Curriculum Vitae

PERSONAL INFORMATION Carmen Galbusera

carmen.galbusera@icps.it

Nationality Italian

WORK EXPERIENCE

5/2012–Present Operator exposure and toxicology expertInternational Centre for Pesticides and Health Risk Prevention (ICPS), University Hospital Luigi Sacco, Milan (Italy)

Toxicological evaluation of Registator Report and preparation of dossiers (mammalian toxicology, risk exposure assessment, exposure models) for the registration of plant protection products and active ingredients in compliance with Regulation (EC) N. 1107/2009 of the European Parliament.

Participation as Italian delegate at EFSA Experts’ Meetings PRAPeR (Pesticides Peer Review).

1/2009–11/2011 Research contract on “Ricerca di marcatori molecolari per la diagnosi della nefropatia diabetica: approccio proteomico in pazienti con diabete di tipo 1 e di tipo 2”Department of Experimental Medicine (DIMS) - Mass Spectrometry Laboratory University of Milano-Bicocca, Faculty of Medicine, Milan (Italy)

Evaluation of the protein profiles obtained from biological fluids (serum, plasma, urines and amniotic fluids) of Diabetic Nephropathy patients to detect differential expression of proteins/peptides and to identify clusters that could help to separate populations.

1/2005–12/2008 Research contract on “Biomarkers identification of Renal Cell Carcinoma in biological fluid by advanced proteomic technique"Department of Experimental and Environmental Medicine and Medical Biotechnology (DIMESAB) - Mass Spectrometry Laboratory University of Milano-Bicocca, Faculty of Medicine, Milan (Italy)

1/2003–12/2004 Research contract of collaboration on “Oxidative stress in patients with Alzheimer disease and Mild Cognitive Impairment: possible diagnostic/prognostic markers and pathogenesis mechanisms”Department of Experimental and Environmental Medicine and Medical Biotechnology (DIMESAB) - Mass Spectrometry Laboratory University of Milano-Bicocca, Faculty of Medicine, Milan (Italy)

Advanced Mass-Spectrometry Techniques applied to proteomics, SDS-PAGE techniques, in-gel digestion, mass spectra evaluation and database search with different algorithms for identification of biomarkers.

1/2001–12/2002 Research fellowship in Biomedical Technologies on “Peripheral biological markers involved in pathogenesis mechanisms of Alzheimer disease”DiBiT(Department of Biological and Technological Research) Science Park Raf, San Raffaele Scientific Institute, Milan (Italy)

1/1999–12/2000 Research for degree thesis entitled: “The role of HEV in acute non-A, non-C hepatitis and the identification of a new variant HEV in Italy” (Supervisors: Professors A. Zanetti and E. Tanzi)Institute of Virology - University of Milano, Milan (Italy)

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Curriculum Vitae Carmen Galbusera

EDUCATION AND TRAINING

2001 National State Exam in Biology - Qualification to practice the Biologist professionUniversity of Milano - Faculty of Mathematical, Physical and Natural Sciences, Milan (Italy)

2001 Theoretical and practical lessons on Mass SpectrometrySCI-Mass Spectrometry branch - University of Siena, Siena (Italy)

Certificate of attendance: 5th Mass Spectrometry course for PhD students 2001

2000 Degree in Biological SciencesUniversity of Milano – Faculty of Mathematical, Physical and Natural Sciences, (Italy)

Experimental thesis title: “The role of HEV in acute non-A, non-C hepatitis and the identification of a new variant HEV in Italy”

1991 High School Diploma in Scientific StudiesLiceo Scientifico Statale “M.G. Agnesi”, Merate (LC) (Italy)

PERSONAL SKILLS

Mother tongue(s) Italian

Other language(s) UNDERSTANDING SPEAKING WRITING

Listening Reading Spoken interaction Spoken production

English B2 B2 B2 B2 B2

French A1 B1 A1 B1 A1

Common European Framework of Reference for Languages

Levels: A1/A2: Basic user - B1/B2: Independent user - C1/C2: Proficient userCommon European Framework of Reference for Languages

Communication skills Good communication skills aquired through participation and organisation of conferences and project meetings.

Flexibility and ability to work efficiently in a multi-cultural team.

Job-related skills Evaluation of registration reports (mammalian toxicology and operator exposure assessment) and preparation of monographs on active substances for the authorisation of plant protection products at national or European level.

Good knowledge of classic biochemical techniques and methodologies.

Techniques: chromatographies, electrophoreses, immuno analyse, spectroscopy and mass spectrometry; methodologies: extraction and purification of proteins and lipids from cells and tissues; spectrophotometric and radioisotopic enzymatic assays, test ELISA.

Good knowledge of Mass Spectrometers: MALDI-ToF (Reflex IV, Bruker Daltonics) and LC-ESIMS/MS (Esquire 3000 plus, Bruker Daltonics). Experience in Robot setting for biological fluids

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Curriculum Vitae Carmen Galbusera

preparation before MS analysis (ClinProt Robot, Bruker Daltonics). Knowledge of Peptide Mass Fingerprinting (PMF) technique for proteins identification through Mass Spectrometry. Good theoretical and practical experience of main chromatographic approaches and ability to use HPLC system (HPLC 1100 from Agilent and Ultimate 3000 from Dionex).

