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PERSONAL DETAILS NAME: INTAN SAFINAR BINTI ISMAIL DEPARTMENT/ FACULTY: Department of Chemistry or Laboratory of Natural Products Faculty of Science Institute of Bioscience Universiti Putra Malaysia Universiti Putra Malaysia 03-89467492 03-89471490 DATE OF BIRTH/AGE: 20 January 1969/ 45 years old
SPECIALISATION: Natural products chemistry and metabolomics SPECIFIC AREA OF INTEREST: Hunting molecules having biologically active properties by using reductive or metabolomics approach.
Scientific experience
Organization
Position
Start Date
End Date
Expertise
Okayama University, Japan
Post-doctoral
Sept. 2003
Sept. 2004
Phytochemistry
Hoshi Medical University, Tokyo, Japan
Post-doctoral
Oct. 2008
Jan. 2009
Natural products chemistry
Academic Qualification
Certificate / Qualification obtained
Name of School / Institution
Year obtained
Area of Specialization
Ph.D Okayama University, Japan
2003 Natural Products Chemistry
M.Sc. University Putra Malaysia
1997 Natural Products Chemistry
B.Sc. Creighton University, USA
1992 Chemistry
2
PREVIOUS ACADEMIC AND OTHER RELEVANT APPOINTMENTS
Employment
Employer Designation Department Start Date Date Ended
Universiti Putra Malaysia
Associate professor
Dept. of Chemistry, Faculty of Science
1 June 2013
Present
Universiti Putra Malaysia
Senior Lecturer Dept. of Chemistry, Faculty of Science
1 August 2005
30 May 2013
University Sains Malaysia, Penang
Lecturer School of Pharmaceutical Sciences
1 Dec 2004
30 June 2005
Mustajab Ind., (Nona Roguy) Kedah
R and D Chemist
R and D April 1998- March 1999
RAZA Manufacturing Bhd., (Pharmaniaga Bhd.) Selangor
R and D Executive
R and D July 1996
March 1998
SM Pharmaceutical Bhd., Kedah
Quality Control Chemist
QC Dept. Aug. 1993
Oct. 1994
TEACHING EXPERIENCE
Lecturer [2005 – Present] Teach courses of Starting School Training for fresh graduates, Organic Chemistry I, II, III, IV and Spectroscopy for undergraduates, Chromatography for postgraduates, and Bridging for laboratory assistants and officers in Universiti Putra Malaysia.
COURSES THOUGHT THROUGHOUT ACADEMIC CAREER YEAR 2005/2006
Code/ Course
Semester
Credit hour/ actual credit
No. of
students
Student assessment
CHM 3202/ Organic Chemistry II
I
4 (3+1)/2
90
4.01
3
CHM 3202/ Organic Chemistry II
II
4 (3+1)/3
68
4.10
CHM 3204/ Organic Chemistry IV
II
3 (2 +1)/1
51
4.47
CHM4999/ Final Year Project
I & II
0.5
2
-
YEAR 2006/2007
Code/ Course
Semester
Credit hour/ actual credit
No. of
students
Student assessment
CHM 3201/ Organic Chemistry I
I
4 (3+1)/4
100
4.11
CHM 3201/ Organic Chemistry I
II
4 (3+1)/3
84
4.45
Coordinator: CHM4999/ Final Year Project
I & II
3
198
-
CHM4999/ Final Year Project
I & II
0.5
6
-
YEAR 2007/2008
Code/ Course
Semester
Credit hour/ actual credit
No. of
students
Student assessment
CHM 3201/ Organic Chemistry I
I
4 (3+1)/4
52
3.82
Coordinator: CHM 3202/ Organic Chemistry II
I
3 (2 +1)/1
61
-
4
CHM 3201/ Organic Chemistry I
II
4 (3+1)/3
74
4.35
CHM4999/ Final Year Project
I & II
0.5
7
-
YEAR 2008/2009
Code/ Course
Semester
Credit hour/ actual credit
No. of
students
Student assessment
Coordinator: CHM 3201/ Organic Chemistry I
I
4 (3+1)/3
61
3.86
CHM 3204/ Organic Chemistry IV
II
3 (2 +1)/1
49
4.65
CHM 3201/ Organic Chemistry I
II
4 (3+1)/3
66
4.33
CHM4999/ Final Year Project
I & II
0.5
5
-
Sabbatical leave study at Hoshi University, Tokyo, Japan (October 2008 until January 2009)
YEAR 2009/2010
Code/ Course
Semester
Credit hour/ actual credit
No. of
students
Student assessment
Sabbatical leave study at Hoshi University, Tokyo, Japan (October 2008 until January 2009)
CHM 3201/ Organic Chemistry I
I
4 (3+1)/3
50
3.96
5
CHM 3402/ Spectroscopy in Chemistry
II
3 (2 +1)/1
39
4.37
CHM 3201/ Organic Chemistry I
II
4 (3+1)/4
56
4.47
CHM4999/ Final Year Project
I & II
0.5
3
-
Starting School
I
32
4.67
YEAR 2010/2011
Code/ Course
Semester
Credit hour/ actual credit
No. of
students
Student assessment
CHM 3201/ Organic Chemistry I
I
4 (3+1)/4
80
4.25
CHM 3203/ Organic Chemistry III
I
3 (2+1)/1
30
4.67
CHM 5402/ Chromatography
II
1
33
4.69
CHM 3201/ Organic Chemistry I
II
4 (3+1)/4
65
-
CHM4999/ Final Year Project
I & II
0.5
5
-
YEAR 2011/2012
Code/ Course
Semester
Credit hour/ actual credit
No. of
students
Student assessment
6
CHM 3201/ Organic Chemistry I
I
4 (3+1)/3
88
4.30
CHM 3203/ Organic Chemistry III
I
3 (2+1)/1
60
4.44
CHM 3202/ Organic Chemistry II
II
4 (3+1)/4
54
4.81
CHM4999/ Final Year Project
I & II
0.5
1
-
YEAR 2012/2013
Code/ Course
Semester
Credit hour/ actual credit
No. of
students
Student assessment
CHM 3202/ Organic Chemistry II
I
4 (3+1)/3
36
4.45
CHM4999/ Final Year Project
I
0.5
3
YEAR 2013/2014
Code/ Course
Semester
Credit hour/ actual credit
No. of
students
Student assessment
CHM 3201/ Organic Chemistry I
I
4 (3+1)/3
66
4.21
CHM 3202/ Organic Chemistry II
I
4 (3+1)/1
36
4.49
CHM 5201/ Spectroscopy
I 3/1 13 -
CHM 3201/ Organic Chemistry I
II
4 (3+1)/3
33
7
LANGUAGE PROFICIENCY Proficiency in Bahasa Malaysia : C3 (SPM) Proficiency in English : C5 (SPM)
585 (TOEFL/ 1991) Proficiency in Japanese : Passed (Level 2)
ADMINISTRATION DUTIES & OTHER RESPONSIBILITIES 1. Administration
Head of Laboratory Laboratory of Natural Product
Institute of Biosciences Universiti Putra Malaysia Feb. 2012-
present
Acting Head of Laboratory Laboratory of Natural Product Institute of Biosciences Universiti Putra Malaysia Nov. 2011-
Jan. 2012
Acting Head of Laboratory Laboratory of Natural Product Institute of Biosciences Universiti Putra Malaysia May-June
2007
Associate Member Laboratory of Natural Product Institute of Biosciences Universiti Putra Malaysia 2005- present
Jawatankuasa Teknikal Penilaian Sebutharga atau Tender 2012/2013 Institute of Bioscience, UPM
Committee Member Curriculum for Organic Chemistry 2011-present Dept. of Chemistry, Faculty of Science, UPM
Advisor Student Chemistry Club 2011-present Dept. of Chemistry, Faculty of Science, UPM
Committee Member Kelab Pegawai Jabatan Kimia 2008-2010 Faculty of Science, UPM
Committee Member Penuntukuran dan Perlupusan 2007-2009 Faculty of Science, UPM
8
Committee Member Infosains Faculty Bulletin 2007-2009 Faculty of Science, UPM
Internal Auditor MS ISO Faculty of Science, UPM 2007-2008
Committee Member Publisiti Faculty of Science, UPM 2006-2008
Editorial Member Infosains (Faculty of Science Bulletin) Faculty of Science, UPM 2006-2008
2. Other responsibilities
Internal Examiner, MSc. and PhD Thesis Examination [2006 – present]
Examiner, Final Year Scientific Project Presentation [2006 – present]
Advisor, Workshop on Quorum Sensing, Laboratory of Natural Products, IBS, UPM [11-12 April, 2013]
Chairperson, Workshop on Basic Chromatography, Laboratory of Natural Products, IBS, UPM [27-28, August 2013]
Advisor, Hari Integrasi Fakulti Sains 2012, Dept. of Chemistry, Faculty of Science, UPM [December 2012]
Bursar of the Organizing Committee, International Conference in Natural Products, Laboratory of Natural Products, Institute of Bioscience, UPM [November 2012]
Bursar of the Organizing Committee, Workshop on Metabolomics 2012, Laboratory of Natural Products, Institute of Bioscience, UPM
[26 June- 4 July 2012]
Facilitator, Workshop on Metabolomics 2012, Laboratory of Natural Products, Institute of Bioscience, UPM
[26 June- 4 July 2012]
Tenaga Pengajar, Kursus Peralihan Pembantu Makmal Tahap 3 Sesi 2- 2010/2012
Organizing Committee, International Symposium of Women in Science and Engineering, Institut Kimia Malaysia. [29-30 September 2011]
Chairperson of a session, International Symposium of Women in Science and Engineering, Institut Kimia Malaysia.
