Rasvkoest pärinevate tüvirakkude ja trombotsüütide rikka plasma ja fibriini kasutamine regeneratiivses meditsiinis 

Üliõpilane: Roman Kornilov Juhendja: Tiia Tamme

Töö eesmärk

• Demonstreerida personaalse meditsiini ühte võimaliku meie tegevus valdkonda

• Trombotsüütide rikas plasma (platelet-rich plasma) s.t. kõrge kontsentratsiooniga trombotsüütide mass väheses plasmas, mille kasutamist alveolaarluu transplantaadile kirjeldas Marx 1998 aastal (Marx jt 1998).

• Sellel meetodil puuduvad äratõuke reaktsioonid. Seega on patsiendile hästi talutavad.

PRP ja PRFTrombotsüütide rikas plasma (PRP) ja trombotsüütide rikas fibriin

(PRF).

•PRP – on tavaline trombotsüütarne mass ning ta koosneb vähekontsentratsioonilisest fibriini koest.

•PRF – on trombotsüütidest tehtud teise generatsiooni toode, millises ühinevad kõrge trombotsüütide ja fibriini kontsentratsioonid ühes lahuses.

Rasvkoest pärinevate mesenhümaalsete tüvirakkude

isolatsioon.

Katsed

Tulemused

PRP kasutamine näo piirkonna noorendamises ja augmentatsioonis

Frederic Braccini, Jerome Paris and David M Dohan “Platelet-rich fibrin during facial lipostructure”The UK Journal of Medical Aesthetics and Anti-Ageinghttp://www.braccini.net/document/PDF/lipostructure_and_growths_factors.pdf

PRP kasutamine näo piirkonna noorendamises ja augmentatsioonis

Frederic Braccini, Jerome Paris and David M Dohan “Platelet-rich fibrin during facial lipostructure”The UK Journal of Medical Aesthetics and Anti-Ageinghttp://www.braccini.net/document/PDF/lipostructure_and_growths_factors.pdf

PRP kasutamine näo piirkonna noorendamises ja augmentatsioonis

Frederic Braccini, Jerome Paris and David M Dohan “Platelet-rich fibrin during facial lipostructure” The UK Journal of Medical Aesthetics and Anti-Ageinghttp://www.braccini.net/document/PDF/lipostructure_and_growths_factors.pdf

Kasvufaktorid(Grow Factors)

B.I. Simon1,*, A.L. Zatcoff1, J.J.W. Kong1 and S.M. O’Connell Clinical and Histological Comparison of Extraction Socket Healing Following the Use of Autologous Platelet-Rich Fibrin Matrix (PRFM) to Ridge Preservation Procedures Employing Demineralized Freeze Dried Bone Allograft Material and Membrane The Open Dentistry Journal, 2009, 3, 92-99

Postoperatiivne parenemine hamba ekstraktsiooni järgselt.

B.I. Simon1,*, A.L. Zatcoff1, J.J.W. Kong1 and S.M. O’Connell Clinical and Histological Comparison of Extraction Socket Healing Following the Use of Autologous Platelet-Rich Fibrin Matrix (PRFM) to Ridge Preservation Procedures Employing Demineralized Freeze Dried Bone Allograft Material and Membrane The Open Dentistry Journal, 2009, 3, 92-99

Postoperatiivne parenemine hamba ekstraktsiooni järgselt.

B.I. Simon1,*, A.L. Zatcoff1, J.J.W. Kong1 and S.M. O’Connell Clinical and Histological Comparison of Extraction Socket Healing Following the Use of Autologous Platelet-Rich Fibrin Matrix (PRFM) to Ridge Preservation Procedures Employing Demineralized Freeze Dried Bone Allograft Material and Membrane The Open Dentistry Journal, 2009, 3, 92-99

Igeme retsessiooni ravi (Parodontoloogia)

Jankovic S, Aleksic Z, Klokkevold P, Lekovic V, Dimitrijevic B, Kenney EB, Camargo P. Use of platelet-rich fibrin membrane following treatment of gingival recession: a randomized clinical trial.Int J Periodontics Restorative Dent. 2012 Apr;32(2):e41-50.

Igeme retsessiooni ravi

Jankovic S, Aleksic Z, Klokkevold P, Lekovic V, Dimitrijevic B, Kenney EB, Camargo P. Use of platelet-rich fibrin membrane following treatment of gingival recession: a randomized clinical trial.Int J Periodontics Restorative Dent. 2012 Apr;32(2):e41-50.

Igeme retsessiooni ravi

Jankovic S, Aleksic Z, Klokkevold P, Lekovic V, Dimitrijevic B, Kenney EB, Camargo P. Use of platelet-rich fibrin membrane following treatment of gingival recession: a randomized clinical trial.Int J Periodontics Restorative Dent. 2012 Apr;32(2):e41-50.

Igeme retsessiooni ravi

Jankovic S, Aleksic Z, Klokkevold P, Lekovic V, Dimitrijevic B, Kenney EB, Camargo P. Use of platelet-rich fibrin membrane following treatment of gingival recession: a randomized clinical trial.Int J Periodontics Restorative Dent. 2012 Apr;32(2):e41-50.

