Pediatric Gastroenterology, Hepatology and Nutrition

Fellowship Program

Barry K. Wershil, MDDivision Head,

Gastroenterology, Hepatology and Nutrition

Program Contact information:Phone: 312.227.4591

Email: jrbrown@luriechildrens.org

Jeffrey B. Brown, MDDirector, Fellowship Training Program

Chicago, IL

Table of Contents

Welcome from Dr. Wershil 3

About Our Fellowship Program 4-5 Program Overview 4 First Year 4 Second Year 4 Third Year 4 Additional Training Opportunities 5 Academic Program 5

About Ann & Robert H. Lurie Children’s Hospital of Chicago 6

About the Division of Gastroenterology, Hepatology and Nutrition 7-17 Division Overview 7 Faculty Members 8-15 Fellows 16 Clinical Nursing and Nutrition Staff 17

Research 18-19 Children’s Hospital of Chicago Research Center 18 Dr. Wershil’s Lab 18 Dr. Whitington’s Lab 19 Center for Intestinal and Liver Inflammation Research 19

Applying to the Program 20

Pediatric Gastroenterology, Hepatology and NutritionFellowship Program

Welcome from Dr. Wershil

Greetings, and thank you for your interest in our Fellowship Program in Pediatric Gastroenterology, Hepatology and Nutrition at Ann & Robert H. Lurie Children’s Hospital of Chicago and Northwestern University’s McGaw Medical Center. We are proud of our recent ranking as 8th in the nation by U.S. News & World Report for pediatric gastroenterology. Our mission is to train the future academic and clinical leaders in pediatric gastroenterology and hepatology. In order to do this, we developed a curriculum that provides an intensive and comprehensive exposure to all the essential elements required of today’s active subspecialist. The first year is predominantly clinical with an exposure to a vast array of gastrointestinal and liver diseases. As well, the fellow will acquire the procedure skills necessary for com-petency. While concentrating on clinical activity, we work with the fellows throughout the first year to develop their individualized agendas for the more research-oriented activities of the second and third years. The Division, Department, and Northwestern Medical Center offer a tremendous depth of activities in both basic and clinical research to draw upon. Our job is to help guide the fellows to the mentors that will best serve their individual goals. In the end, we take great pride in the accomplishments of our fellows and their professional development as they move on to successful careers.

We look forward to the selection process for the coming year and encourage you to contact us with any ques-tions or issues that might arise. Again thank you for considering our program and the best of luck in your future endeavors.

Barry K. Wershil, MDDivision Head, Gastroenterology, Hepatology and Nutrition, Ann & Robert H. Lurie Children’s Hospital of ChicagoProfessor, Northwestern University Feinberg School of Medicine

Program OverviewThe educational mission of the Pediatric Gastroenterology, Hepatology and Nutrition Fellowship Training Program is to provide trainees with the experiences necessary to become competent clinical gastroenterologists and hepatologists, and in the process define their career paths and goals. To do this, we focus on presenting a comprehensive clinical, educational, procedural, and re-search exposure over the course of the program. This fellowship is fully accredited through the Accreditation Council for Gradu-ate Medical Education and meets the training requirements of the American Board of Pediatrics for subspecialty certification in Pediatric Gastroenterology.

The three year fellowship program consists of 12 months of clinical education and 24 months of research experience. The first year of the program predominantly involves the acquisition of clinical and procedural skills and the participation in teaching re-sponsibilities. But the trainee is also introduced to various aspects of clinical and basic research methodology. Over the next two years, there is an increase in research time, while new teaching and administrative tasks are assumed. Some activities are com-mon to all years of fellowship training. Throughout the three years, fellows are required to attend the key departmental, division, and joint fellowship conferences as part of their core educational experience. Administrative responsibilities include scheduling some of these educational activities and maintaining the teaching file for the ambulatory practice.

First YearDuring the first year of fellowship, fellows spend the majority of their time involved in the inpatient and outpatient services. First year fellows have primary clinical responsibility for inpatients (either on the GI or liver service). In addition, fellows perform consultations, attend outpatient clinics, and participate in any and all procedures deemed necessary on patients they evaluate on the inpatient service or in clinic. Fellows participate in weekly divisional conferences and are expected to present in these conferences on average twice per month. During the second half of the year, the fellows begin the process of formulating their individualized research agenda for the second and third years, including identification of a mentor, defining a research project, establishing a scholarly oversight committee, and if necessary, formulate an IRB proposal.

Inpatient Service: 11 monthsCall: 8-10 weeks of call per academic yearClinics: 2-3 sessions per week

Second YearThe majority of time in the second year is devoted to research. Fellows begin work on the project chosen in the latter part of their first year and are encouraged to write a review article and/or case report during the second year of fellowship. Some ad-ditional administrative duties are assigned to second year fellows such as scheduling and organizing the monthly Pathology and Radiology Conferences. Fellows see new patients as well as follow established patients in GI clinic, and attend subspecialty clinics in IBD and intestinal rehabilitation. Their inpatient responsibilities are limited to approximately 4-6 weeks during the year. Fellows participate in any and all procedures deemed necessary on their patients. Second year fellows have increased responsi-bility for teaching residents rotating on the GI service, including providing occasional didactic sessions on common GI problems.

Inpatient Service: 4-6 weeks per academic year Call: 8-10 weeks of call per academic yearClinics: 2 sessions per week

About Our Fellowship Program

Third YearThe emphasis for the third year remains research. Fellows are expected to have at least one research project ready to be sub-mitted as an abstract and presented at a national meeting. Fellows are also encouraged to write and submit a research grant. Fellows continue to see new and established patients in their GI clinic, and have subspecialty clinic exposure in motility and anorectal anomalies. There is flexibility to allow third year fellows to attend clinical experience approximate with their career goals (i.e. hepatology). They have inpatient service for 2-4 weeks during the year. Fellows participate in any and all procedures deemed necessary on their patients. Third year fellows have even greater responsibility for teaching residents and medical stu-dents rotating through the division. Senior fellows are often called upon to give lectures to the pediatric residents and students and many continue as faculty facilitators at the medical school as well.

Inpatient Service: 2-4 weeks per academic year Call: 8-10 weeks of call per academic yearClinics: 2 sessions per week

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Additional Training OpportunitiesWe are one of the few programs in the country that offer an accredited Pediatric Transplant Hepatology fellowship under the direction of Dr. Estella Alonso. This training program is not part of the core Pediatric Gastroenterology, Hepatology and Nutri-tion Fellowship and requires completion of a three-year Pediatric Gastroenterology Fellowship and an application to the pro-gram, which is reviewed on a competitive basis. This additional year of training is recommended for individuals interested in a career in Hepatology and Liver Transplantation.

