Quality of Life through Qualityof Information

Proceedings of MIE2012

Edited by

John Mantas

Health Informatics Laboratory, University ofAthens, Greece

Chair ofthe Scientific Programme Committee

Stig Kjaer Andersen

Department ofHealth Science and Technology, Aalborg University, Denmark

Maria Cristina Mazzoleni

Salvatore Maugeri Foundation, IRCCS, Pavia, Italy

Bernd Blobel

ehealth Competence Center, University Hospital Regensburg, Germany

Silvana QuagliniBiomedical Informatics Laboratory, University ofPavia, Italy

and

Anne Moen

Institute ofHealth and Society, University ofOslo, Norway

IOSPress

Amsterdam • Berlin • Tokyo • Washington, DC

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Contents

Preface v

John Mantas, Stig Kjcer Andersen, Maria Cristina Mazzoleni, Bernd Blobel,Silvana Quaglini and Anne Moen

Reviewers for MIE2012 ix

Keynotes

Challenges of the e-Health Curricular Education in Bio-Medical Engineeringand in Medicine 3

Francesco Pinciroli, Stefano Bonacina, Sara Marceglia, Simona Ferrante

andLuca Mazzola

Personal Health Records 9

Finn Kensing

Enhancing Service Delivering, Improving Quality of Life, PreservingIndependence Through Assistive Technology 14

Roberta Annicchiarico

The Future ofBiomedical Informatics: A Perspective from Academia 19

EdwardH. Shortliffe

Improving Quality of Life Through eHealth - The Patient Perspective 25

Sabine Koch

Methodologies for Information Quality

Conceptual Modeling for Prospective Health Technology Assessment 33

Marion Gantner-Bdr, Anatoli Djanatliev, Hans-Ulrich Prokosch

and Martin SedlmayrData Definition Ontology for Clinical Data Integration and Querying 38

Ariane Assele Kama, Audi Primadhanty, Remy Choquet, Douglas Teodoro,Frank Enders, Catherine Duclos and Marie-Christine Jaulent

Migration Path for Structured Documentation Systems Including Standardized

Medical Device Data 43

Ann-Kristin Kock, JosefIngenerf, Stoyan Halkaliev and Heinz Handels

Quality Requirements for EHR Archetypes 48

Dipak Kalra, Archana Tapuria, Tony Austin and Georges De Moor

Using Archetypes for Defining CDA Templates 53

David Moner, Alberto Moreno, Jose A. Maldonado, Montserrat Robles

and Carlos Parra

Using Enterprise Ontology for Improving Emergency Management in Hospitals 58

David Galego Dias, Luis Velez Lapao and Miguel Mira da Silva

A ClaML-Based Interface for the Import ofMonohierarchical Classifications 63

Sylvie Mn Ngouongo and Jiirgen Stausberg

xiv

An Information Artifact Ontology Perspective on Data Collections and

Associated Representational Artifacts 68

Werner Ceusters

Automatic Generation of MedDRA Terms Groupings Using an Ontology 73

Gunnar Declerck, Cedric Bousquet and Marie-Christine Jaulent

Formal Specification of an Ontology-Based Service for EHR Interoperability 78

Carolina Gonzalez, Bernd G.M.E. Blobel and Diego M. Lopez

Mapping SNOMED CT to ICD-10 83

Kathy Giannangelo andJane Millar

Rare Diseases Knowledge Management: The Contribution of ProximityMeasurements in OntoOrpha and OMIM 88

X. Aime, J. Charlet, F. Furst, P. Kuntz, F. Trichet andF. Dhombres

Design of an Original Interface That Facilitates the Use ofClinical Practice

Guidelines of Infection by Physicians in Primary Care 93

Rosy Tsopra, Jean-Baptiste Lamy, Alain Venot and Catherine Duclos

Knowledge Representation for Fuzzy Inference Aided Medical Image

Interpretation 98

Norbert Gal and Vasile Stoicu-Tivadar

MRI Image Artifact Ontology: A Proposed Method for Improved Recognition 103

Jeremy Lasbleiz, John Morelli, Nicolas Schnel, Anita Burgun,

Regis Davauferrier and Herve Saint Jalmes

Ontology Driven Decision Support Systems for Medical Diagnosis 108

Valery Donfack Guefack, Valerie Bertaud Gounot, Regis Duvauferrier,Annabel Bourde, John Morelli and Jeremy Lasbleiz

The Reproducibility of CLIF, a Method for Clinical Quality Indicator

Formalisation 113

Kathrin Dentier, Ronald Cornet, Annette ten Teije, Kristien Tytgat,Jean Klinkenbijl and Nicolette de Keizer

Virtual Medical Record Implementation for Enhancing Clinical Decision Support 118

Valentin-Sergiu Gomoi, Daniel Dragu and Vasile Stoicu-Tivadar

An Application ofSymbolic Dynamics for FHRV Assessment 123

Mario Cesarelli, Maria Romano, Paolo Bifulco, Gianni Improtaand Gianni D 'Addio

Automated Versus Interactive Spectral Analysis ofHeart Rate Variabilityfrom 24-Hour Holter Recordings in Heart Failure Patients 128

Roberto Maestri, Maria Teresa La Rovere and Gian Domenico Pinna

Probabilistic Graphical Models for Effective Connectivity Extraction in the

Brain Using fMRI Data 133

Mohammad Ali Safari and Majid MohammadbeigiScale-Space Methods for Live Processing of Sensor Data 138

Stein Olav Skravseth, Andre Dias, Lukas Gorzelniak, Fred Godtliebsen

andAlexander Horsch

Segmentation of Crohn, Lymphangiectasia, Xanthoma, Lymphoid Hyperplasiaand Stenosis Diseases in WCE 143

Omid Haji-Maghsoudi, A. Talebpour, H. Soltanian-Zadehand N. Haji-Maghsoodi

Generation of a Probabilistic Arterial Cerebrovascular Atlas Derived from 700

Time-of-Flight MRA Datasets 148

Nils Daniel Forkert, Santiago Suniaga, Jens Fiehler, Heike Wersching,Stefan Knecht and Andre Kemmling