[30 September 2011]
Chairperson of the Organizing Committee, Workshop on Metabolomics 2011, Laboratory of Natural Products, Institute of Bioscience, UPM
[26-27 July 2011]
Judge, Seminar Kimia Industri Ke-15, Dept. of Chemistry, Faculty of Science, UPM [11 May 2011]
PETUGAS BOOTH FAKULTI SAINS BERSEMPENA PESTA KONVOKESYEN DAN EKSPO PERTANIAN UPM KE 35-2011
9
Organizing Committee, UK-Malaysia Symposium on Cancer Drug Discovery & Development [2009-2010]
Secretary of the Organizing Committee, International Workshop on Metabolomics 2010: Basics and Applications in Plant Sciences [12-14 October 2010]
Judge, Seminar Kimia Industri Ke-14, Dept. of Chemistry, Faculty of Science, UPM [10 April 2010]
Organizing Committee, Acara Sukan Rakyat, Bulan Kualiti, Fakulti Sains, UPM [7 Dec 2009]
Deputy Secretary of the Organizing Committee, Seminar Kimia Industri Ke-11, Dept. of Chemistry, Faculty of Science, UPM [28 April 2007]
Secretary of the Organizing Committee, Seminar Kimia Industri Ke-12, Dept. of Chemistry, Faculty of Science, UPM [May 2008]
Chairperson of the Organizing Committee, Hari Keluarga, Dept. of Chemistry, Faculty of Science, UPM [2008]
RESEARCH ACTIVITIES (a) Ongoing Research
Project Title Role Year Source of fund
Status
Metabolomics Approach in Identifying Anticholesterolemic Agents of Mentha piperita (Peppermint)
Project leader
2013 MOHE RM99,000 (May 2015)
NMR-and IR-Metabolomics Approach in Identifying Anti-Pathogen Markers of Andrographis paniculata (Hempedu Bumi)
Project leader
2012 MOHE RM81,000 (Aug. 2014)
Correlation Between the Chemical Profile of Orthosiphon stamineus Leaf Extracts and Their Diuretic, Nephroprotective and Anti-Diabetic Activities using NMR- and FTIR-Based Metabolomics Approach
Project leader
2011 Ministry of Agriculture (MOA)
RM551,900 (June 2014)
NMR-based metabolomics Fingerprinting and Profiling of Andrographis paniculata Varieties and Biofluids (Animal Metabolic Study) in the Detection of Biomarker in Diabetic Induced Rats.
Co-worker
2011 MOA RM448,200 (2013)
MS and NMR-Based Metabolomics Analysis of
Co-worker
2012 MOA RM317, 600 (2014)
10
Phyllanthus niruri extract and biofluids (Animal Metabolic Study) for Detection of Biomarker in Diabetic Induced Rats
11
(b) Past Research Project
Project Title Role Year Source of fund
Amount (RM)
Publication
Anti-cholinesterase and melanin promoter properties of Dysoxylum acutangulum
Project leader
2010-2012
MOHE 43,200 1 – published
Anti-cholinesterase and ichthyotoxicity of Walsura chrysogyne
Project leader
2009-2011
RUGS 129,000 2- published
Characterization of bioactive constituents from several Myrtaceous plants based on ichthyotoxicity test.
Project leader
2007-2009
MOSTI 256,504 2- published
Synthesis and bioactivity studies on the analogues of selected natural oleanan-type triterpenoids from Sandoricum koetjape (Burm. f.) Merr.
Project leader
2006-2008
FRGS RM 73,000
Ichthyotoxicity properties and characterization of anthocyanin from Syzygium malaccense (jambu bol).
Project leader
2005-2006
Skim Penyelidikan Pensyarah Lantikan Baru
10,000 1-published
Chemical characterisation, standardization and biological evaluation of Melicope ptelefolia (Setenggek Burung) and Bacopa monniera (Beremi) towards their development into nutraceuticals products for the prevention of life style diseases .
Co-worker
2007- 2009
IFNM RM1.5 M 5-published
Isolation and identification of bioactive saponins from Xenospermum noronhianum, a Malaysian Sapindaceae.
Co-worker
2007-2009
MOSTI 2-published
12
SUPERVISION OF STUDENTS
MAIN SUPEVISOR Ph. D Program
No.
Student
Study title
Field
Year
1 Nalisha Ithnin Metabolomics Based Profiling of Oil Palm Ganoderma Interaction Utilizing LC-MS and NMR
Metabolomics
2009-present
2 Raghunath Pariyani
Correlation Between the Chemical Profile of Orthosiphon stamineus Leaf Extracts and Their Diuretic, Nephroprotective Activities Including the Histological Studies on Rats Kidney using NMR-Based Metabolomics Approach
Metabolomics
2010-present
3 Ilya Iryani Mahmod
Correlation Between the Chemical Profile of Orthosiphon stamineus Leaf Extracts and Their In Vitro Anti-diabetic and Nephroprotective Activities using IR and NMR-Based Metabolomics Approach
Metabolomics 2012-present
Master Program
No.
Student
Study title
Field
Year
1 Lee Wei Har
Photodynamic therapy (PDT) and ichthyotoxicity properties of Sygyzium polyanthum (Myrtaceae) leaves
Phytochemistry Graduated
2 M. Izwan M. Lazim
Dysoxylum acutangulum (Meliaceae): constituents and bioactivities
Phytochemistry Graduated
3 Ilya Iryani Mahmod
Anti-cholinesterase and ichthyotoxicity of Walsura chrysogyne
Phytochemistry Graduated
4 Low Kok Wah Dysoxylum grande as a Source of Constituents and Bioactivities
Phytochemistry Graduated
13
5 Nur Athifah Yusof
IR-Metabolomics Approach in Identifying the Anti-Pathogen Markers of Andrographis Paniculata (Hempedu Bumi)
Metabolomics
2010-present
6 Nur Zaini Johari
Metabolomics Approach In Identifying Anticholesterolemic Agents of Peppermint (Mentha piperita L.) extract
Metabolomics
2012-present
7 Muhammad Safwan Ahamad Bustamam
Stability-storage conditions of Algerian Nigella sativa antimicrobial constituents using metabolomics approach
Metabolomics
2012-present
8 Nor Nadiah Abdul Rashid
Formation of nanoemulsions using betulinic acid as anticancer drug
Synthesis
Completed
9 Hamisu Abdu Glycosidation of betulinic acid using enzymes
Synthesis Completed
10 Amalina Ahmad Azam
Metabolomics approach of antidiabetic Orthosiphon stamineus in STZ induced diabetic rat
Metabolomics
2012-present
CO-SUPEVISOR Ph. D Program
No.
Student
Study title
Status
1 Khairana binti Husain Bioassay-Guided Isolation of Compound from Anaxagorea Javanica (Annonaceae) and Lasiathus oblongus (Rubiaceae) For Anti-Infammatory Activity In-Vitro
Graduated
2 Madana Behbahani Antioxidant And Anti-Inflammatory Activities Of Leaves, Calli And Cell Suspension Of Barringtonia racemosa
Graduated
3 Tan Pei Jean Phytochemical And Biological Studies On Xerospermum noronhianum
Graduated
4 Loh Khye Er Potential of neem leaf-empty fruit bunch-based vermicompost as biofertiliser-cum-biopesticide
Graduated
5 Umar Lawal Discrimination of Ipomoea variaties and determination of biological
On-going
14
activities based on chemometry of 1H Nuclear Magnetic Resonance spectroscopy
6 Tan Sook Kuan On-going
7 Bukhary Zainal Physico-chemical characterization of hydro-cooled rockmelon after storage
On-going
8 Ahmed Mediani Metabolomics approach to identifying antidiabetic compounds of Phyllanthus niruri and the detection of biomarkers in diabetic induced rats
On-going
9 Ahmad Razi Othman Mode of action of bioactive compound(s) in Jatropha curcas L. roots in anti-inflammation activity
On-going
10 Samira Yousefi Preparation of 5-amino salicylic acid glycol-conjugates via enzymatic esterification
On-going
Master Program
No.
Student
Study title
Status
1 Yeap Soo Fong The Chemical Constituents of Artocarpus Species And Their Biological Activities
Graduated
2 Sadikah Ahmad Phytochemical And Bioactivity Studies of Acacia And Mangifera pajang
Completed
3 Halimatul Saadiah Mohammad Noor
Phytochemical And Bioactivities Studies On Bauhinia thonningii And Curcuma mangga
Completed
4 Khairul Nazri Yusof Phytochemical Analysis Of Selected Malaysian Plants
Completed
5 Abdoulie Ceesay Semi-Polar Saponins of Various Diversity As Spectrum To Exhibit Antibacterial Activity
Graduated
6 Armania Nurdin Isolation Of Bioactive Compound(S) From ‘Lsy’ Plant And Their Cytotoxic Activity Towards Cancer Cell Lines
Graduated
7 Nawwar Fathiah Mohd Fauzi
Synthetic Studies Towards Atranone F: Synthesis Of The A- And B- Lactone Rings Via Radical Cyclisation Approach
Graduated
8 Nazihah Mohd Salehan
Characterization Of Chemical Constituents Of Cosmos caudatus Kunth And Determination Of Its Pesticidal Effects On Plant Pathogens
Graduated
15
9 Muhammad Abubakar Ado
Phytochemical and Bioactivities Of Cynometra and Calicapa mangayi Leaves
On-going
10 Hazwani binti Mohd Rani
Lycopodium Alkaloid : Structural Chemistry And Anticholinesterase Activity
On-going
11 Noratiqah Abd Hamid Identification of Bioactive compound Beneficial for Skin Care Formulation in Germinated Rough Rice, Germinated Brown Rice and Brewers.
