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Roberto Valcavi
Direttore SC di Endocrinologia e Centro Malattie della Tiroide Arcispedale Santa Maria Nuova, Reggio Emilia
www.asmn.re.it
Parma, 23 Febbraio 2008
Patologia nodulare della tiroide
30° Corso di Ecografia Generalista FIMMG-METIS
Alberobello, 20 Giugno 2010
1sabato 16 aprile 2011
AACE - American Association of Clinical EndocrinologistsAME - Associazione Medici Endocrinologi
ETA - European Thyroid Association
Medical Guidelines for Clinical Practice for the Diagnosis and Management
of Thyroid Nodules
Hossein Gharib, MD, MACP, MACE Enrico Papini, MD, FACE
Ralf Paschke, MDDaniel S. Duick, MD, FACP, FACE
Roberto Valcavi, MD, FACE Laszlo Hegedüs, MD
Paolo Vitti, MDfor the AACE/AME/ETA Task Force on Thyroid Nodules
www.aace.comwww.associazionemediciendocrinologi.it
2sabato 16 aprile 2011
Nodulo tiroideoParametri ecografici ! Sede, numero, dimensioni! Ecogenicità: iso, ipo, iperecogeno, anecoico! Struttura: cistica, spongiforme, mista, solida (omogenea/disomogenea)! Margini: regolari, alone, irregolari, invasione! Calcificazioni: presenza/assenza, grossolane, a guscio (integro/interrotto), puntate! Vascolarità: assente, perinodulare, intranodulare regolare, intranodulare caotica
Nuovi parametri! Elastografia (elastico, rigido al centro, rigido nella maggior parte, rigido –Fukunari) ! CEUS! 3D/4D
3sabato 16 aprile 2011
High risk history with suspicious US features
Abnormal cervical lymph nodes, extracapsular invasion
Microcalcifications, Irregular margins
Solid hypoechoicMixed cystic / solid
Spongiform Purely cystic
US criteria for FNAB threshold
4sabato 16 aprile 2011
Spongiform Echotexture. “Leave it alone nodule”
5sabato 16 aprile 2011
Spongiform structure. Very low risk
6sabato 16 aprile 2011
Cystic nodule with thin wall. Very low riskvideo
7sabato 16 aprile 2011
8sabato 16 aprile 2011
Cystic Nodule with Thick Wall.
9sabato 16 aprile 2011
Modest hypoechogenecity.Low risk.
10sabato 16 aprile 2011
Isoechoic/spongiform nodule with halo sign. Low risk
11sabato 16 aprile 2011
Hypoechoic hypervascular noduleScinti scan: hot nodule. Low risk
video
12sabato 16 aprile 2011
13sabato 16 aprile 2011
Isoechoic nodule with liquid area.Low risk. Risk for follicular lesion.
14sabato 16 aprile 2011
Coarse calcification in thyroidparenchyma. Low Risk
15sabato 16 aprile 2011
Eggshell calcification without shadowing.
16sabato 16 aprile 2011
Eggshell Calcifications with Shadowing
Smooth EggshellReassuring
Interrupted EggshellNot reassuring
17sabato 16 aprile 2011
Suspicious US Features of Thyroid nodules
18sabato 16 aprile 2011
Suspicious US Features of Thyroid nodules
Hypoechoic
18sabato 16 aprile 2011
Suspicious US Features of Thyroid nodules
Hypoechoic
No Halo
18sabato 16 aprile 2011
Suspicious US Features of Thyroid nodules
Hypoechoic
No Halo
Irregular margins
18sabato 16 aprile 2011
Suspicious US Features of Thyroid nodules
Hypoechoic
No Halo
Irregular margins
Microcalcifications
18sabato 16 aprile 2011
Suspicious US Features of Thyroid nodules
Hypoechoic
No Halo
Irregular margins
Microcalcifications
Hypervascular color flow mapping
18sabato 16 aprile 2011
Suspicious US Features of Thyroid nodules
Hypoechoic
No Halo
Irregular margins
Microcalcifications
Hypervascular color flow mapping
Size“More tall than wide”
18sabato 16 aprile 2011
Papillary Carcinoma
19sabato 16 aprile 2011
Papillary Carcinoma1. Marked Hypoechogenecity
19sabato 16 aprile 2011
Papillary Carcinoma1. Marked Hypoechogenecity2. No halo
19sabato 16 aprile 2011
Papillary Carcinoma1. Marked Hypoechogenecity2. No halo3. Irregular margins
