Oxygen, Glucose, Ascorbate - Riordan Clinic · 2018. 6. 2. · continuing electron exchange takes place among the body’s C tissues and molecules 1937 Nobel Prize in Medicine for

O

2Oxygen, Glucose, Ascorbate

© Riordan Clinic 2018

Riordan Clinic IVC Academy

CGlucose

e-O:Oe-O2


O2

e-O:Oe-


Life =Electron

Flow


an electronas “seen”by theSuper K Particle Detector in KamiokaObservatoryHida,Japan


On a molecular basis, the whole living

process is nothing more than an orderly

flow and transfer of electrons...- Irwin Stone

The Healing Factor© Riordan Clinic 2018

13,800,000,000Latin: Ga (giga-annum) billion years

Ma (mega-annum) million years

Ka (kilo-annum) thousand years

13.8 x 108 Ga

Univ. atoms = 1080

Earth atoms = 1050

Human cells = 1014

Cells atoms = 1014

Electrons = 1028© Riordan Clinic 2018

Geologic Time• 4.6 Ga

• Prebiotic existence• 3.8 Ga

• CO2 atmosphere• Ribosomes• Membranes• Photosynthesis• Toxic O2 released• Prokaryotic life grows• Anaerobic dominates

• 2.5 Ga• O2 atmosphere• Eukaryotes emerge• Aerobic Organelles• “Nanomachines”

4.567 Ga


Photocatalytic Water Splitting

CO2

O2


Photons

Photo-Synthesis

Oxygen is the 2nd most electronegative atom

The energy of light…

Splits water… H2O Hydrogen and Oxygen

O2 !!© Riordan Clinic 2018

Oxygen is the 2nd most electronegative(electron-attractive)

element


electronegativity = “electro-phyllic”Redox = lectron flow

Electrons always flow from the anode to the cathode or from the oxidation half cell to the reduction half cell.

Electron Flow REDOX


“One definition of life is a state in which an

optimal degree of electron interchange

among cells can take place.”

Dr. Thomas Levy

Curing the Incurable


Oxygen

Multi-cellular

Life …set the stage for

evolution’s big jump to Eukaryotic cells

Oxygen’s energy potential

The electron-attractive power of oxygen…


Eukaryotic Organelles Evolved

“Life is a chemical system capable of Darwinian evolution.”

- Carl Sagan


Aerobic Cellular

Life19 times more Energy

Eukaryotes

Single cells that lived aerobically: Oxygen

Also capable of anaerobic metabolism when stressed

Anaerobiccellular

regression


Photosynthesis & Respiration Cycle


With

O2:

38ATP’s

With

no O2:

2ATP’s


CGlucose


Ascorbate is Synthesized from Glucose

GLO


L-Gulonolactone Oxidase

1972


Comparing Vitamin C Synthesis to

mg/kg/d Human equivalent

humans 1 60 mg/d

dog 3 200 mg/d

pig 8 500 mg/d

monkey* 100 7,000 mg/d

goat 190 14,000 mg/d

sick goat ~1300 100,000 mg/d

Predicted Oral Consumption


Excerpt from The Healing Factor, Part 1 “Our Deadly Inheritance,” Chapter 8 “The Genetic Approach”

• “Here we have the classic conditions for a genetic, missing-enzyme disease, and yet for years these simple facts have been ignored and scurvy has continued to be regarded as avitaminosis.

• In 1966, this author published the paper "On the Genetic Etiology of Scurvy," in which the history and pertinent facts were reviewed and it was pointed out that in scurvy we were dealing with a genetic, liver-enzyme disease and not simply a dietary disturbance.

• Since it is the prerogative of the discoverer to name a new disease, the author called it "hypoascorbemia" because low levels of ascorbic acid in the blood are characteristic of this disease.

• This genetic approach now provides a natural rationale for the use of large amounts of ascorbic acid which served so well in the survival of the mammals in the course of evolution.

• Its implications for health and well-being are vast because it furnishes the basis for the new unexplored fields of preventive medicine and therapeutics (megascorbic prophylaxis and megascorbic therapy).

• It is hoped that the publication of these new ways of using ascorbic acid will stimulate the flood of research similar to that which occurred when ascorbic acid was discovered in the early 1930s.

• Let us see how long it will take to break down the "vitamin-barriers" of current orthodox medical dogma.”

Note – The Healing Factor was originally published in 1972 … 46 years ago!


“…the chronic under-dosing of vitamin C from minimal or no supplementation and from eating depleted food

will facilitate the development of nearly all the chronic degenerative disease that affects man.”

Irwin Stone – The Healing Factor


“hexuronic acid” from adrenalsThe antiscorbutic factor

OC

Albert Szent-Györgyi


CGlucose

e-O:Oe-O2


One of the primary substances assuring that a vigorous,

continuing electron exchange takes place among the body’s

tissues and moleculesC1937 Nobel Prize

in Medicine for the

discovery of vitamin C,

in connection with

biological respiration

e-O:Oe-Two UNPAIRED electrons e-

with parallel spins


e-O:Oe-Amazing factoid:

atmospheric oxygen

O2is relatively unreactive!


Pauli Exclusion Principle:Two electrons

in the same orbit

must have

opposite spins in order to react

with Glucose and other organic molecules Glucose


Glucose

e-O:Oe-O2


Elements:1. Paraffin2. Wick

3. Activated O2

4. Match is Activator

Products:1. Heat 2. Light3. CO24. H2O

A Simple Electron Transfer System


When a glass jar is placed over a lighted candle,

the flame goes out.Why does this happen?


The electro-chemical potential of the hydrocarbon bonds was converted to

heat, light, CO2 + H2O … but not until an

activated electron receiver was available


superoxide

hydrogenperoxide

perhydroxylradical

water

singlet oxygen

atmosphericoxygen

hydroxylradical H2O

H2O2

FreeEnergyKcal/mol water

H2O

O2H

HO

O2

1O2

O2.-


Atmospheric O2e-O:Oe-

exists in the “ground state”

O2 must be activated to be “electron receptive”


e-O:Oe-Atmospheric O2 hastwo single electrons

with same-spin

e- transfers can only happen one electron at a time

low reactivity

O:OActivated O2 has

two opposite-spin paired electrons

e- is now highly reactivewith other pairs of electrons

especially double bonds

e-

e-Activation to

Singlet Oxygen


Activated Oxygen

O:OThis is NOW an

electron receiver

e-e-

Atmospheric Oxygen

O:ORelatively

Unreactive

e-e- O2is gone


Atmospheric O2 must be ACTIVATEDbefore it can act as an

ELECTRON RECEIVER

:O:O: :O:O:


Redox Molecules Electron Donors

Electron Receivers

Electron Transfer

Electron Storage

Electron “Energy Transfer”


“One definition of life is a state in which an

optimal degree of electron interchange

among cells can take place.”

Dr. Thomas Levy

Curing the Incurable


CGlucose

e-O:Oe-O2


Ascorbate as Redoxome “Oil”Optimizing Electron Flow Efficiency


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Oxygen, Glucose, Ascorbate - Riordan Clinic · 2018. 6. 2. · continuing electron exchange takes place among the body’s C tissues and molecules 1937 Nobel Prize in Medicine for