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Name: Claude J Le Saux , PhD
EDUCATION
2009 - 1989 Universite de
Provence, Marseille,
France
BS MajorBiochemistry and
Microbiology
2009 - 1990 Universite de
Provence, Marseille,
France
MS MajorCell and Molecular
Biology
2009 - 1991 Universite de
Provence, Marseille,
France
MENG MajorMicrobiology and
Biotechnology
2009 - 1992 Universite de
Provence, Marseille,
France
PhD MajorCell and Molecular
Biology
PhD AdvisorDr.
Pascal Sommer
PRINCIPAL POSITIONS HELD
2000 - 2009 University of Hawaii, Honolulu, HI Assistant
Researcher
2009 - 2015 University of Texas Health Science
Center at San Antonio
Assistant Professor
Tenure-Track
Medicine,
Cardiology
2015 - present University of Texas Health Science
Center at San Antonio
Assistant
Professor(10%
FTE)
Medicine,
Pulmonary and
Critical Care
2016 - present UCSF Associate Adjunct
Professor
Medicine
Pulmonary and
Critical Care
OTHER POSITIONS HELD CONCURRENTLY
-
HONORS AND AWARDS
1994 Pre-doctoral Fellowship Award Association pour la Recherche sur le
Cancer
1995 Pre-doctoral Fellowship Award Association pour la Recherche sur le
Cancer
1996 Pre-doctoral Fellowship Award Glaxo Pharmaceutical Products
2 of 25
1996 Award for best promising pre-doctoral
fellow
Association de la Technolopole de
Gerland
2012 Young investigator award 17th colloquium on lung and airways
fibrosis, Modena, Italy
2014 Carol Basbaum Award American Thoracic Society Respiratory
Cell and Molecular Biology
KEYWORDS/AREAS OF INTEREST Pulmonary Fibrosis, Senescence, Aging, Macrophage biology, Cardiac Remodeling
PROFESSIONAL ACTIVITIES
MEMBERSHIPS
2001 - present American Thoracic Society
2009 - 2010 American Heart Association
2016 - present Association for Research in Vision and Ophthalmology
SERVICE TO PROFESSIONAL ORGANIZATIONS
2008 - 2008 Canadian Institutes of Health Research Ad Hoc Reviewer
2008 - 2009 The Netherlands Asthma Foundation Ad Hoc Reviewer
2010 - 2016 Respiratory and Cell Molecular Biology Assembly,
American Thoracic Society
Executive
Committee
Member
2010 - present Respiratory Cell and Molecular Biology Assembly Planning
Committee, American Thoracic Society
Committee
Member
2010 - 2013 National Institute of Health Center for Sciences Reviewer
2011 - 2016 Respiratory Cell and Molecular Biology Assembly Aging
Group, American Thoracic Society
Co-leader
2016 - 2016 Respiratory Cell and Molecular Biology Assembly Aging
Group, American Thoracic Society
Member
2012 - 2016 Respiratory Cell and Molecular Biology Program
Committee, American Thoracic Society
Member
2015 - 2015 National institute of Aging, Special Emphasis Panel Reviewer
2016 - 2016 National institute of Heart, Lungs and Blood, Special
Emphasis Panel
Reviewer
2009 - present Chair and co-chair of mini-symposium, symposium, poster
sessions at the American Thoracic Society international
meetings
Co-Chair
3 of 25
2017 - present Member of the Research Advocacy Committee, American
Thoracic Society
Member
2017 - present Respiratory Cell and Molecular Biology Program
Committee, American Thoracic Society
Member
SERVICE TO PROFESSIONAL PUBLICATIONS
2004 - Ad hoc reviewers for several journals related to pulmonary and critical care, cell
biology, immunology, and cardiology
2012 - 2014 Editorial Organizing Committee: reparation of the "Molecular Aspects of Aging"
book to establish a milestone in our knowledge in the processes controlling the
aging of the lungs.
INVITED PRESENTATIONS - INTERNATIONAL
2018 Pushing the Limits of Healthspan and Longevity (D3),
Keystone Symposia, Hannover Germany
2018 International Cell Senescence Association International
Conference Montreal, Canada
Speaker
2014 American Thoracic Society (ATS) 2014 International
Conference, A85-Cellular and Molecular Determinants of
the Aging Lung, ATS, San Diego, CA: Sunrise Seminar
2014 American Thoracic Society (ATS) 2014 International
Conference, A85-Cellular and Molecular Determinants of
the Aging Lung, ATS, San Diego, CA: oral presentation
Speaker
2014 American Thoracic Society (ATS) 2014 International
Conference, A85-Cellular and Molecular Determinants of
the Aging Lung, ATS, San Diego, CA. Oral presentation
Speaker
2014 American Thoracic Society (ATS) 2014 International
Conference, A85-Cellular and Molecular Determinants of
the Aging Lung, ATS, San Diego, CA. Post graduate
course
Speaker
2014 Experimental Biology 2014, Cardiovascular Biology,
American Association of Anatomists, San Diego, CA
Co-presenter
2014 INSERM-U651 Hopital Mondor, Faculte' de Medecine,
Creteil, France
Guest Speaker
2014 Ground Rounds, Department of Medicine, Pulmonary
Division, University of Tulane, New Orleans, LA
Guest Speaker
2014 3rd Munich Lung Conference on Lung Aging: Molecular
mechanisms and clinical relevance, Munich October 2013.
Award winning.
