Process of coronary atherosclerosisinitial endothelial dysfx/"injury"

mech shear stress

morbid HPT

biochem abnorm

↑ LDLDM

↑ plasma homocysteine

immunological factor

free radicals from smoking

inflammation

infxn

genetic alteration

↑ permeability to oxidixed lipoprotein

accumulation o oxidixed

lipoprot

macrophage engulf lipoprot

within endothelium

lipid-laden foam cell

lipid laden foam cellendothelial dysfx

fatty streaks