This one-year fellowship is divided into six months of inpatient coverage on the Hepatology/Transplant service, and six months dedicated to a clinical or basic research project in the area of Hepatology or Transplantation Medicine. Throughout the year, the fellow will participate in weekly Hepatology and Liver Transplant clinics, and play an active role in the pre-operative evaluation of patients for liver transplant as well as the post-operative management. They will also be called upon to give lectures to the pediatric GI fellows, residents and medical students throughout the duration of this fellowship.

Academic ProgramThe weekly “Fellows Conference” is the principal meeting for the purpose of stimulating the active interchange of information and ideas among the fellows. The program director directs the conference and any faculty and staff are welcomed to attend. Case related discussion, literature reviews, research topics, etc. take place in round-table fashion. The topics are known and literature is assigned well in advance, so the meeting can serve to discuss conflicting data and to cement ideas. All fellows are required to attend.

Fellows also participate in the following other conferences: Divisional Conferences: Journal Club – once per month Clinical Subject Review – once per month Research Conference – once per month Radiology Conference – once per month Clinical Case Conference – once per month GI Pathology Conference – twice per month Hepatology Pathology Conference – once per month Transplant Team Meeting – weekly Transplant M&M – monthly Faculty Peer Review (case conference) – quarterly Joint Adult/Pediatric GI Topic Conference – weekly

Departmental Conferences: Pediatric Grand Rounds – weekly Firm Rounds – weekly

Our philosophy is that writing manuscripts and grants at an early stage is absolutely essential to the development of an aca-demic career. Fellows are urged to write and publish clinically-oriented manuscripts during the clinical year and to publish re-sults of research projects. Most fellows publish 2-4 clinical papers, including case reports and clinical studies, and 1-2 designed research papers, by the completion of fellowship.

Teaching skills are improved by giving lectures to students and residents. A member of the faculty often sits in on these lec-tures to provide feedback on the quality and method of presentation. Fellows also present regularly at divisional conferences (i.e., journal club, clinical case conferences, and research conferences) that serve to strengthen skills in verbal presentation that would lead to presenting at one or more national meetings.

About Our Fellowship Program

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On Saturday, June 9, 2012, Children’s Memorial’s main hospital moved to 225 E. Chicago Avenue, and became Ann & Robert H. Lurie Children’s Hospital of Chicago. This new 23-story, state-of-the-art hospital helps further our mission to provide superior care to the region’s most critically ill and injured children. Lurie Children’s:■ Is the only hospital in Illinois that is included in the honor roll of Best Children’s Hospitals by U.S. News & World Report■ Is licensed for 288 beds and all private rooms■ Has an emergency department with 45 beds (increased from 25 beds) to better respond to regional demands and includes three trauma/procedure rooms, four nurse triage rooms, two diagnostic radiology rooms and one dedicated CT scanner.■ Is designed to increase patient safety, accommodate new technology and make care more efficient

Moving to the downtown Chicago campus of Northwestern University Feinberg School of Medicine increases clinical, academic and research opportunities to lead to better care for children. It also:■ Helps us recruit top pediatric specialists to Chicago■ Encourages child and adult health researchers to work closer together■ Allows faster transport for critically-ill newborns from Prentice Women’s Hospital – the largest birthing center in Illinois■ Improves transition of our patients with chronic conditions into adult care at Northwestern Memorial Hospital and the Rehabilitation Institute of Chicago

Lurie Children’s is located at 225 E. Chicago Avenue between Chicago Avenue and Superior Street, just west of Northwestern Memorial Hospital’s Prentice Women’s Hospital. Parking for patients and visitors is available in the Huron-Superior parking garage, which is just across Superior Street from the hospital. There is a pedestrian overpass to provide access to/from the Huron-Superior parking garage. With validation, parking costs $10 for 0-7 hours and $15 for more than 7 hours.

For more information on parking, driving directions, and public transportation options, please visit: http://www.luriechildrens.org/en-us/care-services/parking-locations/Pages/lurie-childrens.aspx

About Ann & Robert H. Lurie Children’s Hospital of Chicago

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Divisional OverviewThe Division of Gastroenterology, Hepatology and Nutrition at Ann & Robert H. Lurie Children’s Hospital of Chicago was recently ranked 8th in the nation by U.S. News & World Report for pediatric gastroenterology. While patient care is paramount, we are also committed to the education and professional development of our fellows. There are 15 full time attending physicians in the division and all hold faculty appointments within the Department of Pediatrics at Northwestern University Feinberg School of Medicine.

The senior faculty members collectively have more than 60 years of experience teaching in this subspecialty. Dr. Barry K. Wershil, Division Head, has more than 25 years of experience in training Pediatric Gastroenterology fellows. Dr. Peter F. Whitington, Director of the Siragusa Transplantation Center, is a leader in the field of Pediatric Hepatology and Transplant Hepatology and has been training subspecialists for more than 30 years. Dr. Estella M. Alonso, Medical Director of Liver Transplantation, provides more than 20 years of experienced leadership and education in the field of Pediatric Hepatology and Liver Transplantation. The division also has an experienced and dedicated nursing and clinical nutrition staff.

The inpatient services are divided into Gastroenterology/Nutrition and Hepatology. On the Gastroenterology service, the typical daily census is 6-12 patients, and the service averages 6-8 consults per week. The average daily

census on the Hepatology inpatient service is 4-8 patients, including 2-4 post-transplant patients, and the service averages about 2-4 consults per week.

The division has approximately 6,000 patient visits in the outpatient setting per year. About two-thirds of those patients are from the Chicago/upper Midwest region, while the rest are from a wide geographic area, including many national and international referrals. Pediatricians and Gastroenterologists refer the majority of patients for tertiary services. Some of the more common diagnoses encountered in our general GI clinics are gastroesophageal reflux, failure to thrive, recurrent abdominal pain, constipation, celiac disease, and allergic bowel disorder.

We also have subspecialty clinics in functional gastrointestinal and motility disorders, inflammatory bowel disease, eosinophilic esophagitis and allergic bowel disease, and intestinal failure. The hepatology outpatient clinic sees an incredible array of liver diseases as it is the only specialized clinic in Illinois and is a referral center for the Midwest.

The main hospital is now located in the downtown Streeterville neighborhood, and we still have an outpatient center located in the Lincoln Park neighborhood in Chicago. Fellows attend outpatient clinics at those two locations, and there is shuttle service between the main hospital and outpatient center. The Division also has satellite gastroenterology outpatient clinics in six suburban partner locations: Arlington Heights, Glenview, Lake Forest, Tinley Park, Westchester, and Winfield.

About the Divison of Gastroenterology, Hepatology and Nutrition

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Ann & Robert H. Lurie Children’s Hospital of Chicago

Gastroenterology, Hepatology and Nutrition Faculty Members

Jeffrey B. Brown, MDAssistant Professor, Northwestern University Feinberg School of MedicineDirector, Fellowship Training Program, Gastroenterology, Hepatology and NutritionAttending Physician, Ann & Robert H. Lurie Children’s Hospital of Chicago

Dr. Brown completed a Pediatric Residency program and Pediatric Gastroenterology Fellowship at Lurie Children’s (formerly Children’s Memorial Hospital) in Chicago, IL.