Senior author
4 of 25
2013 American Thoracic Society 2013 International Meeting,
C108. THE BEST FROM IN VIVO MODELS OF
PULMONARY FIBROSIS,, ATS, Philadelphia, PA
Senior author
2012 17th International Colloquium on Lung and Airways
Fibrosis, Center for Rare Lung Diseases, University of
Modena & Reggio Emilia, Modena, Italy
Invited speaker
2012 INSERM-U651 Hopital Mondor, Faculte' de Medecine,
Creteil, France
Guest Speaker
2012 American Thoracic Society (ATS) 2012 International
Conference, A61- Antifibrotics and Therapeutic Targets in
Expermiental Lung Fibrosis, ATS, San Francisco, CA
Senior Author
2012 Translation of Basic Research to Human Disease and
novel Therapeutics, ATS International Conference, San
Francisco, CA
Invited speaker
2012 Department of Life Sciences, University of Modena and
Reggio Emilia, Modena, Italy
Guest speaker
2011 Anatomy and Cell Biology Department Seminar Series,
School of Medicine, McGill University, Montreal, Canada
Guest Speaker
2010 American Thoracic Society International Conference 2010,
A-19 Preclinical Testing in Mouse Models of Pulmonary
Fibrosis, ATS, New Orleans, LA
Senior author
2009 Telomere Biology and DNA Repair, Poster Abstract,
Keystone Symposia on Molecular and Cellular Biology,
Ashmore, Australia
Senior author
2009 American Thoracic Society 2012 International Meeting,
C107. Prevalence and Regulation of Epithelial
Mesenchymal Transition, ATS, San Francisco, CA
Senior author
2008 American Heart Association, New Orleans, Louisiana Invited Speaker
INVITED PRESENTATIONS - NATIONAL
2019 National Institutes of Health DNA Damage, Telomeres,
and Senescence in Lung Aging and Disease Workshop
Speaker
2019 Scleroderma Workshop, Scleroderma Foundation, San
Francisco, CA
Speaker
2016 Fibrosis 2016 Keystone Conference on Fibrosis: From
Basic Mechanisms to Targeted Therapies
Oral Presenter
2016 Center for Comparative Respiratory Biology and Medicine,
UC Davis seminar
Guest Speaker
2015 San Antonio Nathan Shock Center of Excellence in the
Basic Biology of Aging, San Antonio, TX
Guest Speaker
5 of 25
2014 Seminar. Buck Institute of Aging, Novato, CA. Guest Speaker
2014 Seminar Series, Lovelace Respiratory Research Institute,
Albuquerque, NM
Guest Speaker
2013 Research Seminar Series, Dept. of Regenerative
Medicine and Cell Biology, Medical University of South
Carolina, Charleston, SC
Guest Speaker
2013 Seminar Series, Baylor School of Medicine Guest Speaker
2012 American Academy of Pediatrics Symposium, Perinatal
Section, AAP, Marco Island, FL
Co-author on oral
presentation
2012 Special Seminar, Dept. of Human Genetics, University of
Pittsburgh-Graduate School of Public Health, Pittsburg,
PA
Guest Speaker
2012 Aspen Conference, Aspen, CO Co-author on oral
presentation
2012 American Association of Immunologists 99th Annual
Meeting, AAI, Boston, MA
Co-author on oral
presentation
2012 Fibrosis Across Organ Systems Symposium, American
Thoracic Society Special Emphasis Panel, Denver, CO
Guest Speaker
2012 American Heart Associate Scientific Session,
Inflammation and Adhesion Molecules, American Heart
Association, Orlando, FL
Guest Speaker
2012 Gordon Research Annual Conference, Lung
Development, Injury & Repair, Salve Regina University,
Newport, RI
Senior Author
2011 ATS 2011 International Conference, Respiratory Cell &
Molecular Biology, Denver, CO Sunrise Seminar
Speaker
2011 Keystone Symposia, Lung Development and Repair (B5),
Keystone, Santa Fe, NM
Senior Author
2010 Experimental Biology 2010, Poster Session Title:
Cardiovascular Cell Biology and Disease, Experimental
Biology, Anaheim, CA
Senior Author
2010 Grand Rounds, Pulmonary, Allergy & Critical Care
Medicine, University of Alabama, Birmingham, AL
Guest Speaker
2010 Keystone Symposia, Extracellular Matrix and
Cardiovascular Remodeling (B2), Tahoe City, CA
Senior Author
INVITED PRESENTATIONS - REGIONAL AND OTHER INVITED PRESENTATIONS
2016 12th Bay Area Aging Meeting Invited Speaker
2016 Internal Research Seminar series at the Buck Institute Speaker
6 of 25
2016 Theravance Biopharma Invited Speaker
2016 Touro University Biological and Pharmaceutical Sciences-
College of Pharmacy
Invited Speaker
2015 Research Seminar series, Medicine, UTHSCSA, San
Antonio, TX
Speaker
2014 Pulmonary Conference Presentations, The Division of
Pulmonary Diseases and Critical Care Medicine,
UTHSCSA, San Antonio, TX
Guest Speaker
2013 Research Seminar series, Medicine, UTHSCSA, San
Antonio, TX
Guest Speaker
2013 Women Faculty Association, UTHSCSA, San Antonio, TX Guest Speaker
2012 San Antonio Nathan Shock Center of Excellence in the
Basic Biology of Aging, San Antonio, TX
Guest Speaker
2012 Cardiothoracic Surgery Research Meeting, UTHSCSA, San
Antonio, TX Ground Rounds
Guest Speaker
2012 3rd Annual Frontiers of Translational Science, San Antonio,
TX
Senior Author
2012 Keystone Symposia, Cardiovascular Development and
Regeneration, Taos, NM
Senior Author
2010 National Conference of State Legislatures, Legislators in
the Lab, UTHSCSA, San Antonio, TX
Speaker
2010 Cellular and Structural Biology Seminar Series, Cellular and
Structural Biology, The University of Texas Health Science
Center, San Antonio, TX
Speaker
2010 Research Seminar, Department of Pediatrics, The
University of Texas Health Science Center, San Antonio,
TX
Speaker
2010 Grand Rounds, Division of Cardiothoracic Surgery, The
University of Texas Health Science Center, San Antonio,
TX
Speaker
2010 Pediatrics Research Seminar, Pediatric Department,
UTHSCSA, San Antonio, TX
Speaker
2009 Medicine Research Seminar, Department of Medicine, UT
Health Science Center, San Antonio, TX
Speaker
CONTINUING EDUCATION AND PROFESSIONAL DEVELOPMENT ACTIVITIES
2016 Participant at the Keystone symposia on Fibrosis: From Basic Mechanisms to
Targeted Therapies
7 of 25
2016 Participant Association for Research in vision and ophtalmology international
meeting
2016 Participant at American Thoracic Society Meeting
2015 Participant American Thoracic Society Meeting
2014 Participant American Thoracic Society Meeting
2014 Cardiac Catheterization Lecture Series, "Myectomy for nonobstructive HCM"
2014 Center for Excellence in Women's Health, "Chronic Disease Begins in the
Womb" presented by Kent L. Thornburg, Ph.D., Professor of Medicine, Knight
Cardiovascular Institute Director, Center for Developmental Health, Bob and
Charleen Moore Institute for Nutrition and Wellness Oregon Health and Science
University.
2014 Barshop Seminar Series, "Death, Disease and Aging in Drosophila" presented
by David Walker, Ph.D., Associate Professor, Departments of Integrative
Biology and Physiology, University of California, Los Angeles, CA
2014 Barshop Institute Seminar, "Cellular and Molecular Basis for the Heart Disease
of Aging" presented by Mark Entman, M.D. Professor, Department of Medicine,
Pathology, and Immunology Chief, Cardiovascular Sciences Section Baylor
College of Medicine, Houston, TX.
2104 Barshop Institute Seminar, "Marmoset Monkeys as an Integrating Model of
Development, Obesity and Aging" presented by Suzette Tardif, Ph.D.,
Professor, Barshop/Cellular and Structural Biology, UTHSCSA, San Antonio,
TX
2014 Cellular & Structural Biology Seminar, "Hedgehog and androgen receptor
signaling pathways in prostate cancer" presented by LuZhe Sun, Ph.D.,
Department of Cellular and Structural Biology, UTHSCSA, San Antonio, TX.
2014 Barshop Institute Seminar, "Aging - A Perspective from Proteostasis and the
Health of the Proteome" presented by Richard Morimoto, Ph.D., Bill and Gayle
Cook Professor of Biology, Director, Rice Institute for Biomedical Research,
Department of Molecular Biosciences, Weinberg College of Arts and Sciences
Northwestern University, Evanston, IL
2014 Grant Seeker's program, external review process prior to submission of NIH
R01 entitled "Preventing adverse cardiac remodeling by targeting caveolin-1"
submitted 02.2014
2013 Participant at the American Thoracic Society meeting
2013 Grant Seeker's program, internal review process prior to submission of NIH R01
entitled "Preventing adverse cardiac remodeling by targeting caveolin-1"
submitted 02.2014.
2013 Barshop Institute Seminar, "Redox-Regulation of Monocyte Migration and
Macrophage Recruitment" presented by Reto Asmis, Ph.D., Professor of
Clinical Laboratory Sciences and Biochemistry, UTHSCSA, San Antonio, TX.