On-going
12 Nurliyana Salikin Metabolomics of Antimicrobial Compounds from Endophytic Fungi for Controlling Anthracnose Disease in Dragon Fruit
On-going
13 Khairunnisa Azni Antinociceptive Activities of Methanol Syzygium polyanthum Extract in Mice and Its Mechanism of Action
On-going
14 Haslina Abdul Kadir GC-MS/MS for simultaneous determination of pesticide residues in tea
On-going
15 Nur Ashikin Abdul Hamid
Relationship between the chemical profile of date palm fruit (Phoenix dactylifera L.) extract and biological activities elucidated by NMR-based metabolomics
On-going
Supervisor for Undergraduates (Final Year Project)
No.
Student
Project title
Year
1 Rohaida Daud Identification of ichthyotoxic properties of Plumeria rubra and its flower’s essential oils
2005/6
2 Ahmad Ridhwan Sahrom
Identification of ichthyotoxic properties and anthocyanin contents of Syzygium malaccense
2005/6
3 Mazuriah Abu Darin
Ichthyotoxicity of Selected Herbs 2005/6
4 Mohd Khairulniza Mansor
Isolation of Oleanen-Type Triterpenoids for Sandoricum koetjape
2006/7
5 Ng Wee Siong
Isolation and Identification of Icthyotoxic Compounds from Hexane Extract of Syzygium malaccense Leaves
2006/7
6 Ooi Choo Tian Malaysian Dye & Tannin Producing Plants With Photodynamic Therapy (PDT) Activity.
2006/7
7 Low Kok Wah Isolation and Identification of ichthyotoxic compound from hexane extract of Syzygium malaccense fruits
2006/7
8 Hasniza Md Zan Oleanane type triterpenoid from 2006/7
16
Sandoricum koetjape
9 Norakmar Ismail Characterization of ichthyotoxic fractions/compounds from Syzygium polyanthum (Myrtaceae)
2006/7
10 Felicia Gatun Identification of some compounds from the leaves of Rhodomyrtus tomentosa (Myrtaceae)
2007/8
11 Khoo Jing Hui Identification of some compounds from Syzygium polyanthum (Myrtaceae)
2007/8
12 Lai Kian Leak
Identification of Some Compounds From Hexane Fraction of Syzygium malaccense Leaves
2007/8
13 S.M. Shahrul Nizan b. Shikh Zahari
Ichthyotoxicity of Rhodamnia cinerea leaves (Myrtaceace)
2007/8
14 Tan Qian Hui PDT agent from leaves hexane fraction of Syzygium polyanthum
2007/8
15 Mohd Yazid Rosli Ichthyotoxicity of Rhodamnia cinerea bark (Myrtaceae)
2007/8
16 Santi Sakaran Characterization of triterpenoid from various batches of Sandoricum koetjape barks
2007/8
17 Mohd Azmir B. Ishak
Study on Elaeocarpus petiolatus 2008/9
18 Zulfusarin Bin Amir
Phytochemical study on leaves of Walsura chrysogyne
2008/9
19 Suhanaz binti Mohamad
Identification of Compounds from Hexane Fraction of Syzygium malaccense Leaves
2008/9
20 Syafiqah bt. Mohd Radzi
Study on two medicinal plants. 2008/9
21 Farhana Khalid Studies of Constituents From Ethyl Acetate of Syzygium malaccense Barks
2008/9
22 Nuraini Jamil Constituents of Syzygium polyanthum leaves hexane fraction
2009/10
23 Suzilawaty Azrin Mohd Ahzaman
Phytochemical study of Chisocheton ceramicus (Meliaceae)
2009/10
24 Nur Azila Ag.Sarin
Phytochemical study of Syzygium malaccense leaves
2009/10
25 Nor Azwa Norazmi
Phytochemical study of Walsura chrysogyne barks
2009/10
26 Muhammad Allif Suyut
Optimization of extraction method for Andrographis paniculata
2010/11
27 Malisa Diana Ulul Azmi
Total phenolics of Syzygium malaccense plant parts
2010/11
28 Nur Amalina Kamludin
Total phenolics of Syzygium polyanthum plant parts
2010/11
29 Azlinda Zainal Potential biosurfactant from Acanthaster planci (Crown of Thorns)
2010/11
30 Nur Hafizah Determination of total flavonoids in 2010/11
17
Mahamad Raffek
Syzygium malaccense and Syzygium polyanthum leaves.
31 Suhaili Sarjidi Toxicity of Ganoderma boninense 2011/12
32 Norsuhaili Kamairudin
Ichthyotoxicity of Different Solvent Extractions of Clinachantus nutans
2012/13
33 Che Naszlly Che Yunus
Antimicrobial Properties Related Stability of Nigella sativa
2012/13
34 Charis Tan Ern Hui
Antimicrobial Properties of Acmella uliginosa.
2012/13
35 Heng 2013/14
36 Khairul Amree 2013/14
37 Rabiatul Adawiyah
2013/14
38 Hafizah 2013/14
18
PUBLICATIONS * Corresponding author (a) PUBLISHED OR ACCEPTED MANUSCRIPTS
1. Molecular docking analysis of Curcumin analogues as Human neutrophil elastase (HNE) inhibitors. Radhakrishnan Narayanaswamy*, Lam Kok Wai, Faridah Abas and Intan Safinar Ismail. Bangladesh Journal of Pharmacology, 9: 77-82 (2014)
2. Cosmetic potential of Southeast Asian herbs-An Overview. Radhakrishnan
Narayanaswamy, Yaya Rukayadi, Khozirah Shaari, Faridah Abas and Intan Safinar Ismail*
3. IR- Metabolomics Approach in Detecting Changes of Andrographis paniculata
Metabolites due to Different Harvesting Ages and Times. Nur A’thifah Yusof, Azizul Isha, Intan Safinar Ismail*, Alfi Khatib, Khozirah Shaari, Faridah Abas, Yaya Rukayadi. Metabolomics
4. Stability on Storage Conditions of Algerian Nigella sativa Muhammad
Safwan Ahamad Bustamam, Intan Safinar Ismail *, Faridah Abas and Yaya Rukayadi, Khozirah Shaari, Nordin Lajis. Journal of Agricultural and Food Chemistry
5. Acute toxicity study and 1H NMR Metabolomic evaluation on
hypocholesterolemic properties of the aqueous extract of Mentha piperita in Wistar rats Nor Zaini Johari, Intan Safinar Ismail*, Mohd. Roslan Sulaiman, Faridah Abas, Khozirah Shaari
6. Effect of Cosmos caudatus Kunth Leaves On The Lipid Profile Of A
Hyperlipidemia-Induced Animal Model. Vikneswari Perumal, Azizah Abdul Hamid, Amin Ismail, Khozirah Saari, Faridah Abas, Intan S Ismail, H Maulidiani and Nordin H Lajis. Journal of Food Chemistry and Nutrition
7. Leaf Phenolics as an Indicator of Asymptomatic Ganoderma Infection in Oil
Palm Seedlings. Nalisha Ithnin, Intan Safinar Ismail, Khozirah Shaari, Alfi Khatib, Tony Ooi Eng Keong, Leona Daniela Jeffery Daim and Hirzun Mohd Yusof.
8. Systemic response to basal stem rots disease in oil palm seedlings. Nalisha
Ithnin, Tony Ooi Eng Keong , Leona Daniela Jeffery Daim , Hirzun Md Yusof and Intan Safinar Ismail
9. Metabolite discrimination of different varieties of Phoenix dactylifera L. by 1H
NMR-based metabolomics. Nur Ashikin Abdul Hamid, Faridah Abas, Intan Safinar Ismail, Khozirah Shaari and Nordin Hj Lajis.
10. Discrimination of Nigella sativa from four different countries of origin and the
use NMR fingerprints for determination of the origin of unknown samples.
