Source: Zeiss, vsp, Wikipedia

UV HEV

The skin is continuously exposed to blue light* – digital (TV screens,

smartphones, tablets and computers) and daylight

Blue light: Refers to high-energy visible light (HEV), including violet and blue light, between 380 nm and 495 nm

OxidationEye

Fatigue

Light Therapy

DNA Damage

CircadianRhythm

BUT is Blue light Good OR Bad for your skin?

Memory Performance

Summary: Consumer and scientific views are mixed…

Protect or Not? What IF…

Summary: Consumer and scientific views are mixed…

OxidationEye

Fatigue

Light Therapy

DNA Damage

CircadianRhythm

Memory Performance

Light Powered Skin Care

Designed to deliver holistic cellular

protection with its blue light

activated enzymes

Combats photo and digital aging

thanks to its light powered skin care

technology

The Masters in DNA Repair

Image: Spirulina Maxima

Cyanobacteria Facts: First photosynthetic life in the planet, estimated 3.5B years ago, transforms atmosphere (oxygen), key step in life

evolution; the only photosynthetic prokaryotic cells

Kyanós means Blue in Greek

The Blue Light Experts

The First Cells to Transform Light Energy into Life

Cyanobacteria

Blue Light Enzymes

Two enzymes actively* working to prevent digital and photo aging

*Activated by visible light in the violet – blue spectrum

PhycocyaninPhotolyase CPD

Our every day life includes frequent changes from indoors to outdoors – exposing us to different levels of UV and light conditions.

Image: Major damage types occurring in skin cells after UV and HEV light overexposure.

OxidationDNA Damage

Sunlight UV is the primary cause of photo aging. Blue light (HEV) is

increasingly perceived as a driver of digital aging.

UV HEV

Our every day life includes frequent changes from indoors to outdoors – exposing us to different levels of UV and light conditions.

Image: Most common clinical signs and symptoms of digital and photoaging

Sunlight UV is the primary cause of photo aging. Blue light (HEV) is

increasingly perceived as a driver of digital aging.

Pigmented Spots

Wrinkle Formation

Dull Complexion

Lack of Firmness

2 14 3

UV HEV

Photolyase CPD repairs the DNA directly by cleaving CPD bonds

Image source: Adapted from The Nobel Prize in chemistry 2015 & photolyase mechanism of action

Photolyase CPD: Ancestral enzyme from microalgae (cyanobacteria), photo-activated by visible light, directly cleaves CPD bond and allows

DNA to reconnect normally

DNA Damage

(CPD Bond)Binding1 2

DNA Damage

Photolyase CPD

A = Violet-Blue

A

Photolyase CPD repairs the DNA directly by cleaving CPD bonds

Graphic Source: Adapted from Eker, A. P., et al. "DNA photoreactivating enzyme from the cyanobacterium..." Journal of Biological Chemistry

265.14 (1990): 8009-8015. Photolyase CPD photoactivation peak between 390 and 460 nm (violet-blue light spectrum)

3 Photo-activation

Wavelenght (nm)

Photolyase CPD repairs the DNA directly by cleaving CPD bonds

Image source: Adapted from The Nobel Prize in chemistry 2015 & photolyase mechanism of action

Photolyase CPD: Ancestral enzyme from microalgae (cyanobacteria), photo-activated by visible light, directly cleaves CPD bond and allows

DNA to reconnect normally

4 Repair

10 to 100 times faster

than untreated cells

Phycocyanin is a characteristic blue pigment and a potent antioxidant that delivers a dual action in shielding the skin from the effects of HEV

light via blue light reflection and ROS scavenging.

Phycocyanin prevents digital aging by shielding cells from blue light and

preventing oxidative damage

Oxidation

Phycocyanin

HEV

In Vitro

In Vitro brief: Cellular repair assay in naked DNA (analyzed by immunofluorescence). GenoFix Day (1%) repaired UV damaged DNA in just 1

hour when exposed to white light (outdoors), hybrid white light & electronic device (indoors) and electronic device.

GenoFix Day powers up cellular repair thanks to its light

activated enzymes – even with your smartphone!