8 of 25
2013 Barshop Institute Seminar, "Pneumococcal Pneumonia in the Elderly: How
Chronic Inflammation Opens the Door for The Old Man's Friend" presented by
Carlos Orihuela, Ph.D., Associate Professor of Microbiology and Immunology,
UTHSCSA, San Antonio, TX.
2013 Barshop Institute of Aging Grant Seekers, internal review process prior to
submission of NIH R01 entitled "Telomerase and telomere regulation in
pathobiology of pulmonary fibrosis" submitted 02.2014
2013 Barshop Institute Seminar, "A genomic approach to analysis of the effects of
rapamycin on aging and cancer" presented by Carolina Livi, Ph.D., Assistant
Professor Research, Department of Molecular Medicine, UTHSCSA, San
Antonio, TX
2013 Stem Cell Conference, Conference held at the University of Vermont,
Burlington, VT. I attended this conference to learn the latest knowledge on
therapeutic approaches for pulmonary fibrosis treatment.
2013 Microbiology Seminar Series, "IL-13 modulation of Th17 immune responses"
presented by Ray Stokes Peebles, Jr., MD, Ph.D., Division of Allergy,
Pulmonary & Critical Care Medicine, Vanderbilt University Medical Center,
Nashville, TN.
2013 Cellular and Structural Biology Seminar, "Integrin-mediated inflammasome
activation. Novel insights into epithelial cell derived inflammation" presented by
Peter H. Dube, Ph.D., Department of Microbiology, UTHSCSA, San Antonio,
TX.
2013 Barshop Institute Seminar, "Aging and the Inflammatory Responses After
Injury" presented by Elizabeth J. Kovacs, Ph.D., Professor, Vice Chair for
Research, Departments of Surgery and Cell Biology, Neurobiology, and
Anatomy, Loyola University, Chicago, IL.
2012 Participant at the American Thoracic Society meeting
2012 Participant at the Keystone Symposia Fibrosis: Translation of Basic Research
to Human Disease and Novel Therapeutics
2012 Cellular and Structural Biology Seminar, "LY2157299, A First-in-Class TGF-
beta Type I Receptor Inhibitor" presented by Jonathan Yingling, Ph.D., Eli Lilly
and Company, Indianapolis, IN.
2012 Barshop Institute Seminar, "Aging and Cancer: Rival Demons?" presented by
Judith Campisi, Ph.D., Professor, Buck Institute for Research on Aging, Novato,
CA.
2012 Cellular and Structural Biology Seminar, "Telomere and Age-Related Disease"
presented by Mary Armanios, M.D., Associate Professor of Oncology, John
Hopkins School of Medicine,Baltimore, MD.
2011 Participant at the American Thoracic Society meeting
9 of 25
2011 Cellular and Structural Biology Seminar, "The Plasticity of Aging" presented by
Anne Brunet, Ph.D., Assistant Professor, Department of Genetics, Stanford
University, Stanford, CA.
2011 Barshop Institute Seminar, "Cardiac Remodeling from the Extracellular Matrix"
presented by Merry Lindsey, Ph.D., Associate Professor and Director of the
Cardiovascular Proteomics Center, Department of Medicine and the Barshop
Institute, UTHSCSA, San Antonio, TX
2011 Cellular and Structural Biology Seminar, "miRNAs and Cardiovascular Disease"
presented by Carlos Fernandez-Hernando, Ph.D., Department of Medicine &
Cell Biology, New York University, New York, NY.
2011 Description Mouse Genetics 2011 Conference, The Genetics Society of
America Conference, Washington, DC. Learned how to make a transgenic
mouse model
2011 Barshop Institute Seminar, "Modeling Aging and Cancer in Mice with Telomere
Dysfunction" presented by Sandy Chang, M.D., Ph.D., Associate Professor,
Department of Laboratory Medicine Yale University School of Medicine,New
Haven, CT. Madison, CT
2011 Cellular and Structural Biology Seminar, "Gene expression profiling to study the
mechanisms of calorie restriction and rapamycin in mice" presentated by
Carolina Livi, Ph.D., Assistant Professor, Department of Molecular Medicine,
UTHSCSA, San Antonio, TX
2011 Cellular and Structural Biology Seminar, "TGF-beta Signaling in Colon Cancer
Metastasis" presented by Jing Wang, Ph.D.,Eppley Cancer Institute, University
of Nebraska Medical Center, Omaha, NE.
2011 Cellular and Structural Biology Seminar, "Mitochondrial ROS: a key to
intermediate cardiac aging and hypertrophy" presented Peter S. Rabinovitch,
M.D., Ph.D.,Department of Pathology, University of Washington, Seattle, WA.
GOVERNMENT AND OTHER PROFESSIONAL SERVICE
2008 - 2008 2008- 2008 Canadian Institutes of Health Research Role Ad Hoc Reviewer
2008 - 2009 The Netherlands Asthma Foundation Ad Hoc Reviewer
2010 - 2013 National Institute of Health Center for Sciences Reviewer
2010 - American Heart Association Reviewer
2015 - 2015 National institute of Aging, Special Emphasis Panel Reviewer
2016 - 2016 National institute of Heart, Lungs and Blood, Special
Emphasis Panel
Reviewer
2017 - present National Institutes of Health, Center for Scientific Review,
Small Business Respiratory Study Section
Reviewer
10 of 25
UNIVERSITY AND PUBLIC SERVICE
SCHOOL OF MEDICINE
-
SCHOOL OF DENTISTRY
-
SCHOOL OF NURSING
-
SCHOOL OF PHARMACY
-
SERVICE AT OTHER UNIVERSITIES
2014 - 2015 Co-chair for the organization of the Barshop Institute
Seminar Series
UTHSCSA
2014 - 2014 Judge for Basic & Clinical Research Quality Improvement &
Patient Safety Day
UTHSCSA
2012 - 2015 nterviewer for candidate applying for faculty position in the
Dept of Physiology
UTHSCSA
2011 - 2015 Interviewer for candidate applying for faculty position in the
Dept of Medicine/Pulmonary
UTHSCSA
2012 - 2012 Judge for Honors College Undergraduate Research
Symposium
UTSA
2012 - 2016 Member of the Institutional Review Board UTHSCSA
2011 - 2015 Interviewer for candidate applying for faculty position in the
Dept of Medicine/Cardiology
UTHSCSA
2011 - 2015 Cardiovascular Fellowship Interviewees UTHSCSA
2010 - 2012 Reviewer of applications for Medical Student Summer
Research Program
UTHSCSA
2011 - 2016 Member of the Medical Student Research Review
Committee
UTHSCSA
2010 - 2015 Interviewer for Graduate student candidates UTHSCSA
2010 - 2011 Board Member of the Visual Arts -Connective Tissue
Magazine
UTHSCSA
2010 - 2010 Judge for the Dental Science Symposium UTHSCSA
2009 - 2012 Judge for Medical Student Research Day UTHSCSA
11 of 25
1998 - 2009 Judge for the Biomedical Research Symposium University of
Hawaii
COMMUNITY AND PUBLIC SERVICE
2014 - 2015 Comal County Translational project The mission of the
Translational Advisory Board is to serve as a
representative body which aims to improve community
health through the facilitation of community-based
participatory research and educational outreach activities.
This project is a joint project with UTHSCSA IIMS-
community engagement and the South Central Area
Health Education Center. My contribution as a member of
the Comal County Translational Advisory Board, is to
bring my expertise in lung and cardiac diseases and
experience as an Institutional Review Board (IRB)
member will help in setting the agenda for research and
outreach activities.
