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Page 1: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1
Page 2: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

WHAT? WHY?

Page 3: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

USMLE – WHAT IS IT FOR?

A series of examinations conducted by the National Board of Medical Examiners (NMBE)

Currently, four separate exams:Step 1 – usually taken after the completion of second year of medical schoolStep 2 Clinical Knowledge (CK) – usually taken during the fourth year of medical schoolStep 2 Clinical Skills (CS) – usually taken during the fourth yearStep 3 – typically taken during the first year of post graduate training

Page 4: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

STEP 1Assesses understanding and application of important basic

sciences with special emphasis on principles and mechanisms, underlying health, disease and modes of therapy.

Usually taken after the completion of second year of medical schoolMultiple choice with only ONE best answer (3 to 11 response options arranged logically or alphabetically)Minimum passing score = 189

Page 5: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

STEP 2Assesses application of medical knowledge, skills, and understanding of

clinical science essential for the provision of patient care.usually taken during the fourth year of medical schoolClinical Knowledge (CK):

Multiple choice formatMinimum passing score = 189

Clinical Skills (CS):Assesses data-gathering and communication skills (including spoken English) with standardized patients, and on the ability to complete an appropriate patient note by physician raters. Scores as Pass/Fail

Page 6: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

STEP 3Assesses whether physician possesses and can apply the medical

knowledge and understanding of clinical science considered essential for the unsupervised practice of medicine, with emphasis on patient management in ambulatory care settings.

Typically taken during the first year of post graduate trainingConsists of multiple choice items and computer-based case simulations.Minimum passing score = 190

Page 7: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

USMLE STEP 1 SNAPSHOT

Question total: 322Questions per block: 46

Approximately 1.2 minutes per question

Number of blocks: 7Time per block: 60 minutesTotal exam time: 7 HoursTotal breaks/lunch: 1 Hour

Page 8: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

STEP 1 TEST CONTENT

Step 1 is a broadly based, integrated examination. Test items commonly require you to perform one or more of the following tasks:

interpret graphic and tabular material,identify gross and microscopic pathologic and normal specimens,apply basic science knowledge to clinical problems.

Page 9: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

CONTENT AREAS:

• anatomy

• behavioral sciences

• biochemistry

• microbiology

• pathology

• pharmacology

• physiology

• interdisciplinary topics, such as nutrition, genetics, and agingFind more specific content information on page 6-19 of the 2012 USMLE Bulletin

Page 10: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

STEP 1 SPECIFICATIONS:SYSTEM:25%–35% General principles 65%–75% Individual organ

systems hematopoietic / lymphoreticularnervous/special sensesskin/connective tissuemusculoskeletalrespiratorycardiovasculargastrointestinalrenal/urinaryreproductiveendocrineimmune

PROCESS:20%–30%: Normal structure and function

40%–50%: Abnormal processes

15%–25%: Principles of therapeutics

10%–20% : Psychosocial, cultural, occupational, and environmental considerations

Page 11: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

Bloom's Taxonomy

The Cognitive Process Dimension

The KnowledgeDimension

Remember Understand Apply Analyze Evaluate Create

FACTUAL KNOWLEDGE

List Summarize Classify Order Rank Combine

CONCEPTUAL KNOWLEDGE

Describe Interpret Experiment Explain Assess Plan

PROCEDURALKNOWLEDGE

Tabulate Predict Calculate Differentiate Conclude Compose

META-COGNITIVE

KNOWLEDGE

Appropriate Use

Execute Construct Achieve Action Actualize

Page 12: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1
Page 13: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

PERFORMANCE SCORES FOR 2010: FIRST ATTEMPT

Mean score: 222 (SD 24)

Percent passing:

91%

Mean score: 220 (SD 22)

Percent passing:

94%

N A T I O N A L M E A N S F O R U S M L E S T E P 1

U W S O M U S M L E S T E P 1 M E A N S

Page 14: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1
Page 15: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

PERFORMANCE SCORES FOR 2011: FIRST ATTEMPT

Mean score: 224 (SD 24)

Percent passing:

94%

Mean score: 222 (SD 22)

Percent passing:

95%

N A T I O N A L M E A N S F O R U S M L E S T E P 1

U W S O M U S M L E S T E P 1 M E A N S

Page 16: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1
Page 17: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1
Page 18: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1
Page 19: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

MEAN STEP 1 SCORES PER SPECIALTY - 2011

226244

240223

213227

226230

239225

220240

243226

221214

249214

240

190 200 210 220 230 240 250 260

AnesthesiologyDermatology

Diagnostic RadiologyEmergency Medicine

Family MedicineGeneral Surgery

Internal MedicineInternal Medicine/Pediatrics

Neurological SurgeryNeurology

Obstetrics and GynecologyOrthopaedic Surgery

OtolaryngologyPathologyPediatrics

Physical Medicine and RehabPlastic Surgery

PsychiatryRadiation Oncology

Page 20: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

PLANNING AND SCHEDULING

Page 21: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

TIMELINE 2012

“Students must take Step 1 in the June-July timeframe after the completion of the second year and prior to entering the clinical curriculum.”

Clerkships start on July 9Target date: June 29th (no later than July 3rd if possible)With a few notable exceptions, there should be no need to extend into the first clerkship period.

Page 22: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

JANUARY - FEBRUARY

The Warm Up5-6 dedicated hours weeklyReview content and course work from previous quartersStart assessing strengths and areas of concernQbank, First Aid, etc.

Page 23: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

MARCH - APRIL

The Slow Jog6-8 dedicated hours weeklyReview content and course work from previous quartersReview of questions and supporting materialsUse Qbank (if not previously); tutorial mode is a good idea

Page 24: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

MAY

Slow and Steady Wins the Race!

8-10 hours weekly (as possible)Keep up with content for coursesReview of questions and supporting materialsUse QbankAdd notes

Page 25: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

END OF MAY - JUNE

Sprint for the Finish!8-12 hours dailyDo self-assessments 50-75 Qbank questionsReview of questions and supporting materialsUse Qbank in tutoring mode to study

Page 26: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

TARGET – JUNE 29TH!

Page 27: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

PREPARATION MATERIALSMost used:USMLE World Q-BankFirst Aid for the USMLE Step 1Doctors in TrainingKaplan Step 1 Test Preparation Program

Page 28: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

SUPPORT ACTIVITIES• Individual appointments on scheduling,

anxiety, stress and effective learning• Test taking skills workshop• Stress reduction workshop• Seminars (as needed)

Page 29: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

EXAMPLES OF SUPPORT SESSIONS

Test Taking Skills – 4/2 – 9:00-11:00

• Individual appointments as needed

• Tutoring support as needed

Self-Hypnosis – Joe Barber, PhD – 4/9 – 9:00-11:00

• Other evening activities in planning stages; will be announced

• Individual appointments as needed

A C A D E M I C S K I L L S W E L L N E S S / C O U N S E L I N G

Page 30: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

Sunday Monday Tuesday  Wednesday Thursday Friday Saturday27‐May

RELAX!

28‐MayMEMORIAL DAY 

29‐May 30‐May 31‐May 1‐Jun 2‐Jun

3‐Jun 4‐Jun 5‐Jun 6‐Jun 7‐Jun 8‐Jun 9‐Jun

10‐Jun 11‐Jun 12‐Jun 13‐Jun 14‐Jun 15‐Jun 16‐Jun

17‐Jun 18‐Jun 19‐Jun 20‐Jun 21‐Jun 22‐Jun 23‐Jun

24‐Jun 25‐Jun 26‐Jun 27‐Jun 28‐Jun SELF‐CARE DAY

29‐Jun

TARGET TEST DATE!

30‐Jun

1‐Jul 2‐Jul 3‐Jul 4‐Jul 5‐Jul 6‐Jul 7‐Jul

Weekly Study Schedule

Weekly Study Schedule

Weekly Study Schedule

Weekly Study Schedule

Brush Up Review

RELAX – BREATHE - REFOCUS

Page 31: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

A DAY IN THE LIFE… 10 – 15 HOURS DAILY

• 2-3 “mock blocks” - 1 hour random/timed Qbank questions [46 questions per block]

• 1-2 hours – review the “mock blocks”

• BREAK

• 3-4 hours – Content review: First Aid, Doctors in Training videos, Kaplan videos, Goljan lectures, notes, etc.