Clinical interests : Inflammatory Bowel Disease

Research interests: Inflammatory Bowel Disease, specifically laboratory investigation of intestinal lymphocyte trafficking in models of inflammatory bowel disease and the relationship of inflammation, intestinal stem cells, and colon cancer.

Selected Recent Publications: 1. Brown JB, Cheresh P, Zhang Z, Ryu H, Managlia E, Barrett TA. P-selectin glycoprotein ligand-1 is needed for sequential recruitment of T-helper 1 (Th1) and local generation of Th17 T cells in dextran sodium sulfate (DSS) colitis. Inflamm Bowel Dis. 2011 Aug 29 [epub ahead of print]2. Brown JB, Cheresh P, Goretsky T, Managlia E, Grimm GR, Ryu H, Zadeh M, Dirisina R, Barrett TA. Epithelial phosphatidylinositol-3-kinase signaling is required for �-catenin activation and host defense against Citrobacter rodentium infection. Infect Immun. 2011;79:1863-72. 3. Chogle A, Bu HF, Wang X, Brown JB, Chou PM, Tan XD. Milk fat globule-EGF factor 8 is a critical protein for healing of dextran sodium sulfate-induced acute colitis in mice. Mol Med. 2011;17:502-7.4. Mohamadzadeh M, Pfeiler EA, Brown JB, Zadeh M, Gramarossa M, Managlia E, Bere P, Sarraj B, Khan MW, Pakanati KC, Ansari MJ, O’Flaherty S, Barrett T, Klaenhammer TR. Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid. Proc Natl Acad Sci U S A. 2011, 108 Suppl 1:4623-30. 5. Brown JB, Barrett TA. P110� mutant mice reveal central role for PI3K signaling in intestinal macrophages. Gastroenterology. 2010;139:1451-3.

Dr. Wershil completed a Pediatric Residency and Chief Residency at St. Louis Children’s Hospital in St. Louis, MO. He completed a Pediatric Gastroenterology Fellowship at Massachusetts General Hospital and Children’s Hospital in Boston, MA, and a Research Fellowship in the Department of Pediatrics at Harvard Medical School in Boston, MA.

Clinical Interests: Eosinophilic Esophagitis, Food Allergy

Research Interests: Eosinophilic Esophagitis, Mast cell function in the GI tract

Selected Recent Publications: 1. Kagalwalla AF, Amsden K, Shah A, Ritz S, Manuel-Rubio M, Dunne K, Nelson SP, Wershil BK, Melin-Aldana H. Cow’s milk elimination: A novel dietary approach to treat eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2012 Jul 19 [epub ahead of print].2. Rothenberg ME, Aceves S, Bonis PA, Collins MH, Gonsalves N, Gupta SK, Hirano I, Liacouras CA, Putnam PE, Spergel JM, Straumann A, Wershil BK, Furuta GT. Working with the US Food and Drug Adminstration: Progress and timelines in understanding and treating patients with eosinophilic esophagitis. J Allergy Clin Immunol. 2012;130:617-9.3. Liacouras CA, Furuta GT, Hirano I, Atkins D, Attwood SE, Bonis PA, Burks AW, Chehade M, Collins MH, Dellon ES, Dohil R, Falk GW, Gonsalves N, Gupta SK, Katzka DA, Lucendo AJ, Markowitz JE, Noel RJ, Odze RD, Putnam PE, Richter JE, Romero Y, Ruchelli E, Sampson HA, Schoepfer A, Shaheen NJ, Sicherer SH, Spechler S, Spergel JM, Straumann A, Wershil BK, Rothenberg ME, Aceves SS. Eosinophilic esophagitis: Update consensus recommendations for children and adults. J Allergy Clin Immunol. 2011;128:3-20.4. Shrestha S, Wershil B, Sarwark JF, Niewold TB, Philipp T, Pachman LM. Lesional and nonlesional skin from patients with untreated juvenile dermatomyositis displays increased numbers of mast cells and mature plasmacytoid dendritic cells. Arthritis Rheum. 2010;62:2813-22.5. Ding H, Nedrud JG, Wershil B, Redline RW, Blanchard TG, Czinn SJ. Partial protection against Helicobacter pylori in the absence of mast cells in mice. Infect Immun. 2009;77:5543-50.

Barry K. Wershil, MDProfessor, Northwestern University Feinberg School of MedicineDivision Head, Gastroenterology, Hepatology and Nutrition, Ann & Robert H. Lurie Children’s Hospital of ChicagoAttending Physician, Ann & Robert H. Lurie Children’s Hospital of Chicago

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Lee Bass, MDAssistant Professor, Northwestern University Feinberg School of MedicineDirector of Endoscopy and Clinical Practice Director, Division of Gastroenterology, Hepatology and NutritionAttending Physician, Ann & Robert H. Lurie Children’s Hospital of Chicago

Dr. Alonso completed a Pediatric Residency program at Lurie Children’s (formerly Children’s Memorial Hospital) in Chicago, IL. She completed a Pediatric Gastroenterology Fellowship at the University of Chicago in Chicago, IL, and a Research Fellowship in the Liver Research Laboratory at the University of Southern California in Los Angeles, CA.

Clinical interests: Liver disease and transplantation, acute liver failure, biliary atresia, and primary sclerosing cholangitis

Research interests: Rehabilitation and outcome after liver transplantation, acute liver failure, primary sclerosing cholangitis, and transplant tolerance

Selected Recent Publications:1. Squires RH, Dhawan A, Alonso E, Narkewicz MR, Shneider BL, Rodriguez-Baez N, Olio DD, Karpen S, Bucuvalas J, Lobritto S, Rand E, Rosenthal P, Horslen S, Ng V, Subbarao G, Kerkar N, Rudnick D, James Lopez M, Schwarz K, Romero R, Elisofon S, Doo E, Robuck PR, Lawlor S, Belle SH; for the Pediatric Acute Liver Failure Study Group. Intravenous N-acetylcysteine in pediatric patients with non-acetaminophen acute liver failure: A placebo-controlled clinical trial. Hepatology. 2012 Epub ahead of print.2. Lerret SM, Menendez J, Weckwerth J, Lokar J, Mitchell J, Alonso EM. Essential components of transition to adult transplant services: the transplant coordinators’ perspective. Prog Transplant. 2012;22:252-8.3. Kamath BM, Yin W, Miller H, Anand R, Rand EB, Alonso E, Bucuvalas J; for Studies of Pediatric Liver Transplantation. Outcomes of liver transplantation for patients with alagille syndrome: The studies of pediatric liver transplantation experience. Liver Transpl. 2012;18:940-8. 4. Ekong UD, Mathew J, Melin-Aldana H, Wang D, Alonso EM. Successful resolution of infl ammation and increased regulatory T cells in sirolimus-treated post-transplant allograft hepatitis. Pediatr Transplant. 2012;16:165-75.5. Feng S, Ekong UD, Lobritto SJ, Demetris AJ, Roberts JP, Rosenthal P, Alonso EM, Philogene MC, Ikle D, Poole KM, Bridges ND, Turka LA, Tchao NK. Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants. JAMA. 2012;307:283-93.