Board Member
2014 - 2014 2014 Community Health Summit Facilitator
2012 - 2013 American Heart Association -Doctor‘s Day Faculty
Representative
2011 - 2011 Women's Faculty Association-Science Fair judge
2009 - 2011 National Doctors‘ Day Volunteer Guest Speaker in
several High
Schools
2009 - 2010 American Heart Association Board of Director‘s Meeting Guest Speaker
2009 - 2009 Women's Faculty Association Science Fair Judge
2007 - 2009 Hawaii Lung Association- Asthma camp Volunteer
TEACHING AND MENTORING
TEACHING SUMMARY I intend to mentor students and fellow in the lab. If a formal teaching opportunity arises, I will certainly be glad to contribute.
FORMAL TEACHING
Not
UCSF
Academic Yr Course No. & Title Teaching Contribution School Class
Size
X 2019 - Bio2805 Genetics Lab
course
Lecturer 60
2018 - QB3 2019 Tissue
Repair Pathology
Course
Organization and lecture 20
12 of 25
Not
UCSF
Academic Yr Course No. & Title Teaching Contribution School Class
Size
X 2011 - 2015 INTD5000
Fundamentals of
Biomedical Sciences
(IMGP)
lectures 20
X 2014 - 2015 Analysis of the
senescent Cell
Post graduate seminar 60
X 2014 - 2015 Aging Lungs: From
Physiologic
Conditions to
Pathologies
Sunrise SeminarLecture 20
X 2014 - 2015 Age and age-related
diseases in the lungs:
convergence and
divergence
Lecture for the pulmonary
and critical care fellow
15
X 2010 - 2011 Respiratory Care
Lecture Series
Lecture entitled "Aging
lungs: How and what are the
consequences?"was
presented to the respiratory
therapist students.
45
X 2010 - 2011 Does Telomerase
Activity Only
Lengthen Telomere?
Implications in IPF
Sunrise SeminarLecture 20
X 2010 - 2015 Journal Club for the
cardiology fellow
Director of the Journal
Research Club organizing
schedules, lectures and
other related activities as
needed
15
X 2008 - 2009 Physiology 442 and
442L)
Lectures 40
X 2008 - 2009 Course 622-
Regulation of
Transcription/mRNA
Processing
Lectures 15
X 2006 - 2007 Anatomy &
Physiology Laboratory
in pre-nursing
Curriculum
Lectures 30
13 of 25
Not
UCSF
Academic Yr Course No. & Title Teaching Contribution School Class
Size
X 2006 - 2007 Introduction to Biology
for non-biology Major
Lectures 30
X 2004 - 2009 Ethics and Science:
Data ownership and
Data Management
lectures 10-20
PREDOCTORAL STUDENTS SUPERVISED OR MENTORED
Dates Name Program or
School
Mentor Type Role Current
Position
2013 - 2013 Alejandro Juul St Mary's Hall
School High
School
Summer
internship
Mentor College
student
2013 - 2013 Allison Price UTHSCSA 2nd Year
Medical Student
who took an
elective course
to perform
research
Mentor Resident
2013 - 2013 Greggory
Melish
UTHSCSA 2nd Year
Medical Student
who took an
elective course
to perform
research
Mentor Resident
2013 - 2015 Summer 2013:
Brian Ku, UT
South Western
School of
Medicine,
Dallas, TX
Summer 2014;
Craig Cook,
UTHSCSA,
San Antonio,
TX
UTHSCSA Medical Student
Training in Aging
Research
(MSTAR) Mentor
My role is to mentor
students who have
been selected to
participate in the
MSTAR program
Medical
students
2012 - 2012 Daniel Herlihy UTHSCSA 2nd Year
Medical Student
who took an
elective course
to perform
research
Mentor Resident
14 of 25
Dates Name Program or
School
Mentor Type Role Current
Position
2011 - 2013 Laura Solis UTSA Honor thesis
student
Research mentor Graduate
student
2010 - 2011 Monica
Benavides
UTHSCSA 3rd Year Medical
Student who took
an elective
course to
perform research
Mentor MD
2010 - 2010 Abby
Richmond
UTHSCSA 1st Year Medical
Student who took
an elective
course to
perform research
Mentor MD in
practice
2010 - 2011 Luke Mein Health
Careers High
School
UTHSCSA
Internship Mentor College
student
2010 - 2012 Yosef
Ansarizadeh
Keystone
High School
Internship Mentor College
student
2010 - 2011 Diana Anzueto UTSA Honor thesis
student
Co-Research mentor Research
Assistant
2010 - 2013 Cindy Martinez UTHSCSA BS student Mentor Medical
Laboratory
Technician
2010 - 2012 Justin Moreno UTSA Master
Thesis
Co-Mentor Graduate
student
2009 - 2011 Ariel Vinas University of
Hawaii
Medical Student Mentor
2004 - 2009 Kelsa Teeters PhD
ThesisUniver
sity of Hawaii
Mentor Postdoctoral
fellow
2002 - 2003 Christye Naole Master
ThesisUniver
sity of Hawaii
Rotation Mentor Assistant
Professor
Chaminade
University
Hawaii
2007 - 2009 Rachel Rueili University of
Hawaii
BS student Research Mentor Research
Assistant
15 of 25
Dates Name Program or
School
Mentor Type Role Current
Position
2016 - 2016 Laura
Delacourte
UniversiteUni
versité Pierre
et Marie
Curie (Paris)
Research/Schola
rly Mentor
Research mentor Graduate
Student
2019 - 2019 Richard Ruan UC Berkeley Project Mentor Supervisor Undergraduat
e Student
POSTDOCTORAL FELLOWS AND RESIDENTS MENTORED
Dates Name Fellow Mentor Role Faculty Role Current
Position
2011 - 2013 Ali Jafari Mehr Cardiology Research Mentor Faculty at
UTHSCSA in
Cardiology
div.
2011 - 2013 Julie Hisey Pediatrics Co research
Mentor
2011 - 2013 Pooja
Shivshankar
Research
postdoctoral
Mentor Assistant
Professor,
Texas Tech
University
Health
Science at
Lubbock ·
Department
of Medicine
2011 - 2012 Diego Maseli Pulmonary
and Critical
Care
Research mentor Faculty
UTHSCSA
pulmonary
and critical
care div.
2010 - 2013 Hector Payan Pulmonary
and Critical
Care
Research mentor Private
practice
2010 - 2012 Harshita
Bhatnagar
Research
postdoctoral
Mentor
2009 - 2010 Yelena
Rosenberg
Cardiology Research Mentor Private
practice
2008 - 2009 Christopher
Brampton
Research
postdoctoral
Mentor Junior
Scientist
Biorad
16 of 25
Dates Name Fellow Mentor Role Faculty Role Current
Position
2016 - 2016 Branca Pereira Fellow Project Mentor MD
2016 - 2017 Christopher
Wiley
Research
postdoctoral
Project Mentor Postdoctoral
Fellow
RESEARCH AND CREATIVE ACTIVITIES
RESEARCH AND CREATIVE ACTIVITIES SUMMARY My research activities will focus on understanding the role of senescent cells in aging and fibrotic lungs.