19
Maulidiani, Intan Safinar Ismail, Faridah Abas, Bassem Y. Sheikh, Nordin H. Lajis
11. GC-MS-based metabolite profiling of Cosmos caudatus leaves possessing
alpha-glucosidase inhibitory activity. Javadi, Neda; Abas, Faridah; Abd Hamid, Azizah; Simoh, Sanimah; Shaari, Khozirah; Ismail, Intan Safinar; Mediani, Ahmed; Khatib, Alfi. Journal of Agricultural and Food Chemistry
12. Chemical profile and antiacetylcholinesterase, antityrosinase, antioxidant and
alpha-glucosidase inhibitory activity of Cynometra cauliflora L. leave. Ado, Muhammad; Abas, Faridah; Ismail, Intan Safinar; M. Ghazali, Hasanah; Shaari, Khozirah. Journal of the Science of Food and Agriculture
13. Fucoidan: Versatile cosmetic Ingredient-An Overview. Radhakrishnan
Narayanaswamy*, Byung-Wook Jo, Soo-Kyung Choi and IntanSafinar Ismail (2013). Journal of Applied Cosmetology, 31, 133-140 (2013)
14. Photoprotective and Anti-ageing Properties of Zanthoxylum rhetsa – An In
vitro Analysis. Rameshkumar Santhanam, Syahida Ahmad, Faridah Abas, Intan Safinar Ismail, Yaya Rukayadi and Khozirah Shaari. Journal of Chemical and Pharmaceutical Research, 5(12):1512-1520 (2013)
15. Larvicidal Carbazole Alkaloids from Murraya koenigii Against Dengue Fever
Mosquito Aedes aegypti Linnaeus. MA Sukari, HS Noor, NH Abu Bakar, GCL Ee, IS Ismail, M. Rahmani and A.B. Abdul. Asian Journal of Chemistry, 25(14), pp 7719-7721 (2013)
16. Molecular docking analysis of natural compounds as Human neutrophil
elastase (HNE) inhibitors. Radhakrishnan Narayanaswamy, Lam Kok Wai and Intan Safinar Ismail*. Journal of Chemical and Pharmaceutical Research, 5(10):337-341 (2013)
17. Characterization of Bactrocera dorsalis (fruit fly) Emergence Inhibitor from
Neem Leaf-Empty Fruit Bunch-Based Vermicompost using Metabolomics Approach. Loh Khye Er, Nor Azwady Abd. Aziz, Intan Safinar Ismail, Alvin Hee Kah Wei, Muskhazli Mustafa and Kok Ho Yin. Acta Biologica Malaysiana 2(2): 54-63 (2013)
18. Dillenia suffruticosa exhibited antioxidant and cytotoxic activity through
induction of apoptosis and G2/M cell cycle arrest. Nurdin Armania, Latifah Saiful Yazan, Siti Noorhidayah Musa, Intan Safinar Ismail, Jhi Biau Foo, Chan Kim Wei, Husain Noreen, Abdul Hamid Hisyam, Said Zulfahmi, Maznah Ismail. Journal of Ethnopharmacology 146: 525-535 (2013)
19. Antifungal activity of Cosmos caudatus Kunth extracts against seven
economically important plant pathogens. Nazihah Mohd Salehan, Sariah Meon, Intan Safinar Ismail. International Journal of Agriculture and Biology 15(5): 864-870 (2013)
20
20. Dillenia suffruticosa extract inhibit proliferation of human breast cancer cell lines (MCF-7 and MDA-MB-231) via induction of G2/M arrest and apoptosis. Nurdin Armania, Latifah Saiful Yazan, Intan Safinar Ismail, Foo Jhi Biau, Tor Yin Sim, Ishak Nursyafini, Norsharina Ismail, Maznah Ismail. Molecules 18, 13320-13339; doi:10.3390/molecules181113320 (2013)
21. Terpenes of Walsura chrysogyne, Meliaceae. Ilya Iryani Mahmod, Emilia
Abdul Malek, Hiroshi Morita, Charles Santhanaraju and Intan Safinar Ismail*. Letters in Organic Chemistry 10(8): 584-589 (2013)
22. Optimization of extraction method and qualitative FT-NMR analysis of
Andrographis paniculata leaves. Azizul Isha, Mohamad Allif Suyut, Nur A’thifah Yusof, Siti Nurulhuda Mastuki & Intan Safinar Ismail*. International Journal of Food Science & Technology. 3(4):1-10 (2013)
23. Synthesis of Nitrogen-Substituted Pyran-2-onesvia Radical Cyclisation
Approach. Siti Mariam Mohd Nor, Nawwar Fathiah Mohd Fauzi and Intan Safinar Ismail. International Journal of Education and Research. 1(6): 1-8 (2013)
24. Chrotacumines E and F, Two New Chromone Alkaloid Analogues from
Dysoxylum acutangulum (Meliaceae) Leaves. M. Izwan M. Lazim, Intan S. Ismail*, Khozirah Shaari, Jalifah A. Latip, Nabil Ali-Naji and Hiroshi Morita. Chemistry and Biodiversity 10: 1589-1596 (2013)
25. Quantitative HPLC Analysis of Benzene Derivatives of Melicope ptelefolia
Leaves. Seema Zareen, Intan Safinar Ismail*, Khozirah Shaari, Khairul Nazri Yusof and Muhammad Nadeem Akhtar. International Journal of Food Properties 16:1830–1838 (2013)
26. Phase Behaviour of Ternary System: Soybean Oil/Non-ionic
Surfactants/Deionized Water. Nur Nadiah Abdul Rashid, Faujan B.H. Faujan, Siti Salwa Abdul Gani, and Intan Safinar Ismail*. Asian Journal of Chemistry 25(9): 4929-4931 (2013)
27. Steroids from Dysoxylum grande (Meliaceae). Low Kok Wah, Faridah Abas,
Geoffrey A. Cordell, and Intan Safinar Ismail*. Steroids 78: 210–219 (2013).
28. Vasorelaxant Activity of Indole Alkaloids from Tabernaemontana dichotoma. Kazumasa Zaima, Ikumi Koga, Nobuhide Iwasawa, Takahiro Hosoya, Yusuke Hirasawa, Toshio Kaneda, Intan Safinar Ismail, Nordin Hj Lajis and Hiroshi Morita. Journal of Natural Medicines 67: 9-16 (2013).
29. Novel sesquiterpene and copyrine alkaloids from Anaxagorea javanica
Blume. Khairana Husain, Nordin H. Lajis, Khozirah Shaari, Intan Safinar Ismail, Daud A. Israf, Christian Paetz. Phytochemistry Letters 5: 788-792 (2012)
30. Spectroscopic Data of 3-O--D-Glucopyranoside-betulinic Acid: An Anti-cancer agent. Hamisu Abdu, Faujan H Ahmad, M. Basri, Intan Safinar
21
Ismail and M. B. Abdul Rahman. International Journal of Chemistry 4(5) 28-34 (2012)
31. Potential of neem leaf-empty fruit bunch-based vermicompost as biofertiliser-
cum-biopesticide: I – Chemical properties, humic acid content and enzymes (protease and phosphatase) activity in vermicompost. Loh, Khye Er; Abd Aziz, Nor Azwady; Kok, Ho Yin; Mustafa, Muskhazli; Ismail, Intan Safinar; Mohd Zainudin, Nur Ain Izzati. Scientific Research and Essays 7(42) 3657 –3664 (2012)
32. Two New Phloroglucinol Derivatives and Five Photosensitizing
Pheophorbides from Syzygium polyanthum (Salam) Leaves. Lee Wei Har, Intan Safinar Ismail*, Khozirah Shaari, Lee Hong Boon, Hideyuki Ito and Fadzly A. Kamaruzaman. Natural Products Communication, 7(8) 1033-1036 (2012)
33. Antioxidant activity, total phenolics and total flavonoids of Syzygium
polyanthum leaves. Lee Wei Har and Intan Safinar Ismail*. International Journal of Medicinal and Aromatic Plants, 2(2) 219-228 (2012).
34. Biodiversity and Adaptability of Holothuria leucospilota and Stichopus
japonicus Sea Cucumber Species in Artificial Environment. Abdoulie Ceesay, Mariana Nor Shamsudin, Norfarrah Mohammed Alipiah and Intan Safinar Ismail. Journal of Aquaculture Research and Development, doi:10.4172/2155-9546.1000123, (2012).
35. Betulinic Acid Glycosides: A Review. Hamisu Abdu, Faujan H Ahmad and
Intan Safinar Ismail. Oriental Journal of Chemistry 28 (3): 1123-1133 (2012).
36. Antimalarial Activity of Selected Malaysian Medicinal Plants. Rusliza Basir,
Kit Lam Chan, Mun Fei Yam, Fauziah Othman, Wan Omar Abdullah, Mohamad Aris Mohd Moklas, Aisyah Saad Abdul Rahim, Intan Safinar Ismail, Mohamad Taufik Hidayat, Che Norma Mat Taib and Roziahanim Mahmud. Phytopharmacology, 3(1) 82-92, (2012).
37. Bioassay-guided Identification of an Anti-inflammatory Prenylated
Acylphloroglucinol from Melicope ptelefolia and Molecular Insights into its Interaction with 5-lipoxygenase. Khozirah Shaari, Velan Suppaiah, Lam Kok Wai, Johnson Stanslas, Bimo Ario Tejo, Daud Ahmad Israf, Faridah Abas, Intan Safinar Ismail, Nor Hasifi Shuaib, Seema Zareen and Nordin Hj. Lajis. Bioorganic and Medicinal Chemistry, 19 (21): 6340-6347 (2011).
38. 20S,24S-epoxy-25-hydroxy-A-homo-4-oxadammaran-3-one (Chrysura) from
the Leaves of Walsura chrysogyne. Ilya Iryani Mahmod, Huey Chong Kwong, Mohamed Ibrahim Mohamed Tahir and Intan Safinar Ismail*. Acta Cryst. E67, o3296 (2011).
39. New Vasorelaxant Indole Alkaloids, Villocarines A–D from Uncaria villosa.
Hirotaka Matsuo, Ryuichi Okamoto, Kazumasa Zaima, Yusuke Hirasawa,
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Intan Safinar Ismail, Nordin Hj Lajis, Hiroshi Morita. Bioorganic & Medicinal Chemistry, 19, 4075–4079 (2011).
40. Ichthyotoxic Properties and Essential Oils of Syzygium malaccense
(Myrtaceae). Intan S. Ismail*, NorAkmar Ismail, and Nordin Lajis. Pertanika J. Sci & Technol., 18, 1-6 (2010).
