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Principles of Oncology
Professor Ravi Kant
Concepts
• Cancer= Crab• Some Egyptian mumies have cancer• Rudolf Virchow-1821-1902- Omnes cellula e
cellula• Theodor Boveri-1914 chromosomal
abnormalities• Watson & Crick-1953- DNA
Apoptosis
Cancer cells →
• Undemocratic• Autonomous• Avoid Apoptosis• Neoangiogenesis• Invasion• Proliferation
Cancer cellls
• Genomic instability
Malignant transformation
Gompertzian curve
Kaplan-Meier Curve
Clinical implication of Gompertzian curve
Genetic Cancer
• Breast• Thyroid
Prevention of Cancer
• Diet• Life style
Early detection of cancer
• Screening- for cancer of • Oral: Intraoral examination• Breast: Mammography• Stomach: Upper GI endoscopy • Prostate: PSA level in serum
Diagnosis & Staging
Rx of Cancer
• Surgery• Radiotherapy• Chemotherapy• Isotope Therapy• Immunotherapy• Immuno-modulation• Receptor blockade of cancer
Team
• Multidisciplinary approach
Rx of
• T= Tumour• N= Node• M= Metastasis
Palliation
End of life care
• ? Nobel prize
Quality of life
• Dignity
Thanks