RESEARCH AWARDS - CURRENT
1. U01 HL134766 co-investigator 14 % effort Chapman, HA (PI)
NIH/NHLBI 09/21/2016 05/31/2023
Epithelial stem/progenitor cells as repair agents in
diffuse alveolar damage
The overall objective of this application is to develop human lung epithelial stem/progenitor
cells, either endogenous or derived from iPS cells, as an adjunctive therapy to promote
recovery from severe lung injury, i.e diffuse alveolar damage. The application involves a
multi-disciplinary investigative team and uses influenza infection in both mice and macaques
as pre-clinical models to assess efficacy of cell-based therapy in lung repair.
Perform mouse pre-clinical models and determine whether senescent mesenchymal cells
contribute to the severity of the lung injury.
2. 1R01 HL142265 co-investigator 35 % effort Chapman, HA (PI)
NHI/NHLBI 02/01/2019 01/31/2024
LOXL-2 dependent blockade of TGF Beta1
signaling and lung fibrosis
This proposal aims to translate the recent discovery of a lysyl-oxidase-like-2 (LOXL2)-
dependent pathway for fibroblast-specific inhibition of TGFb1 signaling into a clinical
therapeutic to attenuate pulmonary fibrosis. The specific aims are intended to further define
the LOXL2-dependent inhibition pathway and execute a proof of principle pilot study in
patients scheduled for lung biopsies to determine if combined LOXL2 and TGFb1 inhibition
can be achieved in vivo.
Development of biomarkers that will use in the clinical trial
RESEARCH AWARDS - SUBMITTED
1. Grant Number PI 35 % effort Jourdan Le
Saux, C (PI)
Scleroderma Research Foundation Start Date Start Date
Dynamic expression of senescence-associated
eicosanoids contributes to fibrotic phenotypes in
scleroderma
$ 199,735
direct/yr 1
$ 199,735 total
17 of 25
The major goals of this project are identify the dynamic change in senescence-induced
eicosanoid production in SSc and normal human skin and lung fibroblasts and its relevance
to fibrosis in the skin and the lungs.
I will be directly responsible for overseeing every phase of this project, will develop methods
as necessary to address the project aims, and analyze the data. She will also be responsible
for the dissemination of the results in the scientific community (journal articles, seminars, or
posters).
RESEARCH AWARDS - PAST
1. G12RR-03601 Co-investigator Your Effort %50 %
effort
PI NameTam, E (PI)
Granting Agency NIH-NCRR Start Date 09.2001 Start Date 09.2001
Grant TitleResearch Centers in minority
institutions program
$ Yr 1 Direct Costs
direct/yr 1
$ Total Direct
Costs$650,000 total
Grant Description NIH Research Center for Minorities Institution-Activity 3 pilot Project
Your contribution to the grant to study the Molecular Pathogensis of Airway Remodeling in
Asthma. Our project aimed to determine what are the genetic variations that could explain
the high prevalence of asthma among Asian and Pacific Islanders. We hypothesized that the
variants should be found in genes encoding inflammatory factors and consequently
enhanced airway remodeling.
2. NIH-NCRR 20 RR-1 Junior investigator Your Effort %50 %
effort
PI NameSmith, Dean
(PI)
NIH-NCRR Start Date04/2005 Start Date04/2005
Grant Title Hawaii State Biomedical
Research Infrastructure Network
$ Yr 1 Direct Costs
direct/yr 1
$ Total Direct Costs
total
Grant Description The goal of this grant was to increase the biomedical research capacity of
Hawaii.
Your contribution to the grant Junior investigator in charge of a project on pulmonary
fibrosis.
3. PF-7291 PI Your Effort % 10 %
effort
PI NameLe Saux, C
(PI)
Granting Agency Pfizer Inc. Start Date09/2014 Start Date09/2014
Grant Title Test of Janus Kinase inhibitor in
mouse lung bleomycin model
$ Yr 1 Direct
Costs$80,000
direct/yr 1
$ Total Direct Costs
total
Grant Description contract to test the anti-fibrotic properties of a Janus Kinase inhibitor
compound in mouse lung bleomycin model.
Your contribution to the grant: conduct the studies and prepare report
4. Grant Number PI Your Effort %10 %
effort
PI NameLe Saux,C
(PI)
Granting Agency Janey Briscoe
Distinguished Chair
Start Date09/2013 Start Date09/2013
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Grant TitlePreventive Effect of Tacrolimus on
Restenosis after Coronary Stenting
$ Yr 1 Direct
Costs$10,000
direct/yr 1
$ Total Direct Costs
total
Grant Description This award provided the funding necessary for the supplies to test the
hypothesis that inhaled tacrolimus could limit restenosis after coronary stenting.
Your contribution to the grant conduct the studies and prepare report
5. 10GRNT4020024 PI 10 % effort Le Saux, C (PI)
American Heart Association 07/2010 03/2013
Caveolin-1 prevents the development and
progression of cardiac remodeling.
$ 70,000 direct/yr 1 $ 140,000 total
The goal of this study is to determine how caveolin-1 regulates remodeling of the left
ventricle (LV) following myocardial infarction (MI), focusing on macrophage activation
mechanisms.
Conduct the studies and prepare report
6. 42588 PI 10 % effort Le Saux, C (PI)
HCF Fund-Leahi Fund to Treat and Prevent
Pulmonary Diseases
01/2010 01/2012
Caveolin-1 is a key mediator for the
development and progression of lung fibrosis
$ Yr 1 Direct Costs
$60,000 direct/yr 1
$ Total Direct Costs
$120,000 total
Grant Description The aim of this grant was to determine the role of caveolin-1 in the
regulation of TGF-beta signaling pathway, the main pathway that promotes pulmonary
fibrosis.
Your contribution to the grant conduct the studies and prepare report
7. 20080485 PI 10 % effort Le Saux, C (PI)
Hawaii Community Foundation 09/2008 09/20010
Caveolin-1 in the regulation of TGF-beta
signaling in myocardial remodeling
$ 50,000 direct/yr 1 $ 100,000 total
Grant Description The aim of this grant was to determine the role of caveolin-1 in the
regulation of TGF-beta signaling pathway
Conduct Research
8. 20011744 PI 10 % effort Le Saux, C (PI)
Hawaii Community Foundation
Involvement of IL-4 in airway remodeling:
activation of the lung fibroblasts
The aim of this proposal was to identify the cell and molecular mechanism that was
triggered by IL-4 in airway fibroblasts
Your contribution to the grant conduct the studies and prepare report
9. Grant Number NIH R21-
12167181
PI 40% % effort Le Saux, C (PI)
Granting Agency NIH 06/01/2016 05/31/2018
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Grant TitleCharacterization of the Various
Senescent Cells in the Aging Lungs
$ Yr 1 Direct Costs
direct/yr 1
$ Total Direct Costs
total
Grant Description This work proposes to determine whether senescence cells contribute to
the age-associated structural changes. We will determine whether the presence of
senescence cells is necessary to provoke the age-associated structural changes.
Furthermore, we will characterize the secretome of three main cell types (endothelial and
alveolar epithelial cells, and fibroblasts) and determine their relative contribution to the
structural changes.
Your contribution to the grant is to be directly responsible for overseeing every phase of this
project, develop methods as necessary to address the project aims, and analyze the data. I
will also be responsible for the dissemination of the results in the scientific community
(journal articles, seminars, or posters).