41. Acutaxylines A and B, Two Novel Triterpenes from Dysoxylum acutangulum.
Intan Safinar Ismail, Yuta Nagakura, Yusuke Hirasawa, Takahiro Hosoya,
Mohd Izwan Mohd Lazim, Nordin Hj Lajis, and Hiroshi Morita. Tetrahedron Letters, 50, 4830-4832 (2009).
42. Chrotacumines A–D, Chromone Alkaloids from Dysoxylum acutangulum.
Intan Safinar Ismail, Yuta Nagakura, Yusuke Hirasawa, Takahiro Hosoya,
Mohd Izwan Mohd Lazim, Nordin Hj Lajis, Motoo Shiro, and Hiroshi Morita. J. Nat Pro.,72, 1879-83 (2009).
43. Bidesmosidic Oleanane Saponins from Xerospermum noronhianum. Tan Pei
Jean, Khozirah Shaari, Christian Paetz, Intan Safinar Ismail, Faridah Abas, Nordin H. Lajis and Viqar Uddin Ahmad. Helvetica Chimica Acta, 92,1973-1982 (2009).
44. Flavonoid Glycosides and Benzoic Acid Derivatives from Xerospermum
noronhianum. Tan Pei Jean, Intan Safinar Ismail, Faridah Abas, Nordin Hj.Lajis and Khozirah Shaari. ACGC Chem. Res. Comm., 22, 61-64 (2008).
45. An Ichthyotoxic Procyanidin Oligomer and Four New Hydroxy Acid
Conjugates from the Leaves of Sandoricum koetjape. Intan S. Ismail*, Hideyuki Ito and Takashi Yoshida. ACGC Chem. Res. Comm., 21, 17-23 (2007).
46. Procyanidin Oligomer, an Ichthyotoxic Condensed Tannin. Intan S. Ismail*
Hideyuki Ito and Takashi Yoshida. The Bioscientist, R&D Bulletin, Institute of Bioscience, UPM, 5, 2-4 (2007).
47. Constituents of Cleome arabica Leaves and Twigs. Intan S. Ismail, Hideyuki
Ito, Laid Selloum, Takashi Yoshida. Natural Medicines, 59, 53 (2005).
48. Two New Analogues of Trijugin-type Limonoids from the Leaves of Sandoricum koetjape. Intan S. Ismail, Hideyuki Ito, Tsutomu Hatano, Shoko Taniguchi, Takashi Yoshida. Chem. Pharm. Bull., 52, 1145-1147 (2004).
49. Modified Limonoids from the Leaves of Sandoricum koetjape. Intan S.
Ismail, Hideyuki Ito, Tsutomu Hatano, Shoko Taniguchi, Takashi Yoshida. Phytochemistry, 64, 1345-1349 (2003).
50. Ichthyotoxic and Anticarcinogenic Effects of Triterpenoids from Sandoricum
koetjape Bark. Intan Safinar Ismail, Hideyuki Ito, Teruo Mukainaka, Hiroshi Higashihara, Fumio Enjo, Harukuni Tokuda, Hoyoku Nishino, and Takashi Yoshida. Biol. Pharm. Bull., 26, 1351-1353 (2003).
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51. Isolation of the Cytotoxic Constituent Deoxypodophyllotoxin from the leaves
of Juniperus chinensis. Kazuyoshi Kawazu, Intan S. Ismail, Kyoya Takahata, Abdul Manaf Ali, and Hiroshi Kanzaki. Scientific Reports of the Faculty of Agriculture Okayama University, 86, 1-5 (1997).
52. Anti-tumour Promoting and Anti-tumour Activities of the Crude Extract from
the Leaves of Juniperus chinensis, A. M. Ali, M.M. Mackeen, I. Intan Safinar, M. Hamid, N. H. Lajis, S. H. El-Sharkawy, and M. Murakoshi. Journal of Ethnopharmacology, 53, 165-169 (1996).
(b) PUBLICATION IN CONFERENCE PROCEEDINGS 1. IR-METABOLOMICS APPROACH IN DETECTING THE POSSIBLE CHANGES
OF Andrographis paniculata LEAVES METABOLITES DUE TO DIFFERENT HARVESTING AGES AND TIMES. Nur A’thifah Yusof, Azizul Isha, Intan Safinar Ismail, Alfi Khatib. International Conference on Natural Products 2013 (ICNP 2013), Shah Alam Convention Centre (SACC),Shah Alam, Selangor 4-6 March 2013
2. OPTIMIZATION STUDY ON EXTRACTION METHOD AND QUALITATIVES FT-
NMR ANALYSIS OF Andrographis paniculata LEAVES. Azizul Isha, Mohamad Allif Suyut, Nur A’thifah Yusof, Intan Safinar Ismail. International Conference on Natural Products 2013 (ICNP 2013), Shah Alam Convention Centre (SACC),Shah Alam, Selangor, 4-6 March 2013
3. IR-METABOLOMICS APRROACH IN DISCRIMINATING THREE Andrographis paniculata ASSESSIONS DUE TO DIFFERENT HARVESTING AGES AND TIMES. Nur A’thifah Yusof, Azizul Isha, Intan Safinar Ismail*, Alfi Khatib, Khozirah Shaari and Faridah Abas (Oral presentation). The 26th Symposium of Malaysia Analytical Sciences (SKAM 26) Hilton Kuching, Kuching, Sarawak, 4-5 December 2013
4. STABILITY ON STORAGE CONDITIONS OF ALGERIAN Nigella sativa.
Muhammad Safwan Ahamad Bustamam, Intan Safinar Ismail*, Kamarul Arifin Hadithon, Faridah Abas and Yaya Rukayadi. The 26th Symposium of Malaysia Analytical Sciences (SKAM 26) Hilton Kuching, Kuching, Sarawak, 4-5 December 2013
5. METABOLOMICS APPROACH IN IDENTIFYING ANTICHOLESTEROLEMIC AGENTS OF Mentha piperita (PEPPERMINT) IN RATS. Nor Zaini Johari, Intan Safinar Ismail* and M. Roslan Sulaiman. The 26th Symposium of Malaysia Analytical Sciences (SKAM 26) Hilton Kuching, Kuching, Sarawak, 4-5 December 2013
6. Constituents of selected Meliaceae species, Ismail Intan Safinar, Ilya Iryani
Mahmod, Low Kok Wah and Mohd Izwan Mohd Lazim, International Conference on Biologically Active Substances-Bioactive Okayama, Japan, 13-14th September 2012.
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7. Infection Induced Alteration in Oil Palm Leaf Metabolites.
Nalisha Ithnin, Intan Safinar Ismail and Hirzun Md Yusof. The Open Conference Proceedings Journal: Bentham Open - DOI: 10.2174/2210289201304010225
8. Eight new triterpenoids isolated from Dysoxylum Grande (Meliaceae) by Various
Chromatographic Techniques, Ismail Intan Safinar, Low Kok Wah, 8th International Symposium on Chromatography of Natural Products, Lublin, Poland, 17 - 20 Mei 2012.
9. Enhancement of phosphatase activity and phosphorus availability in neem
leaves-empty fruit bunch-based vermicompost, Loh Khye Er, Nor Azwady Abd Aziz, Kok Ho Yin, Muskhazli Mustafa, Alvin Hee Kah Wei, Intan Safinar Ismail and Nur Ain Izzati Mohd Zainudin. MALAYSIA INTERNATIONAL BIOLOGICAL SYMPOSIUM 2012, Residence Hotel at Uniten, Malaysia.11-12 July 2012.
10. Tapping on Meliaceae Plants, Intan Safinar Ismail, International Conference on
Natural Products 2011, IOI Palm Garden Resort, Putrajaya, Malaysia, 14-16th November 2011.
11. Photosensitizing Agents from Syzygium polyanthum (Salam) Leaves, Intan S.
Ismail, Lee Wei Har, Khozirah Shaari, Lee Hong Boon and Fadzly A. Kamarulzaman, 10th University Malaysia Terengganu Annual International Symposium, Kuala Terengganu, Malaysia, 13- 15th July 2011.
12. Anti-acetylcholinesterase Properties of Dysoxylum acutangulum, Mohd Izwan
Mohd Lazim, Intan Safinar Ismail and Khozirah Shaari, International Conference of Natural Products, Penang, Malaysia, December 2010.
13. Anticholinesterase and Ichthyotoxicity of Walsura chrysogyne Leaves, Intan
Safinar Ismail, Ilya Iryani Mahmod, and Emilia Abd Malek, Natural Products Chemistry of the 11th Eurasia Conference on Chemical Sciences (Dead Sea, Jordan), 6-10 October 2010.
14. New Compounds of Dysoxylum acutangulum, Meliaceae, Intan Safinar Ismail,
Mohd Izwan Mohd Lazim, Hiroshi Morita, Yuta Nagakura, Yusuke Hirasawa, and Takahiro Hosoya, 10th PRPI, Universiti Putra Malaysia, (UPM, Serdang) 20-22nd July 2010- Gold Medal.
15. Anti-cholinesterase and Ichthyotoxicity of Walsura chrysogyne, Ilya Iryani
Mahmod and Intan Safinar Ismail. 16th Malaysian Science Congress (Putra World Trade Center, Kuala Lumpur) 12-14 October 2010.
