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RAJENDRA G. MEHTA Curriculum Vitae

Address: IIT Research Institute 11721 Springbrook Court 10 West 35th Street Orland Park IL 60462 Chicago, IL 60616 (708) 479-7566 (Home) (312) 567-4970 Phone (708) 945-4223 (Cell) (312) 567-4931 Fax e-mail: rajuraksha@gmail.com e-mail: RMehta@iitri.org http://www.cancerbiology-iitri.org University Education: B.Sc. (1966), Zoology/Chemistry, Gujarat University, Ahmedabad, India M.Sc. (1968), Zoology/Cell Biology, Gujarat University, Ahmedabad, India Ph.D. (1974), Life Sciences (Cell Biology), University of Nebraska, Lincoln,

Nebraska (1972-1974); University of California, Berkeley, CA (1969-1972) Research Experience: 2004-Present Assistant Vice President Head, Cancer Biology Division (2010-Present) Head, Carcinogenesis and Chemoprevention (2004-2010)

Head, Drug Discovery Division (2006-2009) IIT Research Institute, Chicago, IL 60616

Professor, Biological Sciences, Illinois Institute of Technology, Chicago, IL 60616 1992-Present Professor, Departments Surgical Oncology/Surgery College of Medicine, University of Illinois, Chicago, IL 60612 1992-1996 Associate Professor 1999-2007 Professor, Department of Human Nutrition, College of Applied

Health Sciences, University of Illinois, Chicago, IL 60612 1977-1992 Life Sciences Research, IIT Research Institute, Chicago, IL

60616 Scientific Advisor 1989-1992, Senior Biochemist 1980-1989, Research Biochemist 1978-1979, Associate Biochemist 1977-1978

1974-1977 Research Associate, Department of Biochemistry, University

of Rochester Cancer Center Rochester, New York and Department of Biochemistry, University of Louisville School of Medicine, Louisville, Kentucky 40201 (Prof. J. L. Wittliff)

Awards and Honors: International Cancer Research Technology Transfer (ICRETT) Award by the

International Union Against Cancer, Geneva, Switzerland, to conduct research at the First Department of Medicine, University of Tokyo, Tokyo, Japan, 1985.

Member Editorial Board, Oncology Reports (1995-2003) Member Editorial Board, Cancer Prevention Research (AACR) 2009-Current

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Member, Editorial Board: Breast Cancer: Basic and Clinical Science 2009-Current Member, Editorial Board Nano-medicine and Biotherapeutics, OMICS Publications 2010- Current Partner/Consultant, GRANATUM - A Social Collaborative Working Space Semantically Interlinking Biomedical Researchers, Knowledge and Data for the Design and execution of In Silico Models and Experiments in Cancer Chemoprevention. Collaboartive Project European Union and United States 2010-2014

Patents:

US Patent 6,900,191, 2005 1α-Hydroxyvitamin D5, its synthesis and use in cancer prevention: Moriarty RM, Penmasta RA, Guo L, Rao MS, Mehta R.G.

US Patent 20090215692, Compositions and methods to prevent cancer with cupredoxins 08-27-2009 T.K. Mehta R.R. C. Beattie, T.K. Das Gupta, Mehta R.G.

Public Service (Study Sections): Member, Metabolic Pathology Study Section, NIH (1991-93) Reviewer, National Science Foundation (Ad Hoc) Member, Biochemical Nutrition Study Section, American Cancer Society 1990 (Ad

Hoc) Program Project site visits, NIH 1888, 1990 Reviewer, Fogarty International Program, NIH (Ad Hoc) Member, Prevention Committee, American Cancer Society, Illinois Branch, Chicago,

IL. (1990-1992) Member, Site Visit Committee for the program Project on Green Tea and Cancer,

American Health Foundation, Valhalla, NY. October 1993. Member, Site Visit Committee for Comprehensive Cancer Center, Dartmouth

College of Medicine, Lebanon, NH November 1993 Reviewer State of New Jersey, Cancer Program Research grants 1993-Current Reviewer, New Research Developmental Awards, American Cancer Society, Atlanta

GA 1994, 1995. Member, Review Committee Breast Cancer Research Program, University of

California, San Francisco, 1995- 2000 Member, Reverse Site Visit Committee for the program Project on Selenium and

Cancer. Washington DC, February 16-17, 1995. Member, Study Section for Program Projects on Nutrition and Cancer. Washington

DC, March 13-16, 1995. Member, Program Project Parent Committee, NCI Council, April 1995. National Institute of Health Reviewers reserve (NRR) 1993-97 Member (ad hoc), Small Business Innovative Research (SBIR) Study Section, 1994-

2002 World Health Organization, International Agency for Research on Cancer, Lyon,

France, IARC Handbook of Cancer Prevention “Vitamin A and esters”, Chairman Experimental Carcinogenesis Section May 1998.

World Health Organization, International Agency for Research on Cancer, Lyon, France, IARC Handbook of Cancer Prevention “Retinoids”, Chairman Experimental Carcinogenesis Section March 1999.

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Member, Review Committee Tobacco Related Disease Research Program, University of California, San Francisco, 1999-2003

Member, Carcinogenesis, Nutrition and the Environment (CNE) Study Section, American Cancer Society, Atlanta, GA 1999-2003

Study Sections, National Cancer Institute, RFAs 1999, 2001, 2002 Member, US Army Breast Cancer Study Section, 1997, 1999-2011 Member, US Army Prostate Cancer Study Section, 2004, 2006, 2007 Member, US Army Breast Cancer Concept Reviews, 2003-2006 Reviewer, Philip Morris External research Program, Linthicum Heights, MD 2001-

2007 Chartered Member, VA Merit Review, Washington DC, 2003-2007 Panel Member USDA Nutrition and Health Program Review Panel 2009 Reviewer grant applications, Israel Science Foundation, Tel Aviv, Israel, 2009 Member, Chemo-dietary Prevention Study Section, NIH 2009, 2010 Reviewer, University of Cyprus grants review committee, 2009 Society Membership: American Association for Cancer Research International Association for Breast Cancer Research Sigma Xi Endocrinology Society International Association of Cancer Chemoprevention

Editorial Services (Review Manuscripts):

Nature , Science, Proc. Natl. Acad. Sci (USA), Cancer research, Clinical Cancer Res., JNCI, Nutrition and Cancer, Life Sciences, J. Biol. Chem. Proc. Exptl Biol and Medicine, J. Natural products, Phytochemistry, Biochem. Pharmacol, Carcinogenesis, Endocrinology and several other journals.

Book Reviews

The SV40 replicon model for analysis of anticancer drugs by Robert M. Snapka, Academic Press

Drug-drug interactions Scientific and regulatory perspectives by Albert Li Advances in pharmacology Academic Press

Tumor marker protocols edited by M. Hanausek and Z. Walaszek Methods in Molecular Medicine, Humana Press.

Invitations:

Workshop, LiSIS platform, Granatum Program, Nicosia, Cyprus. Keynote

Speaker, Chemoprevention, June 2013 Symposium on Technology in Carcinogenesis and Chemoprevention, James

Graham Cancer Center, Louisville, KY, Invited Speaker, May 2013 Third International Cancer Research Symposium, Kolkata, India Invited

speaker and Session Chair, December 2012 University of Michigan, Department of Medicine, Ann Arbor, Invited Seminar

Speaker, September 2011 Boston University Medical Center, Endocrinology Grand Rounds, Invited

Speaker, April 2009. VA Medical Center, Sacramento, California, Invited Speaker, October 2008

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University of California, Davis Cancer Center, Invited Speaker, Grand Rounds, October 2008

International conference on Vitamin D analogs, Krefeld, Germany, Invited speaker, May 2008

Department of Medicine, University of Chicago, Chicago, IL Invited Seminar speaker January 2008

Brown University International Symposium on Vitamin D. Invited Speaker, Member Program Committee, Providence RI September 2005, 2006, 2007.

International conference on Vitamin D analogs, Lubeck, Germany, Invited speaker and Session Chair, May 2005

Department of Biological Sciences, Nicosia, Cyprus, Invited Seminar Vitamin D and Breast cancer prevention and therapy, May 2005.