10. Grant Number AHA
15GRNT25710065
PI 10% % effort Le Saux, C (PI)
Granting Agency American Heart Association 07/2015 Start Date 07/2015
Grant TitleCellular senescence due to
invasive pneumococcal disease leads to
cardiac interstitial fibrosis
$ Yr 1 Direct Costs
$63,500 direct/yr 1
$ Total Direct
Costs$127,000 total
Grant Description This project explores how S. pneumoniae induced cellular senescence in
cardiomyocytes resulting in the release of senescence-associated secreted proteins that
recruit immune cells and elicit a profibrotic response and permanent cardiac alterations that
negatively impact cardiac function.
Your contribution to the grant is to directly be responsible for overseeing every phase of this
project and to develop methods as necessary to address the project aims. I will have final
authority on all aspects of the project.
11. Grant ISSEXEN0012 PI 25% % effort Le Saux, C (PI)
Granting Agency AstraZeneca 6/2016 6/2017
Grant TitleGradient of inflammation in
Adipocytes near Coronary Vessel Wall
Associated with Atherosclerotic Plaque
$ Yr 1 Direct Costs
direct/yr 1
$ Total Direct Costs
$390,848.00 total
Grant Description This project is designed to determine the possible role of the perivascular
fat in atherogenesis in particular the activation of macrophage and inflammatory markers.
Your contribution to the grant is to directly be responsible for overseeing every phase of this
project and to have final authority on all aspects of the project.
12. 7501313/7504366 co-OI 0 % effort Tien (PI)
UCSF-Academic Senate Shared Instrument
Awards
02/01/2017 07/31/2018
Integrated Lung Physiology Platform for
Murine Models
$ 35000 direct/yr 1
To provide an integrated lung physiology platform to improve the quality and reproducibility
of our studies in various lung pathology models.
Provide support to investigators who would like to use the Flexivent (Scireq) equipment
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PEER REVIEWED PUBLICATIONS
1. Baulard A, Jourdan C, Mercenier A, Locht C. Rapid mycobacterial plasmid analysis by electroduction between Mycobacterium spp. and Escherichia coli. Nucleic Acids Research. 1992; 20(15):4105. PMID: 1508702
2. Jourdan Le Saux C, Gleyzal C, Garnier JM, Peraldi M, Sommer P, Grimaud JA. Lysyl oxidase cDNA of myofibroblast from mouse fibrotic liver. Biochemical and Biophysical Research Communications. 1994; 199(2):587-92. PMID: 7510957
3. Jourdan Le Saux C, Gleyzal C, Raccurt M, Sommer P. Functional analysis of the lysyl oxidase promoter in myofibroblast-like clones of 3T6 fibroblast. Journal of Cellular Biochemistry. 1997; 64(2):328-41. PMID: 9027591
4. Jourdan Le Saux C, Le Saux O, Donlon T, Boyd CD, Csiszar K. The human lysyl oxidase-related gene (LOXL2) maps between markers D8S280 and D8S278 on chromosome 8p21.2-p21.3. Genomics. 1998; 51(2):305-7. PMID: 9722957
5. Jourdan Le Saux C, Tronecker H, Bogic L, Bryant-Greenwood GD, Boyd CD, Csiszar K. The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in reproductive tissues. The Journal of Biological Chemistry. 1999; 274(18):12939-44. PMID:10212285
6. Reynaud C, Gleyzal C, Jourdan Le Saux C, Sommer P. Comparative functional study of the lysyl oxidase promoter in fibroblasts, Ras-transformed fibroblasts, myofibroblasts and smooth muscle cells. Cellular and Molecular Biology. 1999; 45(8):1237-47. PMID: 10643973
7. Jourdan Le Saux C, Le Saux O, Gleyzal C, Sommer P, Csiszar K. The mouse lysyl oxidase-like 2 gene (mLOXL2) maps to chromosome 14 and is highly expressed in skin, lung and thymus. Matrix Biology. 2000; 19(2):179-83. PMID: 10842102
8. Hein S, Yamamoto SY, Okazaki K, Jourdan Le Saux C, Csiszar K, Bryant-Greenwood GD. Lysyl oxidases: expression in the fetal membranes and placenta. Placenta. 2001; 22(1):49-57. PMID: 11162352
9. Jourdan Le Saux C, Tomsche A, Ujfalusi A, Jia L, Csiszar K. Central nervous system, uterus, heart, and leukocyte expression of the LOXL3 gene, encoding a novel lysyl oxidase-like protein. Genomics. 2001; 74(2):211-8. PMID: 11386757
10. Lozanoff S, Johnston J, Ma W, Jourdan Le Saux C. Immunohistochemical localization of Pax2 and associated proteins in the developing kidney of mice with renal hypoplasia. The journal of Histochemistry and Cytochemistry. 2001; 49(9):1081-97. PMID: 11511678
11. Chan DS, Callahan CW, Beckham S, Kishaba G, Yamamoto K, Malone FJ, Boychuk R, Tam E, Jourdan Le Saux C, Underwood G, Vogt TM, Takafuji E. Report of the first annual Hawaii Asthma Research Consortium. Hawaii Medical Journal. 2002; 61(9):194-8. PMID: 12422384
12. Jourdan Le Saux C, Bollt O, Orozco C, Concepcion J, Yamaga K, Yamamoto F, Haymer D, Tam EK. A base substitution in the interleukin-10 (IL-10) promoter between Sp1 and ets-1 binding sites is not associated with variation of IL-10 levels. Cellular and Molecular Biology. 2003; 49(7):1109-15. PMID: 14682393
13. Tam EK, Jourdan LeSaux C, Stauder S, Bollt O, Reber B, Yamamoto F, Haymer D. Polymorphisms in the interleukin-4 receptor alpha chain: association with traits of allergy
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and asthma in an admixed population in Hawaii. Cellular and Molecular Biology. 2003; 49(8):1345-9. PMID: 14984008
14. Hayashi K, Cao T, Passmore H, Jourdan Le Saux C, Fogelgren B, Khan S, Hornstra I, Kim Y, Hayashi M, Csiszar K. Progressive hair loss and myocardial degeneration in rough coat mice: reduced lysyl oxidase-like (LOXL) in the skin and heart. The Journal of Investigative Dermatology. 2004; 123(5):864-71. PMID: 15482472
15. Harrigan RC, Easa D, Jourdan Le Saux C, Millar L, Kagihara LE, Shomaker TS, Greer MH, Beck JD, Offenbacher S. Oral health disparities and periodontal disease in Asian and Pacific Island populations. Ethnicity & Disease. 2005; 15(4 Suppl 5):S5-39-46 PMID: 16315381