16. Anti-cholinesterase and Ichthyotoxicity of Walsura chrysogyne, Ilya Iryani
Mahmod and Intan Safinar Ismail. Fundamental Science Congress, Faculty of Science, UPM (Kompleks Mahasiswa, UPM) 18-19 May 2010.
17. Dysoxylum acutangulum (Meliaceae): Constituents and Bioactivities, Mohd Izwan
Mohd Lazim, Intan Safinar Ismail, Khozirah Shaari, and Hiroshi Morita.
25
Fundamental Science Congress, Faculty of Science, UPM (Kompleks Mahasiswa, UPM), 18-19 May 2010.
18. Photodynamic Therapy and Ichthyotoxicity Properties of Syzygium polyanthum.
Lee Wei Har , Intan Safinar Ismail, Khozirah Shaari, Lee Hong Boon, Fadzly Adzhar Kamarulzaman. 1st UK-Malaysia Symposium on Drug Discovery and Development for Cancer (Subang, Selangor) 24 and 25th February 2010 – First Prize Winner (Poster)
19. Phytochemical study of Walsura chrysogyne barks. Nor Azwa Norazmi, Ilya
Iryani Mahmod and Intan Safinar Ismail. Seminar Kimia Industri Ke 14 (Fakulti Perubatan dan Sains Kesihatan, UPM) 10 April 2010
20. Saponins from Xerospermum noronhianum, Tan Pei Jean, Khozirah Shaari,
Christian Paetz, Intan Safinar Ismail, Faridah Abas, Nordin H. Lajis and Viqar Uddin Ahmad. 2nd Joint Symposium on Future Prospect of Pharmaceutical Sciences (Tokyo, Japan) 29-31st October, 2009.
21. センダン科 Dysoxylum acutangulum
に含有される新規クロモンアルカロイドの構造研究星薬大）○杉浦莉央，長倉悠(
太，細谷孝博, 平澤祐介, 森田博史,（UPM大) Intan Safinar Ismail，Nordin Hj
Lajis, (リガク) 城始勇), Japanese Pharmacognosy Soceity Conference (Kyoto,
Japan), October 2009. 22. Two Novel Triterpenes, Acutaxylines A and B, from Dysoxylum acutangulum,
Ismail Intan S., Nagakura, Yuta, Hirasawa Yusuke, Hosoya Takahiro, Mohd Lazim M. I., Lajis Nordin and Morita Hiroshi. 13th Asian Chemical Congress, (Shanghai, China) 13-16th September, 2009.
23. Chrotacumines A-D, New Chromone Alkaloids from Dysoxylum acutangulum,
Intan Safinar Ismail, Yuta Nagakura, Yusuke Hirasawa, Takahiro Hosoya, Mohd Izwan Mohd Lazim, Nordin Hj Lajis, and Hiroshi Morita. 42nd IUPAC Congress: Chemistry Solutions, (Glasgow, UK) 2-7th Aug. 2009.
24. Photodynamic Therapy Properties of Syzygium polyanthum, Lee Wei Har, Intan
S. Ismail, Khozirah Shaari, Lee Hong Boon, and Fadzly Azhar Kamaruzaman. Fundamental Science Congress, (Universiti Putra Malaysia) 18-19th June, 2009.
25. Syzygium polyanthum (Myrtaceae) – a Potential Source of Photo-sensitizers.
Intan S. Ismail, Lee Hong Boon, Norakmar Ismail, Norshahida Mohd Shofian
and Fadzly Azhar Kamaruzaman PRPI, 2007 (UPM). 26. Ichthyotoxic and anticarcinogenic effects of triterpenoids, and five new limonoids
from Sandoricum koetjape (Meliaceae). Intan S. Ismail, Ito H, Mukainaka T, Higashihara H, Enjo F, Tokuda H, Nishino H, Yoshida T. 12th Asian Chemical Congress, PWTC, Kuala Lumpur, Malaysia, 2007.
27. Characterization of Proanthocyanidin as the Ichthyotoxic Principle of Sandoricum
koetjape. Yoshida Takashi, Ismail Intan and Ito Hideyuki. The 4th Tannin
26
Conference-Plant Polyphenols: Chemistry, Biology, Function, (Philadelphia, USA) Aug. 22-26, 2004.
28. New Limonoids from the Leaves of Sandoricum koetjape-2 (4). Ismail Intan, Ito
Hideyuki, Hatano Tsutomu, Taniguchi Shoko, Yoshida Takashi. 50th Annual Japanese Pharmacognosy Conference (Tokyo) Sept., 2003.
29. Characterization of Ichthyotoxic and Anticarcinogenic Triterpenoids, and New
Limonoids from Sandoricum koetjape. Intan. S. Ismail, Hideyuki Ito, Tsutomu Hatano, Shoko Taniguchi, Teruo Mukainaka, Hurukuni Tokuda, Hoyoku Nishino, and Takashi Yoshida. 3rd International Symposium on Natural Drugs, (Naples, Italy) October 2-4, 2003.
30. New Limonoids from the Leaves of Sandoricum koetjape (3). Ismail Intan, Ito
Hideyuki, Hatano Tsutomu, Taniguchi Shoko, Yoshida Takashi. 123rd Annual Japanese Pharmaceutical Sciences Conference (Nagasaki, Kyushu) March, 2003.
31. Hydroxy Acid Derivatives from the Leaves of Sandoricum koetjape (2). Ismail
Intan, Ito Hideyuki, Yoshida Takashi. 41st Annual Chugoku Shikoku Conference (Yonago, Tottori) Nov., 2002.
32. Ichthyotoxic Constituents of Sandoricum koetjape (1) Ismail Intan S., Ito
Hideyuki, Tokuda Harukuni, Nishino Hoyoku, Yoshida Takashi. 122nd Annual Japanese Pharmaceutical Sciences Conference, March (Chiba, Tokyo) 2002.
REVIEWER 1. JOURNAL 1. Phytochemical investigation of the leaves of Tetracera scandens Linn. and antidiabetic activity of hypoletin in vitro- World Applied Science Journal 8 March 2013 2. Production of xanthorrhizol from in vitro derived rhizome of Curcuma xanthorrhiza Roxb. for pharmaceutical and cosmeceutical industry- World Applied Science Journal 8 March 2013 3. Temperature Influences on the Secondary Metabolite Profile in Different Populations of Polygonum minus Huds.- PLOS ONE 22 April 2013 4. Characterization of nine traditional Chinese plant extracts with specific acid dissociation constants by UV-Vis spectrophotometry- International Journal of Food Properties 14 May 2013 5. In vitro antioxidant activities of stem bark, leaves and callus extracts from Amoora rohituka – African Journal of Biotechnology 27 May 2013 5. Isolation and Structure Elucidation of Acetyl Cholinesterase Inhibitor form Gyrostoma helianthus of the Red Sea, Egypt- African Journal of Microbiology Research 3 December 2012 6. Acetylcholinesterase Inhibitors from Croton sylvaticus Leaf Extracts and their Mutagenic Effects- Natural Products Communication 30 September 2012 7. Metabolic Profiling of Oil Palm Towards Understanding Basal Stem Rot Disease, Journal of Oil Palm Research 5 September 2012
27
8. Determination of Phenol as Benzene Biomarker for Workplace Exposure Using GC-FID Method- Malaysian Journal of Pharmaceutical Sciences 25 January 2011 9. A New Xanthone from Garcinia nitida- Natural Product Research Nov. 2010 10. Isolation and Conformational Study of Lignans from Durio carinatus Mast. (Bombacaceae) - Chemical Research Communications Dec. 2009 11. Chemical Components of Hopea sangal - Chemical Research Communications November 2009 12. β,e - Carotene 3,3’- diol ( (all-E)-lutein), a Carotenoid From Toona sureni (Blume) Merr - Chemical Research Communications April 2009 13. Characterization of Xanthones from Calophyllum inophyllum – Pertanika June 2008 14. Chemical Constituents of Garcinia rigida - Chemical Research Communications May 2007 (b) ASSESOR- PROPOSAL 1. Laporan Kemajuan dan Laporan Akhir Penyelidikan Institut Biosains, UPM
3 Ogos 2012- 2 Ogos 2015 2. RUGS, FRGS, ERGS 2012 3. FRGS- Search for lead compounds from Mesua beccariana. 6 January 2011 4. RUGS 19 March 2010 5. RUGS 10 September 2009 6. FRGS- Search for lead compounds from Mesua beccariana and M. ferea &
chemical modifications of major compounds leading to discovery of potential new drugs for cancer. 9 September 2009
(c) THESIS/STUDENT MSc: (2013) 1. Faiqah Ramli: 2. Vikneshwari: (2012) 1. Ahmed Mediani: Influence of drying methods, growth stages and harvesting
season on phytochemicals content and antioxidant activity of Cosmos caudatus leaves.
2. Winda Oktima: Chemical constituents and biological activities of Evodia malayana Ridl. and Clausena excavata Burm. F.
3. Rahayu Utami Omar: Phytochemicals and biological activities of Elaeorcarpus floribundus Blume., Barringtonia conoidea Griff and Cosinium fenestratum (Gaertn.) Colebr
4. Noor Idayu Mhd Tahir: LC-MS-Based Metabolomics of Oil Palm (Elaeis guineensis Jacq.) Leaf
(2011) 1. Faridah Haryani Ab. Aziz: Modulation of melanin biosynthesis by Tarrena
curtisii using human epidermal melanocyte (Hemn) cells.