Estella M. Alonso, MDProfessor, Northwestern University Feinberg School of MedicineMedical Director of Liver Transplantation, Ann & Robert H. Lurie Children’s Hospital of ChicagoAttending Physician, Ann & Robert H. Lurie Children’s Hospital of Chicago

Dr. Bass completed a Pediatric Residency and Chief Residency at St. Louis Children’s Hospital in St. Louis, MO. He completed a Pediatric Gastroenterology, Hepatology and Nutrition Fellowship at Lurie Children’s (formerly Children’s Memorial Hospital) in Chicago, IL.

Clinical interests: Gastroesophageal refl ux, cholestatic liver disease, primary sclerosing cholangitis with Infl ammatory Bowel Dis-ease, autoimmune liver disease, portal hypertension, therapeutic endoscopy, Capsule endoscopy

Research interests: Novel uses of capsule endoscopy, innovative teaching approaches of endoscopy to trainees

Selected Recent Publications: 1. Shneider BL, Abel B, Haber B, Karpen SJ, Magee JC, Romero R, Schwarz K, Bass LM, Kerkar N, Miethke AG, Rosenthal P, Turmelle Y, Robuck PR, Sokol RJ; for the Childhood Liver Disease Research and Education Network (ChiLDREN). Cross-sectional Multi- center Analysis of Portal Hypertension in 163 Children and Young Adults with Biliary Atresia. J Pediatr Gastroenterol Nutr. 2012 Aug 16. [Epub ahead of print] 2. Bass LM, Barsness K, Benya E, Proytcheva M, Kagalwalla A. Mesenteric Castleman’s Disease detected by Capsule Endoscopy. J Pediatr Gastroenterol Nutr. 2012 Jun 12. [Epub ahead of print] 3. Bass LM, Misiewicz L. Use of a Real Time Viewer for Endoscopic Deployment of Capsule Endoscope in the Pediatric Population. J Pediatr Gastroenterol Nutr. 2012 Jun 8. [Epub ahead of print] 4. Omenetti A, Bass LM, Anders RA, Clemente MG, Francis H, Guy CD, McCall S, Choi SS, Alpini G, Schwarz KB, Diehl AM, Whitington PF. Hedgehog activity, epithelial-mesenchymal transitions, and biliary dysmorphogenesis in biliary atresia. Hepatology. 2011;53:1246-58. 5. Bass LM, Patil D, Rao MS, Green RM, Whitington PF. Pancreatic adenocarcinoma in type 2 progressive familial intrahepatic cholestasis. BMC Gastroenterol. 2010;10:30.

Faculty Members

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Ashish Chogle, MD, MPH Instructor, Northwestern University Feinberg School of MedicineAttending Physician, Ann & Robert H. Lurie Children’s Hospital of Chicago

Dr. Chogle completed his residency in General Pediatrics at Children’s Hospital at SUNY Downstate and fellowship in Pediatric Gastroenterology, Hepatology and Nutrition at Lurie Children’s Hospital (formerly Children’s Memorial Hospital) in Chicago, IL. Dr. Chogle has helped build our center of excellence for children

with gastrointestinal motility and functional bowel disorders.

Clinical interests: Swallowing disorders, dysphagia, esophageal achalasia, refractory nausea, gastroparesis, intestinal pseudo-ob-struction, chronic constipation, anal dysfunction, cyclic vomiting syndrome, functional abdominal pain and irritable bowel syn-drome. Comprehensive holistic approach in treatment of functional GI disorders including use of natural medications and psycho-therapy.

Research interests: Gastrointestinal motility and functional disorders.

Selected Recent Publications: 1. Saps M, Adams P, Bonilla S, Chogle A, Nichols-Vinueza D. Parental report of abdominal pain and abdominal pain-related functional gastrointestinal disorders: a community survey. J Pediatr Gastroenterol Nutr. 2012 Jun 28, epub ahead of print.2. Chogle A, Sztainberg M, Bass L, Youssef NN, Miranda A, Nurko S, Hyman P, Cocjin J, Di Lorenzo C, Saps M. Accuracy of pain recall in children. J Pediatr Gastroenterol Nutr. 2012, 55:288-291.3. Chogle A, Bu HF, Wang X, Brown JB, Chou PM, Tan XD. Milk fat globule-EGF factor 8 is a critical protein for healing of dextran sodium sulfate-induced acute colitis in mice. Mol Med. 2011, 17(5-6):502-7.4. Saps M, Dhroove G, Chogle A. Henoch-schonlein purpura leads to functional gastrointestinal disorders. Dig Dis Sci. 2011, 56:1789-93.

Dr. Cohran completed a Pediatric Residency program, Pediatric Gastroenterology Fellowship, and an Advanced Clinical Research Fellowship at Cincinnati Children’s Hospital Medical Center in Cincinnati, OH.

Clinical Interests: Intestinal rehabilitation and transplantation

Research Interests: Outcomes in transplantation, specifi cally stem cell activation and its role in intestinal adaptation

Selected Recent Publications: 1. Mazariegos GV, Superina R, Rudolph J, Cohran V, Burns RC, Bond GJ, Jaffe R, Sindhi R. Current status of pediatric intestinal failure, rehabilitation, and transplantation: summary of a colloquium. Transplantation. 2011, 92:1173-80.2. Mohamadzadeh M, Durmaz E, Zadeh M, Pakanati KC, Gramarossa M, Cohran V, Klaenhammer TR. Targeted expression of anthrax protective antigen by Lactobacillus gasseri as an anthrax vaccine. Future Microbiol. 2010, 5:1289-96.3. Listernick R, Katz B, Fuleihan R, Cohran V, Liem R, Morgan E, Fangusaro J, Melin-Aldana H. A 17-year-old boy with fever, sore throat, and headache. Pediatr Ann. 2009, 38:9-10.4. Putchakayala K, Polensky S, Fitzhugh J, Cohran V, Buchman A, Fryer J. An evaluation of the model for end-stage liver disease and serum C-reactive protein as prognostic markers in intestinal failure patients on parenteral nutrition. JPEN J Parenter Enteral Nutr. 2009, 33:55-61.5. Eisengart LJ, Chou PM, Iyer K, Cohran V, Rajaram V. Rotavirus infection in small bowel transplant: a histologic comparison with acute cellular rejection. Pediatr Dev Pathol. 2009, 12:85-8.