1h+

+49%

+29%

0%

+34%

In Vivo Volunteers

10 x female, 25 to 50 years

Normal / Dry skin with light to moderate wrinkles

Light Powered Skin Care

Improves Firmness

Reduces Wrinkle Depth

Rapidly Corrects Age Spots

In Vivo Study: Double blind placebo controlled randomized study with 10 volunteers working with electronic devices (PC, tablet,

smart phone, etc..) and also do sport outdoors and who are exposed to sun radiation; GenoFix Day (2%) and placebo applied once a day

(half face each, randomly chosen).

Boosts Skin Radiance

GenoFix Day boosts skin radiance by preventing digital and

photo aging (p<0.001)

In Vivo Study: Evaluation of skin brightness – gloss parameter (Colorimeter CM-700D Konica-Minolta)

In Vivo

0%

5%

10%

Glo

ss P

ara

met

er v

s. T

0 (%

)

In Vivo – Skin Brightness

Placebo

ALGAKTIV®GenoFix Day 2%

Day 10 Day 28

+6.5%

+1.8% +2.1%

+9.2%

GenoFix Day corrects age spots by shielding melanocytes with

its photo activated enzymes

In Vivo Study: Volunteer 2; ALGAKTIV® GenoFix Day in vivo studies demonstrate its age spot removal effectiveness.

In Vivo

Day 0 Day 10

Day 0 Day 10

GenoFix Day corrects age spots by shielding melanocytes with

its photo activated enzymes

In Vivo Study: Volunteer 4; ALGAKTIV® GenoFix Day in vivo studies demonstrate its age spot removal effectiveness.

In Vivo

GenoFix Day helps restore the natural firmness of the skin for a

rejuvenated look (p<0.001)

In Vivo Study: Firmness variation assessed in the face area. Measurements made by Cutometer® MPA 580.

In Vivo

0%

2%

4%

6%

8%

10%

R0

Para

met

er v

s. T

0 (%

)

In Vivo – Skin Firmness

Placebo

ALGAKTIV®GenoFix Day 2%

Day 10 Day 28

+9.1%

+5%

+1.1%+0.6%

GenoFix Day combats digital and photo aging with its active

enzymes – reducing wrinkle depth by 20% (p<0.05)

In Vivo Study: Wrinkle reduction in the eye area. Measurements made by skin profilometry (PRIMOS – wrinkles)

In Vivo

-25%

-20%

-15%

-10%

-5%

0%

Skin

Pro

filo

met

ry v

s. T

0 (%

)

In Vivo – Wrinkle Depth Reduction

Placebo

ALGAKTIV®GenoFix Day 2%

Day 10 Day 28

-15.8%

+0.8%

-2.4%

-22%

GenoFix Day combats digital and photo aging with its active

enzymes – reducing wrinkles in just 10 days

In Vivo Study: Volunteer 3; Measurements made by skin profilometry (PRIMOS – wrinkles)

In Vivo

Day 0 Day 10

GenoFix Day combats digital and photo aging with its active

enzymes – reducing fine lines and wrinkles

In Vivo Study: Volunteer 7; Measurements made by skin profilometry (PRIMOS – wrinkles)

In Vivo

Day 0 Day 28

GenoFix Day combats the signs of photo and digital aging thanks to its

blue light powered skin care technology

Corrects Age Spots

Reduces Wrinkles

Boosts Skin Radiance

Increases Firmness

2 14 3

Image: GenoFix Day addresses the most common clinical signs and symptoms of digital and photoaging

UV HEV

✓ Not cytotoxic✓ Not irritant to the eye✓ Not phototoxic

✓ Not irritating✓ Not sensitizing

INCI name: Sucrose (and) Spirulina Maxima Extract (and) LecithinCAS #: 57-50-1, 36993-92-7, 8002-43-5EC #: 200-334-9, 293-445-7, 232-307-2

Appearance: Blue to whitish powderSolubility: Water-solublePreservative system: Free

Tested level: 0.1% - 0.2% (see rehydration protocol)Guidelines: Add below 45°C, at the end of the process

_Natural, GMO-free, vegan_Free of allergens, pesticides, solvents and heavy metals_REACH compliant_China, EU, Japan, Canada, Australia and USA compliant

REGULATORYFORMULATION

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TOXICOLOGY In Vitro In Vivo

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