28
2. Maizatulakmal Yahayu: Chemical constituents and biological activities of Helliconia rostrata, Glycosmis macrantha Merr. and Cratoxylum abrorescens.
3. Asiri, Sumayyah Muhammad O: Phytochemical and biological activities of Callicarpa maingayi.
(2010) 1. Nor Hasiffi Shuib: Metabolite profiling of Melicope ptelifolia Champ Ex. Benth
leaf extract using 1H Nuclear Magnetic Resonance and multivariate analysis. 2. Mohammad Fairuz Zulkifli: Structural and functional characterization of
Leucosporidium antartcticum antifreeze protein (AFP). 3. Siti Aminah Gunong @ Mohd Shah: Modelling and optimization study of
lipase-catalyzed of 3-O-(3’, 3’-dimetyhlsuccinyl)-betulinic acid by response surface methodology (RSM).
(2008) 1. AMY YAP LI CHING: PHYTOCHEMICAL STUDIES AND HPLC PROFILING
OF VARIOUS EXTRACTION TECHNIQUES OF BOESENBERGIA PANDURATA (ROXB.) SCHLTR
2. SHIREEN SHAHARINA MOHAMED SHAMAUN: CHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITY OF ARTOCARPUS ALTILIS (MORACEAE) AND MICROMELUM MINUTUM (RUTACEAE)
(2007) 1. Maulidiani: Chemical constituents and cytotoxic activity of Globba pendula. 2. Md. Uwaisulqarni Osman: Synthesis, characterization, and biological studies
of new Schiff bases derived from thiophene and their transition metal complexes.
(2006) 1. Ahmad Haniff Jaafar: In silico protein engineering- Molecular approach in
designing semisynthetic metalloenzyme. 2. Kee Cheng Ling: screening and isolation of cytotoxic compounds from marine
Aaptos sp. Ph.D (2012) 1. Mah Siau Hui: Chemical constituents and biological activities of Callophyllum
specis (Clusiaceae) (2011) 1. Nabil Ali Naji: Phytochemical and biological activities on the constituents
isolated from Kacip Fatimah (Labisia pumila), Penaharan (Horsfieldia superba) and Paku Layar (Odontosoria chinensis).
(2009) 1. Idha Kusumawati: Penetapan senyawa marker dan profil metabolit sebagai
kontrol kualitas estrak daun jambu biji (Psidium guajava L.) bahan aktif obat fitofarmaka untuk terapi demam berdarah dengue.
2. Wiwied Ekasari: Identification of biochemical target of bioactive compound isolated from Cassia siamea Lamk. leaves.
29
CONSULTANCY WORKS
Editor, ACGC Journal of Chemical Research Communication: 2007-2010
Collaborator- Research and Development of Natural Products: Sime Darby Technology Center Sdn. Bhd.; 2005-2006
Advisory Committee and collaborator, project – ‘Up-scaling the Production and Extraction of Red Fermented Rice for Nutraceutical Ingredients’: MARDI; January 2011- July 2012.
Advisory Committee, project- ‘Metabolomics Based Profiling of Oil Palm-Ganoderma Interaction Utilizing Liquid Chromatography-Mass Spectroscopy (LC-MS) and Nuclear Magnetic Resonance (NMR)’: Sime Darby Technology Center Sdn. Bhd.; 2009-present
Collaborator- Study of Natural and Synthetic Compounds (Compounds) for Anti-Cancer Activities: Cancer Research Initiatives Foundation (CARIF): 2012-present
Collaborator- Correlation Between the Chemical Profile of Orthosiphon stamineus Leaf Extracts and Their Diuretic, Nephroprotective and Anti-Diabetic Activities using NMR- and FTIR-Based Metabolomics Approach: Energy Impulse Sdn. Bhd.: 2012-present
CONFERENCES, SEMINARS AND COURSES/WORKSHOP ATTENDED (a) CONFERENCES AND SEMINARS
1. Oral presenter- International Conference on Biologically Active Substances-Bioactive Okayama, Japan, 13-14th September 2012.
2. Poster presenter- 8th International Symposium on Chromatography of Natural
Products, Lublin, Poland, 17 - 20 Mei 2012.
3. Oral presenter-International Conference on Natural Products 2011, IOI Palm Garden Resort, Putrajaya, Malaysia, 14-16th November 2011.
4. Poster presenter- 10th University Malaysia Terengganu Annual International
Symposium, Kuala Terengganu, Malaysia, 13- 15th July 2011.
5. Poster presenter- International Conference of Natural Products, Penang, Malaysia, December 2010.
6. Poster presenter- Natural Products Chemistry of the 11th Eurasia Conference
on Chemical Sciences (Dead Sea, Jordan), 6-10 October 2010.
30
7. 10th PRPI, Universiti Putra Malaysia, (UPM, Serdang) 20-22nd July 2010- Gold Medal.
8. 16th Malaysian Science Congress (Putra World Trade Center, Kuala Lumpur)
12-14 October 2010.
9. Fundamental Science Congress, Faculty of Science, UPM (Kompleks Mahasiswa, UPM) 18-19 May 2010.
10. Fundamental Science Congress, Faculty of Science, UPM (Kompleks
Mahasiswa, UPM), 18-19 May 2010.
11. 1st UK-Malaysia Symposium on Drug Discovery and Development for Cancer (Subang, Selangor) 24 and 25th February 2010 – First Prize Winner (Poster)
12. 2nd Joint Symposium on Future Prospect of Pharmaceutical Sciences (Tokyo,
Japan) 29-31st October, 2009.
13. Japanese Pharmacognosy Society Conference (Kyoto, Japan), October 2009.
14. Oral presenter-13th Asian Chemical Congress, (Shanghai, China) 13-16th
September, 2009.
15. 42nd IUPAC Congress: Chemistry Solutions, (Glasgow, UK) 2-7th Aug. 2009.
16. Seminar Kimia Industri ke 13 (Palm Garden Resort, IOI, Putrajaya) 11 April 2009
17. Seminar Kimia Industri ke 14 (Fakulti Perubatan dan Sains Kesihatan, UPM) 10 April 2010
18. Fundamental Science Congress, (Universiti Putra Malaysia) 18-19th June,
2009.
19. 7th PRPI, Universiti Putra Malaysia, (UPM, Serdang) 20-22nd July, 2007 (UPM)- Silver Medal
20. Oral presenter-12th Asian Chemical Congress, PWTC, Kuala Lumpur,
Malaysia, 2007.
21. The 4th Tannin Conference-Plant Polyphenols: Chemistry, Biology, Function, (Philadelphia, USA) Aug. 22-26, 2004.
22. 50th Annual Japanese Pharmacognosy Conference (Tokyo) Sept., 2003.
23. 3rd International Symposium on Natural Drugs, (Naples, Italy) October 2-4, 2003.
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24. 123rd Annual Japanese Pharmaceutical Sciences Conference (Nagasaki, Kyushu) March, 2003.
25. Oral presenter-41st Annual Chugoku Shikoku Conference (Yonago, Tottori)
Nov., 2002.
26. 122nd Annual Japanese Pharmaceutical Sciences Conference, March (Chiba, Tokyo) 2002.
(b) COURSES/WORKSHOP 2006 1) Learning Outcomes Initiatives I & II - CADe, UPM
Feb – Jun 2006
2) Postgraduate Supervision Course - Hotel Marriot, 14-15 June 2006 Putrajaya
3) Bengkel Pemantapan Pengurusan Projek Penyelidikan - Fakulti
19 December 2006 Kejuruteraan, UPM
4) Kursus Induksi Modul Umum dan Khusus Kumpulan - Hotel Pengurusan dan Professional 4/2006 Residence, 2-23 Mei, 2006 UNITEN
5) Bengkel Learning Outcomes 2 - UPM Mac 23-24, 2006
6) Seminar Sesi Latihan Data Scorpus - UPM
Mac 20, 2006 7) Bengkel Learning Outcomes 1 - UPM
Feb 14-15, 2006
8) Bengkel Pengenalan MS ISO 9001:2000 - Fakulti Sains Feb 8-9, 2006 UPM
2007 1) Bengkel Induksi MS ISO 9001:2000 - Fakulti Sains,
25-26 Jan 2007 UPM 2) Seminar Kimia Industri, XIII - Fakulti Sains,
11 April 2009 UPM 3) Bengkel Penulisan Manuskrip - Fakulti Sains,
Jun 18-21, 2007 UPM 4) Seminar Sains - Fakulti Sains,
Ogos 4, 2007 UPM
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2008 1) Bengkel Penulisan Manuskrip Fakulti Sains - Fakulti Sains,
Jun 24-25, 2008 UPM. 2) Bengkel Kromatografi, - Dewan Kuliah 6,
Jun 30, 2008 Fakulti Perubatan, UPM.
2009 1) Bengkel Kewartawanan JK Penerbitan Infosains - Fakulti Sains,
May 5, 2009 UPM. 2) Bengkel ‘Training of Trainers’, 4th Starting School - Hotel Marriott
Jun 24-25, 2009 Putrajaya 3) Monitoring Workshop Science Fund Projects - Hotel Marriott
(Biotechnology Cluster), February 29, 2009 Putrajaya 4) Penilaian Tahap Kecekapan 4, UPM - Palace Beach 15-19 Jun, 2009 & Spa, Mines 5) REAXYS WORKSHOP: ELSEVIER - Fakulti Sains, 12 Nov. 2009 UPM 6) Natural Products Repository Center Workshop - Hotel Marriott 8 Nov. 2009 Putrajaya 2010 1) Bengkel Pengurusan Jenazah - Masjid, UPM
20-21 February 2010
2) Seminar Kimia Industri XIV - F. Perubatan & Sains 10 April 2010 Kesihatan, UPM
3) 3rd Workshop on Metabolomics: Basics and - Leiden
Applications to Plant Sciences: 12-16 April 2010 University, The Netherlands
4) Workshop on Metabolomics 2010: Basics and - UPM, Malaysia
Applications to Plant Sciences: 12 – 14 October 2010.