Customization of Biomedical Terminologies 153

Julien Homo, Laetitia Dupuch, Allel Benbrahim, Natalia Grabar

and Marie DupuchIRMA Code II: Unique Annotation of Medical Images for Access and Retrieval 159

Tim-Christian Piesch, Henning Miiller, Christiane K. Kuhl

and Thomas M. Deserno

Method for Mapping the French CCAM Terminology to the UMLS

Metathesaurus 164

Cedric Bousquet, Julien Souvignet, Tayeb Merabti, Eric Sadou,Beatrice Trombert andJean-Marie Rodrigues

Semantic Relations ofBinary Compounds Annotated with SNOMED CT 169

Dimitrios Kokkinakis

The Issue ofBuilding Generative Terminologies for Automatic Medical Data

Aggregation 174

Ihssen Belhadj, Jerome Nobecourt, Sylvie Despresand Christian Jacquelinet

Towards a Bilingual Alzheimer's Disease Terminology Acquisition Usinga Parallel Corpus 179

Khadim Drame, Gayo Diallo andFleur MouginAn Ontological Approach to Manage and Harmonize Document Types 184

Frank Oemig and BerndBlobel

Patient Support ICT Tool for Hypertension Monitoring 189

Morten Algy Bonderup, Stine Veje Hangaard, Pernille HeyckendorffLilholt,Mette Dencker Johansen and Ole K. Hejlesen

RAVEL: Retrieval and Visualization in ELectronic Health Records 194

Frantz Thiessard, Fleur Mougin, Gayo Diallo, Vianney Jouhet,

Sebastien Cossin, Nicolas Garcelon, Boris Campillo, Wassim Jouini,Julien Grosjean, Philippe Massari, Nicolas Griffon, Marie Dupuch,Fayssal Tayalati, Edwige Dugas, Antonio Balvet, Natalia Grabar,Suzanne Pereira, Bruno Frandji, Stefan Darmoni and Marc Cuggia

Standard Based Multiclient Medical Data Visualization 199

Georgy KopanitsaAn Advanced Search Engine for Patent Analytics in Medicinal Chemistry 204

Emilie Pasche, Julien Gobeill, Douglas Teodoro, Arnaud Gaudinat,Dina Vishnyakova, Christian Lovis and Patrick Ruch

Classification and Prioritization ofBiomedical Literature for the ComparativeToxicogenomics Database 210

Dina Vishnyakova, Emilie Pasche, Julien Gobeill, Arnaud Gaudinat,

Christian Lovis and Patrick Ruch

CliniQA: Highly Reliable Clinical Question Answering System 215

Yuan Ni, Huijia Zhu, Peng Cai, Lei Zhang, Zhaoming Qui and Feng Cao

Development and Representation of Health Indicators with Thematic Maps 220

Simona Dalle Carbonare, Carlo Cerra and Riccardo Bellazzi

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Efficient Medical Information Retrieval in Encrypted Electronic Health Records 225

Cedric Pruski and Francois Wisniewski

The Use of Linked Registries to Assess Long-Term Mortality of ICU Patients 230

Sylvia Brinkman, Evert de Jonge, Ameen Abu-Hanna, Dylan W. de Lange

and Nicolette F. de Keizer

Grouping the Pharmacovigilance Terms with a Hybrid Approach 235

Marie Ditpuch, Laetitia Dupuch, Amandine Perinet, Thierry Hamon

and Natalia Grabar

Information Extraction from SMS Text Related to a Reminder Service

for Outpatients 240

Stefania Rubrichi, Stephanie Eku Ndam, Andrea Battistotti

and Silvana QuagliniInventory ofTools for Dutch Clinical Language Processing 245

RonaldCornet, Armand van Eldik andNicolette de Keizer

Linguistic Analysis of Large-Scale Medical Incident Reports for Patient Safety 250

Katsuhide Fujita, Masanori Akiyama, Keunsik Park,

Etsuko (Nakagami) Yamaguchi and Hiroyuki Furukawa

Measuring Lexical Similarity Methods for Textual Mapping in Nursing

Diagnoses in Spanish and SNOMED-CT 255

Jorge Cruanes, M. Teresa Romd-Ferri and Elena Lloret

A "Meta"-Perspective on "Bit Rot" ofBiomedical Research Data 260

Frank Dickmann, Romanus Grutz and Otto Rienhoff

A Semantic Approach for Digital Long-Term Preservation of Electronic Health

Documents 265

Stephan Kiefer, Michael Schafer andJochen RauchAutomated Realtime Data Import for the i2b2 Clinical Data Warehouse:

Introducing the HL7 ETL Cell 270

Raphael W. Majeedand Rawer Rohrig

Coupling K-Nearest Neighbors with Logistic Regression in Case-Based

Reasoning 275

Boris Campillo-Gimenez, Sahar Bayat and Marc CuggiaFlexible Solution for Interoperable Cloud Healthcare Systems 280

Mihaela Marcella Vida, Oana Sorina Lupse, Lacrdmioara Stoicu-Tivadar

and Elena Bemad

TEDIS, Pervasive Developmental Disorder' Patients Information System,Preliminary Results 285

Mohamed Ben Said, Laurence Robel, Marie Pellegrin-Touati,Berangere Rousselot-Pailly, Bernard Golse, Jean Philippe Jais

and Paul Landais

Characteristics of Patients at Risk for Adverse Drug Events: Designing for

Patient Safety and Decision Support 290

Elizabeth Borycki, JeffBarnett, Susan Walisser, Paule Bellwood,

Melissa Clarke and David GreigClinical Diagnosis Support System Based on Case Based Fuzzy CognitiveMaps and Semantic Web 295

Nassim Douali, Jos De Roo and Marie-Christine Jaulent

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Comparing Drools and Ontology Reasoning Approaches for TelecardiologyDecision Support 300

Pascal Van Hille, Julie Jacques, Julien Taillard, Arnaud Rosier,

DavidDelerue, Anita Burgun and Olivier Dameron

Decision Support in Trauma Management: Predicting Potential Cases of

Ventilator Associated Pneumonia 305

Adrian Pearl and David Bar-Or

Knowledge-Based Tacrolimus Therapy for Kidney Transplant Patients 310

Walter Seeling, Max Plischke and Christian Schuh

Proposal ofDiagnostic Process Model for Computer Based Diagnosis 315

Yasushi Matsumura, Toshihiro Takeda, Shiro Manabe, Hirokazu Saito,Kei Teramoto, Shigeki Kuwata and Naoki Mihara