Cancer chemoprevention and treatment. Is there a role for vitamin D? Vitamin D workshop and National Cancer Institute Conference, Bethesda, MD. Invited Speaker November 2004

CHS National Cancer Control Center, Israel and National Cancer Institute, Bethesda, MD Translational Cancer Prevention Workshop, Haifa, Israel, Invited Speaker May 2004

CHS International Educational Cancer Prevention Workshop, Dead Sea, Israel, Invited Speaker, May 2004

University of Chicago, Department of Hematology Oncology, Seminar March 2004

Karmanos Cancer Institute, Vitamin D and breast cancer, October 2003 Brown University International Vitamin D Symposium, Invited Speaker,

September 2003. Biotech Invest 2003, Genome valley project, Invited speaker for drug

discovery from bench to clinic, Hydrabad, India February 2003. International workshop on vitamin D analogs, Homburg, Germany, May 1-4

2002 Invited speaker and Session-Chair University of Missouri, Columbia, January 2003, Seminar Convention of Onco-Pathologists of India, Ahmedabad, India January 26-27,

2002. Faculty member. Dietary and Medicinal antimutagenesis and anticarcinogens: Molecular

mechanisms and chemopreventive potential, Seoul, Korea Oct.17-19, 2001 Tumor Prevention and Genetics 2000, First International meeting of the Int.

Society of cancer Chemoprevention, St Gallen, Switzerland, Feb 16-19, 2000 Moderator, Speaker

World Health Organization, IARC Handbook on vitamin A and retinyl esters, Chair, Experimental data, Lyon, France May 1998; March 1999

First International conference on chemistry and biology of vitamin D analogs, Brown University, Providence Rhode Island. Organizing committee member, Sept 27-29, 1999

World Health Organization, IARC Handbook on Retinoids, Chair, Experimental data, Lyon, March 1999,

Brown University symposium on chemistry and biology of vitamin D analogs, Providence Rhode Island. Sept. 18-20, 1998

Tenth International workshop on vitamin D, Strasbourg, France May 1997. Invitation to organize a symposium at the First World Congress on Oncology,

Athens, Greece, October 1995. International Cancer Congress, New Delhi India October 1994, Speaker Conference on Designer's Food Rutgers University May 1994, Speaker Cell Pathways Inc. Denver, CO Consultant, 1992- Current) Steroids Inc, Chicago, IL Consultant,

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The Golden Jubilee Symposium on Cancer chemoprevention, Tata Cancer Center and Hospital, Chairman, Session on Nutrition and Experimental cancer. 1992, Speaker.

The National Cancer Research Institute, Tokyo, Japan 1992, Seminar Mitsubishi Kasei, Tokyo, Japan 1992, seminar and consultation Nippon Roche Pharmaceutical Kasei, 1992, Seminar AMC Cancer Research Institute, Lakewood, CO. 1991, Seminar Progress in Retinoids, Retinoids in Cancer and other diseases, Palermo, Italy,

1989, Speaker John Hopkins Center for Alternative Approach to In Vivo Tests (CAAT),

policy making session, Houston, TX 1989, Speaker University of Tokyo, School of Medicine, Tokyo, Japan, 1985, Seminar Aichii Cancer Center, Nagoya, Japan, 1985, Speaker Annual Tissue Culture conference, Symposium on Chemoprevention,

Houston TX 1988, Speaker University of Louisville, Cancer Center, 1987, Seminar Nutrition Center, University of New Hampshire, Durham, New Hampshire,

1987, Seminar, Gujarat Cancer Research Center, Ahmedabad, India. Consultant,

Examiner PhD Theses Bowman Grey School of Medicine, Department of Medicine, Winston-Salem,

NC 1986, Seminar International Breast Cancer Conference, London, U.K. Mini-symposium,

1983, Speaker

Committee Membership: Radiation Safety Committee, IIT Research Institute 1988-1992 Interface for non resident Indian Scientists and Technology Transfer Center, New Delhi, Faculty Advisory Committee, UIC, 1993-1996 Animal Care Committee (BRL) Small animal Subcommittee, UIC, 1993-1996 Chancellors Committee on Student Judiciary Procedures, UIC, February 1994 Executive Committee, Functional Foods for Health, UIC, 1994-1997, 2002- 2005

Chair, Promotion and Tenure Committee, Department of Surgical Oncology, College of Medicine, Chicago, IL 60612 2006-2010 Illinois Institute of Technology, Campus Committee on zpromotion and Tenure (CAMCOPT) 2009-2012

Collaborative Research Projects:

Northwestern University Cancer Center, Chicago, IL Prevention of breast cancer with antiprogestin, Proellex (Dr. Seema Khan)

University of Chicago, College of Medicine, Chicago, IL Chemoprevention of lung cancer (Dr. Ravi Salgia).

University of Michigan, Ann Arbor, MI Vitamin D and breast cancer stem cells (Dr Dean Brenner)

University of Illinois, College of Medicine, Chicago, IL Vitamin D and colon cancer (Dr. Richard Benya)

University of Illinois, College of Pharmacy, Chicago, IL Growth hormone and breast cancer (Dr. Steve Swanson)

Washington University, St. Louis, MO Vitamin D and parathyroid function (Dr. Alex Brown)

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Brown University, Providence, RI Vitamin D analog metabolism (Dr. S. Reddy)

University of Texas, Austin, TX Chemopreventive agents in MMOC (Dr. Kimberley Kline)

University of Cyprus, Nicosia, Cyprus Flavanoids and chemoprevention (Dr. Andreas Constanitinou)

University of Missouri, Columbia, MO Vitamin D and prostate cancer (Dr Ruth MacDonald, Dr. Dennis Lubhan)

IIT Research Institute, Chicago, IL (Dr. D.L. McCormick) Vitamin D and Prostate cancer in rats; Vitamin D preclinical Toxicity

University of Notre Dame, West Lafayette, IN Vitamin D and breast cancer (Dr. JoEllen Welsh)

Boston University, Boston, MA Mechanism of action of novel vitamin D analogs (Dr. Rahul Ray)

Guru Nank Dev University, Amritsar, India Chemoprevention by bark extracts of indigenous plants (Dr. Saroj Bala Arora)

University of Southern California Los Angeles, CA. Combination chemoprevention by retinoids and troglitazone peroxisome proliferators receptor ligand. (Dr. P. Koeffler)

University of California, San Francisco, San Francisco, CA Vitamin D and genomic instability and DNA repair mismatch (Dr. R. Dahiya)

Burnham Cancer Research Institute, LaJolla, CA. Transfection of VDR in human breast cancer cells and to study mechanism of vitamin D action (Dr. Xiao-Kun Zhang)

Iowa State University, Department of Biochemistry, Ames, IA; Retinoid glucuronide in mammary carcinogenesis, (Dr. J. Olson).

Bowman Gray School of Medicine, Winston-Salem, NC; Flow cytometric evaluations of DNA after retinoid treatment, (Dr.T.E. Kute). Strang Cancer Research Institute, New York, NY;

Effects of retinoids in normal, preneoplastic and H-ras transfected mammary epithelial cells, (Dr. N. Telang).

Istituto Nazionale Tumori, Milan, Italy; Retinoid metabolism in human mammary tissues from patients in 4-HPR chemoprevention clinical trial, (Dr. A. Costa and Dr. Formelli)

University of Southern Illinois, School of Medicine, Springfield, IL; Retinoid metabolism in acne patients, (Dr. J. Wortsman).

National Cancer Research Institute, Tokyo, Japan; Evaluation of new cancer chemopreventive agents in vitro and in vivo assays, (Dr. H. Fujiki).

Rush University School of Medicine, Chicago, IL; Chemotherapy by retinoids, (Dr. K. Dowlatshahi). Illinois Cancer Council and Rush Presbyterian Hospital, Chicago, IL;

Retinoid metabolism in human plasma and tissue samples from a retinoid/tamoxifen clinical trial, (Dr. M. Cobleigh).

AMC Cancer Research Institute, Denver, CO; Effects of retinoids in mammary carcinogenesis, DNA apoptosis, (Dr. H. Thompson).

University of Minnesota, School of Medicine Minneapolis, MN Chemoprevention of chemical carcinogenesis by novel agents, (Dr. L. Wattenberg)

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Industrial Affiliations: Consultant Cell Pathways, Philadelphia, PN 1994-1996 Partner OncQuest Inc, Chicago, IL 1999-Current Advisor Rimonest Ltd. Nesher, Israel 2001-2005 Consultant Repros Pharma , The Woodlands, TX 2002-current Advisor Epimer Inc. Providence, RI 2004-2009 Advisor Cardiavent Inc, Ann Arbor, MI 2009-Current Teaching Experience: 1968 Instructor, Summer School for college teachers, Gujarat University, Ahmedabad, Gujarat, India (In collaboration with instructors from the USA) 1992-1997 University of Illinois School of Medicine, Chicago, IL l) Special topics in Endocrinology; 2) Endocrine Pharmacology;

3) Methods of evaluating biologically active natural products (PMP 480)

PMMP 322, Chemical aspects of drug action (1993-2010) 2001-2004 HN 530 Methods in Nutrition Research, Nutrition and Genetics 2002-2003 Department of Human Nutrition, University of Illinois 2007 - Current BIOL 426, Concepts in Cancer Biology, Department of

Biological, Chemical and Physical Sciences, Illinois Institute of Technology, Chicago, IL 60616

Press Coverage:

J. Natl. Cancer Inst. 1997 Publication on vitamin D5: All major TV media and News papers in this country and abroad covered the identification of a novel analog of vitamin D5 (1-Hydroxyvitamin D5) as a potential chemopreventive and/or therapeutic agent for breast cancer. Science 1997 publication on resveratrol in grapes:

Extensive coverage through out the world in hundreds of news articles as well as on television.