Valeria C. Cohran, MDAssistant Professor, Northwestern University Feinberg School of MedicineMedical Director, Small Bowel Transplantation and Intestinal Rehabilitation ProgramAttending Physician, Ann & Robert H. Lurie Children’s Hospital of Chicago

Faculty Members

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Dr. Fishbein completed both a Pediatric Residency program and Pediatric Gastroenterology Fellowship at the University of Chicago in Chicago, IL.

Clinical interests: Feeding aversion and feeding disorders

Research interests: Nonalcoholic fatty liver disease, quality of life for families of children with feeding disorders, and the relationship between grocery shopping and obesity

Selected Recent Publications: 1. Fishbein M, Flock S, and Benton K. Self-Assessment of Pediatric Feeding Therapists in the State of Illinois. (accepted for publication) ASHA SIG 13 (Perspectives) 20132. Fishbein M, Fraker C, Walbert L, Branham C, and Scarborough D. The Incidence of Oropharyngeal Dysphagia In Infants With GERD-like Symptoms. (accepted for publication) JPEN 20123. Guy CD, Suzuki A, Zdanowicz M, Abdelmalek MF, Burchette J, Unalp A, Diehl AM; NASH CRN. Hedgehog pathway activation parallels histologic severity of injury and fi brosis in human nonalcoholic fatty liver disease. Hepatology. 2012;55:1711-21.4. Brunt EM, Kleiner DE, Wilson LA, Belt P, Neuschwander-Tetri BA; NASH Clinical Research Network (CRN). Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings. Hepatology. 2011;53:810-20. 5. Fishbein MH, Mogren C, Gleason T, Stevens WR. Relationship of hepatic steatosis to adipose tissue distribution in pediatric non alcoholic fatty liver disease. J Pediatr Gastroenterol Nutr. 2006;42:83-8.

Mark H. Fishbein, MDAssociate Professor, Northwestern University Feinberg School of MedicineAttending Physician, Ann & Robert H. Lurie Children’s Hospital of Chicago

Faculty Members

Dr. Greene completed a Pediatric Residency program at Monmouth Medical Center in Long Branch, NJ. She completed a Pediatric Gastroenterology, Hepatology and Nutrition Fellowship at Lurie Children’s (formerly Children’s Memorial Hospital) in Chicago, IL.

Clinical interests: Feeding/swallowing diffi culties, failure to thrive/growth failure, pancreatic disorders

Research interests: Dysphagia, swallowing disorders

Selected Recent Publications:1. Greene MT, Whitington PF. Outcomes in pediatric autoimmune hepatitis. Curr Gastroenterol Rep. 2009;11:248-51. 2. Greene MT, Ercolini AM, DeGutes M, Miller SD. Differential induction of experimental autoimmune encephalomyelitis by myelin basic protein molecular mimics in mice humanized for HLA-DR2 and an MBP(85-99)-specifi c T cell receptor. J Autoimmun. 2008;31:399-407.3. Triantafyllapoulou M, Whitington PF, Melin-Aldana H, Benya EC, and Brickman W. Hepatic adenoma in an adolescent with elevated androgen levels. J Pediatr Gastroenterol Nutr 2007;44:640-2.4. Teitelbaum J, Saeed S, Triantafyllopoulou M, Daum F. Infl iximab in pediatric Crohn’s disease patients with entervesicular fi stulas: a case series. J Pediatr Gastroenterol Nutr 2007;44:279-82.

Maria T. Greene, MDAssistant Professor, Northwestern University Feinberg School of MedicineAttending Physician, Ann & Robert H. Lurie Children’s Hospital of Chicago

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Dr. Kagalwalla completed a Pediatric Residency program and a Pediatric Gastroenterology Fellowship at Children’s Hospital of Michigan in Detroit, Michigan.

Clinical interests: Food Allergies

Research interests: Eosinophilic Esophagitis

Selected Recent Publications: 1. Furuta GT, Kagalwalla AF, Lee JJ, Alumkal P, Maybruck BT, Fillon S, Masterson JC, Ochkur S, Protheroe C, Moore W, Pan Z, Amsden K, Robinson Z, Capocelli K, Mukkada V, Atkins D, Fleischer D, Hosford L, Kwatia MA, Schroeder S, Kelly C, Lovell M, Melin-Aldana H, Ackerman SJ. The oesophageal string test: A novel, minimally invasive method measures mucosal infl ammation in eosinophilic oesophagitis. Gut. 2012 Aug 15. [Epub ahead of print].2. Kagalwalla AF, Amsden K, Shah A, Ritz S, Manuel-Rubio M, Dunne K, Nelson SP, Wershil BK, Melin-Aldana H. Cow’s milk elimination: A novel dietary approach to treat esoinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2012 Jul 19. [Epub ahead of print].3. Kagalwalla AF, Akhtar N, Woodruff SA, Rea BA, Masterson JC, Mukkada V, Parashette KR, Du J, Fillon S, Protheroe CA, Lee JJ, Amsden K, Melin-Aldana H, Capocelli KE, Furuta GT, Ackerman SJ. Eosinophilic esophagitis: Epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment. J Allergy Clin Immunol. 2012;129:1387-1396.4. Kagalwalla AF, Shah A, Li BU, Sentongo TA, Ritz S, Manuel-Rubio M, Jacques K, Wang D, Melin-Aldana H, Nelson SP. Identifi cation of specifi c foods responsible for infl ammation in children with eosinophilic esophagitis successfully treated with empiric elimination diet. J Pediatr Gastroenterol Nutr. 2011;53:145-9.5. Shah A, Kagalwalla AF, Gonsalves N, Melin-Aldana H, Li BU, Hirano I. Histopathologic variability in children with eosinophilic esophagitis. Am J Gastroenterol. 2009;104:716-21.

Amir Kagalwalla, MDAssociate Professor, Northwestern University Feinberg School of MedicineAttending Physician, Ann & Robert H. Lurie Children’s Hospital of Chicago

Faculty Members

Dr. Mohammad completed a Pediatric Residency program at Vanderbilt Children’s Hospital, Nashville, TN. He completed fellowships in Pediatric Gastroenterology and Transplant Hepatology at Lurie Children’s (formerlyChildren’s Memorial Hospital) in Chicago, IL.

Clinical interests: Childhood liver disease and transplantation, acute liver failure, cholestatic liver disease.

