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PHS 3505 Clinical Immunology, SSI 2012 Dr. F.A. Barile, Ph.D., R.Ph.

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6. COURSE OUTLINE:

Topic Chapters in text1. Overview of the Immune System 12. Innate immunity & Acquired Immunity 2

a. Lymphatic systemb. Humoral immunityc. Cell mediated immunityd. Characteristics of the immune responsee. Inflammation & cytokines 11

3. Immunogens & Antigens 3a. Chemical complexityb. Haptensc. Classes of antigensd. Cross reactivity

e. Adjuvants

4. Antibody structure & function 4a. Characterizationb. Structurec. Classes of immunoglobulinsd. Genetic basis of antibody structuree. Biological properties

5. Antigen-Antibody interactions 51. Affinity and avidity

2. Agglutination reactions3. Precipitation reactions4. Immunoassays5. lmmunofluorescence6. Immunoabsorption & immunoadsorption7. Monoclonal antibodies

Midterm Exam, TBA

6. Genetic basis of antibody structure 6

7. Complement 13

8. Hypersensitivity Reactions & the Cytokines1. Type I - AB-mediated reactions 142. Type II - AB-mediated cytotoxic reactions 153. Type III - Immune complex reactions 154. Type IV - Delayed type hypersensitivity 16

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Topic Chapters in text

9. Disorders of the Immune System - Autoimmunity 12, 17a. Autoimmune hemolytic anemiab. Rheumatoid Arthritis

c.

SLEd. Myasthenia gravise. Graves diseasef. Hashimoto's diseaseg. Multiple sclerosis.h. Autoimmune reactions of the kidney

10. Other disorders of the immune system 171. Immunodeficiency disorders2. Acquired immunodeficiency syndrome3. Gammopathies

4.

B and T cell malignancies11. Immunotherapy 19, 20

a. Immunizationb. Production of vaccinesc. Immunostimulationd. Adverse immune reactions to drugs

Final Exam, Thursday June 28th, 2012