New Products June 20061180 E. Ellsworth Road Ann Arbor, MI 48108 • (800) 364-9897 • www.caymanchem.com

June 2006prices and availability subject to change

Perifosine 10008112Perifosine is an alkylphospholipid that induces apoptotic cell death in a variety of tumor cell lines. Apoptosis is induced in a time- and dose-dependent manner in U937 and Jurkat T human leukemia cell lines but not in normal vascular endothelial cells. Perifosine causes inhibition of PC-3 prostate carcinoma cell growth and is associated with rapidly decreased Akt activation. In addition, perifosine induces p21WAF1 expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest.

5 mg 10 mg 50 mg 100 mg

O P

OH

O

O

N+

Palmitoleic Acid ethyl ester 10008204Palmitoleic acid ethyl ester (ethyl palmitoleate) is a more lipophilic form of the free acid. It is one of the fatty acid ethyl esters that increase cytosolic Ca2+ concentration leading to pancreatic acinar cell injury due to excessive consumption of ethanol. This fatty acid ethyl ester is also a potential biomarker for fetal exposure to alcohol.

100 mg 500 mg 1 g 5 g

O

O

Prostaglandin D2 methyl ester 10008385PGD2 methyl ester is a more lipid-soluble, cell-permeable prodrug form of PGD2. It binds to the human and murine PGD2 receptors (DP1 and CRTH2/DP2) with 5-10 fold lower affinity than PGD2.

1 mg 5 mg 10 mg 50 mg

OH

COOCH3

OH

O

9,11-methane-epoxy Prostaglandin F1α 100078509,11-methane-epoxy PGF1α is a stable epoxymethano analog of PGH1 that produces a strong and dose-related aggregation of washed rabbit platelets (EC50 = 0.88 µM) and contraction of rabbit aortic strips (EC50 = 0.11 µM). 9,11-methane-epoxy PGF1α induces contraction of guinea pig tracheas (EC50 = 3.4 µM) with a maximal contraction of about 60% of that caused by a submaximal dose of histamine.

100 µg 500 mg 1 mg 5 mg O

OH

COOH

N-acetyl-2-carboxy Benzenesulfonamide 10008284N-acetyl-2-carboxy Benzenesulfonamide is a is a structural analog of aspirin that acts as a non-selective inhibitor of COX with a COX-2 selectivity index of 0.23. In vitro studies showed that N-acetyl-2-carboxy Benzenesulfonamide is a more potent inhibitor of COX-1/COX-2 (0.06 µM and 0.25 µM, respectively) than aspirin (0.35 µM and 2.4 µM, respectively).

1 mg 5 mg 10 mg 50 mg

COOH

S

O

O

O

H

N

Leelamine 10006148Leelamine is a diterpene molecule whose name derives from the Sanskrit word leela which means ‘play’. It has weak affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, exhibiting 20% displacement of [3H]-CP55940 at a concentration of 10 µM. Leelamine inhibits pyruvate dehydrogenase kinase (PDK) with an IC50 value of 9.5 µM. Derivatives of leelamine exhibit anti-inflammatory activity and show moderate inhibition of PLA2 activity from a variety of sources.

5 mg 10 mg 50 mg 100 mg

H2N

HH3C

CH3

Related product: Leelamine Hydrochloride (10008614)

Lauric Acid ethyl ester 10008203Lauric acid ethyl ester is a more lipophilic and less toxic form of the free acid. It is one of the medium-chain fatty acid ethyl esters that is released during the anaerobic fermentation of Saccharomyces cerevisiae along with the free acid.

100 mg 500 mg 1 g 5 g

O

O

GW 610 10008313GW 610 is an antitumor benzothiazole that shows inhibitory activity against several cancer cell lines. In MCF-7 and MDA 468 human cancer cell lines, potent antiproliferative activity (growth inhibition (GI50) < 0.1 nM) was observed. Potent and selective activity was also observed in the NCI 60 human cancer cell line panel.

1 mg 5 mg 10 mg 50 mg

O

O

F N

S

N-hexanoyl-L-Homoserine lactone-d3 10007897N-hexanoyl-L-Homoserine lactone-d3 (C6-HSL-d3) contains three deuterium atoms at the C-6 position. It is intended for use as an internal standard for the quantification of C6-HSL by GC- or LC-mass spectrometry.

1 mg 5 mg 10 mg 50 mg

O

D

DD

N

HO

O

N-butyryl-L-Homoserine lactone-d5 10007899N-butyryl-L-Homoserine lactone-d5 (C4-HSL-d5) contains five deuterium atoms at the 3, 3’, 4, 4, and 4 positions. It is intended for use as an internal standard for the quantification of C4-HSL by GC- or LC-mass spectrometry.

