
Novel Treatment for Attention Deficit
Hyperactivity Disorder
Supernus
3/16/2017 8:30 AM to
11:45 AM Late-Breaking Poster Session 6 3281/P250 G. Krishna
Comparative Repeat Dose Toxicity Studies in
Adult and Juvenile Rats for Viloxazine (spn-
812), a Norepinephrine Reuptake Inhibitor,
Investigated as a Novel Treatment for Attention
Deficit Hyperactivity Disorder
Supernus
3/16/2017 8:30 AM to
11:45 AM Late-Breaking Poster Session 3 3372/P343 Kristin Noell
Parasites as an Alternative Model for Lipid
Metabolism: Gene Expression Analysis of an
Oyster Parasite Perkinsus marinus during Lipid
Starvation
University of
Maryland
Eastern Shore
22
NCAC-SOT 2017 Spring Symposium: Safety Assessment of Over-the-Counter Botanicals and
Nutraceuticals: Update and Challenges
Safety Assessment of Over-The-Counter Botanicals and Nutraceuticals:
Update and Challenges
Time: 4/19/2017, Wednesday, 8:30 AM-4:10 PM
Location: Lister Hill Center Auditorium, National Institutes of Health, Bethesda, Maryland
Registration link: In person registration: https://www.surveymonkey.com/r/X2FXJTQ
Webcast registration: https://aim-hq.webex.com/aim-
hq/onstage/g.php?MTID=eae77ba5054c30c3f2819202c5a5101d9
There is no fee to attend the event but registration is required by 5 PM, Monday, April 17.
Synopsis:
Like drugs, the efficacy and safety of over-the-counter (OTC) botanicals and nutraceuticals are important to the
public health. Their broader accessibility to the public makes the above concerns more prominent. Due to their
complexity in nature, the analysis and evaluation of these products are challenging. The goal of the symposium
is to provide an update and overview of these challenges from different perspectives.
Lunch: Cafeteria is on the floor below LHC auditorium. Attendees can easily go downstairs and have lunch
there.
TENTATIVE AGENDA
Please see the draft agenda on the next page.
During our symposium, we will hold a mentoring luncheon from 11:30 AM to 12:30 PM. This event is an
opportunity for our members to learn more about careers in academia, government, and industry in an informal
setting. Participants to the mentoring luncheon will receive boxed lunches free of charge. Pre-registration by
March 27 (using the above link) is required for your participation. Interested mentors and mentees: please
contact Dr. Nancy Beck at [email protected] if you have questions or require further
information.
We would also like to invite our NCAC members, undergraduate students, graduate students, and
postdoctoral researchers to join our Poster Session (12:30-1:30 PM) by submitting and sharing your research
projects with our community. Pre-registration by March 27 (using the above link) is required for your
participation. Once your registration is complete, please contact Dr. Elena Braithwaite at
[email protected] to provide your poster abstract and acquire additional information.
Participating undergraduate students and graduate students: please keep your receipts/records and contact
Dr. Nancy Beck at [email protected] for travel reimbursements post event.
23
Tentative Agenda:
Time Topic Speaker
8:30-9:00 AM Registration opens
9:00-9:05 AM Introductory welcome comments, logistics Tracy Chen, Symposium Chair
(NCAC-SOT President)
9:05-9:45 AM
Botanical identity, uses, and safety translated
to new dietary ingredient notification (NDIN)
information
Steven Casper, Center for Food
Safety and Applied Nutrition
(CFSAN), U.S. Food and Drug
Administration (FDA)
9:45-10:30 AM
Applying toxicology and other data to
support clinical development of botanical
drugs
Jinhui Dou, Center for Drug
Evaluation and Research (CDER),
FDA
10:30-10:45 AM Break
10:45-11:30 AM
USP botanical quality standards:
contributions in quality control & safe use of
botanicals
Hellen Oketch, United States
Pharmacopeia (USP)
11:30 AM -1:30 PM
Lunch: Cafeteria is on the floor below LHC
auditorium.
Mentoring Luncheon: 11:30 AM-12:30 PM
Poster Session: 12:30-1:30 PM
General audience: Lunch on your
own.
Participants in the mentoring
luncheon will meet at the lobby area
to receive boxed lunches and to join
the activity. Please contact Dr. Nancy
Beck for details.