Research interests: Long term outcomes after liver transplantation, Comparative effectiveness research, Transition of care

Selected Recent Publications: 1. Mohammad S, Hormaza L, Neighbors K, Boone P, Tierney M, Azzam RK, Butt Z, Alonso EM. Health status in young adults two decades after pediatric liver transplantation. Am J Transplant. 2012;12:1486-95.2. Chaudhury S, Hormaza L, Mohammad S, Lokar J, Ekong U, Alonso EM, Wainwright MS, Kletzel M, Whitington PF. Liver transplantation followed by allogeneic hematopoietic stem cell transplantation for atypical mevalonic aciduria. Am J Transplant. 2012;12:1627-31.3. Mohammad S, Alonso EM. Approach to optimizing growth, rehabilitation, and neurodevelopmental outcomes in children after solid-organ transplanatation. Pediatr Clin North Am. 2010;57:539-57.4. Mohammad S, Naiditch JA, Jaffar R, Rothstein D, Bass LM. Granular cell tumor of the esophagus in an adolescent girl. J Pediatr Gastroenterol Nutr. 2012;54:715.

Saeed Mohammad, MDAssistant Professor, Northwestern University Feinberg School of MedicineAttending Physician, Ann & Robert H. Lurie Children’s Hospital of Chicago

Dr. Prozialeck completed his Pediatric Residency and his Pediatric Gastroenterology Fellowship at Lurie Children’s (formerly Children’s Memorial Hospital) in Chicago, IL.

Clinical Interest: Intestinal rehabilitation, advanced endoscopy

Research Interests: Short gut, quality improvement, endoscopic procedures, nutrition support

Selected Recent Publications:1. Bonilla S, Prozialeck JD, Malladi P, Pan X, Yu S, Melin-Aldana H, Whitington PF. Neonatal iron overload and tissue siderosis due to gestational alloimmune liver disease. J Hepatol 2012;56:1351-5.

Joshua Prozialeck, MDAssistant Professor, Northwestern University Feinberg School of MedicineAttending Physician, Ann & Robert H. Lurie Children’s Hospital of Chicago

Faculty Members

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Dr. Saps completed a Pediatric Gastroenterology and Hepatology Residency program at Hospital Ramon y Cajal, Hospital La Paz in Madrid, Spain. He completed a Clinical Research Fellowship in Pediatric Gastroenterology, Hepatology and Nutrition at California Pacifi c Medical Center in San Francisco, CA. He then pursued a Pediatric Residency at Maimonides Medical Center in Brooklyn, NY, and then a Pediatric Gastroenterology, Hepatology and Nutrition Fellowship at Children’s Hospital of Pittsburgh in Pittsburgh, PA.

Clinical Interests: Functional bowel disorders and motility disorders

Research Interests: Treatment pathogenesis and epidemiology of functional gastrointestinal disorders

Selected Recent Publications: 1. Saps M, Adams P, Bonilla S, Chogle A, Nichols-Vinueza D. Parental report of abdominal pain and abdominal pain-related functional gastrointestinal disorders: A community survey. J Pediatr Gastroenterol Nutr. 2012 Jun 28. [Epub ahead of print].2. Lavigne JV, Saps M, Bryant FB. Reexamining the factor structure of somatization using the children’s somatization inventory (CSI-24) in a community sample. J Pediatr Psychol. 2012 Apr 27. [Epub ahead of print].3. Bonilla S, Saps M. Pharmacological treatment of abdominal pain related functional gastrointestinal disorders. J Pediatr Gastroenterol Nutr. 2011, 53 Suppl 2:S38-40. 4. Chogle A, Dhroove G, Sztainberg M, Di Lorenzo C, Saps M. How reliable are the Rome III criteria for the assessment of functional gastrointestinal disorders in children? Am J Gastroenterol. 2010;105:2697-701. 5. Saps M, Youssef N, Miranda A, Nurko S, Hyman P, Cocjin J, Di Lorenzo C. Multicenter, randomized placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders. Gastroenterology. 2009;137:1261-9.

Miguel Saps, MDAssociate Professor, Northwestern University Feinberg School of MedicineDirector, Gastrointestinal Motility and Functional Bowel Disorders Program, Ann & Robert H. Lurie Children’s Hospital of ChicagoAttending Physician, Ann & Robert H. Lurie Children’s Hospital of Chicago

Dr. Strople completed both a Pediatric Residency program and Pediatric Gastroenterology, Hepatology and Nutrition Fellowship at Cincinnati Children’s Hospital Medical Center in Cincinnati, OH. Dr. Strople also obtained a Masters of Science in Epidemiology and Biostatics at the University of Cincinnati while in fellowship training.

Clinical Interests: Infl ammatory Bowel Disease

Research Interests: Infl ammatory Bowel Disease, specifi cally outcomes and quality improvement

Selected Recent Publications: 1. Strople J, Lovell G, Heubi J. Prevalence of subclinical vitamin K defi ciency in cholestatic liver disease. J Pediatr Gastroenterol Nutr. 2009, 49:78-84.2. Marcus SB, Strople JA, Neighbors K, Weissberg-Benchell J, Nelson SP, Limbers C, Varni JW, Alonso EM. Fatigue and health- related quality of life in pediatric infl ammatory bowel disease. Clin Gastroenterol Hepatol. 2009;7:554-61.3. Bousvaros A, Goldsmith J, Strople J, et al. Making the Right Diagnosis: Differentiating Between Crohn’s Disease and Ulcerative Colitis in Children and Young Adults, A case-Based Monograph focusing on Pediatric Infl ammatory Bowel Disease, published by NASPGHAN and CDHNF, May 20094. Marcus SB, Strople JA, Neighbors K, Weissberg-Benchell J, Nelson SP, Limbers C, Varni JW, Alonso EM. Tubulointerstitial nephritis: an extraintestinal manifestation of Crohn disease in children. Clin Gastroenterol Hepatol. 2009;7:554-61.5. Strople J, Kaul A. Pediatric gastroesophageal refl ux disease—current perspectives. Curr Opin Otolaryngol Head Neck Surg. 2003;11:447-51.

Jennifer Strople, MDAssistant Professor, Northwestern University Feinberg School of MedicineAttending Physician, Ann & Robert H. Lurie Children’s Hospital of Chicago

Faculty Members

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Dr. Wechsler completed a Pediatric Residency program at Riley Hospital for Children in Indianapolis, IN. He completed a Pediatric Gastroenterology, Hepatology, and Nutrition Fellowship at Lurie Children’s (formerly Children’s Memorial Hospital) in Chicago, IL.

Clinical interests: Eosinophilic Esophagitis and allergic bowel disordersResearch interest: Role of mast cells and their effector molecule, histamine, in the pathogenesis of gastrointestinal infl ammation.

Selected Recent Publications: 1. Smuda C, Wechsler JB, Bryce PJ. TLR-induced activation of neutrophils promotes histamine production via a PI3 kinase dependent mechanism. Immunol Lett. 2011;141:102-8. 2. Saps M, Pensabene L, Di Martino L, Staiano A, Wechsler J, Zheng X, Di Lorenzo C. Post-infectious functional gastrointestinal dis orders in children. J Pediatr. 2008;152:812-6.