Computer skills Good knowledge of Microsoft Windows, Microsoft Office (Word, Excel, PowerPoint) and Internet Explorer. Specific Mass Spectrometry software (FlexControl,FlexAnalysis, DataAnalysis, Biotools, ClinProTools) and statistical software (Systat e MedCalc).Good knowledge of the main databases (SwissProt, Genebank, Mascot).

Driving licence B

Related document(s):

ADDITIONAL INFORMATION

SCIENTIFIC PUBLICATIONS: 1) Magni F., Ferrarese C., Cattaneo A., Galbusera C., Begni B., Zoia C.,Brighina L., Galli Kienle M. (2001). HNE-Abeta adducts evaluatedin vitro and in washed platelets by HPLC-ESI-MS. Clinical Chemistry and Laboratory Medicine,vol. 39; p. P0-B047, ISSN: 1434-6621.

2) Magni F., Galbusera C., Tremolada L., Ferrarese C. and Galli Kienle M. Characterisation of adducts of the lipid peroxidation product 4-hydroxy-2-nonenal and amyloid β-peptides by liquid chromatography/electrospray ionisation mass spectrometry. Rapid Commun. Mass Spectrom. 2002;16:1485-1493.

3) M. Facheris, G. Galimberti, C. Galbusera, F. Magni, M.E. Raggi, M. Galli-Kienle, C. Ferrarese(2002). Oxidative stress and immune activation as pre-clinical markers in Alzheimer Disease: correlation with disease severity. Neurological Sciences, vol. 23; p. S123, ISSN: 1590-3478.

4) L. Tremolada, C. Galbusera, C. Valsecchi, C. Sarto, G. Musi, S. Casellato, S. Ferrero Bogetto, S. Bosari, F. Magni, P. Mocarelli, M. Galli Kienle. Preliminary results of the proteoma evaluation of normal and tumor renal tissues (RCC) by advances mass spectrometric technique. The Italian Journal of Biochemistry 2003; 52 Suppl n.1: 70.

5) C. Galbusera, L. Tremolada, C. Valsecchi, C. Sarto, G. Musi, S. Cesellato, C.Arizzi, S Ferrero Bogetto, S. Bosari, F. Magni, P. Mocarelli, M. Galli Kienle. Confronto tra proteoma di corteccia renale umana normale e tumorale (RCC) mediante 2-DE e MALDI-TOF: risultati preliminari. Biochimica Clinica 2003; 27 Suppl n.4: 39-40.

6) Galbusera C., Facheris M., Magni F., Galimberti G., Sala G., Tremolada L., Isella V.,Guerini F.R., Appollonio I., Galli Kienle M., Ferrarese C. Increased susceptibility to plasma lipid peroxidation in Alzheimer disease patients. Current Alzheimer Research 2004; 1 (2):103-109.

7) Magni F., Sarto C., Valsecchi C., Casellato S.,Ferrero Bogetto S., Bosari S., Di Fonzo A., Perego R. A., Corizzato M., DoroG., Galbusera C., Rocco F.,Mocarelli P., Galli Kienle M. Expanding the proteome two-dimensional gel electrophoresis reference map of human renal cortex by peptide mass fingerprinting. Proteomics 2005; 5:816-825.

8) N.Bosso, C. Chinello, S.C.M. Picozzi, E. Gianazza, V. Mainini, C. Galbusera, F. Raimondo, R. Perego, S. Casellato, F. Rocco, S. Ferrero, S. Bosari, P. Mocarelli, M. Galli Kienle and F. Magni. Human urine biomarkers of renal cell carcinoma evaluated by ClinProt. Proteomics Clin. Appl. 2008; 2:1036-1046.

9) I. Zoppis, E. Gianazza, C. Chinello, V. Mainini, C. Galbusera, C. Ferrarese, G. Galimberti, Sorbi, B. Borroni, F. Magni and G. Mauri. A mutual information approach to data integration for Alzheimer’s disease patients. C. Combi, Y. Shahar, andA. Abu-Hanna (Eds.): Artificial Intelligence in Medicine (AIME 2009). Proceedings, 2009; LNAI5651, 431–435.

10) Gianazza E, Mainini V, Castoldi G, Chinello C, Zerbini G, Bianchi C, Galbusera C, Stella A, Mauri G, Zoppis I, Magni F, Kienle M G. Different expression of Fibrinopeptide A and related fragments in serum of type 1 diabetic patients with nephropathy. J Proteomics 2010 Jan3;73(3):593-601.

11) Chinello C, Gianazza E, Zoppis I, Mainini V, Galbusera C, Picozzi S, Rocco F, Galasso G, Bosari S, Ferrero S, Perego R, Raimondo F, Bianchi C, Pitto M, Signorini S, Brambilla P, Mocarelli P, Galli Kienle M, Magni F. Serum biomarkers of Renal Cell Carcinoma assessed using a protein profiling approach based on ClinProt technique. Urology. 2010 Apr;75(4):842-7.

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Curriculum Vitae Carmen Galbusera

12) Zoppis I, Gianazza E, Borsani M, Chinello C, Mainini V, Galbusera C, Ferrarese C, Galimberti G, Sorbi S, Borroni B, MagniF, Antoniotti M, Mauri G. Mutual Information Optimization for Mass Spectra Data Alignment. IEEE/ACM Trans Comput Biol Bioinform. 2011 Apr 19.

I authorize the release of my personal data in accordance with the current Italian Data Protection Law 196/2003 art. 76.

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