Igeme retsessiooni ravi

Jankovic S, Aleksic Z, Klokkevold P, Lekovic V, Dimitrijevic B, Kenney EB, Camargo P. Use of platelet-rich fibrin membrane following treatment of gingival recession: a randomized clinical trial.Int J Periodontics Restorative Dent. 2012 Apr;32(2):e41-50.

Igeme retsessiooni ravi

Jankovic S, Aleksic Z, Klokkevold P, Lekovic V, Dimitrijevic B, Kenney EB, Camargo P. Use of platelet-rich fibrin membrane following treatment of gingival recession: a randomized clinical trial.Int J Periodontics Restorative Dent. 2012 Apr;32(2):e41-50.

Igeme retsessiooni ravi

Pavan Bajaj*, Nishanth S Rao*, Esha Agarwal*, A.R.Pradeep* ”Treatment of intrabony defect with platelet rick fibrin: Case report” Archives of Oral Sciences & Research 2011;1(2):90-94.http://www.aosr.co.in/files/7.pdf

Igeme retsessiooni ravi Tulemused

Pavan Bajaj*, Nishanth S Rao*, Esha Agarwal*, A.R.Pradeep* ”Treatment of intrabony defect with platelet rick fibrin: Case report” Archives of Oral Sciences & Research 2011;1(2):90-94.http://www.aosr.co.in/files/7.pdf

Simultaan siinus-lifting ja implantatsioon, kasutades mini-implantaate ning PRF membraani mis olid ainsad

autoloogilised transplantaat materialid: kuue-aastane kogemus

Alain Simonpieri, DDS, Joseph Choukroun, MD, Marco Del Corso, DDS, Gilberto Sammartino, MD, PhD, and David M. Dohan Ehrenfest, DDS, MS, PhDSimultaneous Sinus-Lift and Implantation Using Microthreaded Implants and Leukocyte- and Platelet-Rich Fibrin as Sole Grafting Material: A Six-Year ExperienceIMPLANT DENTISTRY / VOLUME 20, NUMBER 1 2011

Simultaan siinus-lifting ja implantatsioon, kasutades mini-implantaate ning PRF membraani mis olid ainsad

autoloogilised transplantaat materialid: kuue-aastane kogemus

Alain Simonpieri, DDS, Joseph Choukroun, MD, Marco Del Corso, DDS, Gilberto Sammartino, MD, PhD, and David M. Dohan Ehrenfest, DDS, MS, PhDSimultaneous Sinus-Lift and Implantation Using Microthreaded Implants and Leukocyte- and Platelet-Rich Fibrin as Sole Grafting Material: A Six-Year ExperienceIMPLANT DENTISTRY / VOLUME 20, NUMBER 1 2011

Simultaan siinus-lifting ja implantatsioon, kasutades mini-implantaate ning PRF membraani mis olid ainsad

autoloogilised transplantaat materialid: kuue-aastane kogemus

Alain Simonpieri, DDS, Joseph Choukroun, MD, Marco Del Corso, DDS, Gilberto Sammartino, MD, PhD, and David M. Dohan Ehrenfest, DDS, MS, PhDSimultaneous Sinus-Lift and Implantation Using Microthreaded Implants and Leukocyte- and Platelet-Rich Fibrin as Sole Grafting Material: A Six-Year ExperienceIMPLANT DENTISTRY / VOLUME 20, NUMBER 1 2011

Platelet-Rich-Fibriini kasutamine hammaste pulbi revitalisatsioonis, avatud

hamba apexi korral

Vasundara Yayathi Shivashankar1, Dexton Antony Johns, S Vidyanath, M Ramesh Kumar “Platelet Rich Fibrin in the revitalization of tooth with necrotic pulp and open apex” Department of Conservative Dentistry and Endodontics, Government Dental College, Calicut, Kerala, India Department of Oral and Maxillofacial Pathology, Government Dental College, Calicut, Kerala, India Year : 2012 | Volume : 15 | Issue : 4

Platelet-Rich-Fibriini kasutamine hammaste pulbi revitalisatsioonis, avatud

hamba apexi korral

Vasundara Yayathi Shivashankar1, Dexton Antony Johns, S Vidyanath, M Ramesh Kumar “Platelet Rich Fibrin in the revitalization of tooth with necrotic pulp and open apex” Department of Conservative Dentistry and Endodontics, Government Dental College, Calicut, Kerala, India Department of Oral and Maxillofacial Pathology, Government Dental College, Calicut, Kerala, India Year : 2012 | Volume : 15 | Issue : 4

Photo: 9,000-Year-Old Drilled Teeth Are Work of Stone Age Dentists

Archaeologists Find A 6,500 Year Old Dental Filling

http://news.nationalgeographic.com/news/bigphotos/1948258.html http://www.forbes.com/sites/alexknapp/2012/09/22/archaeologists-find-a-6500-year-old-dental-filling/

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