16. Hoffmann PR, Jourdan Le Saux C, Hoffmann FW, Chang PS, Bollt O, He Q, Tam EK, Berry MJ. A role for dietary selenium and selenoproteins in allergic airway inflammation. Journal of Immunology. 2007; 179(5):3258-67. PMID: 17709542
17. Hoffmann PR, Gurary A, Hoffmann FW, Jourdan Le Saux C, Teeters K, Hashimoto AC, Tam EK, Berry MJ. A new approach for analyzing cellular infiltration during allergic airway inflammation. Journal of Immunological Methods. 2007; 328(1-2):21-33. PMID: 17825315
18. Jourdan Le Saux C, Teeters K, Miyasato SK, Hoffmann PR, Bollt O, Douet V, Shohet RV, Broide DH, Tam EK. Down-regulation of caveolin-1, an inhibitor of transforming growth factor-beta signaling, in acute allergen-induced airway remodeling. The Journal of Biological Chemistry. 2008; 283(9):5760-8. PMID: 18056268
19. Le Saux O, Teeters K, Miyasato S, Choi J, Nakamatsu G, Richardson JA, Starcher B, Davis EC, Tam EK, Jourdan Le Saux C. The role of caveolin-1 in pulmonary matrix remodeling and mechanical properties. American Journal of Physiology. Lung Cellular and Molecular Physiology. 2008; 295(6):L1007-17. PMID: 18849439
20. Jourdan Le Saux C, Zhang J, Lindsey ML. Extracellular matrix roles during cardiac repair. Life sciences. 2010; 87(13-14):391-400. PMID: 20670633
21. Miyasato S, Loeffler J, Shohet R, Zhang J, Lindsey M, Jourdan Le Saux C. Caveolin-1 modulates TGF-β1 signaling in cardiac remodeling. Matrix Biology. 2011; 30(5-6):318-29. PMID: 21641995
22. Shivshankar P, Boyd A, Jourdan Le Saux C, I-Tien Yeh, Orihuela C. Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia. Aging Cell. 2011; 10(5):798-806. PMID:21615674
23. Shivshankar P, Brampton C, Miyasato S, Kasper M, Thannickal VJ, Jourdan Le Saux C. Caveolin-1 deficiency protects from pulmonary fibrosis by modulating epithelial cell senescence in mice. American Journal of Respiratory Cell and Molecular Biology. 2012; 47(1):28-36. PMID: 22362388
24. Ramirez TA, Jourdan Le Saux C, Joy A, Zhang J, Dai Q, Mifflin S, Lindsey ML. Chronic and intermittent hypoxia differentially regulate left ventricular inflammatory and extracellular matrix responses. Hypertension Research. 2012; 35(8):811-8. PMID: 22495609
25. Jourdan Le Saux C, Davy P, Brampton C, Ahuja S S, Fauce S, Shivshankar P, Nyugen H, Ramaseshan M, Tressler R, Pirot Z, Harley CB, Allsopp R. A novel telomerase activator suppresses lung damage in a murine model ofidiopathic pulmonary fibrosis. PloS one. 2013; 8(3):e58423. PMID: 23516479
22 of 25
26. Gabehart, KE, Royce, S, Maselli Caceres D, Miyasato, S, Davis, E, Tang, M, Jourdan Le Saux C. Airway hyperresponsiveness is associated with airway remodeling but not inflammation in aging Cav1-/- mice. Respiratory Research. 2013; 14:110. PMID: 24138138
27. Medina JL, Coalson JJ, Brooks EG, Jourdan Le Saux C, Winter WT, Chaparro A, Principe MFR, Solis L, Kannan TR, Baseman JB, Dube PH. Mycoplasma pneumoniae CARDS toxin exacerbates ovalbumin-induced asthma-like inflammation in BALB/c mice. PloS one. 2014; 9(7):e102613. PMID: 25058417
28. Hung JY, Horn D, Woodruff K, Prihoda T, Jourdan Le Saux C, Peters J, Tio F, Abboud-Werner SL. Colony-stimulating factor 1 potentiates lung cancer bone metastasis. Laboratory Investigation. 2014; 94(4):371-81. PMID: 24468794
29. Royce, S and Jourdan Le Saux C. Role of caveolin-1 in asthma and chronic inflammatory respiratory diseases. Expert Review of Respiratory Medicine. 2014; 8(3):339-47. PMID: 24742020
30. Brown AO, Mann B, Gao G, Hankins JS, Humann J, Giardina J, Faverio P, Restrepo MI, Halade GV, Mortensen EM, Lindsey ML, Hanes M, Happel KI, Nelson S, Bagby GJ, Lorent JA, Cardinal P, Granados R, Esteban A, Jourdan Le Saux C, Tuomanen EI, Orihuela CJ. Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function. PLoS pathogens. 2014; 10(9):e1004383. PMID: 25232870
31. Shivshankar P, Payan H, Calhoun C, William R, Jahgidair J, Levine S, Peters J, Jourdan Le Saux C. Inhaled Tacrolimus Modulates Fibrosis Development without Promoting Inflammation in Bleomycin-Injured Mouse Lungs. Journal of Drug Delivery Science and Technology. 2014 September.
32. Shivshankar P, Halade GV, Calhoun C, Escobar GP, Mehr AJ, Jimenez F, Martinez C, Bhatnagar H, Mjaatvedt CH, Lindsey ML, Jourdan Le Saux C. Caveolin-1 deletion exacerbates cardiac interstitial fibrosis by promoting M2 macrophage activation in mice after myocardial infarction. Journal of Molecular and Cellular Cardiology. 2014; 76:84-93. PMID: 25128086
33. Sanders YY, Cui Z, Jourdan Le Saux C, Horowitz JC, Rangarajan S, Kurundkar A, Antony VB, Thannickal JV. SMAD-independent down-regulation of caveolin-1 by TGF-β: effects on proliferation and survival of myofibroblasts. PloS one. 2015; 10(2):e0116995. PMID: 25658089
34. Calhoun C, Shivshankar P, Sloane LB, Orihuela CJ, White E, Richardson A, Jourdan Le Saux C. Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs. The Journals of Gerontology. Series A, Biological sciences and medical sciences. 2015; PMID: 25568097
35. Sanon VP, Sawaki D, Mjaatvedt CH, Jourdan Le Saux C. Myocardial tissue caveolae. Comprehensive Physiology. 2015; 5(2):871-86. PMID: 25880516
36. Pinkerton KE, Harbaugh M, Han MK, Jourdan Le Saux C, Van Winkle LS, Martin Ii WJ, Kosgei RJ, Carter EJ, Sitkin N, Smiley-Jewell SM, George M. Women and Lung Disease: Gender Differences and Global Health Disparities. American Journal of Respiratory and Critical Care Medicine. 2015; PMID: 25945507
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37. Halaney DL, Zahedivash A, Phipps JE, Wang T, Dwelle J, Jourdan Saux C, Asmis R, Milner TE, Feldman MD. Differences in forward angular light scattering distributions between M1 and M2 macrophages. J Biomed Opt. 2015 PMID: 26538329.