Quality Through Evaluation

Challenges in Evaluating Telehealth Through RCT-The Problem of

Randomization 323

Urvashi Sharma, Julie Reed, Cathal Doyle andDerek Bell

eHealth Indicators: Results ofan Expert Workshop 328

Hannele Hypponen, Elske Ammenwerth, Christian Nohr, Arild FaxvaagandAke Walldius

eHealth Interoperability Evaluation Using a Maturity Model 333

Wded Guedria, Hanan Bouzid, Guido Bosh, Yannick Naudet

and David Chen

Exploring a Methodology for eHealth Indicator Development 338

Hannele Hypponen, Elske Ammenwerth andNicolet de Keizer

Population-Based Clinical Decision Support: A Clinical and

Economic Evaluation 343

Eric L. Eisenstein, Kevin J. Anstrom, Rex Edwards, Janese M. Willis,

Jessica Simo and David F. Lobach

Quality Assurance and Effectiveness ofthe Medication Process ThroughTablet Computers? 348

Amanda Buus, Louise Nyvang, Sisse Heiden and Louise Pape-HaugaardA Framework for User Involvement and Context in the Design and

Development of Safe e-Health Systems 353

Andre Kushniruk and Paul Turner

Analysis of Metrics for the Usability Evaluation of EHR Management Systems 358

Georgy Kopanitsa, Zhanna Tsvetkova and Hasan Veseli

Low-Cost Rapid Usability Testing for Health Information Systems: Is It Worth

the Effort? 363

Tristin B. Baylis, Andre W. Kushniruk and Elizabeth M. BoryckiPatient Safety-Oriented Usability Testing: A Pilot Study 368

Romaric Marcilly, Stephanie Bernonville, Costanza Riccioli

and Marie-Catherine Beuscart-ZephirThe Role of Simulation in Clinical Information Systems Development 373

Sanne Jensen, Karen Marie Lyng and Christian Nohr

Using Video Observation to Gain Insight into Complex Clinical Work Practices 378

Anna Marie Balling HostgaardandPernille Bertelsen

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ICU Nurses' Evaluations ofIntegrated Information Displays on User

Satisfaction and Perceived Mental Workload 383

Sven H. Koch, Dwayne Westenskow, Charlene Weir, Jim Agutter,

Maral Haar, Matthias Gorges, DavidLiu and Nancy Staggers

Proactive Authenticated Notifications for Health Practitioners: Two WayHuman Computer Interaction Through Phone 388

Raphael W. Majeed, Mark R. Stohr andRainer RbhrigSmall Cause - Big Effect: Improvement in Interface Design Results in

Improved Data Quality - A Multicenter Crossover Study 393

Janko Ahlbrandt, Michael Henrich, BerndA. Hartmann,

Bettina B. Bundschuh, Julia Schwarz, Joachim Klasen and Rainer Rohrig

The Use and Usability of EPR Systems in Oncology 398

Thomas Poulter and Peter A. Bath

Usability Evaluation of a Guideline Implementation System for Cardiac

Rehabilitation: Think Aloud Study 403

Mariette van Engen-Verheul, Linda Peute, Ellen Kilsdonk, Niels Peek

and Monique Jaspers

Quality of Care Delivery Process

A Semantic Wiki for Editing and Sharing Decision Guidelines in Oncology 411

Thomas Meilender, Jean Lieber, Fabien Palomares, Gilles Herengtand Nicolas Jay

An Engine for Compliance Checking ofClinical Guidelines 416

Jing Mei, Haifeng Liu, Guotong Xie and Geetika T. Lakshmanan

Application ofthe Logical Elements Rule Method for Formalization of

Clinical Rules: Case Study of ACOVE-NLI 421

Stephanie Medlock, Saeid Eslami, Dedan Opondo, Marjan Askari,

Sophia de Rooij andAmeen Abu-Hanna

Clinical Guideline Representation in a CDS: A Human Information

Processing Method 427

Ellen Kilsdonk, Rinke Riezebos, Leontien Kremer, Linda Peute

and Monique JaspersComputerized Clinical Guidelines: Current Status & Principles for Future

Research 432

Haridimos Kondylakis and Manolis Tsiknakis

Ontology-Based Computerization of Acute Coronary Syndrome ClinicalGuideline for Decision Support in the Emergency Department 437

Mostafa Omaish, Samina Abidi and Syed Sibte Raza Abidi

A Semiotic View on Paper and Mobile Care Data Quality 442

Retha De La Harpe

Challenges and Issues of Geolocation in Clinical Environment 447

David-Zacharie Issom, Claire Hagry, Laetitia Wodia Mendo,Henry Seng, Frederic Ehrler and Christian Lovis

Empower the Patients with a Dialogue-Based Web Application 452

Charlotte D. Bjernes, Elizabeth Cummings and Christian NohrFrom Clinical Requirement to Personalized Wellness Decision Support:A Data-Driven Framework for Computer-Supported Guideline Refinement 457

Pei-Yun Hsueh, Ci-Wei Lan, Vincent Deng andXinxin Zhu

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Interoperability Design ofPersonal Health Information Import Service 462

Mika Tuomainen andJuha Mykkanen

Using a Patient-Centered Approach for Health and Social Care Integration 467

Mikaela Poulymenopoulou, Despoina Papakonstantinou,Flora Malamateniou and George Vassilacopoulos

Accuracy of Clinical Data Entry when Using a Computerized Decision

Support System: A Case Study with OncoDoc2 472

Brigitte Seroussi, Brigitte Blaszka-Jaulerry, Laurent Zelek,

Jean-Pierre Lefranc, Rosa Conforti, Jean-Philippe Spano,Alexandra Rousseau and Jacques Bouaud

Elicitating Patient Patterns of Physician Non-Compliance with Breast

Cancer Guidelines Using Formal Concept Analysis 477

Jacques Bouaud, Nizar Messai, Cedric Laouenan, France Mentre

and Brigitte Seroussi

Evidence Based Electronic System to Ensure Quality of Care in Trauma Patients 482