1:30-2:10 PM Advising cancer patients regarding risks and
benefits of botanicals and nutraceuticals
Jeff D. White, National Cancer
Institute (NCI)
2:10-2:50 PM Analytical developments for identification
and authentication of botanicals
James Harnly, United States
Department of Agriculture (USDA)
2:50-3:30 PM National Institutes of Health support of
dietary supplement research
Barbara Sorkin, Adam Kuszak,
Office of Dietary Supplements
(ODS), National Institutes of Health
(NIH)
3:30-4:00 PM Panel discussions Moderator: Jinhui Dou
4:00-4:10 PM Wrap-up Tracy Chen (NCAC-SOT President)
Interested in joining NCAC-SOT? Please browse our website (homepage and membership) for additional
information or contact our board members (list here) if you have questions.
24
Outreach Activities
Update from the Chairs
Dear NCAC-SOT members,
The Education and Outreach Committee is coordinating efforts for judging at 8 Regional Science Fairs (RSF)
around the Capital area. We will judge toxicology-related projects and present the NCAC-SOT Toxicology
Award consisting of a Certificate and a first prize for $100 and a Certificate and second prize for $50. Funding
for this activity was kindly provided by SRC, a not-for-profit research and development company in the Capital
Area.
The Committee would like to invite NCAC members to volunteer and participate in these efforts. NCAC
volunteers are expected to be at the RSF usually at 8:00 am, have breakfast and organize among themselves for
the judging session. RSF usually ends by 2:00 pm. Volunteers are asked to take pictures of the judging team and
during presentation of awards.
If you would like to volunteer, please send an email to [email protected] indicating your choice of 1
or more RSF. It is a great opportunity for interaction with youth minds and a rewarding exercise being able to
touch lives of future scientists. You will be amazed at the new ideas, deep understanding of science and
thoughts of many High School students presenting at these RSF. Looking forward to receiving your choice(s).
Regional Science Fairs Sat. March 4 Anne Arundel County at North County High School, Glen Burnie, MD
Sat. March 11 DC STEM Fair at Dunbar High School, Washington, DC
Sat. March 11 Prince William County at Kelly Leadership Center, Manassas, VA
Sat. March 18 Prince Georges County at Charles Herbert Flowers High School, Springdale, MD
Sat. March 18 Fairfax County at Robinson (High) Secondary School, Fairfax, VA
Sat. March 18 Science Montgomery at FDA White Oak Campus, Silver Spring, MD
Thu. March 23 Loudoun County at Riverside High School, Leesburg, VA
Sat. March 25-26 Baltimore Science Fair at Towson University, Townson, MD
THANK YOU FOR VOLUNTEERING
Gladys Erives
Gopala Krishna
Pedro L. Del Valle
- // -
NCAC-SOT Outreach Program Survey
Dear NCAC members,
In an effort to promote the field of toxicology to students, the members of the Executive Board of the National
Capital Area Chapter of the Society of Toxicology (NCAC-SOT) would like to learn from the NCAC members
about their interest and availability to participate in various activities outlined in the survey that can be accessed
at the following link: https://www.surveymonkey.com/r/LYFT2BC. The activities included in the survey have
been suggested by our colleague and fellow member of NCAC-SOT, Dr. Deepa Rao.
We appreciate you taking the time to fill out this brief survey. Please complete the survey by 31 March 2017.
Thank you for your time and input and we look forward to your participation in these proposed educational and
outreach activities.
NCAC-SOT Executive Board
25
WHAT’S NEW IN TOXICOLOGY?
In this Spring issue of the NCAC-SOT Newsletter, we invited the President of Alternatives Research and
Development Foundation (ARDF), Ms. Sue Leary, to share with us her perspective on the contribution of
research grants supporting the field of in vitro toxicology. As the current ARDF Grant Review Coordinator, I
greatly enjoy the collaboration with ARDF and wanted to connect through the means of our Newsletter the
NCAC-SOT community with the strong supporter of alternative methods to animal testing that ARDF is.
Grants for Alternatives Research
By Sue Leary
In 1993, the first ‘World Congress on Alternatives and Animal Use in the Life Sciences’ was held in
Baltimore - organized by Professor of Toxicology Alan Goldberg, Founding Director of the Center for
Alternatives to Animal Testing at Johns Hopkins University. It signaled the establishment of an international
network of in vitro scientists and science policy-minded advocates for animals. They recognized that serious
work to advance alternatives and the 3Rs would require expansion of an intellectual community drawn from
academia, industry, government and NGOs. That same year, the Alternatives Research & Development
Foundation (ARDF) was incorporated in order to focus on funding development of alternative methods.
