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ApiewataeFadolescents were discriminated from non BPD through their coping profile. Thisstudy has enabled the identification of targets for psychoeducative and treatingprograms.
42 IACAPAP 2012 – 20th World congress / Neuropsychia
ackground.– Medial temporal cortical dysfunction and perturbed glutamatergiceurotransmission are regarded as fundamental pathophysiological features ofsychosis and animal models suggest that they are interrelated.ethods.– We used a combination of functional magnetic resonance imaging
nd magnetic resonance spectroscopy to investigate the relationship betweenedial temporal activation during a memory task and local glutamate levels in
2 individuals at ultra high-risk for psychosis and 14 healthy volunteers.esults.– We observed a significant between-group difference in the couplingf medial temporal activation with local glutamate levels.onclusions.– In individuals at ultra high-risk for psychosis, medial temporalysfunction seemed related to a loss of the normal relationship with local glu-amate levels. This study provides the first evidence that links medial temporalysfunction with the central glutamate system in humans and is consistent withvidence that drugs that modulate glutamatergic transmission might be usefuln the treatment of psychosis.
ttp://dx.doi.org/10.1016/j.neurenf.2012.05.149
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tructural and functional imaging correlates of liability tosychosis. Borgwardt
Department of Psychiatry, University of Basel, Basel, Switzerland
he onset of psychosis is preceded by a prodromal phase characterized byunctional decline and subtle prodromal symptoms, which include attenuatedsychotic phenomena and a decline of cognitive and socio-occupational func-ion. Preventive interventions during this phase are of great interest because ofhe impressive clinical benefits. However, available clinical criteria employed toefine an at-risk mental state for psychosis have relatively low validity and spe-ificity. Consequently, there is an urgent need of reliable neurocognitive markersinked to the pathophysiological mechanisms that underlie schizophrenia. Neu-oimaging techniques have rapidly developed into a powerful tool in psychiatrys they provide an unprecedented opportunity for the investigation of braintructure and function. Neuroimaging studies of the prodromal phases of psy-hosis have the potentials to identify core structural and functional markers of anmpending risk to psychosis and to clarify the dynamic changes underlying tran-ition to psychosis and to address significant correlations between brain structurer function and prodromal psychopathology. Additionally, neurochemical andultimodal methods can address the key role played by neurotransmitters such
s dopamine and glutamate during the psychosis onset.
ttp://dx.doi.org/10.1016/j.neurenf.2012.05.150
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ey determinants of longer duration of untreatedsychosis in adolescents.D.G. Dominguez Barrera a,∗, H. Fisher b, S. Johnson c, M. Hodes d
Academic Unit of Child and Adolescent Psychiatry, Imperial college,ondon, UKInstitute of Psychiatry, Kings College, London, UKDepartment of Mental Health Sciences, University College, London, UKChild And Adolescent Psychiatry, Imperial College, London, UKCorresponding author.
ntroduction.– Duration of Untreated Psychosis (DUP) has been found to bewo times higher in adolescent (< age 18) than adult-onset psychosis in fourorldwide publications. Recent UK policy set a target of reducing DUP (< 3onths). This is the first study comparing DUP in adolescents and adults in theK, and first investigation of the determinants of DUP amongst adolescents.ethod.– First episode psychosis cases referred to Early Intervention Psychosis
eams in London from 2004 to 2009. Standardised clinical assessments carriedut by Teams.esults.– Adolescents showed significantly greater median DUP (179 days) than
dults (81 days, P = 0.005). Younger age of onset, lifetime cannabis use andhite ethnicity predicted significant delay in treatment uptake for adolescents. h
e l’enfance et de l’adolescence 60S (2012) S12–S63
iscussion.– These findings suggest that treatment delay may be a critical pro-lem in adolescents in the UK and other countries. Health professionals need toe trained to manage psychosis at early stages.
ttp://dx.doi.org/10.1016/j.neurenf.2012.05.151
rotective factors in adolescent suicidal behaviors
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nfluence of age and gender on protective factors forepression and suicidal behaviors
. Breton a,∗, R. Labelle b, C. Berthiaume a, C. Royer a, M. St-Georges a,. Ricard a, S. De Armas a
Pédopsychiatrie, hôpital Rivière-des-Prairies, Montréal, CanadaCentre de recherche Fernand-seguin, hôpital Rivière-des-Prairies, Montréal,anadaCorresponding author.
he presentation is based on secondary analyses of a psychometric study onrotective factors among 283 adolescents aged 14 to 17 years in Quebec French-peaking schools completed in 2007. The protective factors analyzed wereeasons for living (Reasons for Living Inventory for Adolescents), Spirituality
Spirituality Scale) and Coping (Adolescent Coping Scale). Three risk factorsere also added namely Life events (Life Events Questionnaire), Depression,
Beck Depression Inventory-II) and Hopelessness (Beck Hopelessness Scale).theoretical model of the interaction between protective and risk factors will
e presented. Descriptive, univariate and multiple regression analyses on thenfluence of protective and risk factors on depression and suicidal ideas wille presented for each gender (120 girls and 163 boys) and each age group (167ouths aged 14 and 15 years and 116 aged 16 and 17 years). Clinical implicationsf the results will be discussed.
ttp://dx.doi.org/10.1016/j.neurenf.2012.05.152
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rotective factors and borderline personality disorder indolescence. Knafo a,∗, B. Kharij a, N. Bapt-Cazalets a, V. Belloncle b, N. Bodeau c,. Condat d, D. Cohen c, P. Gérardin b, C. Mille a, J. Renaud e, J.-J. Breton f,. Labelle f, J.-M. Guilé a
CHU d’Amiens, Amiens, FranceCHU de Rouen, Rouen, FranceService de psychiatrie de l’enfant et de l’adolescent, hôpitalitié-Salpêtrière, Paris, FranceMeaux, FrancePsychiatrie, institut santé mental Douglas, Montréal, CanadaHôpital Rivière-les-Prairies, Montréal, CanadaCorresponding author.
mong a cohort of French suicidal 11–17 year-old youths recruited in a pros-ective study, adolescents with traits of Borderline Personality Disorder weredentified with the Abbreviated-Diagnostic Interview for Borderlines (Guiilét al., 2009). Analyses indicated that BPD symptoms were negatively correlatedith CGAS (P < 0.05) and significantly correlated with the number of suicide
ttempts (P < 0.01) and the depressive symptoms assessed independently withhe Beck depression Inventory (P < 0.001). With respect to the profile of risknd protective factors as evaluated by the Adolescent Coping Scale (Frydenbergt Lewis, 1993), the Spirituality Scale (Delaney et al., 2005) and the Reasonsor Living Inventory for Adolescents RFL-A (Osman et al., 1998), those BDP
ttp://dx.doi.org/10.1016/j.neurenf.2012.05.153