19sabato 16 aprile 2011
Papillary Carcinoma1. Marked Hypoechogenecity2. No halo3. Irregular margins4. Microcalcifications
19sabato 16 aprile 2011
Papillary Carcinoma1. Marked Hypoechogenecity2. No halo3. Irregular margins4. Microcalcifications5. Scanty vascularity
19sabato 16 aprile 2011
Papillary Carcinoma1. Marked Hypoechogenecity2. No halo3. Irregular margins4. Microcalcifications5. Scanty vascularity6. Round shaped (as tall as wide)
19sabato 16 aprile 2011
Papillary micro carcinomaBulky aspect. Suspicious
video
20sabato 16 aprile 2011
21sabato 16 aprile 2011
Papillary carcinomaMultifocal, microcalcification
video
22sabato 16 aprile 2011
23sabato 16 aprile 2011
Modest hypoechogenecityBenign nodule
24sabato 16 aprile 2011
Halo sign, hypervascularityPapillary carcinoma
video
25sabato 16 aprile 2011
26sabato 16 aprile 2011
Chronic autoimmune thyroiditis with papillary carcinoma
27sabato 16 aprile 2011
Papillary carcinoma 4 cm.
28sabato 16 aprile 2011
Medullary carcinomaHypoechoic with punctate spots
29sabato 16 aprile 2011
Inhomogeneous. Follicular Carcinoma
30sabato 16 aprile 2011
Extra-thyroidal tumor Schwannoma
31sabato 16 aprile 2011
Thyroid lymphoma
32sabato 16 aprile 2011
Anaplastic tumor, left lobe
Video soft tissue invasionVideo Jugular Vein thrombosis
33sabato 16 aprile 2011
34sabato 16 aprile 2011
Thyroid Tumor Recurrence
35sabato 16 aprile 2011
Hurthle cell carcinomaRecurrence on thyroid cartilage
video
36sabato 16 aprile 2011
37sabato 16 aprile 2011
Neck Lymph NodesUltrasonographic diagnosis
38sabato 16 aprile 2011
Neck Lymph Nodes Levels
39sabato 16 aprile 2011
Neck compartments
CENTRAL COMPARTMENT
Levels VI-VII
LATERAL COMPARTMENT Levels II-III-IV-V 40sabato 16 aprile 2011
Reactive vs metastatic lymph node
41sabato 16 aprile 2011
Metastatic lymph nodes
42sabato 16 aprile 2011
Cystic central neck compartment metastatic lymph node
video
43sabato 16 aprile 2011
44sabato 16 aprile 2011
Papillary tumor. Mixed metastatic lymph node level III
45sabato 16 aprile 2011
Papillary carcinoma, upper left throid lobe. Level III metastases
video
46sabato 16 aprile 2011
47sabato 16 aprile 2011
Right central neck compartment metastatic lymph node
video
48sabato 16 aprile 2011
49sabato 16 aprile 2011
VII level Metastatic Lymph node.Tg + WBS -
video
50sabato 16 aprile 2011
51sabato 16 aprile 2011
Lymph node mass involving large vessels. Jugular vein thrombosis
52sabato 16 aprile 2011
Thyroid tumors: ultimate diagnosisUltrasound guided FNA cytology
In selected cases: ultrasound guided CNB histology
53sabato 16 aprile 2011
US features and thyroid malignancyMalignant Benign
Margins Irregular, invasion Well definedShape Irregular RegularMicrocalcifications Yes NoEchogenicity Hypo Iso/HyperStructure Solid
InhomogeousSpongiformdMixed/cystic
Color flow mapping Intranodular PeripheralMore tall than wide Yes NoPathologic l.nodes Yes No
54sabato 16 aprile 2011
US characteristics(references)
Sensitivity (%) Specificity (%) Positive Predictive Value (%)
Negative Predicitve Value (%)
Microcalcifications (1-5)
26-59 86-95 24-71 42-94
Hypoechogenicity
(2-5)
27-87 43-94 11-68 74-94
Irregular margins or no halo (2-5)
17-78 39-85 9-60 39-98
Solid (4-6)
69-75 53-56 16-27 88-92
Intranodule vascularity (3,6)
54-74 79-81 24-42 86-97
US characteristics associated with thyroid cancer
Society of Radiologists in Ultrasound Consensus StatementFrates et al. Radiology 2005
1.Khoo et al. Head Neck 20022.Kim et al. Am J Roentgenol 20023.Papini et al. J Clin End Metab 2002
4.Pacini et al. J Endocrinol Invest 20025.Frates et al. Radiological Society of Noth America 20046.Frates et al. J Ultrasound Med 2003