Int. J. Cancer 2003 Publication on deguelin and colon cancer:

Reuters Health: Deguelin as a possible chemotherapeutic agent

Publications

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LIST OF PUBLICATIONS RAJENDRA G. MEHTA, Ph.D. 1. Banerjee, M. R., Mehta, R. G., and Wagner, J. E. DNA polymerase activity and

DNA synthesis in preneoplastic nodule outgrowths of BALB/c and C3H mouse mammary gland. J. Natl. Cancer Inst. 50: 339, 1973.

2. Banerjee, D. N., Banerjee, M. R., and Mehta, R. G. Hormonal regulation of rapidly

labeled RNA in normal, preneoplastic and neoplastic tissues of mouse mammary gland. J. Natl. Cancer Inst. 51: 843, 1973.

3. Mehta, R. G., Washburn, L. L., Young, P. N., Banerjee, M. R., and Bern, H. A.

Proliferation of preneoplastic mammary nodule outgrowth in mammary fat pads of BALB/c mice in organ culture. J. Natl. Cancer Inst. 52: 1013, 1974.

4. Mehta, R. G., and Banerjee, M. R. Progesterone receptors and possible role of

prolactin for its regulation in the mammary gland. J. Cell Biol. 63: 220, 1974. 5. Mehta, R. G., and Banerjee, M. R. Hormonal regulation of macromolecular

biosynthesis during lobulo-alveolar development of mouse mammary gland in organ culture. Acta Endocrinol. 80: 501, 1975.

6. Wittliff, J. L., Mehta, R. G., Boyd, P. A., and Goral, J. E. Steroid binding proteins of

the mammary gland and their clinical significance in breast cancer. J. Toxicol. Environ. Health (Suppl.) 1: 231, 1976.

7. Wittliff, J. L., Mehta, R. G., and Kute, T. E. Interaction of R5020 with binding sites

in normal and neoplastic mammary tissues. In: Progesterone Receptors in Normal and Neoplastic Tissues. W. L. McGuire, et al. (eds.), Raven Press, NY, p. 39, 1977.

8. Mehta, R. G., Park, D. C., Boyd, P. A., and Wittliff, J. L. Estrogen receptors in

lactating mammary gland of rat. J. Steroid Biochem. 9: 819, 1978. 9. Park, D. C., Mehta, R. G., and Wittliff, J. L. Activation of estrogen receptors and

stimulation of RNA synthesis in vitro in lactating mammary gland of the rat. J. Toxicol. and Environ. Health (Suppl.) 3: 493, 1978.

10. Greenman, D. L., Mehta, R. G., and Wittliff, J. L. Interaction of "Fusarium"

mycotoxins with estradiol binding sites in the nuclear fraction of uteri from immature mice. J. Toxicol. Environ. Health 5: 593, 1979.

11. Mehta, R. G., Fricks, C. M., and Moon, R. C. Androgen receptors in chemically-

induced colon carcinogenesis. Cancer 45: 1085, 1980. 12. Mehta, R. G., Cerny, W. L., and Moon, R. C. Distribution of retinoic acid binding

proteins in normal and neoplastic mammary tissues. Cancer Res. 40: 47, 1980. 13. Mehta, R. G., and Moon, R. C. Inhibition of DNA synthesis by retinyl acetate during

chemically-induced mammary carcinogenesis. Cancer Res. 40: 1109, 1980.

Publications

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14. Mehta, R. G., and Moon, R. C. Hormonal regulation of retinoic acid binding

proteins in the mammary gland. Biochemical J. 200: 591, 1981. 15. Mehta, R. G., Kute, T. E., Hopkins, M., and Moon, R. C. Retinoic acid binding

proteins and steroid receptor levels in human breast cancer. Eu. J. Cancer 18: 221, 1982.

16. Mehta, R. G., Cerny, W. L., and Moon, R. C. Nuclear interaction of retinoic acid

binding protein in chemically-induced adenocarcinoma. Biochem. J. 208: 731, 1982.

17. McCormick, D. L., Radcliffe, J. D, Mehta, R. G., Thompson, C. A., and Moon, R. C.

Temporal association between arterial cholesterol deposition, thymidine uptake, and atherosclerosis in Japanese quail fed an atherogenic diet. Atherosclerosis 42: 1, 1982.

18. McCormick, D. L., Mehta, R. G., Thompson, C. A., Dinger, N., Caldwell, J. and

Moon, R. C. Enhanced inhibition of mammary carcinogenesis by combination N-(4-hydroxyphenyl)-retinamide and ovariectomy. Cancer Res. 42: 508, 1982.

19. Mehta, R. G., McCormick, D. L., Cerny, W. L., and Moon, R. C. Correlation

between retinoid inhibition of N-methyl-N-nitrosourea-induced mammary carcinogenesis and levels of retinoic acid binding proteins. Carcinogenesis 3: 89, 1982.

20. Moon, R. C. and Mehta, R. G. Retinoid binding in normal and neoplastic mammary

tissue. Adv. Exptl. Med. and Biol. (Hormones and Cancer, W. L. Leavitt [ed.]), 138: 231, 1982.

21. Wittliff, J. L., Mehta, R. G., Boyd, P. A., Lewko, W. L., and Park, D. C. Steroid

receptor interaction in normal and neoplastic mammary tissues. In: Biochemical Markers of Cancer, T. M. Chu (ed.), Marcel Decker Inc., New York, NY, p. 183, 1982.

22. Moon, R. C., McCormick, D. L., and Mehta, R. G. Chemoprevention of animal

tumors by retinoids. In: Modulation of Cancer by Vitamin, F. L. Meyskens and K. N. Prasad (eds.), S. Karger AG, Basel, p. 47, 1983.

23. Mehta, R. G., Cerny, W. L., and Moon, R. C. Retinoids inhibit prolactin induced

development of the mammary gland in vitro. Carcinogenesis 4: 23, 1983. 24. Moon, R. C., McCormick, D. L., and Mehta, R. G. Inhibition of carcinogenesis by

retinoids. Cancer Res. 43: 2469s, 1983. 25. Moon, R. C., McCormick, D. L., and Mehta, R. G. Retinoid and hormone

interaction in mammary carcinogenesis. Proc. 13th International Congress on Chemotherapy Part 270, p. 35, 1983.

Publications

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26. Moon, R. C., Mehta, R. G., and McCormick, D. L. Suppression of mammary cancer by retinoids. In: Cancer: Etiology and Prevention, Elsevier Publication, p. 275, 1983.

27. Dowlatshahi, K., Mehta, R. G., Levin, B., Cerny, W. L., and Skinner, D. B., and

Moon, R. C. Retinoic acid binding proteins in normal and neoplastic human esophagus. Cancer 54: 308, 1984.

28. Mehta, R. G., Cerny, W. L., Madigan, M. J., and Moon, R. C. Modification of mouse

mammary gland organ culture. J. Tissue Culture Methods 8: 27, 1984. 29. Mehta, R. G., Cerny, W. L., and Moon, R. C. Antiestrogen binding sites in

mammary tissues. Oncology 4l: 387, l984. 30. Mehta, R. G., Moon R.C. and McCormick, D. L. Retinoids and mammary gland

differentiation. In: Retinoids Differentiation and Disease. Ciba Foundation Symposium ll3: l56, l985.

31. Mehta, R. G., and Moon, R. C. Can maturation be induced in breast cancer. In:

Breast Cancer: Treatment and Prognosis, Basil A. Stoll (ed.), Blackwell Press, 300, l986.

32. Moon, R. C., Mehta, R. G., and McCormick, D. L. Modulation of carcinogenesis by

retinoids. In: Vitamins, Nutrition and Cancer, K. N. Prasad (ed.), S. Karger AG, Basel, p. 20, 1984.

33. Hultin, T. A., Mehta, R. G., and Moon, R. C. A simple high- pressure liquid

chromatographic method for the separation of retinoids including N-(4-hydroxyphenyl)-all-trans- retinamide. J. Chromatogr. 34l: l87, l985.