• BREAK – Workout/self-care

• 3-4 hours – Q-bank questions in tutorial mode based on previous content

• 1-2 hours – Review the material for the day and prepare for tomorrow

Page 32: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

MAY/ JUNE 2012BREAKDOWN BY FIRST AID TOPICS - Example

SUNDAY MONDAY TUESDAY WEDNESDAY THURSDAY FRIDAY SATURDAY

27 28Microbiology

29Microbiology

30Biochemistry

31Biochemistry

1Neurology

2Musculo…

3PRACTICEEXAM -ASSESSMENT

4Embryology

5Cardio

6Renal

7Respiratory

8Immunology

9Catch-up/Review/ Q-bank

10PRACTICEEXAM -ASSESSMENT

11Pharmacy

12Pathology

13Endocrine

14Hematology/Oncology

15Gastro

16Reproductive

17Behavioral Sciences

18Psychiatry

19Catch-up/Review/ Q-bank

20Catch-up/Review/ Q-bank

21 NBMEASSESSMENT –Diagnostic

22PRN

23PRN

24PRN

25PRN

26“GentleReview” –First Aid

27“GentleReview” – First Aid

28Self-Care

29Test Date

30

Page 33: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

Weekly Schedule UWSOM

Monday Tuesday Wednesday Thursday Friday Saturday Sunday5:30 AM6:00 AM Breakfast Breakfast Breakfast Breakfast Breakfast6:30 AM

Self-Assessment

Study Study Study Study7:00 AM7:30 AM8:00 AM8:30 AM Breakfast Breakfast

9:00 AM Break Break Break Break

Study Social/Family Time

9:30 AM

Study Study Study Study10:00 AM10:30 AM11:00 AM11:30 AM12:00 PM Lunch/Break Lunch/Break Lunch/Break Lunch/Break Lunch/Break Lunch/Break Lunch/Break12:30 PM1:00 PM

Study Study Study Study Study Study Study1:30 PM2:00 PM2:30 PM3:00 PM3:30 PM

Physical Activity / Self-Care

Physical Activity / Self-Care

Physical Activity / Self-Care

Physical Activity / Self-Care

Physical Activity / Self-Care

Social/Family Time

Break 4:00 PM

Study

4:30 PM5:00 PM5:30 PM Dinner Dinner Dinner Dinner Dinner6:00 PM6:30 PM

Study Study Study Study Study7:00 PM Dinner7:30 PM8:00 PM

Social/Family Time

8:30 PM9:00 PM Social/Family

TimeSocial/Family

TimeSocial/Family

TimeSocial/Family

Time Social/Family Time

9:30 PM10:00 PM10:30 PM Bedtime Bedtime Bedtime Bedtime Bedtime11:00 PM11:30 PM Bedtime12:00 AM

Page 34: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

Weekly Schedule UWSOMMonday Tuesday Wednesday Thursday Friday Saturday Sunday

5:30 AM Breakfast Breakfast Breakfast Breakfast Breakfast Breakfast

Sleep In / Breakfast

6:00 AM6:30 AM Review Review Review Review Review Review7:00 AM7:30 AM

Assessment

Study - Qbank (tutorial by topic per assessment)

Study - Qbank(tutorial by topic per assessment)

Study - Qbank (tutorial by topic per assessment)

Study - Qbank (tutorial by topic per assessment)

Study - Qbank (tutorial by topic per assessment)

8:00 AM8:30 AM9:00 AM9:30 AM10:00 AM Break Break Break Break Break

Study - TBD

10:30 AMStudy - Qbank

(random tutorial)Study - Qbank

(random tutorial)Study - Qbank

(random tutorial)Study - Qbank

(random tutorial)Study - Qbank

(random tutorial)11:00 AM11:30 AM12:00 PM

Lunch12:30 PMLunch Lunch Lunch Lunch Lunch1:00 PM

1:30 PM2:00 PM

Study - First Aid Study - First Aid Study - First Aid Study - First Aid Study - First Aid