Joshua Wechsler, MDInstructor, Northwestern University Feinberg School of MedicineAttending Physician, Ann & Robert H. Lurie Children’s Hospital of Chicago

Dr Whitington completed a Pediatric Residency and Chief Residency at the University of Tennessee Center for the Health Sciences in Memphis, TN. He completed Gastroenterology Fellowship at The Johns Hopkins Hospital in

Baltimore, MD and at the University of Wisconsin in Madison, WI. He has been on the academic faculty at the University of Tennessee center for the Health Sciences (1978-1984), The University of Chicago (1984-1997) and Northwestern University (1997-present).

Clinical interests: Childhood liver diseases, in particular neonatal hemochromatosis, genetic cholestasis, and biliary atresia, and pediatric liver transplantation.

Research interests: Mechanisms of liver injury in gestational alloimmune liver disease; improving diagnosis and treatment of gesta-tional alloimmune liver disease; mechanisms of liver injury and repair in cholestatic liver disease; clinical trials in biliary atresia and NAFLD/NASH.

Selected recent publications:1. Shneider BL, Magee JC, Bezerra JA, Haber B, Karpen SJ, Raghunathan T, Rosenthal P, Schwarz K, Suchy FJ, Kerkar N, Turmelle Y, Whitington PF, Robuck PR, Sokol RJ; for the Childhood Liver Disease Research Education Network (ChiLDREN). Effi cacy of fat-soluble vitamin supplementation in infants with biliary atresia. Pediatrics. 2012;130:e607-e614. 2. Debray FG, de Halleux V, Guidi O, Detrembleur N, Gaillez S, Rausin L, Goyens P, Pan X, Whitington PF. Neonatal liver cirrhosis without iron overload caused by gestational alloimmune liver disease. Pediatrics. 2012;129:e1076-9.3. Whitington PF, Pan X, Kelly S, Melin-Aldana H, Malladi P. Gestational alloimmune liver disease in cases of fetal death. J Pediatr. 2011;159:612-6.4. Omenetti A, Bass LM, Anders RA, Clemente MG, Francis H, Guy CD, McCall S, Choi SS, Alpini G, Schwarz KB, Diehl AM, Whitington PF. Hedgehog activity, epithelial-mesenchymal transitions, and biliary dysmorphogenesis in biliary atresia. Hepatology. 2011;53:1246-58.5. Syn WK, Choi SS, Liaskou E, Karaca GF, Agboola KM, Oo YH, Mi Z, Pereira TA, Zdanowicz M, Malladi P, Chen Y, Moylan C, Jung Y, Bhattacharya SD, Teaberry V, Omenetti A, Abdelmalek MF, Guy CD, Adams DH, Kuo PC, Michelotti GA, Whitington PF, Diehl AM. Osteopontin is induced by hedgehog pathway activation and promotes fi brosis progression in nonalcoholic steatohepatitis. Hepatology. 2011;53:106-15.

Peter F. Whitington, MDThe Sally Burnett Searle Professor of Pediatrics and Transplantation, Northwestern University Feinberg School of MedicineDirector, Siragusa Transplantation Center, Ann & Robert H. Lurie Children’s Hospital of ChicagoAttending Physician, Ann & Robert H. Lurie Children’s Hospital of Chicago

Faculty Members

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Sunpreet Kaur, MD Dr. Kaur graduated from SUNY Stony Brook School of Medicine in New York and completed her Pediatric Residency at Mount Sinai Medical Center in New York, NY.

Jacob Kurowski, MDDr. Kurowski graduated from The Ohio State University College of Medicine in Columbus, OH, and completed his Pediatric Residency training at Ann & Robert H. Lurie Children’s Hospital of Chicago (formerly Children’s Memorial Hospital) in Chicago, IL.

Daniel O’Connell, MDDr. O’Connell completed a combined Internal Medicine and Pediatrics Residency at the University of Michigan in Ann Arbor. He served as Pediatric Chief Resident at Michigan following his residency. He is working on a Masters in Clinical Investigation at Northwestern during his fellowship. His research interests are nutritional therapies for the treatment of GI disease and specifically gluten-free and low carbohydrate diets for irritable bowel syndrome.

Marisa Rodriguez, MD Dr. Rodriguez completed her Pediatric Residency training at Baylor College of Medicine/Texas Children’s Hospital in Houston, TX. She is currently working on a clinical research project entitled “Assessing self-efficacy in adolescents with inflammatory bowel disease”.

Akihiro Asai, MD Dr. Asai completed his Pediatric Residency training at NewYork-Presbyterian Morgan Stanley Children’s Hospital in New York, NY. He is currently working on a transplational research project entitled “The fibrogenic role of Sonic Hedgehog pathway in Gestational Alloimmune Liver Disease/ Neonatal Hemochromatosis”.

John Rosen, MD Dr. Rosen completed his pediatric residency training at NYU Medical Center in New York, NY. He is currently working on a translational research project entitled “Role of TRPV1 in Post-Infectious Chronic Abdominal Pain”.

Third Year Fellows:

Second Year Fellows:

First Year Fellows:

Gastroenterology, Hepatology and Nutrition Current Fellows

Henry Lin, MD Dr. Lin completed his Pediatric Residency training at at Ann & Robert H. Lurie Children’s Hospital of Chicago (formerly Children’s Memorial Hospital) in Chicago, IL and his Pediatric Gastroenterology Fellowship training at the Children’s Hospital of Philadelphia in Philadelphia, PA. He is currently working on research projects entitled “Humoral Mediated Liver Injury in Childhood Liver Diseases” and “Long-term Follow-up of Minimization of Immunosuppression in Pediatric Liver Transplantation”.

Fourth Year Fellow:

Current Fellows (from left to right): John Rosen, MD, Jacob Kurowski, MD, Henry Lin, MD, Akihiro Asai, MD, Daniel O’Connell, MD, and Sun-preet Kaur, MD. Not pictured: Marisa Rodriguez, MD.