Among our first projects was a series of grants to develop alternative methods of producing, on a small
to medium scale, monoclonal antibodies without ascites in mice. Commercial bioreactors could serve larger
scale production, but bench scientists apparently considered in vitro production a barrier. A series of
collaborative grants were awarded and a system using a gas-permeable bag and other readily available lab
equipment ultimately provided an alternative to animal use that was cost-effective and practical, with basic in
vitro skills.
A clear goal was identified and target achieved, which is a dream of most funders. But in spite of this
early success, ARDF became aware that many areas had potential for utilizing alternative methods - particularly
toxicology where long-established test methods seemed to be ready for a ‘refresh.’
And so ARDF’s annual ‘Alternatives Research Grant Program’ became known as an open call for
proposals addressing any area in research, testing or education with a potential for replacing or reducing animal
use. After a decade, in 2003, an important change occurred: ARDF enlisted the expertise of the Institute for In
Vitro Sciences (IIVS) and principals Drs. Rodger Curren and John Harbell. This collaboration continues today
with IIVS coordinating the scientific review of all proposals received. Over the years, IIVS and ARDF have
engaged experts in the a number of fields who have kindly agreed to review grant proposals.
Another milestone was after the publication in 2007 of the National Academy of Sciences Report,
‘Toxicity in the 21st Century: A Vision and a Strategy’. That prompted ARDF to encourage submissions of
proposals that addressed the approaches articulated in the report. Technological developments and growing
interest regarding in vitro and in silico methods have combined to bring very thoughtful and innovative
scientists to ARDF seeking support.
Today, ARDF attracts a select group of applicants who are involved in developing non-animal disease
models, models for educational demonstrations, and models for toxicity testing. Grants in 2016 were awarded to
projects that included ‘cervix-on-a-chip’ and a blood brain tumor barrier study, reflecting the modern days of in
vitro toxicology.
Funding goes mostly to U.S. universities, although the requirement is only that applicants be associated
with “non-profit, tax-exempt, educational and/or research institutions, or a foreign equivalent.”
ARDF has definitely contributed to the needed expansion of the intellectual community around
alternatives. For example, in 1999 and 2000, grants were awarded to the lab of Dr. Damir Janigro, at Cleveland
Clinic. Dr. Luca Cucullo, one of his post-docs at the time, went on to establish his own lab at Texas Tech
Health Sciences University, and now receives grant support for his lab. Those are the rewards of running a grant
program: the people who bring their best resources to the problem and embrace the work as a career.
ARDF’s current grant application deadline is May 1, 2017. Information and application materials are
available at: www.ardf-online.org.
26
MEMBERS ACCOMPLISHMENTS CORNER (September, 2016 through March 2017)
At NCAC-SOT we like to acknowledge the accomplishments of our members. The Newsletter Editor will
send an email to the members asking to share their publications, presentations and other accomplishments from
the last number of the newsletter to date to be included in the next number. We are happy to spread the word of
your successes, so please take advantage of this opportunity to share them with your colleagues.
Publications and Presentations
Presented in alphabetical order based on the author who is member of the NCAC-SOT (underlined)
Manuscripts
Birlea S.A., Costin G.E., Roop D.R., Norris D.A. Trends in Regenerative Medicine: Repigmentation in Vitiligo
Through Melanocyte Stem Cell Mobilization. Med. Res. Rev. 2016 Dec 28. Doi: 10.1002/med.21426 (Epub
ahead of print).
Walters R.M., Gandolfi L., Mack M.C., Fevola M., Martin K., Hamilton M.T., Hilberer A., Barnes N., Wilt N.,
Nash J.R., Raabe H.A., Costin G.E. In Vitro Assessment of Skin Irritation Potential of Surfactant-Based
Formulations Using a 3-D Skin Reconstructed Tissue Model and Cytokine Response. Altern Lab Anim.
2016, 44: 523-532.
Costin GE. Decoding and modulating the color of human skin. Cosmetic Chemist 2016. Available at:
http://d19cgyi5s8w5eh.cloudfront.net/eml/VPwvPaYmSi-
Uohf6UcNzhA?e=roger_mcmullen%40fdu.edu&a=Hn7-iRf_ToiDAzh-g4Tduw&f=&t=1.
Clippinger A.J., Hill E., Curren R., Bishop P. Bridging the gap between regulatory acceptance and industry use
of non-animal methods. ALTEX. 2016, 33: 453-458.