55sabato 16 aprile 2011
56sabato 16 aprile 2011
AME-AACE-ETA guidelines, March 2010
56sabato 16 aprile 2011
AME-AACE-ETA guidelines, March 2010FNA is recommended for nodules
56sabato 16 aprile 2011
AME-AACE-ETA guidelines, March 2010FNA is recommended for nodules
• of any size, in patients with history of neck irradiation or family history of PTC, MTC or MEN II
56sabato 16 aprile 2011
AME-AACE-ETA guidelines, March 2010FNA is recommended for nodules
• of any size, in patients with history of neck irradiation or family history of PTC, MTC or MEN II
• of any size, when US findings suggestive of extracapsular growth or metastatic cervical lymph nodes are present
56sabato 16 aprile 2011
AME-AACE-ETA guidelines, March 2010FNA is recommended for nodules
• of any size, in patients with history of neck irradiation or family history of PTC, MTC or MEN II
• of any size, when US findings suggestive of extracapsular growth or metastatic cervical lymph nodes are present
• smaller than 10 mm with no high-risk history: only if suspicious US findings are present (grade C, BEL 4)
56sabato 16 aprile 2011
Probability of a benign FNAB to identify a „truly benign“ nodule
!90% probability of benign histology after one FNAB!in 570 patients who underwent surgery
!98% probability of benign histology after repeat FNAB!In 126 (of 1277) patients who underwent surgery
Oertel et al, Thyroid, 2007many previous studies
57sabato 16 aprile 2011
Ways to minimize false-negative results
• Use UGFNA biopsy (grade C; 1)
• Aspirate multiple nodule sites (grade D; 1)
• Follow up cytologically benign nodule(s) (grade D; 1)
• Consider repeat UGFNA biopsy for follow-up of benign nodules (grade D; 1)
• For multiple nodules, prioritize according to US findings (grade D; 1)
• For cystic lesions, sample solid areas with UGFNA biopsy and submit cyst fluid for examination (grade D; 1)
• Review slides with an experienced cytopathologist (grade D; 1)
58sabato 16 aprile 2011
59sabato 16 aprile 2011
Follow-up
59sabato 16 aprile 2011
Follow-up
•Cytologically benign nodules should be followed-up
59sabato 16 aprile 2011
Follow-up
•Cytologically benign nodules should be followed-up
•Repeat clinical and US examination and TSH measurement in 6 to 18 months
59sabato 16 aprile 2011
Follow-up
•Cytologically benign nodules should be followed-up
•Repeat clinical and US examination and TSH measurement in 6 to 18 months
•Repeat UGFNA in cases of appearance of clinical or US suspicious features or a greater than 50% increase in nodule volume
59sabato 16 aprile 2011
Follow-up
•Cytologically benign nodules should be followed-up
•Repeat clinical and US examination and TSH measurement in 6 to 18 months
•Repeat UGFNA in cases of appearance of clinical or US suspicious features or a greater than 50% increase in nodule volume
•Consider routine a repeat UGFNA in 6 to 18 months, even in patients with initially benign cytologic results
59sabato 16 aprile 2011
Thyroid ultrasoundNew perspectives (1)
! Nodular blood flow ! Sensitive Doppler! B-flow technology
! Compound technology! Enhanced visualization of borders and interfaces! Speckle noise cut down
! Deep masses detection! tissue harmonic! microconvex array transducers
60sabato 16 aprile 2011
Nodular Blood FlowSensitive Doppler
2000 2008
61sabato 16 aprile 2011
Autoimmune chronic thyroiditis.Sensitive color flow mapping
2000 2009
62sabato 16 aprile 2011
63sabato 16 aprile 2011
Compound technologyBorder enhancementSpickle artifact reducedWithout compound With Compound
64sabato 16 aprile 2011