1 mg 5 mg 10 mg 50 mg

N

H

O

O

OD

DD

DD

New Products June 2006

2,3-dinor-6-keto Prostaglandin F2α EIA Kit 515121Cayman’s 2,3-dinor-6-keto PGF1α EIA utilizes a highly selective monoclonal antibody that exhibits no cross reactivity with 6-keto PGF1α, thus providing a method for accurate measurement of systemic PGI2 production. These measurements are highly relevant to vascular biology research, especially as is relates to the elevated risk of myocardial infarction and stroke associated with the use of COX-2 selective inhibitors.

96 wells 480 wells

Arachidonic Acid ethyl ester 10008200Arachidonic acid ethyl ester is a more lipophilic form of arachidonic acid that can be incorporated into dietary regimens or fed to cultured cells as a source of exogenous arachidonate. It is one of the fatty acid ethyl esters that increase cytosolic Ca2+ concentration leading to pancreatic acinar cell injury due to excessive consumption of ethanol.

25 mg 50 mg 100 mg 1 g

O

O

Palmitic Acid ethyl ester 10008202Palmitic acid ethyl ester is a neutral, lipid soluble form of the free acid. It is one of the fatty acid ethyl esters that increase cytosolic Ca2+ concentration leading to pancreatic acinar cell injury due to excessive consumption of ethanol.

100 mg 500 mg 1 g 5 g

O

O

ASP EIA Kit 10008673Domoic acid (DA) and DA derivatives are water-soluble neurotoxins produced by a number of marine algae, in particular those of the genus Pseudo-nitzschia. Blooms of Pseudo-nitzschia may lead to the accumulation of DA in shellfish filter feeders and other marine species. Ingestion of DA-contaminated shellfish causes amnesic shellfish poisoning (ASP) and has been linked to the death of animal and human consumers in severe cases. The assay is primarily intended for use in routine monitoring of DA levels in bivalve molluscs, but is also applicable for DA quantification in other marine matrices.

96 wells

15-keto Iloprost 1000861615-keto Iloprost is the C-15 oxidized derivative of iloprost, a second generation structural analog of PGI2 (prostacyclin). Iloprost displays ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. There are no published studies of the pharmacological properties of 15-keto iloprost.

500 µg 1 mg 5 mg 10 mg

HO

CH3

COOH

O

Pranlukast 10008319Pranlukast is a potent, selective and orally active CysLT1 receptor antagonist. Sold under the trade name Ultair, it was the first cysteinyl (peptidyl) leukotriene receptor antagonist (LTRA) marketed for the treatment of asthma. Pranlukast binds to the human CysLT1 and CysLT2 receptors with IC50 values of approximately 4-7 nM and 3600 nM, respectively.

10 mg 100 mg 500 mg 1 g

O

NN

NH

O

O

ON

N

H

OSU03012 10008005OSU03012 is an analog of Celecoxib™ that exhibits anti-cancer activity in a COX-2-independent manner via inhibition of the phosphatidyl inositol-3-kinase(PI3K)/Akt pathway. It has an IC50 of 5 µM for inhibition of 3-phosphoinositide-dependent kinase-1 (PDK-1), and therefore Akt activation, with no measurable COX-2 inhibition up to 50 µM. OSU03012 is a potent inhibitor of tumor cell growth with an average inhibitory concentration of 1.1 µM across a panel of 60 cancer cell lines.

1 mg 5 mg 10 mg 50 mg

NH2

F3C

O

H

N

NN

Zafirlukast 10008282Zafirlukast is a potent, selective CysLT1 receptor antagonist sold under the trade name Accolate for the treatment of asthma as well as for the symptoms associated with allergic rhinitis. It binds to the human CysLT1 and CysLT2 receptors with IC50 values of approximately 5 nM and 7,400 nM, respectively.

10 mg 100 mg 500 mg 1 g H

N

O

H

N

O

O

O

N

OS

O

Tienilic Acid 10008517Tienilic acid is a CYP2C9 specific suicide substrate.

5 mg

4’-Hydroxydiclofenac 100085184’-Hydroxydiclofenac is a CYP2C9 metabolite of diclofenac.

5 mg

6β-Hydroxytestosterone 100085196β-Hydroxytestosterone is a CYP3A metabolite of testosterone.

5 mg

4-Hydroxytolbutamide 100085204-Hydroxytolbutamide is a CYP2C9 metabolite of tolbutamide.

5 mg

11α-Hydroxytestosterone 1000864711α-Hydroxytestosterone is a CYP3A metabolite of testosterone.

5 mg

2,3-dinor-6-keto Prostaglandin F1��(pg/ml)

%B

/B0

%C

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