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source mainly from kumar & clerk
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Process of coronary atherosclerosisinitial endothelial dysfx/"injury"
mech shear stress
morbid HPT
biochem abnorm
↑ LDLDM
↑ plasma homocysteine
immunological factor
free radicals from smoking
inflammation
infxn
genetic alteration
↑ permeability to oxidixed lipoprotein
accumulation o oxidixed
lipoprot
macrophage engulf lipoprot
within endothelium
lipid-laden foam cell
lipid laden foam cellendothelial dysfx
fatty streaks