Vasiliki Mpletsa, Ioannis Kaklamanos, Konstantinos Birbas

andJohn Manias

OpenEHR-Based Representation of Guideline Compliance Data Throughthe Example of Stroke Clinical Practice Guidelines 487

Nadim Anani, Rong Chen, Tiago Prazeres Moreira and Sabine Koch

Towards Collaborative Chronic Care Using a Clinical Guideline-Based

Decision Support System 492

Haifeng Liu, Jing Mei and GuotongXieA Standardized Middleware as the Core of a Telemonitoring European Project 497

Fabio Vergari, Roberta Gazzarata, Francesco Morandi, Viola Parodi,Simone Naso, Alessandra Arezza, Tulio Salmon Cinotti

and Mauro Giacomini

Dicoogle Mobile: A Medical Imaging Platform for Android 502

Carlos Viana-Ferreira, Daniel Ferreira, Frederico Valente,Eriksson Monteiro, Carlos Costa andJose Luis Oliveira

Does Telecare Reduce the Number of Treatment Days? 507

Yuji Akematsu and Masatsugu TsujiEstablishing End-to-End Security in a Nationwide Network for Telecooperation 512

Martin Staemmler, Michael Walz, Gerald Weisser, Uwe Engelmann,Robert Weininger, Antonio Ernstberger and Johannes Sturm

Quality Through and for Research

A Loosely Coupled Framework for Terminology Controlled Distributed EHR

Search for Patient Cohort Identification in Clinical Research 519

Lei Zhao, Sarah N. Lim Choi Keung, Adel Taweel, Edward Tyler,Ire Ogunsina, James Rossiter, Brendan C. Delaney, Kevin A. Peterson,F.D. Richard Hobbs and Theodoros N. Arvanitis

Key-Linked On-Line Databases for Clinical Research 524Thomas H. Miiller

Standardised Representation of Healthcare Information in Secondary CareResearch: A Central England Case Study 529

Sarah N. Lim Choi Keung, Ire Ogunsina, James Rossiter, Gavin Langford,Edward Tyler and Theodoros N. Arvanitis

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The Electronic Healthcare Record for Clinical Research (EHR4CR)

Information Model and Terminology 534

David Ouagne, SajjadHussain, Eric Sadou, Marie-Christine Jaulenl

and Christel Daniel

A DICOM Architecture for Clinicians and Researchers 539

Michael Onken

Ophiucus: RDF-Based Visualization Tool for Health Simulation Models 544

Andrew Sutcliffe, Anya Okhmatovskaia, Arash Shaban-Nejadand DavidBuckeridge

Validation and Discovery of Genotype-Phenotype Associations in Chronic

Diseases Using Linked Data 549

Jyotishman Pathak, Richard Kiefer, Robert Freimuth

and Christopher Chute

A Web-Based Tool for Patients Cohorts and Clinical Trials Management 554

P. Fraccaro and Mauro Giacomini

Designing and Implementing a Biobanking IT Framework for Multiple

Research Scenarios 559

Hans-Ulrich Prokosch, Sebastian Mate, Jan Christoph, Andreas Beck,

Felix Kopcke, Stefanie Stephan, Matthias W. Beckmann, Tilman Rau,

Arndt Hartmann, Bernd Wullich, Bernhard Breil, Kai-Uwe Eckardt,

Stephanie Titze, Jens K. Habermann, JosefIngenerf, Michael Hackmann,Markus Ries, Thomas Biirkle and Thomas Ganslandt

Interoperability in Clinical Research: From Metadata Registries to

Semantically Annotated CDISC ODM 564

Philipp Bruland, Bernhard Breil, Fleur Fritz and Martin DugasRequirements for Semantic Biobanks 569

Andre Q. Andrade, Markus Kreuzthaler, Janna Hastings,Maria Krestyaninova and Stefan Schulz

A Semantic Model for Multimodal Data Mining in Healthcare Information

Systems 574

Dimitris Iakovidis and Christos Smailis

Assessing the Clinical Uses of Fuzzy Detection Results in the Automated

Detection ofCVC-Related Infections: A Preliminary Report 579

Jeroen S. de Bruin, Alexander Blacky and Klaus-Peter AdlassnigAssessing the Feasibility ofData Mining Techniques for Early Liver

Cancer Detection 584

Mu-Hsing Kuo, Chang-Mao Hung, JeffBarnett and Fabiola Pinheiro

Automatic Extracting of Patient-Related Attributes: Disease, Age, Gender

and Race 589

Huijia Zhu, Yuan Ni, Peng Cai, Zhaoming Qiu and Feng Cao

Estimating Rheumatoid Arthritis Activity with Infrared Image Analysis 594

Monique Prize andAbiola OgungbemileFine-Grained Clinical Outcome Extraction and Polarity Classification 599

Peng Cai, Yuan Ni, Huijia Zhu and Feng Cao

Evicase: An Evidence-Based Case Structuring Approach for Personalized

Healthcare 604Boaz Carmeli, Paolo Casali, Anna Goldbraich, Abigail Goldsteen,Carmel Kent, Lisa Licitra, Paolo Locatelli, Nicola Restifo, Ruty Rinott,Elena Sini, Michele Torresani and Zeev Waks

xxi

Reusable Data in Public Health Databases - Problems Encountered in Danish

Children's Database 609

Anna Marie Hostgaard and Louise Pape-HaugaardSecondary Use ofClinical Data in Healthcare Providers - An Overview

on Research, Regulatory and Ethical Requirements 614

Matthias Wiesenauer, Christian Johner and Rainer RohrigStandardizing Intensive Care Device Data to Enable Secondary Usages 619

JosefIngenerf, Ann-Kristin Kock, Marcel Poelker, Konrad Seidl,

Georg Zeplin, Stefan Mersmann and Heinz Handels

Why Is Clinical Information Not Reused? 624

Gert Galster

Supporting Decisions

Archetype Based Search in an IHE XDS Environment 631

Christoph Rinner, Michael Kohler, Gudrun Hubner-Bloder,Samrend Saboor, Elske Ammenwerth and Georg Duftschmid