38. Wan F, Letavernier E, Jourdan Le Saux C, Houssaini A, Abid S, Czibik G, Sawaki D, Marcos E, Dubois-Rande JL, Baud L, Adnot S, Derumeaux G, Gellen B. Calpastatin overexpression impairs postinfarct scar healing in mice by compromising reparative immune cell recruitment and activation Am J Physiol Heart Circ Physiol. 2015. PMID: 26453333
39. Wei Y, Kim TJ, Peng DH, Duan D, Gibbons DL, Yamauchi M, Jackson JR, Le Saux CJ, Calhoun C, Peters J, Derynck R, Backes BJ, Chapman HA. Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis. J Clin Invest. 2017;127(10):3675-3688. doi: 10.1172/JCI94624. Epub 2017 Sep 5. PMID:/> 28872461
40. Jourdan Le Saux C, Chapman HA. Idiopathic Pulmonary Fibrosis: Cell Death and Inflammation Revisited. American Journal of Respiratory Cell and Molecular Biology. 2018; 59(2): 137 doi.org/10.1165/rcmb.2018-0083ED
41. Pereira BI, Devine OP, Vukmanovic-Stejic M, Chambers ES, Subramanian P, Patel N, Virasami A, Sebire NJ, Kinsler V, Valdovinos A, Jourdan Le Saux C, Passos JP, Antoniou A, Rustin MHA, Campisi J, Akbar AN. Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition. Nature Communications. 2019; 10:2387. 10.1038/s41467-019-10335-5
42. Ying Wei, M.D., Julia Jackson, B.S., Genevieve Montas, B.S., Darren Leong, B.S., Jeffrey A. Golden, M.D., Binh N. Trinh, M.D., Ph.D., Elena Foster, M.S., Justin M. Oldham, M.D., Angela L. Linderholm, Ph.D., Paul J. Wolters, M.D., Xiaopeng Li, M.D., Julia Klesney-Tait, M.D., Ph.D., Prerna Kotak, M.S., Martin Decaris, Ph.D., Scott Turner, Ph.D., Jin Woo Song, M.D., Ph.D., Claude Jourdan Le Saux, Ph.D., Kirk Jones, M.D., and Harold A. Chapman, M.D. Reversal of TGFb1-driven Profibrotic State in Pulmonary Fibrosis Patients. Submitted
43. Christopher D. Wiley, Alexis N. Brumwell, Sonnet S. Davis, Julia R. Jackson, Alexis Valdovinos, Cheresa Calhoun, Fatouma Alimirah, Carlos A. Castellanos, Richard Rui, Ying Wei, Harold A. Chapman, Arvind Ramanathan, Judith Campisi, and Claude Jourdan Le Saux. Secretion of Leukotrienes by Senescent Lung Fibroblasts promotes Pulmonary Fibrosis. J Clin Invest In-sight. In Revision
44. Fan H, Rosson G, Wolf M, Sadtler K, Elisseeff J, Pardoll D, Houssean F, Wu X, Narain E, Chung L, Lebid A, Mageau A, Jourdan Le Saux C, Tam A, Vanderzee I, Čiháková D, Maestas D, Zhang X, Andorko, J.Interleukin-17 and senescence regulate the foreign body. Science Translational Medicine. In Revision
BOOKS AND CHAPTERS
1. Shivshankar P, Jourdan Le Saux C. Molecular Aspects of Aging. Rojas M, Meiners S, Jourdan Le Saux C, editors. Hoboken, New Jersey: John Wiley et sons Inc.; 2014. Chapter 5, The cellular senescence program; p.8.
24 of 25
2. Keyt H, Levine S, Jourdan Le Saux C. The Aging Lung: Mechanism and Clinical Sequeia. Lee P, Bucala R, editors. Washington DC: World Scientific Press; 2015. Chap 7, Environmental and Genetic Factors - Race Ethnicity and Gender
3. Molecular aspects of aging. Rojas M, Meiners S, Jourdan Le Saux C, editors. Hoboken, New Jersey: John Wiley et sons Inc.; 2014. 207p.
SIGNIFICANT PUBLICATIONS
1. I am interested in the mechanisms by which aging and injury trigger cellular senescence in
the lungs leading to the remodeling of the pulmonary tissue. I have built over the course of
the last 20 years my expertise on remodeling/fibrosis and in the last 5 years on cellular
senescence. This publication is one of the first ones to demonstrate not only the presence
of senescent cells in aged lungs but their causal role of the age-associated remodeling
features of the lungs
Calhoun C, Shivshankar P, Saker M, Sloane LB, Livi CB, Sharp ZD, Orihuela CJ, Adnot S,
White ES, Richardson A, Jourdan Le Saux C. Senescent Cells Contribute to the
Physiological Remodeling of Aged Lungs. J Gerontol A Biol Sci Med Sci. 2015 Jan
7;PubMed PMID: 25568097.
Senior Author
2. My initial work focused on the characterization of the transcriptional regulation of lysyl
oxidase and collagen type I in the liver fibrosis. At that time only 2 members were
characterized in the family of lysyl oxidase and lysyl oxidase-like family. By RNA screening
and computer analysis, we identified additional unknown members. I spent my postdoctoral
fellowship cloning and characterizing these additional members of the lysyl oxidase family in
mouse and human (Lysyl oxidase-2, -3 and -4). Because of the identification and
characterization of these additional proteins, a better understanding of the substrate
specificity could be achieved and these proteins are now used as therapeutic targets in
various fibrotic disorders
Jourdan-Le Saux C, Tronecker H, Bogic L, Bryant-Greenwood GD, Boyd CD, Csiszar K.
The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in
reproductive tissues. J Biol Chem. 1999 Apr 30;274(18):12939-44. PubMed PMID:
10212285.
First author
25 of 25
3. I initiated a project on gene variations implicated in the immune response in asthma and the
frequencies of these alleles in Asian and Pacific Islanders to determine how they differ from
those described in Caucasian, Hispanic, or African-American populations. My research
project evolved on airway remodeling in asthma to combine my new expertise in
inflammation and previous one on fibrosis. Our work demonstrated the regulation of
caveolin-1 by interleukin-4 and subsequent activation of TGF-beta signaling in airway
remodeling identifying a link between the inflammation and the remodeling processes
characteristic of asthma. Our studies were among the first ones to demonstrate a role for
caveolin-1 in pulmonary diseases./> a. Le Saux CJ, Teeters K, Miyasato SK, Hoffmann PR,
Bollt O, Douet V, Shohet RV, Broide DH, Tam EK. Down-regulation of caveolin-1, an
inhibitor of transforming growth factor-beta signaling, in acute allergen-induced airway
remodeling. J Biol Chem. 2008 Feb 29;283(9):5760-8. PubMed PMID: 18056268.
b. Shivshankar P, Brampton C, Miyasato S, Kasper M, Thannickal VJ, Le Saux CJ.
Caveolin-1 deficiency protects from pulmonary fibrosis by modulating epithelial cell
senescence in mice. Am J Respir Cell Mol Biol. 2012 Jul;47(1):28-36. PubMed PMID:
22362388; PubMed Central PMCID: PMC3402795.
Senior Author
4. We broaden our discovery on caveolin-1 regulating TGF-beta signaling in the airways to its
role in pulmonary fibrosis. We demonstrated that caveolin-1 prevents fibrosis by regulating
cellular senescence and therefore modulating cellular senescence could potential become a
therapeutic target. The importance of cellular senescence was at the time not thought to be
relevant for pulmonary fibrosis. We further studied cellular senescence and discovered that
it was an important process not only in repair of the lungs in the context of inflammation but
in aging as well./> a. Shivshankar P, Boyd AR, Le Saux CJ, Yeh IT, Orihuela CJ. Cellular
senescence increases expression of bacterial ligands in the lungs and is positively
correlated with increased susceptibility to pneumococcal pneumonia. Aging Cell. 2011
Oct;10(5):798-806. PubMed PMID: 21615674; PubMed Central PMCID: PMC3173515.
b. Shivshankar P, Brampton C, Miyasato S, Kasper M, Thannickal VJ, Le Saux CJ.
Caveolin-1 deficiency protects from pulmonary fibrosis by modulating epithelial cell
senescence in mice. Am J Respir Cell Mol Biol. 2012 Jul;47(1):28-36. PubMed PMID:
22362388; PubMed Central PMCID: PMC3402795.
c. Le Saux CJ, Davy P, Brampton C, Ahuja SS, Fauce S, Shivshankar P, Nguyen H,
Ramaseshan M, Tressler R, Pirot Z, Harley CB, Allsopp R. A novel telomerase activator
suppresses lung damage in a murine model of idiopathic pulmonary fibrosis. PLoS One.
2013;8(3):e58423. PubMed PMID: 23516479; PubMed Central PMCID: PMC3597721.
Senior Author