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Optic nerve Chiasma ral Geniculate ucleus (LGN) ptic radiations Area V1 Area V1 OPTIC CHIASMA

Optic nerve Chiasma Lateral Geniculate Nucleus (LGN) Optic radiations Area V1 OPTIC CHIASMA

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Page 1: Optic nerve Chiasma Lateral Geniculate Nucleus (LGN) Optic radiations Area V1 OPTIC CHIASMA

Optic nerve

Chiasma

Lateral Geniculate Nucleus (LGN)

Optic radiations

Area V1 Area V1

OPTIC CHIASMA

Page 2: Optic nerve Chiasma Lateral Geniculate Nucleus (LGN) Optic radiations Area V1 OPTIC CHIASMA

1

2

3

4

5

posterieur(caudal)

antérieur(rostral)

ventral

dorsal

latéral

médial

Page 3: Optic nerve Chiasma Lateral Geniculate Nucleus (LGN) Optic radiations Area V1 OPTIC CHIASMA

HM

VM

Left UVF Right UVF

Right LVFLeft LVF

posterieur

antérieur

posterieur

antérieur

ventral

dorsal

latéralmédial

Page 4: Optic nerve Chiasma Lateral Geniculate Nucleus (LGN) Optic radiations Area V1 OPTIC CHIASMA

HM

VM

Right UVF

Right LVFLeft LVF

V1V2

V3 V4

V4V3

V2

V1

TEO

Page 5: Optic nerve Chiasma Lateral Geniculate Nucleus (LGN) Optic radiations Area V1 OPTIC CHIASMA

HM

VM

UVF

LVF

V1 V2 V3

V3A

V3V2

V1

V3A

Page 6: Optic nerve Chiasma Lateral Geniculate Nucleus (LGN) Optic radiations Area V1 OPTIC CHIASMA

Chez le singe :

• electrophysiologie, traceurs chimiques

• compilation de nombreux cas

Chez l’homme :

• IRMf

• études individuelles

- carte complète chez chaque animal - reproductibilité- homologies avec l’homme (MT,V4,V3A)

Page 7: Optic nerve Chiasma Lateral Geniculate Nucleus (LGN) Optic radiations Area V1 OPTIC CHIASMA

• 4 awake macaque monkeys

• fixation task (2x2 deg) [80-98] %

• contrast agent : MION 6-11 mg/kg i.v.

• Siemens 1.5T clinical scanner

• 40000 EPI volumes in 16 days

• standard surface coil

• voxel size : 2x2x2 mm

Methods

Page 8: Optic nerve Chiasma Lateral Geniculate Nucleus (LGN) Optic radiations Area V1 OPTIC CHIASMA

StimuliStatic wedges which include Motion and Color

• Black and white, color checkerboards

• moving dots

• moving lines

Page 9: Optic nerve Chiasma Lateral Geniculate Nucleus (LGN) Optic radiations Area V1 OPTIC CHIASMA

Horizontal and Vertical Meridians

Page 10: Optic nerve Chiasma Lateral Geniculate Nucleus (LGN) Optic radiations Area V1 OPTIC CHIASMA

Upper and Lower Visual Fields

Page 11: Optic nerve Chiasma Lateral Geniculate Nucleus (LGN) Optic radiations Area V1 OPTIC CHIASMA

Central and Peripheral Visual Fields

Page 12: Optic nerve Chiasma Lateral Geniculate Nucleus (LGN) Optic radiations Area V1 OPTIC CHIASMA

Summary view

V1

V1V2

V3V4

TEO

V2V3

V3A

V4

MT *FST *

* Vanduffel et al. Neuron 2000

Page 13: Optic nerve Chiasma Lateral Geniculate Nucleus (LGN) Optic radiations Area V1 OPTIC CHIASMA

Left hemispheres Right hemispheres

4 Monkeys

Page 14: Optic nerve Chiasma Lateral Geniculate Nucleus (LGN) Optic radiations Area V1 OPTIC CHIASMA

M4Right Hem.

Page 15: Optic nerve Chiasma Lateral Geniculate Nucleus (LGN) Optic radiations Area V1 OPTIC CHIASMA

M1Right Hem.

Page 16: Optic nerve Chiasma Lateral Geniculate Nucleus (LGN) Optic radiations Area V1 OPTIC CHIASMA

Similarities beyond V1 V2 V3 V3A

• V4v anterior border : horizontal meridian• V4d (monkey) / LOS (human) :

similar orientation of excentricity lines

Differences

• MT : clear retinotopy in monkeys,

not observed yet in humans

Comparison with human retinotopy

Page 17: Optic nerve Chiasma Lateral Geniculate Nucleus (LGN) Optic radiations Area V1 OPTIC CHIASMA

Rapport avec le feed-back…

-Feed-forward : la taille des champs recepteurs

des neurones s’agrandit avec la “hiérachie” des

aires : haut-niveau : absence d’organisation

rétinotopique (plutôt par modules fonctionnels

ex visages, lieux)

-Feed-back sur V1-2-3-4 = projection sur des

aires dans lesquelles l’organisation de l’espace

est représentée par voisinage, avec des

résolutions différentes

Page 18: Optic nerve Chiasma Lateral Geniculate Nucleus (LGN) Optic radiations Area V1 OPTIC CHIASMA

M3Right Hem.