Pioneering Solutions in Fluorochemicals

Ron Epstein

Sales Director

History

• Halocarbon was founded in 1950 to make inert lubricants.

• First commercial producer of CTFE inert lubricants.

• First and largest producer of TFA, TFE, TFAC and TFAA.

• First commercial quantities of CFC substitute HFC-134a and HFC-32.

• First U.S. producer of fluorinated anesthetics.

Halocarbon Today

Three product lines based on our fluorochemicals experience

• Inert lubricants

• Inhalation anesthetics

• Fluorochemicals

Staff

• 150 employees (20 technical staff)

Manufacturing

• Extensive complex in South Carolina USA

• Grams to tons capability in technical development area

• Hundreds of tons capability in production area

Halocarbon Complex

Halocarbon Quality

0

100

200

300

400

500

600

700

0 5 10 15 20 25 30 35 40 45 50 55

•TFA >99.9%

•TFE >99.98%

•ETFA >99.9%

•TFAA >99.5%

Our Expertise

High quality grams to tons production at competitive prices

• Halogenation – radical, exchange, etc.

• Oxidation/reduction

• Amination/amidation

• Esterification/alcoholysis

• Alkylation

Benefits of Fluorination

• Pharmaceuticals

• Anesthetics

• Biomedical uses

• Agricultural chemicals

• Fluoroplastics

• Fluoroelastomers

• Chlorofluoropolymers

• Membranes

Basic Building Blocks

• TFAC trifluoroacetyl chloride

• CDFAC chlorodifluoroacetyl chloride

• DFA difluoroacetic acid

• HFA hexafluoroacetone

• ETFAA ethyl trifluoroacetoacetate

F3C Cl

O

F3C OH

O

F3C OH

F3C OR

OF3CO

OF3C

O

Trifluoroacetyl chlorideTrifluoroacetic anhydride

Trifluoroethanol

Trifluoroacetic acid

R = Et, Me, i-Pr

Alkyl trifluoroacetates

F3C OCHF2

Cl

Isoflurane

TFAC and Derivatives

F3C Cl

OF3C NHR F3C NHR

O

F3C H

RO OH

Trifluoroacetyl chlorideTrifluoroethyl amines

R = H, Me

Trifluoroacetaldehyde hemiacetal

R = Me, Et

R = H, Me

Trifluoroacetamides

TFAC and Derivatives

HFA and Derivatives

F3C CF3

O

F3C CF3

OH

F3C CF3

OCH2F

CF3

CF3OH

CF3

CF3

OH

F3C

CF3

OH

Hexafluoroacetone Hexafluoroisopropanol Sevoflurane

Norbornene HFIP

Vinyl HFIP

Allyl hexafluoroisopropanol

CF3

F3C OH

2-Phenyl HFIP

(via Grignard reactions)

Global Business

• Distributors – Europe, Middle East, Asia

• Growth

• 60% of sales

• Focus– Development investment

Recap

• Pioneer in fluorochemicals

• Grams to tons capabilities

• Focus on custom synthesis

• Global distribution

• Working with major pharma companies

• “What Can We Make For You?”

For more information,please visit Halocarbon at booth

812

Ron Epstein - Sales Directorrepstein@halocarbon.com

201-262-8899 Ex. 36

www.halocarbon.com