Regulating the Cell Regulating the Cell CycleCycle

Controls on cell divisionControls on cell division

Normally developing cells Normally developing cells

Demonstrate anchorage dependenceDemonstrate anchorage dependence

Demonstrate density dependent Demonstrate density dependent

inhibitioninhibition

Are stimulated to grow by growth Are stimulated to grow by growth factorsfactors

Proteins regulationProteins regulation

Proteins called cyclins regulate the Proteins called cyclins regulate the timing of the cell cycle in normal timing of the cell cycle in normal eukaryotic cellseukaryotic cells

Other regulatory proteins includes Other regulatory proteins includes internal & external regulatorsinternal & external regulators

Uncontrolled cell growthUncontrolled cell growth

Cancer, a disease where cells do not have Cancer, a disease where cells do not have a properly functioning cell-cycle control a properly functioning cell-cycle control systemsystem

As a result, tumors form which may be As a result, tumors form which may be malignant or benign.malignant or benign.

Malignant=cancers=cell growths where Malignant=cancers=cell growths where the cells are replicating without any the cells are replicating without any inhibition of cell growth….will cause death inhibition of cell growth….will cause death of the organism if allowed to continue of the organism if allowed to continue growinggrowing

Understanding cancer Understanding cancer cont’d..cont’d..

Benign: excessive cell growth that will Benign: excessive cell growth that will not cause significant harm to the not cause significant harm to the organismorganism

Metastasis-the spread of the cancer Metastasis-the spread of the cancer beyond its original sitebeyond its original site

Common cancers: Where are they?Common cancers: Where are they?

Carcinoma, Osteomas, Leukemias,Carcinoma, Osteomas, Leukemias,

LymphomasLymphomas

Virtual Lab Review:Virtual Lab Review:

What are leading cancers in this What are leading cancers in this country?country?

What are believes causes for them?What are believes causes for them?