5) Asian Regional Conference on Systems Biology - Universiti (ARCSB): 29 November 2010 Kebangsaan
Malaysia
6) Bengkel ‘Training of Trainers’, 5th Starting School - Hotel Marriot Jun 24-25, 2010 Putrajaya
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7) Bengkel Pemurnian Amali Jabatan Kimia - UNITEN
May 2010 8) Penilaian Tahap Kecekapan 5, UPM - UPM 29 Nov-6 Dec, 2010 2011 1) Nutrition, Metabolomics & Bioinformatics - FSKB, UKM, 27 June - 7 July 2011. 2) Plant Metabolomics Workshop 2011 - Institute of
26 – 27 July 2011 Bioscience UPM
3) Intellectual Property Clinic - Faculty of 15 June 2011 Science, UPM 3) Bengkel Pengubalan Sains Forensik - Residence Jabatan Kimia, 23-24 May 2011 Hotel, UNITEN
4) Bengkel Business Plan - Fakulti
7 April 2011 Kejuruteraan, UPM
5) CapNMR Probe Training - Laboratory of
21-25 March 2011 Natural Products, IBS 6) Workshop on Structural Elucidation of Organic - International Compounds – 1D, 2D-NMR and Mass Interpretation Medical Univ. 1-3 March 2011 Bukit Jalil 7) ACD/Labs Structure Elucidator Training - Crystal Crown
13-14 January 2011 Hotel, Petaling Jaya 2012 1) Workshop on Metabolomics - Institute of
26 June – 4 July 2012 Bioscience UPM
2) Introduction Workshop on Laboratory Animal Care and - UKM, Kuala Management: 19 July 2012 Lumpur
3) ‘Future Roles of Herbal Products in the Global Arena: - PICC, Challenges to Malaysia’: 3 October 2012 Putrajaya
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4) Multivariate Data Analysis Course – SIMCA 13: - Institute of 7-9 Nov 2012 Bioscience
UPM
5) Metacore Seminar: 8 February 2012 - Faculty of Medicine, UPM 6) Academic Leaders Induction Program: 11-12 July 2012 - Faculty of Agriculture, UPM 7) Bicarawara Perlaksanaan Saraan Baru Perkhidmatan - Faculty of Awam (SBPA): 5 January 2012 Science, UPM 8) Perbincangan Sasaran Kerja Tahunan (SKT) Akademik - Dewan Senat Bagi Jawatan Pentadbiran UPM HONOURS/AWARDS RECEIVED
Name of awards
Title Award Authority
Award Type Year
AIEJ Scholarship
Graduate Student Exchange Program
Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan
International 1995-1996
Monbusho Scholarship
Graduate Student Fellowship
Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan
International 1999-2003
Monbusho Scholarship
Post-Doctoral Fellowship
Scientific Research from the Ministry of Education, Culture, Sports,
International Sept. 2003- Sept.2004
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Science, and Technology of Japan
Pengajar Cemerlang
Organic Chemistry I
Faculty of Science, UPM
Faculty 2006
Open Research Center Project
Post-Doctoral Fellowship
Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan
International Sept. 2008-Jan. 2009
Silver Award (PRPI 2007)
PRPI 2007 UPM University Nov. 2007
Sponsorship Award
2nd Joint Symposium on Future Prospect of Pharmaceutical Sciences (Tokyo, Japan)
Hoshi University
International 29-31st October, 2009
Cemerlang
Penilaian Tahap Kecekapan 4, UPM
UPM University 15-19 Jun, 2009
Excellent Service Award
2009 Faculty of Science, UPM
Faculty May 2010
Excellent Service Award
2009 University Putra Malaysia
University June 2010
Gold Award (PRPI 2010)
PRPI 2010 UPM University July 2010
Pengajar Cemerlang
2010/2011
Faculty of Science, UPM
Faculty January 2011
Cemerlang
Penilaian Tahap Kecekapan 5, UPM
UPM University 18 March, 2011
Excellent Service Award
2010 Faculty of Science, UPM
Faculty August 2011
Excellent Service Award
2010 University Putra Malaysia
University June 2011
Excellent Service
2011 Faculty of Science,
Faculty October 2012
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Award UPM
Extracts of Dillenia suffruticosa for medical treatment
Patented: 2012 (PI20120034)
UPM University 2 August 2012
EXTENSION AND PUBLIC SERVICES
Badminton player, Inter-department Match, Faculty of Science, UPM [9-11 June 2009]
Bowling player, Inter-department Match, Faculty of Science, UPM [30 July 2009]
Faculty representative, Dialogue session with ASM chemical sciences discipline group, Dept. of Chemistry, Faculty of Science, UPM
[11 March 2009]
Assessor Panel, Soalan Peperiksaan Semester Program Matrikulasi, Corus Paradise Resort, Port Dickson [22-25 June 2010]
Pemeriksa Skrip Matrikulasi, Soalan Peperiksaan Semester Program Matrikulasi [2010]
Technical Review Panel, Appointment on Tenure Track Scheme- Dr. Muhammad Irshad, COMSATS Institute of Technology, Pakistan [Dec 2010]
Master of Ceremony for lucky draw – Majlis Makan Malam Gemilang Fakulti Sains [2011]
Penggubal Soalan Kimia, Peperiksaan Semester Program Matrikulasi, Kementerian Pelajaran Malaysia [2011]
Speaker, Workshop on Metabolomics 2011, Laboratory of Natural Products, Institute of Bioscience, UPM [26-27 July 2011]
Referee, Institut Kimia Malaysia (IKM) Member Application- Dr. Faridah Abas [2012]
Speaker, HPLC Workshop, Anjuran Pejabat TNCPI, UPM [23 & 24 October 2012]
Panelist, Human Life Advancement Foundation Scholarship [11 Dec 2012]
PENASIHAT PAKAR (EXPERT GROUP), PENUBUHAN PROGRAM BARU
DI FAKULTI FARMASI, UNIVERSITI TEKNOLOGI MARA (UiTM) [Dec 2012]
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EXTRACURRICULAR ACTIVITIES (a) Societies/Professional Bodies
Member, Malaysian Natural Products Society [2005 – present]
Member, American Chemical Society (ACS) [7 July 2009 –present]
Member, Japanese Pharmaceuticals Society (JPS) [27 May 2008- present]
Associate Member, Institut Kimia Malaysia (IKM) [October 2010-present]
STUDENT DEVELOPMENT
Menghadiri Makan Malam Pelajar-pelajar Tahun Akhir: 5 Mac, 2007, Putrajaya.
AJK Bebas Menukartaraf MSc ke PhD: Eltayeb Elamin Muhammed Eid- October 2009
AJK Bebas Menukartaraf MSc ke PhD: Devandran Krishnan – November 2012
Chairperson - Viva Mohd Lip Jabit [2005] - Viva Nurul Waznah Mohamad Sharif [2009] - Viva Sim Wei Chung [2010] - Viva Teo Seow Hwa [2010]
- Viva Aesya Sofea Abdul Rahim [2011] - Viva Noor Haslinda Noor Hashim [2011] - Viva Mohd Rizal Chumati [2011] - Viva Nadiah Mad Nasir [2011] - Viva Suhaizam Shahrul Affendy Suhaimi [2012] - Viva Noorul Adawiyah Mustahil [2012] - Viva Mohd Hanif Mohamad [2012]
Facilitator - Starting School, Pusat Kokurikulum, UPM [Sem I, 2009/2010] Starting School, Pusat Kokurikulum, UPM [Sem I, 2010/2011]
Examiner – Postgraduate seminar, Dept. of Chemistry, Faculty of Science, UPM [Sem I, 2009/2010]
Assessor – Postgraduate seminar, Institute of Bioscience [22 April 2010]
Advisor Kelab Kimia Jabatan Kimia – Program Gerak Ilmu 2011 [9 October 2011]
Advisor Majlis Makan Malam SKI – Dewan Banquet, UPM [11 May 2011]
Penceramah/Fasilitator - Bengkel MInda Gemilang, Kolej Matrikulasi Johor [3 March 2012]
Assessor – Postgraduate seminar, Institute of Bioscience [19 December 2012]
Advisor – Hari Integrasi Fakulti Sains: Aktiviti Kelab Kimia [December 2012]
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ACADEMIC REFEREES Prof. Dr. Geoffrey Alan Cordell Natural Product Inc. Evanston, Chicago, USA Email: [email protected] Prof. Dr. Abdul Manaf Ali Faculty of Agriculture and Biotechnology Universiti Sultan Zainal Abidin (UniSZA), Kampus Kota, Jalan Sultan Mahmud, 20400 Kuala Terengganu. MALAYSIA Email: [email protected] Prof. Dr. Gwendoline Ee Chiang Lian Department of Chemistry Faculty of Science Universiti Putra Malaysia 43400 UPM Serdang, Selangor Email: [email protected]