Study - TBD

2:30 PM Lunch3:00 PM3:30 PM

Study - TBD

4:00 PM Break Break Break Break Break4:30 PM

Study - Goljan Study - Goljan Study - Goljan Study - Goljan Study - Goljan5:00 PM5:30 PM

Dinner/ Social

6:00 PM6:30 PM7:00 PM

Dinner/ Workout Dinner/ Workout Dinner/ Workout Dinner/ Workout Dinner/ Social

7:30 PM

Dinner/ Workout8:00 PM8:30 PM9:00 PM9:30 PM10:00 PM Bed! Bed! Bed! Bed! Bed! Bed!10:30 PM11:00 PM 10.5 hrs 10 hrs 10 hrs 10 hrs 10 hrs 9 hrs 8 hrs11:30 PM12:00 AM

Page 35: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

THE PENN METHODApproximately 30 days; Content is specific for assigned days

Sample calendar will be included in packet3-4 days – First Aid for the Boards4-5 days – Biochemistry; 50 biochem questions3-4 days – Microbiology; 50 microbio questions1-2 days – Immunology; 50 immuno questions1 day – Embryology; 50 embryo questions1-2 days – Anatomy; 50 anatomy questions1 day – Neuroanatomy; 50 neuro questions3 days – Physiology; 50 physio questions4-6 days – Pharmacology; 50 pharm questions3-4 days – Pathology; 50 path questions1 day – Histology; 50 histo questions1 day – Behavioral Sciences; 50 behavioral sciences questions

Page 36: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

MAY/ JUNE 2012UWSOM Penn Method Example

SUNDAY MONDAY TUESDAY WEDNESDAY THURSDAY FRIDAY SATURDAY

27 28Biochemistry; 50+ Qbank

29Biochemistry; 50+ Qbank

30Biochemistry; 50+ Qbank

31Biochemistry; 50+ Qbank

1Microbiology; 50+ Qbank

2Microbiology; 50+ Qbank

3Microbiology; 50+ Qbank

4Microbiology; 50+ QbankPRACTICE EXAM

5Immunology; 50+ Qbank

6Immunology; 50+ Qbank

7Embryology; 50+ Qbank

8Anatomy; 50+ Qbank

9Anatomy; 50+ Qbank

10Neuroanatomy; 50+ Qbank

11Physiology; 50+ Qbank

12Physiology; 50+ Qbank

13Physiology; 50+ Qbank

14Pharmacology; 50+ Qbank

15Pharmacology; 50+ Qbank

16Pharmacology; 50+ Qbank

17Pharmacology; 50+ Qbank

18Pharmacology; 50+ Qbank

19Pathology; 50+ Qbank

20Pathology; 50+ Qbank

21 Pathology; 50+ Qbank

22Pathology; 50+ Qbank

23Histology; 50+ Qbank

24Behavioral Sciences; 50+ Qbank

25Review First Aid

26Review First Aid

27Review First Aid

28Self-Care

29Target Test Date

30

Page 37: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

CONTENT REVIEW SESSIONS

Page 38: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

A. Candida albicansB. Haemophilus influenzae C. Staphylococcus aureusD. Staphylococcus

epidermidisE. Viridans (alpha-hemoloytic)

streptococci

A 25 year old man is brought to the Emergency Department because of a high fever and shaking chills. He has a history of intravenous drug abuse, but a test for HIV-antibodies is negative. Physical examination reveals a systolic murmur, and he complains of shortness of breath. Which of the following is a pathogenic feature of the microorganisms that will most likely be isolated from this patient’s blood cultures?

Page 39: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

Case 1

A 25 year old man is brought to the Emergency Department because of a high fever and shaking chills. He has a history of intravenous drug abuse, but a test for HIV-antibodies is negative. Physical examination reveals a systolic murmur, and he complains of shortness of breath. Which of the following is a pathogenic feature of the microorganisms that will most likely be isolated from this patient’s blood cultures?