Concepts for a Personal Health Record 636

Cdndido Santos, Tiago Pedrosa, Carlos Costa and Jose Luis Oliveira

Enhancing the Many-to-Many Relations Across IHE Document SharingCommunities 641

Luis S. Ribeiro, Carlos Costa and Jose Luis Oliveira

Standardized EHR Interoperability - Preliminary Results of a German

Pilot Project Using the Archetype Methodology 646

Hasan Veseli, Georgy Kopanitsa andHans Demski

The FBE Development Project: Toward Flexible Electronic Standards-Based

Biopsycho-Social Individual Records 651

Lucilla Frattura, Andrea Simoncello, Giovanni Bassi, Andrea Soranzio,

Stefano Terreni and Fulvio Sbroiavacca

An EMR Based Cancer Diary - Utilisation and Initial Usability Evaluation

ofa New Cancer Data Visualization Tool 656

Markus Ries, Henriette Golcher, Hans-Ulrich Prokosch,Matthias W. Beckmann and Thomas Biirkle

Automatic Detection of Inconsistencies Between Free Text and Coded

Data in Sarcoma Discharge Letters 661

Ruty Rinott, Michele Torresani, Rossella Bertulli, Abigail Goldsteen,Paolo Casali, Boaz Carmeli and Noam Slonim

Fragmentation of Diabetes Treatment in Austria - An Indicator for the

Need for Shared Electronic Health Record Systems 667

Georg Duftschmid, Wolfgang Dorda, Gottfried Endel, Karl Froschl,

Walter Gall, Wilfried Grossmann and Milan HronskyHealth Data Collecting and Sharing: Case Studies ofCzech e-Health

Applications 672

Jana Zvdrovd, Lenka Lhotskd, Libor Seidl andKarel Zvdra

Ontology-Based Reusable Clinical Document Template Production System 677

Sejin Nam, Sungin Lee, James G. Boram Kim and Hong-Gee KimThe Distributed Use ofElectronic Emergency-Department Whiteboards 683

Morten Hertzum

xxii

A Data-Driven Living Review for Pharmacogenomic Decision Support in

Cancer Treatment688

Gdkhan Karakiilah, Ash Suner, Klaus-Peter Adlassnigand Matthias Samwald

Electronic Medication Ordering with Integrated Drug Database and Clinical

Decision Support System693

Andreja Cufar, Anze Droljc andAndrej Orel

Isolation of Patients with Vancomycin Resistant Enterococci (VRE): Efficacy

ofan Electronic Alert System698

Damian Borbolla, Vanina Taliercio, Bibiana Schachner,

Ana Maria Gomez Saldano, Estela Salazar, Daniel Luna

and Fernan Gonzalez Bernaldo De Quiros

Knowledge-Analytics Synergy in Clinical Decision Support 703

Noam Slonim, Boaz Carmeli, Abigail Goldsteen, Oliver Keller,

Carmel Kent and Ruty Rinott

Quality of Data and Patients' Safety

Indicators of Data Quality: Revision of a Guideline for Networked

Medical Research 711

Jiirgen Stausberg, Ron Pritzkuleit, Carsten O. Schmidt, Thomas Schroder

and Michael Nonnemacher

Relevance of Drug-Drug Interaction in the ICU - Perceptions of Intensivists

and Pharmacists 716

Marjan Askari, Saied Eslami, Mathijs Louws, Dave Dongelmans,

Peter Wierenga, Rob Kuiper andAmeen Abu-Hanna

Organizing Data Quality Assessment of Shifting Biomedical Data 721

Carlos Sdez, Juan Martinez-Miranda, Montserrat Robles

andJuan Miguel Garcia-Gomez

Quality Assessment ofAutomatically Extracted Data from GPs' EPR 726

Etienne De Clercq, Sarah Moreels, Viviane Van Casteren,

Nathalie Bossuyt, Geert Goderis and Stefaan Bartholomeeusen

Safety of a Web-Based Insulin Titration System for Patients with Type 2

Diabetes Mellitus - Pilot Study 731

A.C.R. Simon, F. Holleman, W.T. Gude, J.B.L. Hoekstra andN. Peek

The Role of Electronic Checklists - Case Study on MRI-Safety 736

Andreas Landmark, May-Britt Seines, Elisabeth Larsen,

Astrid Svensli, Linda Solum and Berit Brattheim

EHR and Data Protection Issues in Italy 741

Maria Gabriella Virone

Ontology Based Log Content Extraction Engine for a Posteriori SecurityControl 746

Hanieh Azkia, Nora Cuppens-Boulahia, Frederic Cuppensand Gouenou Coatrieux

Recognition and Privacy Preservation of Paper-Based Health Records 751

Stefan Fenz, Johannes Heurix and Thomas Neubauer

Towards Human-Centric Visual Access Control for Clinical Data

Management 755

Sascha Fahl, Marian Harbach and Matthew Smith

xxiii

Watermarking as a Traceability Standard 761Gouenou Coatrieux, Catherine Quantin and Francois-Andre Allaert

A Statistics-Based Approach ofContextualization for Adverse Drug Events

Detection and Prevention 766

Emmanuel Chazard, Stephanie Bernonville, Gregoire Ficheurand Regis Beuscart

Identifying Types and Causes of Errors in Mortality Data in a Clinical

Registry Using Multiple Information Systems 771Antonie Koetsier, Niels Peek andNicolette de Keizer

Implementation ofComputerized Physician Order Entry (CPOE) with Clinical

Decision Support (CDS) Features in Riyadh Hospitals to Improve Qualityof Information 776

Mariam S. Almutairi, Rana M. Alseghayyir, Anwar A. Al-Alshikh,Hayat M. Arafah and Mowafa S. Househ

Information-Based Sequential Selection of Clinical Tests in Risk Assessment 781

Naama Parush, Tal El-Hay, Michal Ozery-Flato, Ligita Ryliskyte,Zydrune Visockiene andAleksandras Laucevicius

Using EHR Data for Monitoring and Promoting Patient Safety: Reviewingthe Evidence on Trigger Tools 786

Persephone Doupi

Added Value of Web-Based Services

Architectural Approach for Quality and Safety Aware HealthCareSocial Networks 793