34. Kute, T. E., Mehta, R. G., Linville, C., and Moon, R. C. Cell kinetics in normal and

neoplastic mammary tissues by flow cytometric analysis. Cytometry 6: 362, l985.

35. Mehta, R. G., and Moon, R. C. Role of hormones on the induction of retinoic acid-

binding protein in mouse mammary gland organ culture. Carcinogenesis 6: 1103, l985.

36. Mehta, R. G., Schiff, L. J., Moore, S. J., Buckley, A. M., and Dawson, M. I. Cellular

retinoic acid binding protein and its relationship to the biological activity of new synthetic retinoids in hamster trachea. In Vitro Cell Develop. Biol. 22: l64, l986.

37. Moon, R. C., and Mehta, R. G. Anticarcinogenic effects of retinoids in animals. In:

Essential Nutrients in Carcinogenesis. L.A. Poirier, P.M. Newberne, and M.W. Parize (eds.), Plenum Press, p. 300, l986.

38. Mehta, R. G., and Moon, R. C. Effects of l2-0-tetra-decanoyl-phorbol-l3-acetate

(TPA) on carcinogen-induced mammary lesions in organ culture. Cancer Res. 46: 5832, l986.

Publications

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39. Mehta, R. G., Hultin, T. A., and Moon, R. C. Metabolism of the chemopreventive retinoid, N-(4-hydroxyphenyl)retinamide, by mammary gland in organ culture. Biochem J. 256, 579, l988.

40. Mehta, R. G., Hawthorne, M. E., and Moon, R. C. Effect of all-trans-retinoic acid on

nucleic RNA polymerase activity in chemically induced rat mammary tumors. Cancer Lett. 42, l, l988.

41. Matsuoko, L. Y., Wortsman, J., Parker, L. N., and Mehta, R. G. The effect of

isotretinoin in acne is not mediated by adrenal androgens. J. Am. Acad. Dermatol. 20, l28, l989.

42. Moon, R. C., Pritchard, F. J., Mehta, R. G., Nomides, C. T., Thomas, C. F., and

Dinger, N. M. Suppression of rat mammary cancer development by N-(4-hydroxyphenyl)retinamide (4-HPR) following surgical removal of first palpable tumor. Carcinogenesis l0, l645, l989.

43. Dowlatshahi, K., Mehta, R. G., Thomas, C. F., Dinger, N., and Moon, R. C.

Therapeutic effect of N(-4-hydroxyphenyl)retinamide on N-methyl-N-nitrosourea induced mammary cancer. Cancer Lett. 47: l87, l989.

44. Moon, R. C., and Mehta, R. G. Chemoprevention of experimental carcinogenesis

in animals. Preventive Medicine 18: 576-59l, l989. 45. Moon, R.C. and Mehta, R.G. Chemoprevention of mammary cancer by retinoids.

In: Antimutagenesis and Anticarcinogenesis Mechanisms II. Kuroda, Y., Shankel, D.M., and Waters, M.D. (eds.), Plenum Press, New York, pp. 2l3-224, l990.

46. Moon, R. C., and Mehta, R. G. Retinoid inhibition of experimental carcinogenesis.

In: Chemistry and Biology of Retinoids, CRC Critical Reviews. Dawson, M. I., and Okamura, W. H. (eds.), CRC Press, Inc., p. 50l, l990.

47. Moon, R.C., and Mehta, R.G. Cancer chemoprevention by retinoids: animal

models. Methods in Enzymol. l90: 395, l990. 48. Ratko, T.A., Mehta, R.G., Detrisac, C.J., Kelloff, G.J., and Moon, R.C. Inhibition of

rat mammary gland chemical carcinogenesis by dietary dehydroepiandrosterone or a fluorinated analogue of dehydroepiandrosterone. Cancer Res. 5l: 48l, l99l.

49. Moberhan, S., Seitz, H. K., Mehta, R. G., Hupert, J., Friedman, H., Layden, T. J.,

Maidani, A., and Russell, R. M. Age related effects of chronic ethanol on vitamin A status in rats. J. Nutrition, 121: 510, l991.

50. Mehta, R.G., Moon, R.C., Hawthorne, M., Formelli, F., and Costa, A. Distribution of

fenretinide in the mammary gland of breast cancer patients. Eu. J. Cancer, 27: 138, l99l.

Publications

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51. Mehta, R.G., Moon, R.C., Steele, V., and Kelloff, G.J. Influence of thiols and inhibitors of prostaglandin biosynthesis on the carcinogen-induced development of mammary lesions in vitro. Anticancer Res. 11: 587, l99l.

52. Mehta, R.G., and Moon, R.C. Characterization of effective chemopreventive

agents in mammary gland in vitro using an initiation-promotion protocol. Anticancer Res. 11: 593, l99l.

53. Moon, R.C., and Mehta, R.G. Vitamin A and prevention of cancer. In: Cutaneous

Malignancy. (Franks, et al., eds), Blackwell Scientific Publ., Oxford, England, pp. l-l5, l99l.

54. Moon R. C., Mehta R. G., Detrisac C. J. and Ratko T. A. Chemoprevention of

experimental breast cancer. In: Chemoimmuno prevention of cancer. First International conference, Vienna, Austria. Pastorino U. and Hong W. K. (eds.), Thieme Medical Publishers, Inc. New York NY. pp 57-63, 1991.

55. Matsuoka L.Y., Wortsman J., Tang G., Parker L., Mehta, R.G. and Russell, R.M. In

search of an endogenous anti-acne factor Arch. Dermatol. 20: 128, 1991. 56. Mehta R.G., Barua A.B., Olson J.A. and Moon R.C. Effects of retinoid glucuronides

on mammary gland development in organ culture. Oncology 48: 509, 1991. 57. Mehta R.G., Barua A.B., Olson J.A. and Moon R.C. Retinoid glucuronides do not

interact with retinoid binding proteins. Int. J. of Vitamin and Nutr. Res. 62: 143, 1992

58. Mobarhan S., Greenberg B., Mehta R.G., Friedman H. and Barch D. Zinc

deficiency reduces hepatic cellular retinoic acid binding protein in rats J. of Vitamin and Nutr. Res. 62: 148, 1992.

59. Moon, R.C., Mehta, R.G., and Detrisac, C.J. Retinoids as chemopreventive agents

for breast cancer. Cancer Detection and Prevention 16: 73, 1992. 60. Cobleigh M.A., Dowlatshahi K., Deutsh T.A., Mehta R.G., Moon R.C., Minn F.,

Benson A.B., Rademaker A.W., Ashenhurst J.B., Wade J.L. and Wolter J. Phase I/II trial of tamoxifen with or without fenretinide, an analog of vitamin A, in women with metastatic breast cancer. J. Clin. Oncol. 11, 474-477 1993.

61. Mehta, R.G., and Moon, R.C. Chemoprevention of mammary cancer by retinoids in

chemoprevention of carcinogenesis. In: Chemoprevention of Cancer. Bhide S.V. and G. B. Maru (eds) Omega Press, Bombay, India, pp 69-82, l992

62. Mehta R.G, Liu J., Constantinou A., Hawthorne M., Pezzuto J. M., Moon R. C., and

Moriarty R. M. Structure activity relationships of brassinin in preventing the development of carcinogen induced mammary lesions in organ culture. Anticancer Res. 14, 1209- 1214 1994.

63. Moon R.C. Steele V.E. Kelloff G.J. Thomas C.F., Detrisac C.J., Mehta R.G. and

Lubet R.A. chemoprevention of MNU-induced tumorigenesis by hormone

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response modifiers: tormefene, RU 16117, tamoxifen, aminoglutathemide and progesterone. Anticancer Res. 14, 1-5 1994.

64. Moon R.C., Mehta R. G. and Rao K.V.N. Retinoids and cancer. In: The Retinoids,

2nd edition, Sporn M.B., Roberts A.B.and Goodman D.S. (eds.), Raven Press.273-295, 1994

65. Constantinou A., Stoner G.D., Heur Y., Mehta R.G., Rao K., Runyan C. and Moon

R. C. The dietary anticancer agent Ellagic acid is a potent inhibitor of human DNA topoisomerases. Nutrition and Cancer 23: 121-130, 1995.

66. Shamon L. A., Chen C., Mehta R. G.,Steele V., Moon R.C. and Pezzuto J.M. A

correlative approach for the identification of antimutagens that demonstrate chemopreventive activity. Anticancer Res. 14: 1775-1778,1995

67. Constantinou A. Mehta R.G., Rao K.V.N. and Moon R.C. Topoisomerase I and II

inhibition by plant flavonoids: Structure activity relationships and biological significance J. Natural Products 58: 217-225, 1995.