A. Candida albicansB. Haemophilus influenzae C. Staphylococcus aureusD. Staphylococcus epidermidisE. Viridans (alpha-hemoloytic) streptococci

Page 40: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

Case 1 Endocarditis, FA p. 301

• Causes of endocarditis in IV drug users• Staph aureus• Pseudomonas• Candida

Page 41: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

Case 1

A. Candida albicans-More often in severely immunocompromised patients, e.g. AIDS

B. Haemophilus influenzae -A minority of cases are caused by the HACEK group:

-Haemophilus, actinobacillus, cardiobacterium, eikenella, kingella

C. Staphylococcus aureus-Staph from the skin enters the blood stream from IV drug use site

-More commonly associated with tricuspid valve

D. Staphylococcus epidermidis-Tends to be endocarditis of prosthetic valves

E. Viridans (alpha-hemoloytic) streptococci-Tends to be endocarditis of prosthetic or congenitally abnormal valves-Usually subacute with better clinical prognosis

Page 42: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

A. Alpha Toxin

B. Endotoxin

C. Enterotoxin

D. Neurotoxin

E. Superantigen toxin

A 32 year old man is struck by a car and sustains crash injuries to both legs. Two days later, he develops a severe infection of the legs. Physical examination shows crepitus of the tissue of the legs. An x-ray of the legs shows radioluscent pockets in the soft tissues. Which of the following toxins produced by the most likely causal organism is responsible for these findings?

Page 43: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

Case 2

A 32 year old man is struck by a car and sustains crash injuries to both legs. Two days later, he develops a severe infection of the legs. Physical examination shows crepitus of the tissue of the legs. An x-ray of the legs shows radioluscent pockets in the soft tissues. Which of the following toxins produced by the most likely causal organism is responsible for these findings?

A. Alpha ToxinB. EndotoxinC. EnterotoxinD. NeurotoxinE. Superantigen toxin

Page 44: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

Gas Gangrene

• Clostridium perfringens• Spore forming anaerobe• Grows in necrotic tissue• Produces α-toxin

• Lecithinase: phopholipase• Myonecrosis and hemolysis

• May see pockets of soft tissue on X-ray

Page 45: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

The other answers

• Endotoxin (especially lipid A)• Lipopolysaccharides found in gram negative organisms• Leads to Shock

• Enterotoxin• C. perfringens has a mild enterotoxin causing watery diarrhea

• Neurotoxin• C. tetanus and C. botulinum have neurotoxins, but not C. perfringens

• Superantigen toxin• Cause fever, petechial rash, and DIC• Staph spp: TSST-1• Strep pyogenes: exotoxin A

Page 46: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

Bacterial Toxins, FA p. 152-3

• Inhibit protein synthesis• C. diphtheriae• P. aeruginosa• Shigella• EHEC (O157:H7)

• Increase fluid secretion• ETEC• ETEC• Y. enterocolitica• B. Anthracis• V. Cholerae

• Inhibit phagocytotic ability• B. pertussis

• Inhibit neurotransmitter release• C. tetani• C. botulinum

• Lyse cell membranes• C. perfringens• S. pyogenes

• Superantigens leading to shock• S. pyogenes• S. aureus

• Mechanisms, Toxin, and symptoms found on this must know table (FA, p. 152-3)• It is intimidating, but you will get at least 2 questions about it on your exam

Page 47: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

MOVING FORWARD:

• Increase awareness from the beginning of first year• Debrief effectiveness of strategies

• July – August 2012 – Poll students about evaluation of preparation programs; revise/rewrite review plan

• Implement comprehensive preparation plan for 2012-2013

• Continue to expand USMLE style questions into content throughout the curriculum

• Other ideas?

Page 48: Preparing our students for USMLE Cheek AWARE 2012depts.washington.edu/gowwami/AWARE/documents2012/CheekUSM… · Medical Examiners (NMBE) Currently, four separate exams: Step 1

Jamey Cheek, EdDHSB: T-557Email:

[email protected]:

206-616-9606