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Advanced Practice Nurses

Beata Borawski, RN, MSN, APNSpecialty: General Gastroenterology, Inflammatory Bowel Disease

Ilana Lee Cabrera, RN, MSN, CPNPSpecialty: Liver transplant

Tracy Kruger, RN, MSN, CPNPSpecialty: Intestinal Rehabilitation and Transplant

Maria Manuel Rubio, RN, MSN, APN, PNPSpecialty: General Gastroenterology, Eosinophilic Esophagitis

Jessica Zimont, RN, MSN, APN/FNP-BCSpecialty: Intestinal Rehabilitation and Transplant

Gastroenterology, Hepatology and Nutrition Clinical Nursing and Nutrition Staff

Registered Nurses

Joyce Chesniak, RN, BSNSpecialty: General Gastroenterology

Amelia Cima, RN, BSNSpecialty: General Gastroenterology, Endoscopy

Theresa Cristino, RN, BSNSpecialty: General Gastroenterology

Dolores Cupuro, RN, BSNSpecialty: General Gastroenterology, Gastrointestinal Motility Disorders

Dhey Delute, RNSpecialty: Heptatology Clinical Research

Emily Ellisor, RN, BSNSpecialty: General Gastroenterology, Eosinophilic Esophagitis , Inflammatory Bowel Disease

Therese Hess, RN, BSNSpecialty: Hepatology

Sue Kelly, RN, BSNSpecialty: Heptatology Clinical Research

Cindy Riazi, RN, BSN, CPNSpecialty: Hepatology

Ronda Shaykin, RN, BSNSpecialty: General Gastroenterology, Eosinophilic Esophagitis

Clinical Nutritionists

Karin Ballard, MS, RD, LDNSpecialty: Hepatology and Liver transplant, Inpatient Gastroenterology

Sally Schwartz, RD, CSP, LDNSpecialty: Outpatient General Gastroenterology, In-flammatory Bowel Disease, Eosinophilic Esophagitis, Celiac disease

Lisa Sharda, RD, LDN, IBCLCSpecialty: Outpatient General Gastroenterology, In-flammatory Bowel Disease, Eosinophilic Esophagitis, Celiac disease

Carmyn Zoller, RDSpecialty: Intestinal Rehabilitation

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After the first year, fellows devote about 80 percent effort to research. Each fellow can choose a course of either basic or clinical research and opportunities are not limited to the resources of the Division. While there are adequate resources for research and mentorship within the division, fellows may pursue their research education in laboratories at Northwestern. The Division of Gastroenterology, Hepatology and Nutrition currently has about 60 active research projects, 26 of which have received peer review funding, and have had more than 50 peer reviewed journal articles published between January 2006 and present.

Children’s Hospital of Chicago Research CenterBasic science research occurs in the Children’s Hospital of Chicago Research Center (CHCRC). It is the only institution dedicated to pediatric research in Illinois and one of only a handful in the nation. CHCRC’s mission is to generate new knowledge leading to ad-vancements in the prevention, diagnosis, and treatment of diseases that affect the development of children through adolescence as well as adult disorders that derive from them. In 2007, the center was awarded $28.5 million in external grants and contracts, 60 percent of which came from the federal government, including the National Institutes of Health (NIH). CHCRC is one of 13 multidisciplinary centers of Northwestern University’s Feinberg School of Medicine, where principal investigators who are part of CHCRC are full time faculty members.

The laboratory facilities at CHCRC are fully equipped with standard biochemical, molecular biological, and tissue culture facilities. Each floor also has conference areas equipped with VCRs and slide projectors for teaching and lab meetings. Most laboratories at

CHCRC are outfitted with standard biochemical, molecular biological, tissue culture facilities, -20° and -80° freezers, bench top centrifuges, gel electrophoresis boxes and power supplies, tissue culture hoods and incubators, gel drying and speed vac equipment, luminometer, balances, and pH meters. CHCRC has common equipment space on each floor. Each laboratory, therefore, has ready access to isotope preparation areas, PCR preparation areas, cold rooms, centrifuge ar-eas with ultracentrifuges, and other heavy equipment. There are two labs of 250 NSF equipped for ES cell tissue culture with laminar flow hood, centrifuges, CO2 incubators, needle pullers, microforge, in-verted phase microscopes and a Leitz micromanipulator. The animal facilities are fully approved by the NIH. The animals are housed under VAF conditions using microisolator caging in laminar flow cubicles. Centralized computers control water, temperature and light cycles. Gene knockout and transgenic facilities are also located in CHCRC.

Gastroenterology and Hepatology Laboratory Staff

Dr. Wershil’s LabResearch Scientist: Ming Wang, MD

Dr. Wershil’s research interests include the role of mast cells in GI inflammation and homeostasis. This work involves the use of mouse models to investigate mast cells and mast cell mediators in a variety of inflammatory reactions, including allergic, neurogenic, and immune inflammation. The lab is also interested in the pathogenesis of eosinophilic esophagitis, and specifically the mediators that influence the pathology of the esophagus.

Research

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Barry Wershil, MD and Ming Wang, MD

Center for Intestinal and Liver Infl ammation ResearchDirector: Xiao-Di Tan, MD

The center was created in 2011 with a mission to promote a better understanding of the pathogenic mechanisms and therapies of diseases of the digestive system, in particular the immune mecha-nisms of infl ammatory diseases, transplantation and tolerance. The center is investigator-driven, consisting of a small group of dedicated, enthusiastic, and productive researchers, all of whom study the mechanisms of diseases involving the liver and intestines. They have common interests in immunology, cell signaling, and cell death as they relate to digestive diseases.

Principal Investigators: Jeffrey B Brown, MD: Pathogenesis of Infl ammatory Bowel Disease; Animal Models of IBD Valeria Cohran, MD: Epithelial Signal Transduction Pathways involved in Growth and Repair Isabelle DePlaen, MD: Pathogenesis of Necrotizing Enterocolitis Xiao-Di Tan, MD: Mechanisms of Gut Mucosal Injury and Repair Barry K Wershil, MD: Mast cell function in the gut; Mechanisms of eosinophil-mediated infl ammation Peter F Whitington, MD: Mechanism of Liver Injury; Congenital Hemochromatosis

Xiao-Di Tan, MD

Research

Dr. Whitington’s LabLab Manager: Padmini Malladi, MSResearch Associate: Xiaomin Pan, MD

Dr. Whitington and his lab are involved in translational research utilizing animal and cell-based models and molecular approaches to understand the immune mechanisms involved in the pathogenesis of neonatal hemochromatosis and biliary atresia. He is also interested in hepatocyte “survival” cell signaling involved in nutrient sensing and fatty liver disease and in the protective response to cholestasis.

Peter Whitington, MD and Padmini Malladi

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Thank you for your interest in our Fellowship Program. We accept applications through ERAS. We have two fellowship positions available each academic year, and we typically interview applicants in February, March, and April.

When submitting your application through ERAS, you will need to submit the following:1. Completed application form2. Photo3. Curriculum Vitae • Where applicable, please include the following: education, post-graduate training, additional training, work experience, honors or awards, research experience, publications, and presentations4. Personal Statement outlining your career goals in Pediatric Gastroenterology5. Three letters of recommendation • One letter should be from the pediatric department chair, residency program director, or chief of staff from the hospital in which your residency training was done • If letters are being submitted electronically, they should be sent in PDF format, signed electronically, and sent directly from the author’s email address6. USMLE Scores for Steps 1, 2, and 3 7. Copy of Medical License (if applicable)8. Medical School Transcripts (required for foreign medical graduates only)9. ECFMG (required for foreign medical graduates)

Applying to Our Pediatric Gastroenterology, Hepatology and Nutrition Fellowship Program

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