68. Mehta R.G., Mehta R.R., Constantinou A. and Moon R.C. Distribution of epidermal

growth factor receptors in normal and neoplastic mammary tissues. Oncology Reports 2: 281-284,1995.

69. Mehta R.G., Liu J., Constantinou A., Thomas C.F., Hawthorne M., You M.,

Gerhauser C., Pezzuto J.M., Moon R.C., and Moriarty R. M., Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage Carcinogenesis 16: 399-404,1995.

70. Gerhauser C., Woonghon M., Suh N., Yingde L., Kosmeder J., Moriarty R.M.,

Luyengi L., Kinghorn D.A., Fong H.H., Mehta R.G., Constantinou A. Moon R.C. and Pezzuto J. M. . Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase Nature Medicine 1995 1: 260-266, 1995

71. Constantinou A.I., Mehta R.G., and Vaughan A., Inhibition of N-methyl-N-

nitrosourea-induced mammary tumors in rats by the soybean isoflavones Anticancer Res. 16: 3293-3298, 1996.

72. Constantinou A.I., Mehta R.G. and Vaughan A. Inhibition of N-methyl-N-

nitrosourea induced mammary tumors in rats by the soybean isoflavones. Anticancer Res.16: 3293- 3298, 1996.

73. Mehta R. G. Steele V., Pierson H., Constantinou C., and Moon R.C. Licorice:

Absorption, Distribution, metabolism and cancer chemoprevention. J. Clin Nutr. 74. Mehta R. G., Moriarty R.M., Mehta R.R., Penmasta R., Lazzaro G., Constantinou

A.,and Guo L. Prevention of preneoplastic mammary lesion development by a novel vitamin D analog 1(hydroxy) vitamin D5 JNCI 89: 212-219, 1997.

75. Gerhauser C.L., You M., Liu J., Moriarty R.M., Hawthorne M., Mehta R.G., Moon

R.C. and Pezzuto J.M. Cancer chemopreventive potential of sulforamate, a

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novel analog of sulforaphan that induces phase 2 drug-metabolizing enzymes Cancer Res 57: 272-278, 1997.

76. Mehta R.G., Hawthorne M. And Steele V. Induction of carcinogen-induced

precancerous lesions in mouse mammary gland organ culture. Methods in Cell Science 19: 19-24, 1997.

77. Steele V. E., Sharma S., Mehta R.G., Elmore E., Rudd C., Bahgeri D., Sigman C.

C., and Kelloff G.J. Use of in vitro assays to predict the efficacy of chemopreventive animals in whole animals. J. Cell. Biochem. 265: 29-53, 1997.

78. Thompson H.J., Jiang C., Lu J., Mehta R.G., Piazza G., Paranka N.S. and Ahnen

D., Sulfone metabolite of sulindac inhibits mammary carcinogenesis Cancer Res. 57: 267- 271, 1997.

79. Gerhauser C., Lee S.K., Kosmeder J.W., Moriarty R.M., Hamel E., Mehta R.G.,

Moon R.C. and Pezzuto J.M. Regulation of ornithine decarboxylase induction by deguelin, a natural product cancer chemopreventive agent Cancer Res. 57: 3429-2435, 1997

80. Jang M., Udeani G., Sowing-Barillas K., Thomas C., Beecher C.W.W., Fong H.,

Farnsworth N.R., Kinghorn A.D., Mehta R.G., Moon R.C., and Pezzuto J.M. Cancer chemopreventive activity of resveratrol, a component of the human diet derived from Vitis vinifera (the grape) Science 275: 218-220, 1997.

81. Mehta R.R., Hawthorne M.E., Graves J., Thomas C.F., Moon R.C. and Mehta R.G.

Inhibition of human breast cancer and melanoma cells by N-[4-hydroxyphenyl]retinamide may be dependent on its major metabolite N-[4methoxyphenyl]retinamide. Eu. J. Cancer 34: 02-907, 1998.

82. Mehta R.G. and Banerjee M. R. Mammary gland organ culture In Protocols in

Cell and tissue Culture, 1997. (Complete reference not available) 83. Pezzuto J.M., Beecher C.C.W., Fong H.S., Farnsworth N.R., Mehta R.G., Hedayat

S., Udeani G.O., Moriarty R.M., and Kinghorn A.D. Discovery and characterization of natural product cancer chemopreventive agents 1997.

84. Lazzaro G., Mehta R. R., Shilkaitis A., Das Gupta T. K. and Mehta R. G.

Transformation of human breast epithelial cells by 7,12, dimethylbenz(a)anthracene, but not by N-methyl-n-nitrosourea, is accompanied by up-regulation of basic fibroblast growth factor. Oncology reports 4: 1175-1180, 1997

85. Lazzaro G., Sharpless S. Qing W., Mehta R. R., Das Gupta T. K. and Mehta R. G.

Study of nm23 gene expression in an N-methyl-N-nitrosourea transformed human breast epithelial cell line. Int. J. Oncology 11: 765-769, 1997

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86. Agadir A., Lazzaro G., Zheng Y., Zhang X-K., and Mehta R. G. Resistance of HBL100 human breast epithelial cells to Vitamin D action. Carcinogenesis 20: 577-582, 1999.

87. Lee S.K., Qing W., Mar W., Luyengi L., Mehta R.G., Kawanishi K., Fong H.H.S.,

Beecher C.W., Kinghorn A.D. and Pezzuto J.M. Angoline and chelerythrine benzophenenthridine alkaloids that do not inhibit protein kinase C. J. Biol. Chem. 231: 19829-19833, 1998.

88. Kinghorn A.D., Fong H.H.S., Farnsworth N.R., Mehta R.G., Moon R.C., Moriarty

R.M., and Pezzuto J.M. Cancer chemopreventive agents discovered by activity guided fractionation: A Review. Current organic Chemistry 2: 597-612, 1998.

89. Pezzuto J.M., Song L.L., Lee S.K., Shamon L.A., Mata-Greenwood E., Jang M.,

Jeong H-J., Pisha E., Kinghorn A.D. and Mehta R.G. Bioassay methods useful for activity guided isolation of natural product cancer chemopreventive agents CBP 81-109, 1998.

90. Moriarty R.M., Penmasta R.,Rao M.S., Guo L. Werner F. and Mehta R.G. Syntheis

of novel vitamin D analogs Pure and Applied Chemistry 70: 373-376, 1998 91. Lee S.K., Luyengi L., Mar W., Gerhauser C., Lee K., Mehta R.G. Kinghorn A.D.

and Pezzuto J.M. Inhibitory effect of munetone, an isoflavanoid on 12-O-tetardecanoylphorbol 13-acetate induced ornithine decarboxylase activity Cancer Lett. 136: 59-65, 1999.

92. Steele V.E., Bagheri D., Belentine D.S., Boone C.W., Mehta R.G., Morse M.,

Sharma S., Sigman C.C., Stoner G., Wargovich M.J., Weisberger J.H., Zhu S., and Kelloff G.J. Preclinical efficacy studies of green and black tea extracts Proc. Exptl. Biol. Med. (suppl.) pp 210-212,1999.

93. Jinno H., Steiner M.G., Osborne M.P. and Mehta R.G. and Telang N.T. Inhibition

of aberrant proliferation and induction of apoptosis in HER2/neu oncogene transformed human mammary epithelial cells by N-[4-hydroxyphenyl]retinamide Carcinogenesis 20: 229-236, 1999.

94. Chung H.S., Chang L.C., Lee S.K., Shamon L.A., VanBreemen R.B., Mehta R.G.,

Farnsworth N.R., Pezzuto J.M. and Kinghorn A.D. Flavonoid constituents of Chorizanthe diffusa with potential cancer chemopreventive activity J. Agr. And Food Chem. 47: 36-41, 1999

95. Christov K., Shilkaitis A., Green A., Grubbs C.J., Mehta R.G., Kelloff G.J. and Lubet

R. Cellular responses of mammary carcinomas to aromatase inhibitors Effects of vorozole. Breast Cancer Res and Treat. 2000, 60: 1171-1178, 2000.

96. Mehta R.G., Williamson E. Patel M. and Koeffler H.P. PPAR Ligand and retinoids

prevent preneoplastic mammary lesions JNCI 92: 418-423, 2000 97. Mehta R.R., Bratescu L., Graves J.M. and Mehta R.G. Differentiation of human

breast carcinoma cells by a novel vitamin D analog: 1 hydroxyvitamin D5 Int. J. Oncology 16: 65-73, 2000.