Barroso J., Ahn I.Y., Caldeira C., Carmichael P.L., Casey W., Coecke S., Curren R., Desprez B., Eskes C.,
Griesinger C., Guo J., Hill E., Roi A.J., Kojima H., Li J., Lim C.H., Moura W., Nishikawa A., Park H., Peng
S., Presgrave O., Singer T., Sohn S.J., Westmoreland C., Whelan M., Yang X., Yang Y., Zuang V.
International Harmonization and Cooperation in the Validation of Alternative Methods. Adv. Exp. Med.
Biol. 2016, 856: 343-386.
Curren R.D., Poth A., Raabe H.A. Implementation of New Test Methods into Practical Testing. Adv. Exp. Med.
Biol. 2016, 856: 189-203.
Hsu C.W., Hsieh J.H., Huang R., Pijnenbrug D., Khuc T., Hamm T., Zhao J., Lynch C., van Beuningen R.,
Chang X., Houtman R., Xia M. Differential Modulation of FXR Activity by Chlorophacinone and
Ivermectin analogs. Toxicol. Appl. Pharmacol. 2016; 313: 138-148.
Krishna G., Gopalakrishnan G., Goel S. Adult and Juvenile Toxicity Studies on Molindone Hydrochloride, a
Dopamine D2 Receptor Antagonist. Toxicology Mechanisms and Methods. 2017.
Stanton K., Kruszewski F.H. Quantifying the benefits of using read-across and in silico techniques to fulfill
hazard data requirements for chemical categories. Reg. Toxicol. Pharmacol. 2016; 81: 250-259.
Nakamura N., Gwenn M., Inselman A., Sloper D., Del Valle P.L., Sato T., Ogawa T., Hansen D. Evaluation of
Culture Time and Media in an in vitro Testis Organ Culture System. Birth Defects Research. Accepted
January 1, 2017 DOI:10.1002/bdr2.1002.
Abstracts
Krishna G., Gopalakrishnan G., Ganiger S., Krishnappa H., Kamala K. Urethane-Induced Carcinogenesis in
Tg.rasH2 Mice: a Comparative Study with Literature. American College of Toxicology Annual Meeting.
2016.
27
Krishna G., Gopalakrishnan G., Goel S., Yu G., White T. Battery of Reproductive Toxicology Studies
Supporting the Safety of a Dopamine Receptor Antagonist, Molindone. Submitted to the Teratology Society
Annual Meeting to be held in June 2017.
Lectures
Sheehan D., Diersen V., Pham R., Pidathala A., Lamm M., Krawiec L., Raabe H., Curren R., Costin G.E.
“Optimization of the Validated in vitro Skin Irritation Test (OECD TG 439) to Address the Assignment of
EPA Hazard Categories”. 5th
Annual Meeting of the American Society for Cellular and Computational
Toxicology, Raleigh, NC, September 29, 2016.
Kruszewski F.H. FDA Efforts to Finalize the OTC Monograph Regulations for Topical Antiseptic Drug
Products and Industry’s Response. Cleaning Products US 2016, November 9-11, 2-16, Washington, D.C.,
USA.
Rao D.B. “Bringing it All Together: Overview, Platform, and Discussion” for the Symposium on “Small
Compartment Toxicity: ‘CN VIII’: Hearing Loss, Tinnitus, and Balance Disorders. Invited Speaker at the
37th
Annual Meeting of the American College of Toxicology, Baltimore, MD, November 7, 2016.
Rao D.B. “Neuropathology Assessments in Toxicology Studies: Challenges and Principles”. Invited Speaker at
the 6th
Conference and Continuing Education Program on the Toxicologic Pathology of Nervous and
Musculoskeletal Systems, Society of Toxicologic Pathology – India, Pune, India, October 21, 2016.
Rao D.B. “Basic Neuroanatomy, Physiology and Chemistry for Neuropathologists”. Invited Speaker at the 6th
Conference and Continuing Education Program on the Toxicologic Pathology of Nervous and
Musculoskeletal Systems, Society of Toxicologic Pathology – India, Pune, India, October 21, 2016.
Posters
Kruszewski F.H. Risk Assessment Guidance for Enzyme-containing Products”. The International Society of
Exposure Science, October 9-13, 2016, Utrecht, Netherlands.
Training Course
Presentation (5 full day training course): Ross M., Walker T., Fritz J. Risk Assessment Training Experience
(RATE): Understanding and Application of Risk Assessments. Training course provided by the U.S.
Environmental Protection Agency, and organized by the Institute for International Environmental
Policy, Policy Research Center for Environment and Economy, on behalf of the Ministry of Environmental
Protection, P.R. China. 11/21/2016 - 11/25/2016, Beijing, P.R. China.