Tissue harmonicDeep masses detection
video
65sabato 16 aprile 2011
66sabato 16 aprile 2011
Microconvex array probe
video
67sabato 16 aprile 2011
68sabato 16 aprile 2011
Thyroid ultrasoundNew perspectives (2)
! Extended view! Digital compound reconstruction! Continuous scan reconstruction
Contrast media enhancement ! Volume ultrasound! Ultrasound tomography! 3D/4D anatomical reconstruction with rotating planes
!Elastography! Neoplastic tissue stiffness
69sabato 16 aprile 2011
Extended viewDigital Compound
video
70sabato 16 aprile 2011
71sabato 16 aprile 2011
Extended view Continuous scan reconstruction
72sabato 16 aprile 2011
Contrast enhanced ultrasound
Bartolotta et al, Eur Radiol 2006; 16:2234-41
73sabato 16 aprile 2011
Volume UltrasoundUltrasound tomography
74sabato 16 aprile 2011
Biopsy with Ultrasound Tomography
75sabato 16 aprile 2011
Volume Ultrasound3D/4D Ultrasound
76sabato 16 aprile 2011
Thyroid Elastography: Papillary Carcinoma VIDEO
77sabato 16 aprile 2011
78sabato 16 aprile 2011
Thyroid Elastography: Cystic and Mixed Nodules
79sabato 16 aprile 2011
Thyroid Elastography: Tissue Stiffness 2 years after Laser Ablation
VIDEO
80sabato 16 aprile 2011
81sabato 16 aprile 2011
SERVIZIO SANITARIO REGIONALE EMILIA ROMAGNA
Azienda Ospedaliera di Reggio Emilia Arcispedale S. Maria Nuova
http://www.asmn.re.it/
Dr. Roberto ValcaviDirettoreSC Endocrinologia
82sabato 16 aprile 2011
Thyroid Tumors Ultrasound Diagnosis
83sabato 16 aprile 2011
La patologia nodulare della tiroide.
Parametri ecografici ! Sede, numero, dimensioni! Ecogenicità: iso, ipo, iperecogeno, anecoico! Struttura: solida, mista, cistica! Margini: regolari, irregolari, alone! Calcificazioni: presenza/assenza, grossolane o puntate! Vascolarità: mappatura colore
84sabato 16 aprile 2011
US-guided Not US-guided
Sensitivity 96% 88%
Specificity 91% 90%
Accuracy 94% 94%
Positive Predictive Value 96% 95%
Negative Predictive Value 91% 75%
Impact of US guidance on FNAB diagnostic performance
Takashima et al J Clin Ultrasound 22:535,199485sabato 16 aprile 2011
Tiroidite Cronica Autoimmune
!Pattern ipoecogeno: Mild - Dark!Tessitura diffusamente disomogena!Evidenza della trama interstiziale!Pseudonoduli!Linfonodi ricorrenziali reattivi!Pattern colore
Hashimoto’s= intenso, medio, scarsoGraves’= intenso/diffuso (“inferno”)
86sabato 16 aprile 2011
Tiroidite subacuta (De Quervain)
!Aree iposoniche a margini indefiniti!Aree di tessuto normale!Andamento migrante!Flusso vascolare intraparenchimale scarso!Restitutio ad integrum con la guarigione
87sabato 16 aprile 2011
Ten tips for good clinical thyroid ultrasound
1.Good resolution instrument is critical: minimum requirement is digital technology, 10-14 mHz linear probe, doppler facility
2.Sit comfortably in front of the US system, have all the switchboard at hand 3.Have the patient supine with hyper-extended neck.4.Do not be too anxious to start examination. Be mentally neutral. 5.Hold the probe firm in your hand, move it gently and slowly. Examine the whole
neck from clavicle to jaw.
88sabato 16 aprile 2011
6.Always use the same procedure. Take transverse scans, rotate the probe clockwise at 90°until having longitudinal images.
7.Take pictures of standard projections plus all the relevant findings. Indicate where the probe was placed.
8.Measure the three dimensions of nodular findings. Use volume calculation to make more reproducible serial measurements.
9.Be concise and thorough in your report. 10.Operator enthusiasm may overlook unpredicted pathology. Expect for
unexpected findings.
Ten tips for good clinical thyroid ultrasound
89sabato 16 aprile 2011