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98. Lazzaro G., Agadir A., Qing W., Poria M., Mehta R.R., Moriarty R.M., Zhang X-

K and Mehta R.G. Induction of differentiation by 1hydroxyvitamin D5 in T47D human breast cancer cell and its interaction with vitamin D receptors Eur. J. Cancer 36: 780-786, 2000.

99. Steele V.E., Kelloff G.J., Balentine D, Boone C.W., Mehta R.G., Bagheri D.,

Sigman C.C., Zhu S. and Sharma S. Comparative chemopreventive mechanisms of green tea, black tea and selected polyphenol extracts measured by in vitro assays. Carcinogenesis 21: 63-67, 2000.

100. Mehta R.G., Hawthorne M.E., Uselding L., Albenescu D., Moriarty R.M.,

Christov K. and Mehta R.R. Prevention of N-Methyl-N-nitrosourea induced mammary carcinogenesis in rats by 1-hydroxyvitamin D5 JNCI 92: 1836-1840, 2000.

101. Mehta R.G. Experimental basis for prevention of breast cancer Eu. J. Cancer,

36: 1275-1282, 2000. 102. Salti G.I., Kichina J.V., Das Gupta T.K., Uddin S., Bratescu L., Pezzuto J.M.,

Mehta R.G., and Constantinou A.I. Betulinic acid reduces ultraviolet-C-induced DNA breakage in congenital melanocytic naeval cells: evidence for a potential use as a chemopreventive agent Melanoma Res. 11, 99-104, 2001

103. Mehta R. G. Bhat K.P.L., Hawthorne M.E., Kopelovich L., Mehta R.R., Christov

K., Kelloff G.J., Steele V.E. and Pezzuto J.M. Induction of atypical hyperplasia in mouse mammary gland organ culture. JNCI 93: 1103-1106, 2001.

104. Mata-Greenwood E., Ito A., Westenberg H., Cui B., Mehta R.G., Kinghorn A. D.

and Pezzuto J.M. Discovery of novel inducers of cellular differentiation using HL-60 promyelocytic cell. Anticancer Res. 21: 1763-1770, 2001

105. Gu J-Q., Park E.J., Luyengi L., Hawthorne M.E., Mehta R.G., Pezzuto J.M., and

Kinghorn A.D. Constituents of eugenia sandwicensis with potential cancer chemopreventive activity Phytochemistry 58(1):121-7 2001

106. Bhat K.P.L., Lantvit D., Christov K., Mehta R.G., Moon R.C. and Pezzuto J.M.

Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. Cancer Res. 61: 7456-7463, 2001.

107. Murillo G. and Mehta R.G. Cruciferous vegetables and cancer

chemoprevention. Nutrition and Cancer 41: 17-28, 2001 108. Kim N.D., Mehta R.G., Yu W., Neeman I., Liveney T., Amichay A., Poirier D.,

Nicholls P., Kirby A., Jiang W., Mensel R., Ramchandran C. Rabi T., Kaplan B.,

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and Lansky E. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer Breast Cancer Res. and Treatment 71: 203-217, 2002

109. Ito A., Shamon L.A., Yu B., Mata-Greenwood E., Lee S.K., Van Breemen R.B.,

Mehta R.G., Farnsworth N.R., Fong H.S., Pezzuto J.M. and Kinghorn A.D. Antimutagenic constituents of Casmiroa edulis with potential cancer chemopreventive activity J. Agr. And Food Chem. 2002.

110. Waffo-Teguo P., Hawthorne M.E., Cuender M., Merillon J-M., Kinghorn A.D.,

Pezzuto J.M. and Mehta R.G. Potential cancer chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutrition and Cancer 40: 173-179, 2002.

111. Chatterton R.T., Lydon J.P., Mehta R.G., Mateo E.T., Pletz A. and Jordan

V.C. Role of progesterone receptor (PR) in susceptibility of mouse mammary gland to dimethylbenz(a)anthracene-induced preneoplastic lesions in vitro. Cancer Letters 188:47-52, 2002

112. Kaur K., Arora S., Hawthorne M.E., Kaur S., Kumar S. and Mehta R.G.

Expression of antimutagenic and chemopreventive activity of certain Indian medicinal plants Drug Toxicol and Pharmacol. 25:39-64, 2002 .

113. Mehta R.G. and Mehta R.R. Vitamin D and Cancer J. Nutr. Biochem. 13: 252-

264, 2002 114. Su B-N., Cuendet M., Hawthorne M.E., Kardono L.B.S., Riswan S., Fong H.,

Mehta R.G., Pezzuto J.M., and Kinghorn A.D. Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity J. Nat. Products 65: 163-169, 2002

115. Mehta R.R., Bretascu L., Graves G., Shilkaitis A., Green A., Mehta R.G. and

Das Gupta T.K. In Vitro transformation of human congenital naevus to malignant melanoma Melanoma Res. 12: 27-33, 2002

116. Rimando A.M., Cuendet M., Desmarcheller C., Mehta R.G., Pezzuto J.M., and

Duke S.D. Cancer chemopreventive and antioxidant activities of pterostilbene a naturally occurring analogue of resveratrol J. Agr. Food Chem 50: 3453-3457, 2002

117. Hawthorne M.E., Steele V.E. and Mehta R.G. Evaluation of selective

chemopreventive agents present in common foods I mouse mammary gland organ culture Pharmaceutical Biology 40: 70-74, 2002

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118. Mehta R.G. and Pezzuto J.M. Discovery of cancer preventive agents from natural products: from plants to prevention Curr. Oncol. Rep 4: 478-486, 2002

119. Murillo G. Salti G.I., Kosmeder J.W., Pezzuto J.M. and Mehta R.G. Deguelin

inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest Eu. J. Cancer 38: 2446-2454, 2002.

120. Yu C., Shin Y.G., Chow A., Li Y., Kosmeder J.W., Lee Y.S., Hirschelman W.H.,

Pezzuto J.M. Mehta R.G. and van Breeman R.B. Human, rat and mouse metabolism of resveratrol Pharmaceutical Res. 19: 1907-1914, 2002

121. Jang D.S., Park E.J., Hawthorne M.E., Vogi J.S., Graham J.G., Cabieses F.,

Santarseiro B.D., Mesecar A.D., Fong H.H.S., Mehta R.G., Pezzuto J.M. and Kinghorn A.D. Constituents of Musa X paradisiacal cultivar wit the potential to induce Phase I enzyme, quinone reductase. J. Agr. And Food Chem. 50: 6330-6334, 2002

122. Su B., Chang L., Cuendet M., Santarsiero B., Mesecar A., Mehta R.G., Fong H.,

Pezzuto J.M., and Kinghorn A.D. Bioactive constituents of the seeds of brucea javanica Planta Med 68: 730-733, 2002

123. Gu J-Q Gills J., Jung E., Mata-Greenwood E., Hawthorne M., Axelrod F.,

Chavez P.,Fong H., Mehta R.G., Pezzuto J.M., and A.D. Kinghorn Sesquiterpenoids from Tithonia diversifolia with potential cancer chemopreventive activity. J. Nat. Prod. 65: 532-536, 2002

124. Jang D.S., Park J., Hawthorne M., Vigo J.S., Graham J.G., Cabieses F.,

Santarsiero B.D., Mesecar A.D., Fong H., Mehta R.G., Pezzuto J.M. and Kinghorn A.D. Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (Tonka Beans) J. Nat. Prod. 66: 583-587, 2003.

125. Duncan CJ, Cuendet M, Fronczek FR, Pezzuto JM, Mehta RG, Hamann MT,

Ross SA. Chemical and biological investigation of the fungus Pulveroboletus ravenelii. J Nat Prod. 66(1):103-107, 2003.

126. Jang D.S., Cuendet M., Hawthorne M.,Kardono L.B., Kawanishi K., Fong H.H.,

Mehta R.G., Pezzut6o J.M, Kinghorn A.D. Prenylated flavanoids of the leaves of Macaranga conifera with inhitiory activity against cyclooxygenase-2 Phytochemistry 61: 867-872, 2003.

127. Jang DS, Park EJ, Kang YH, Su BN, Hawthorne ME, Vigo JS, Graham JG,

Cabieses F, Fong HH, Mehta RG, Pezzuto JM, Kinghorn AD. Compounds obtained from sida acuta with the potential to induce quinone reductase and to inhibit 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesions in a mouse mammary organ culture model. Arch Pharm Res. 26(8):585-590, 2003.

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128. Murillo G., Kosmeder J.W., Pezzuto J.M., Pezzuto J.M. and Mehta R.G.

Deguelin suppresses the formation of carcinogen-induced aberrant crypt foci in the colons of CF-1 mice Int. J. Cancer 104: 7-11, 2003

129. Constantinou A.I., Mehta R.G., Husband A. Phenoxodiol, a novel isoflavone

derivative, inhibits DMBA-induced mammary carcinogenesis in female Sprague Dawley rats Eu. J. Cancer 39: 1012-1018, 2003.