Diego M. Lopez, Bernd Blobel and Carolina Gonzalez

Human Rights Monitoring in Virtual Community 798Christo El Morr

Impact of the Social Networking Applications for Health Information

Management for Patients and Physicians 803

Tony Sahama, Jian Liang and Renato Iannella

Mobile Social Networking Health (MSNet-Health): Beyond the mHealth

Frontier 808

Mowafa Househ

On the Support of Flexible Patient Privacy Policies in Social-Medical

Discovery 813

Haggai Roitman, Sivan Yogev, Yevgenia Tsimerman and Yardena PeresTechnical Requirements of a Social Networking Platform for Senior Citizens 818

Hans Demski, Claudia Hildebrand, Jose Lopez Bolds, Winfried Tiedge,Stefanie Wengel, Daire O. Broin and Ross Palmer

A Real-Time Disease Surveillance Architecture Using Social Networks 823

Mustafa Sofean and Matthew Smith

Experiences in the Creation of an Electromyography Database to Help Hand

Amputated Persons 828

Manfredo Atzori, Arjan Gijsberts, Simone Heynen,Anne-Gabrielle Mittaz Hager, Claudio Castellimi,Barbara Caputo and Henning Miiller

Exploring the Community Structure of a Diabetes Forum 833Andre Dias, Taridzo Chomutare and Taxiarchis Botsis

xxiv

Leveraging Social Media for Preventive Care - A Gamification System

and Insights838

RaymundJ. Lin andXinxin Zhu

Online Health Information Search: What Struggles and Empowers the Users?

Results ofan Online Survey843

Natalia Pletneva, Alejandro Vargas, Konstantina Kalogianni

and Celia Boyer

Finding Online Health-Related Information: Usability Issues of Health Portals 848

Nergis A. Gurel Koybasi and Kursat CagiltayHow Medical Doctors and Students Should Use Social Media: A Review

of the Main Guidelines for Proposing Practical Recommendations 853

Miguel Angel Mayer, Angela Leis, Alex Mayer

and Alejandro Rodriguez-Gonzalez

Tracking Changes in Search Behaviour at a Health Web Site 858

Ann-Marie Eklund

Trustworthiness and Relevance in Web-Based Clinical Question Answering 863

Sarah Cruchet, Celia Boyer and Lonneke van der Plas

Learn from Experiences and Critical Thinking

A Culture and Power Perspective on the Management of Health Information

Technology in Hospitals 871

Lone Stub Petersen and Pernille Bertelsen

Economic Impact ofa Nationwide Interoperable e-Health System Using

the PENG Evaluation Tool 876

L. Parv, J. Saluse, A. Aaviksoo, M. Tiik, R. Sepper and P. Ross

How Should We Define eHealth, and Does the Definition Matter? 881

Chris Showell and Christian Nohr

Medical Device Software: A New Challenge 885

Daniela Luzi and Fabrizio Pecoraro

The Intellectual Property Management for Data Sharing in a German Liver

Cancer Research Network 891

Shan He, Matthias Ganzinger and Petra KnaupThe Nature ofUnintended Benefits in Health Information Systems 896

Craig E. Kuziemsky, Elizabeth Borycki, Christian Nohr

andElizabeth Cummings

Envisioning Electronic Health Record Systems as Change Management:The Experience of an English Hospital Joining the National Programmefor Information Technology 901

Amirhossein Takian

Method for Modeling Social Care Processes for National Information

Exchange 906

Aki Miettinen, Juha Mykkdnen and Maarit Laaksonen

On the Attitudes of GPs Toward Novel Features ofTheir Next EPRs 911

Federico Cabitza

Proposal of an Architecture for the National Integration ofElectronic Health

Records: A Semi-Centralized Approach 917

Asma Al Jarullah andSamir El-Masri

XXV

Uniforming Information Management in Finnish Social Welfare 922Maarit Laaksonen, Jarmo Kdrki andErjaAilio

Quality Through Education

Assessment in Health Care Education - Modelling and Implementationof a Computer Supported Scoring Process 929

Jayne Alfredsson, Patrick Plichart and Nabil ZaryeHealth Education of Professionals in the Baltic Sea Area 934

Ann Bygholm, Julia Giinther, Pernille Bertelsen and Christian NohrIs It Worth Investing in Online Continuous Education for Healthcare Staff? 939

M. Cristina Mazzoleni, Chiara Maugeri, Carla Rognoni, Alessio Cantoni

and Marcello Imbriani

Nursing Informatics Competences Still Challenging Nurse Educators 944

Elina Rajalahti and Kaija Saranto

Teaching Medicine with a Terminology/Ontology Portal 949Mien Grosjean, Tayeb Merabti, Nicolas Griffon, Badisse Dahamnaand Stefan J. Darmoni

Criteria to Assess the Quality of Virtual Patients 954

Inga Hege, Nabil Zary andAndrzej A. KononowiczNew Approaches to Linking Clinical Guidelines to Virtual Patients 958

Andrzej A. Kononowicz, Inga Hege, Pawel Krawczyk and Nabil ZaryRecommendation of Standardized Health Learning Contents Using Archetypesand Semantic Web Technologies 963

Maria del Carmen Legaz-Garcia, Catalina Martinez-Costa,Marcos Mendrguez-Tortosa and Jesualdo Tomds Ferndndez-Breis

SIScaR-GPU: Fast Simulation and Visualization of Intraoperative ScatteredRadiation to Support Radiation Protection Training 968

Markus Wagner, Klaus Dresing, Wolfram Ludwig,Christoph Alexander Ahrens and Oliver J. Bott

Towards a mLearning Training Solution to the Adoption of a CPOE System 973

Despoina Pakonstantinou, Mikaela Poulymenopoulou,Flora Malamateniou and George Vassilacopoulos

Virtual Patient Simulation: A Comparison of Two Approaches for CapacityBuilding in Sub-Saharan Africa 978

Georges Bediang, Marc-Andre Raetzo andAntoine Geissbuhler

Quality Through Support

An Integration ofEmergency Department Information and AmbulanceSystems 985

Nada Al-Harbi, Samir El-Masri and Basema Saddik

Analyzing Primary Care Data to Characterize Inappropriate EmergencyRoom Use 990

Justin St-Maurice and M.H. KuoCOCPIT: A Tool for Integrated Care Pathway Variance Analysis 995

John Ainsworth and Iain Buchan

xxvi

Flexible Medical Image Management Using Service-Oriented Architecture

Oded Shaham, Alex Melament, Yuval Barak-Corren,

Igor Kostirev, Noam Shmueli and Yardena Peres

Measuring Health Care Process Quality with Software Quality Measures

Ozkan Yildiz and Onur Demirors

Bringing Research to the Point of Care: Hypergenes Project Study

Edward Vitkin, Hani Neuvirth-Telem, Boaz Carmeli, Amnon Shabo

and Ariel Farkash

Do Worklists Work? A Quantitative Approach to the Assessment of an

Electronic Patient Record Function

Petter Hurlen

Log Analysis to Understand Medical Professionals' Image Searching

Behaviour

Theodora Tsikrika, Henning Miiller and Charles E. Kahn Jr.

