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“Primum non nocere!”Hipokrat, 460-377. god. pre nove ere
Schematic pedigree diagram showing the main routes for biological transmission of the effects of exposure to the next
generation(s). Left, female line; right, male line
Pembrey M, et al. J Med Genet. 2014;51:563–72.
Mellor J. Biochemist. 2010;32(5):6-7.
Main components of the epigenetic code
Epigenetic mechanismare afected by these factors and proceses: ● Development (in utero, childhood) ● Environmental chemicals ● Drugs ● Aging ● Diet
Health endpoints● Cancer ● Autoimmune disease ● Mental disorders ● Diabetes ● Obesity● Allergy
Proteinsko-kalorijski deficit
Deficit gvožđa i cinka
Negativan bilans kalcijuma
Hipovitaminoza B12 i D
Deficit derivata alfa-linolenske kiseline (omega-3 LCPUFA)
Posledice vegetarijanske
i makrobiotičke ishrane u dečjoj dobi
Committee on Nutrition, American Academy of Pediatrics. Pediatric Nutrition Handbook, 6th ed. Elk Grove Village, IL:AAP; 2009: 201-24.
Di Genova T, Guyda H. Paediatr Child Health. 2007;12(3):185-8. Schürmann S, et al. Eur J Nutr. 2017 Mar 15.