130. Jang D.S., Park E.J., Kang Y-H., Su B-N., Hawthorne M.E., Vigo J.S., Graham

J.G., Cabiesse F. Fong H., Mehta R.G., Pezzuto J.M. and Kinghorn A.D. Compounds obtained from Sida acuta with the potential to induce quinone reductase and to inhibit 7,12 dimethylbenz(a)anthracene-induced preneoplastic lesions in mouse mammary organ culture model Arch. Pharm Res. 26: 585-590, 2003

131. Hussain E.A., Mehta R.R., Ray R., Das Gupta T.K., Mehta R.G. Efficacy and

mechanism of action of 1-hydroxy-24-ethyl-cholecalciferl (1(OH)D5) in breast cancer prevention and therapy. Recent Results in Cancer Res.4: 476-486, 2003

132. Mehta R.G., Hussain E.A., Mehta R.R., and Das Gupta T.K. Chemoprevention

of mammary carcinogenesis by 1-hydroxyvitamin D5 a synthetic analog of vitamin D. Mutation Res. 523-524:253-264, 2003

133. Jang D.S., Park E.J., Kang Y-H,Hawthorne M.E., Vigo J.S., Graham J.G.,

Cabieses F., Fong H., Mehta R.G., Pezzuto J.M. and Kinghorn A.D. Potential cancer chemopreventive flavonoids from the stems of Tephrosia toxicaria. J. Nat. Prod. 66: 1166-1170, 2003

134. Mehta R.G. Lansky E. Breast Cancer Chemopreventive Properties of

Pomegranate (Punica Granatum) Fruit Extracts in a Mouse Mammary Organ Culture (MMOC) Eu. J. Cancer Prevention, 13: 345-348, 2004

135. Murillo G., Choi J.K., Pan O., Constaninou A.I. and Mehta R.G. Efficacy of

garbanzo and soybean flour in suppression of aberrant crypt foci in the colons of CF-1 mice. Anticancer Res. 24: 3049-3056, 2004

136. Mehta R.G. Vitamin D and Cancer Chemoprevention Editorial Review, Int. J.

Cancer Prevention 1: 77-88, 2004 137. Mehta R.G., and Pezzuto J. M. Phytochemicals as potential cancer

chemopreventive agents In Phytopharamceuticals in cancer chemoprevention, D. Bagchi and H.G. Preus Eds. CRC Press Pp.237-246. 2004.

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138. Gafner S., Lee S.K., Cuendet M., Barthelemy S., Vergnes L., Labidalle S.,

Mehta R.G., Boone C.W. and Pezzuto J.M. Biologic evaluation of curcumin and structural derivatives in cancer chemoprevention model systems Phytochemistry 65: 2849-2859, 2004

139. Mehta R. G. Stage specific inhibition of mammary carcinogenesis by 1-

Hydroxyvitamin D5 Eu. J. Cancer 40: 2331-2337, 2004 140. Swamy N., Chen T.C., Paleg S., Dhawan P., Christakos S., Stewart L. V.,

Weigel NL., Mehta R.G. Holick M.F. and Ray R. Antiproliferative and apoptotic effects of 25-hydroxyvitamin D3-3-(2)-bromoacetate a non-toxic and vitamin D receptor alkylating analog of 25-hydroxyvitamin D3 in prostate cancer cells. Clin. Cancer Res. 10: 8018-8027, 2004

141. Packianathan S., Mehta R.G., Mehta R.R., Hall W.H., Boerner P.S., Beckett

L.A. and Vijayakumar S. Designing randomized Phase I/II prostate chemoprevention trial using 1α-hydroxy-24-ethyl-cholecalciferol, an analog of Vitamin D3 The Cancer Journal 10: 357-367, 2004

142. Peng X. Mehta R.G., Tonetti D.A. and Christov K. Identification of novel

RARbeta2 transcript variants with short 5'-UTRs in normal and cancerous breast epithelial cells. Oncogene 26: 1296-1301, 2005.

143. Chow A.W., Murillo G., Yu C, van Breemen R.B., Boddie A.W., Pezzuto J.M.,

Das Gupta T.K., Mehta R.G. Resveratrol inhibits rhabdomyosarcoma cell proliferation. Eu.J.Cancer Prevention 13:14: 351-356, 2005.

144. Murillo G. Mehta R.G. Chemoprevention of chemically induced mammary and

colon carcinogenesis by 1α-hydroxyvitamin D5 J. Steroid Biochem and Mol. Biol. 97, 129-136 2005

145. Matusiak D., Murillo G., Carroll R.E., Mehta R.G. and Benya R.V. Expression of

vitamin D receptor and 25-hydroxyvitamin D3-1(alpha)-hydroxylase in normal and malignant human colon Cancer. Epidemiol.Biomarkers Prev. 14:2370-2376, 2005

146. Vijaykumar S., Mehta R.R., Boerner P. Pakianathan S. and Mehta R.G. Clinical

trials involving vitamin d analogs in prostate cancer The Cancer J. 2005, 11: 362-373.

147. Hussain-Hakimjee E., Peng X., Mehta R.R. and Mehta R.G. Growth inhibition of

carcinogen-transformed MCF-12F breast epithelial cells and hormone-sensitive BT-474 breast cancer cells by 1α- hydroxyvitamin D5. Carcinogenesis 27: 551-559,2006

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148. Gu L-Z,Hu W-Y, Antic N., Mehta R., Turner J.R. and de Lanerolle P. Inhibiting

myosin light chain kinase retards the growth of mammary and prostate cancer cells Eu. J. Cancer 42: 947-957, 2006

149. Jung H-A, Bao-Ning S., Keller W.J., Mehta R.G., Kinghorn A.D. Antioxidant

xanthones from the pericarp of Garcinia mangostana (Mangostin). Journal of Agricultural and Food Chemistry 54: 2077-2082, 2006

150. Peng X., Mehta R.R., Wang S., Srikumar C. and Mehta R.G. Prohibitin is a target

gene of vitamin D involved in its antiproliferative action in breast cancer cells. Cancer Res. 66:7361-7369, 2006

151. Jones G., Byford V., West S., Masuda S., Ibrahim G., Kaufmann M., Knutson J.,

Strgnell S. and Mehta R. Hepatic activation of clinically relevant vitamin D analogs and prodrugs Anticancer Res. 26: 2589-2596, 2006

152. Choi J.K., Murillo G., Su B-N, Pezzuto J.M., Kinghorn A.D., and Mehta R.G.

Ixocarpalactone A isolated fro the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells FEBS J.273: 5714-5723, 2006.

153. Vijayakumar S., Boerner M.A., Mehta R.R., Packianathan S., Mehta R.G., Das

Gupta T.K. Clinical trials with chemopreventive agents for the treatment of breast cancer. The Cancer J. (In Press) 2007.

154. Peng X. and Mehta R.G. Differential expression of prohibitin is correlated with

dual action of vitamin D as a proliferative and antiproliferative hormone in breast epithelial cells. J. Steroid Biochem. and Mol. Biol. 103: 446-450 2007

155. Murillo G, Hirschelman WH, Ito A, Moriarty RM, Kinghorn AD, Pezzuto JM,

Mehta RG. Zapotin, a phytochemical present in a Mexican fruit, prevents colon carcinogenesis. Nutr Cancer. 2007;57(1):28-37

156. Murillo G., Matusiac D., Benya R.V., Mehta R.G. Chemopreventive efficacy of

25-hydroxyvitamin D3 in colon cancer J. Steroid Biochem. Mol. Biol. 103, 763-767, 2007

157. Peng X., Jhaveri P., Hussain-Hakimjee E. and Mehta R.G. Overexpression of ER

and VDR is not sufficient to make ER-negative MDA-MB231 breast cancer cells responsive to 1{alpha}-Hydroxyvitamin D5. Carcinogenesis. 28: 1000-1007, 2007

158. Zhang X., Mehta R.G., Lantvit D.D., Coschigano K.T., Kopchick J.J., Green J.E.,

Hedayat S. Christov K.,Ray V.H. Unterman T.G. and Swanson S.M. Inhibition of

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estrogen-independent mammary carcinogenesis by disruption of growth hormone signaling. Carcinogenesis. 28:143-50, 2007. [Epub 2006 Aug 17.]