Ontology-Supported Clinical Profiling for the Evaluation ofObesity and

Related Comorbidities

Paolo L. Scala, Davide Di Pasquale, Daniele Tresoldi,

Claudio L. Lafortuna, Giovanna Rizzo and Marco Padula

Texture Analysis Software: Integration with a Radiological Workstation

Regis Duvaiiferrier, Joan Bezy, Valerie Bertaud, Gregoire Toussaint,

John Morelli and Jeremy Lasbleiz

A Smartphone Application for Preventing Exercise-Induced GlycemicImbalances in Type 1 Diabetic Patients

Omar Vuattolo, Maria Pia Francescato, Vincenzo Delia Mea

and Agostino Accardo

An Android-Enabled Mobile Framework for Ensuring Quality ofLife

Through Patient-Centric Care

Vassiliki Koufi, Flora Malamateniou and George VassilacopoulosModel Driven Mobile Care for Patients with Type 1 Diabetes

Stein Olav Skrovseth, Eirik Arsand, Fred Godtliebsen

and Ragnar M. Joakimsen

Personalized Adherence Activity Recognition via Model-Driven Sensor Data

Assessment

Mark Hsiao, Pei-Yun Hsueh and Sreeram Ramakrishnan

Achieving IT-Supported Standardized Nursing Documentation ThroughParticipatory Design

Stine Loft Rasmussen, Karen Marie Lyng and Sanne Jensen

Consistency ofNurses' Daily Predictions of Survival in the Intensive Care

Lilian Minne, Dave A. Dongelmans, E. de Jonge andAmeen Abuhanna

Development of Pain Flowsheet Based on Electronic Nursing Record SystemJitngMin Lee, YoungAh Kim, Hyunsoon Jung and Malsoon Song

Electronic Nursing Documentation in a Paediatrics Hospital: Impact on

Quality ofCare by Using OpenEHR, IHE and HL7

Majda Ostir, Marinka Purkart, Anita Stih, Biljana Princic and

Andrej OrelICNP Catalogues for Supporting Nursing Content in Electronic Health

Records

Amy Coenen, Tae Youn Kim, Claudia C. Bartz, KayJansenand Nicholas Hardiker

xxvii

INCA - Individual Nomad Clinical Assistant - Supporting Nurses withMobile Devices 1079

Frederic Ehrler, Magali Walesa, Evelyne Sarrey, RolfWipfliand Christian Lovis

Posters

A System-Theoretical, Architecture-Based Approach to Ontology Management 1087Bernd Blobel, Mathias Brochhausen, Carolina Gonzalez,Diego M. Lopez and Frank Oemig

Characteristics of Health Interventions: A Systematic Analysis ofthe AustrianProcedure Catalogue 1090

Sabrina B. Neururer and Karl-Peter PfeifferDescribing the Sublanguage of Wound Care in an Adult ICU 1093

Riitta Danielsson-Ojala, Heljd Lundgren-Laine and Sanna Salanterd

Developing a Patient Education Method - The e-Knowledge Test withFeedback 1096

Mervi Siekkinen and Helena Leino-KilpiRepresenting Clinical Communication Knowledge Through Database

Management System Integration 1099SaifKhairat, Catherine Craven and Yang Gong

Semantic Enrichment of Medical Forms - Semi-Autding ofODM-Elementsvia Web Services 1102

Bernhard Breil, Andreas Watermann, Peter Haas, Philipp DziuballeandMartin Dugas

Conducting Requirements Analyses for Research Using RoutinelyCollected Health Data: A Model Driven Approach 1105

Simon de Lusignan, Josephine Cashman, Norman Poh,Georgios Michalakidis, Aaron Mason, Terry Desombre and Paul Krause

Classification of Ischaemic Episodes with ST/HR Diagrams 1108Jana Faganeli Pucer, Janez Demsar and Matjaz Kukar

Collaborative Development of Knowledge-Based Support Systems: A CaseStudy 1111

Helena Lindgren, Patrik J. Winnberg and Chunli Yan

Integration of Data Analysis Methods in Syndromic Surveillance Systems 1114Dimitrios Zikos and Marianna Diomidous

Statistical Disclosure Limitation ofHealth Data Based on Pk-Anonymity 1117Eizen Kimura, Koji Chida, Dai Ikarashi, Koki Hamada and Ken Ishihara

Ultradian Rhythms During Day and Night in Normal and COPD Subjects 1120Agostino Accardo, Monica Cusenza, Alberto De Felice, Elisa Fornasaand Giovanni D 'Addio

A Literature Overview and Comparison of Driving Impairing ConditionAssessment Approaches by Health Enabling Technologies 1123

Nina Reichwaldt, Susanne Maslak, Klaus-Hendrik Wolfand ReinholdHaux

CARDIO-i2b2: Integrating Arrhythmogenic Disease Data in i2b2 1126Daniele Segagni, Valentino Tibollo, Arianna Dagliati,Carlo Napolitano, Silvia G. Priori and Riccardo Bellazzi

xxviii

Impact ofComputerized Order Sets on Practitioner Performance 1129

Leila Ahmadian and Reza KhajoueiIT as an Enabler of Sustainable Use ofData from Innovative Technical

Components for Assisted Living1132

Petra Knaup and Lothar Schope

IT Behind a Platform for Translational Cancer Research - Concept and

Objectives\\2>5

Michael Steffens, Gabriele Husmann, Mithat Koca, Martin Lablans,

Martina Komor, Sylke Zeissig, Katharina Emrich, Christian Brandts,

Hubert Serve, Maria Blettner and Frank Uckert

Psychological Evaluation of24-Hour Home Nursing Care: Application

ofan Analytic Hierarchy Process to Improve Quality of Life 1138

Takeo Shibata, Yoko Shimizu andHiroko Wada

A Clinical Research Analytics Toolkit for Cohort Study 1141

Yiqin Yu, Yu Zhu, Xingzhi Sun, Ying Tao, Shuo Zhang, Linhao Xu

and Yue Pan

An Encapsulated R Application for the Guided Analysis of Genomic Data 1144

Matthias Ganzinger, Miriam Kesselmeier, Jasmin Fabian

andPetra KnaupFirst Experiences in Implementing a Software-Based Support for Patient

Recruitment at Heidelberg University Hospital 1147

Bjorn Schreiweis, Gunter Griiber and Bjorn BerghMedical Students and e-Health 1150

Mira Hercigonja-Szekeres, Vesna Ilakovac and Kresimir Solid

Multiple Disciplines Synergy Tools for Ph.D. Students of Biomedical

Informatics at Charles University in Prague 1153

Jana Zvarova, Stepan Svacina, Tatjana Dostalova, Michaela Seydlova

and Karel Zvara

Translational Meta-Analysis Tool for Temporal Gene Expression Profiles 1156

Guenter Tusch and Olvi Tole

Pluripotent Stem Cells in Mice 1159

Rainer Schmidt, Lena Scheubert, Mitja Lustrek, Dirk Repsilberand Georg Fuellen

Introducing a Composite Index of Information Quality for Medical Web Sites 1162

Federico Cabitza

Concise Healthcare-Associated Infection Reporting and Benchmarking with

Minimal Staff Resources 1165

Walter Koller, Jeroen de Bruin, Alexander Blacky, Harold Mandl

andKlaus-Peter Adlassnig

Developing an eLeaming Tool Formalizing in YAWL the Guidelines Used

in a Transfusion Medicine Service 1168

Paola Russo, Miriam Piazza, Giorgio Leonardi, Layla Roncoroni,Carlo Russo, Salvatore Spadaro and Silvana Quaglini

e-Learning for Neurological Bladder Management 1171

Carlo Rognoni, Gabriella Fizzotti, Caterina Pistarini

and M. Cristina Mazzoleni

Patient Empowerment in the Process of Sickness Certificates 1174

Gunnar O. Klein and Kjell Andersson

Patient Satisfaction in a Context-Aware Hospital Guidance SystemEunhye Kim, Sooyoung Yoo, Hwang Hee, Hyunchul Park, Gunhee Kimand Sungdo Ha

A Special Query Tool in the Hospital Information System to RecognizePatients and to Increase Patient Numbers for Clinical Trials

Mithat Koca, Gabriele Husmann, Jurgen Jesgarz, Martin Overath,Christian Brandts and Hubert Serve

Design of a Computerized Provider Order Entry System for OrderingofChemotherapy

SunHee Lee, KiHyuk Lee, Eun-Young Cho, Hee Hwang, KiDong Kim,Young-Jae Cho, JungEun Kim, Jae Hyuk Lee, Rong Min Baekand YoungSik Jeon

Development and Evaluation of an Expert System for the Diagnosis of ChildAutism

Pashalina Lialiou, Dimitrios Zikos andJohn MantasICF Machine: A Web-Based System for Collection of ICF Data

Vincenzo Delia Mea and Valerio Fioresi

'Onco Alerts' to Support Acute Oncology ServicesThomas Poulter and Peter A. Bath

Promoting Generic Medication Prescribing by Order Interface Redesign:Small Change, Large Impact

Sameer Malhotra, Jessica S. Ancker, J. Travis Gossey,Curtis L. Cole, Rainu Kaushal and Adam D. Cheriff

Study of Iranian Breast Cancer Registration via Established Online SystemDuring 2011

Mohammad Zare, Abolfazl Rezaee, Sholeh Zakiani and Amir ZareClinical Decision Support for Monitoring Drug-Drug-Interactions and

Potassium-Increasing Drug Combinations: Need for Specific AlertsEmmanuel Eschmann, Patrick E. Beeler, Vladimir Kaplan,Markus Schneemann, Gregor Ziind and Jiirg Blaser

Decision Support System Based Semantic Web for Personalized Patient CareNassim Douali, Jos De Roo and Marie-Christine Jaulent

Development of an Electronic Nursing Records System Based on InformationModels and Clinical Practice Guidelines

Hyeoun-Ae Park, Yul Ha Min, Eunjoo Jeon, Younglan Kimand Hyun-YoungKm

Formative Usability Evaluation of a Web-Based Insulin Self-Titration System:Preliminary Results

Wouter T. Gude, Airin C.R. Simon, Linda W.P. Peute, Frits Holleman,Joost B.L. Hoekstra, Niels Peek and Monique W.M. Jaspers

MInD: Moving in the DarkA. Pepino, G. Sicignano, M. Rovani and G. D 'Addio

An Example of a Multi-Professional Process-Oriented StructuredDocumentation Bound to SNOMED CT

Carina Zetterberg, Karin Ahlzen, Erika Ericsson and Bengt KronClinicians' Experiences with Videoconferencing in Psychiatry

Rolf Wynn, Svein Bergvik, Gunn Pettersen and Sturla Fossum

XXX

Development and Management of Public Health Education System Against

Emerging Infectious Diseases 1221

Myungja Koh, Parvati Dev, Eun-Jung Lee, Byung-Ki Koo,

Kyung-Oak Lee, Kukhwa Ha, Heesun Yang, Gilwon Kangand Youngsung Lee

Pharmaceutical Validation of Medication Orders Using an OWL Ontology and

Business Rules 1224

Amina Chniti, Abdelali Boussadi, Patrice Degoulet, Patrick Albert

andJean Charlet

A Way to Motivate Danish GPs to Implement a New National Service 1227

Alice Kristensen and Bente WenglerTrend Analysis and Future Development ofTaiwan Electronic Medical Records 1230

Wan-Chi Ke, Yi-Chung Hsieh, Yen-Chen Chen, En-Te Lin

andHung-Wen Chiu

Subject Index

Author Index

1233

1243