159. Wiehle R.D., Christov K., Mehta R.G. Anti-progestins suppress the growth of

established tumors induced by 7,12, dimethylbenz(a)anthracene: Comparision between RU486 sand a new 21-substituted-19—nor progestin Oncology reports 18: 167-174, 2007

160. Shen Q., Lantvit D., Li Y., Christov K., Wang Z., Utterman T. Mehta R.G.,

Swanson S.M. Depenedence of advanced rat mammary cancers on the growth hormone/IGF-I axis. Endocrinology 148: 4536-4544, 2007

161. Whyte L.,Huang Y.Y., Torres K., Mehta R.G. Molecular mechanisms of

resveratrol action in lung cancer cells using dual protein and microarray analyses Cancer Res. 67: 12007-12017, 2007.

162. Murillo G., Naithani R., Mehta R.G. Efficacy of Herbal Products in Colorectal

Cancer Prevention Current Colorectal Cancer Reports 4: 34-48, 2008 163. Naithani R., Huma L., Moriarty R.M., McCormick D.L. and Mehta R.G.

Comprehensive review of cancer chemopreventive agents evaluated in experimental carcinogenesis models and clinical trials Current Med. Chem. 15: 1044-1071, 2008

164. Naithani R., Huma L., Holland L., Shukla D., McCormick D.L., Mehta R.G. and

Moriarty R.M. Antiviral activity of phytochemicals: A comprehensive Review Mini Rev. Med. Chem. 8: 1106-1133, 2008

165. Mehta R.G., Naithani R., Huma L., Hawthorne M.E., Moriarty R.M., McCormick

D.L., Steele V.E. and Kopelovich L. Efficacy of chemopreventive agents in mouse mammary gland organ culture (MMOC) model: A Comprehensive Review Curr. Med. Chem. 15: 2785-2825, 2008

166. Peng X., Vaishanav A, Hawthorne M., St-Arnaud R. and Mehta R.G. 25-

Hydroxyvitamin D(3) is a natural chemopreventive agent against carcinogen induced precancerous lesions in mouse mammary gland organ culture. Breast Cancer Res Treat. 113: 31-41, 2009

167. Hussain-Hakimjee E.A. and Mehta R.G. Regulation of steroid receptor

expression by 1a-hydroxyvitamin D5 in hormone responsive breast cancer cells Anticancer Res (Suppl.) 29,: 3555-3562, 2009

Publications

23

168. Murillo G, Peng X, Torres K.E., Mehta R.G. Deguelin inhibits growth of breast cancer cells by modulating the expression of key members of the Wnt signaling pathway Cancer Prev. Res. 2: 942-950 2009

169. Thoennissen N.H., O’Kelly J., Lu D., Iwanski G.B., La D.B. Abbassi S., Leiter A,

Karlan A, Mehta R.G, Koeffler H.P. Caspsaicin causes cell cycle arrest and apoptosis in ER positive and ER-nehgative breast cancer cells by modulating the EGF/Her-2 pathway Oncogene 29: 285-296, 2010 (Epub 2009 Oct 26.)

170. Murillo G., Nagpal V., Tiwari N., Benya R.V., Mehta R.G. Actions of vitamin D are

mediated by the TLR4 pathway in inflammation-induced colon cancer J. Steroid Biochem. Mol. Biol. 121: 403-407, 2010 [Epub ahead of print]

171. Mehta R.G., Murillo G, Naithani R, Peng X. Cancer chemoprevention by Natural

Products: How far have we come? Pharm. Res. 27: 950-951, 2010 [E-pub ahead of print March 18, 2010]

172. Saleiro D. Murillo G., Lubhan D.B., Kopelovich L., Korach K.S. and Mehta R.G.

Enhanced Induction of Mucin-Depleted Foci in Estrogen Receptor {beta} Knockout Mice. Cancer Prev. Res (Phila Pa) 3: 1198-1204, 2010.

173. Peng X. Vaishnav A., Murillo G., Alimirah F., Torres K. And Mehta R.G.

Protection against cellular stress by 25-dihydroxyvitamin D3 in breast epithelial cells J. Cell Biochem. 110: 1324-1333, 2010

174. Alimirah F., Vaishnav A., McCormick M. Echchgadda I., Chatterjee B, Mehta

R.G. and Peng X. Functionality of unliganded VDR in breast cancer cells: Repressive action on CYP24 basal transcriptin Mol Cell Biochem. 342: 143-150, 2010 [Epub 2010 May 4.PMID: 20440542]

175. Mehta RR, Hawthorne M, Peng X, Shilkaitis A, Mehta RG, Beattie CW, Das

Gupta TK. A 28 amino acid peptide fragment of the cupredoxin azurin prevents carcinogen induced mouse mammary lesions Cancer Prev Res (Phila). 3: 1351-1360, 2010 Sep 14. [Epub ahead of print]

176. Mooso B., Madhav A., Johnson S., Roy M., Moore M., Moy C., Loredo GA,

Mehta R.G., Vaughan ATM., Ghosh P.M. Androgen receptor regulatin of vitamin D receptor in response of castration-resistant prostate cancer cells to 1a-hydroxyvitamin D5: A calcitriol analog Genes and Cancer 1: 927-940, 2010.

177. Mackinnon AC, Tretiakova M, Henderson L, Mehta RG, Yan BC, Joseph L,

Krausz T, Husain AN, Reid ME, Salgia R. Paxillin expression and amplification in early lung lesions of high-risk patients, lung adenocarcinoma and metastatic disease. J Clin Pathol. 64:16-24, 2011

Publications

24

178. Alimirah F, Peng X, Murillo G, Mehta R.G. Functional significance of vitamin D receptor FokI polymorphism in human breast cancer cells.. PLoS One. 6:e16024, 2011

179. Swarup V. P., Huang Y, Murillo G, Saleiro D, Mehta R.G., and Bishnoi S.W. Modeling the cellular impact of nanoshell-based biosensors using mouse alveolar macrophage cultures Metallomics, 3: 1218-1226 2011, (Advance Article DOI: 10.1039/C1MT00089F)

180. Peng X., Tiwari N., Roy S., Yuan L., Murillo G., Mehta R.R., Benya R.V. and Mehta

R.G. Regulation of CYP24 splicing by 1,25-dihydroxyvitamin D3 in human colon cancer cells J. Endocrinol. 212: 207-215, 2012

181. Saleiro D, Murillo G., Benya R. V., Bissonnette M., Hart J., and Mehta R. G.

Estrogen Receptor- Protects Against Inflammation and Neoplasia in the AOM/DSS Model Int. J. Cancer 131(11):2553-2561, 2012.

182. Alimirah F, Peng X, Yuan L, Mehta RR, von Knethen A, Choubey D, Mehta RG.

Crosstalk between the peroxisome proliferator-activated receptor γ (PPARγ) and the vitamin D receptor (VDR) in human breast cancer cells: PPARγ binds to VDR and inhibits 1α,25-dihydroxyvitamin D(3) mediated transactivation. Exp Cell Res. 15; 318: 2490-2497, 2012.

183. Gupta A., Mehta R., Alimirah F., Peng X., Murillo G., Mehta R.G. Efficacy and

mechanism of action of Proellex, an antiprogestin in aromatase overexpressing and Letrozole resistant T47D breast cancer cells J. Steroid Biochem. Mol. Biol. 133: 30-42, 2013.

184. Mehta RG, Peng X, Roy S, Hawthorne M, Kalra A, Alimirah F, Mehta RR, Kopelovich L. PPARγ antagonist GW9662 induces functional estrogen receptor in mouse mammary organ culture: potential translational significance. Mol Cell Biochem. 372:249-256, 2013 [Epub ahead of print]

185. Mehta RG, Peng X, Alimirah F, Murillo G, Mehta R.R. Vitamin D and Breast

Cancer: Emerging Concepts, Cancer Letters (In Press). 2013

186. Mehta R., Katta H., Aimirah F., Patel R., Murillo G., Peng X., Muzzio M., Mehta R.G. Deguelin action involves c-Met and RGFR signaling pathways in triple negative breast cancer cells. PLOS ONE Jun 10;8(6):e65113. doi: 10.1371/journal.pone.0065113 2013.

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25

187. Mehta R.R., Katta H., Kalra A., Patel R., Gupta A., Alimirah F., Murillo G., Peng X., Unni A., Muzzio M. Mehta R.G. Efficacy and mechanism of action of Deguelin in suppressing metastasis of 4T1 cells Clinical and Experimental Metastasis (e- pub ahead of print) 2013.

188. Peng X., Li W., Yuan L., Mehta R.G., Kopelovich L., McCormick D.L. Inhibition of proliferation aand induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR-182 and P21. PLoS One 2013 (In Press)

Peer reviewed Papers: 157 Review Chapters in Books: 31 Abstracts: 160+ (Not Included)

Abstracts

26