Research Institute

For

Endocrine Sciences

Tehran, I.R. Iran

Research Institute for Endocrine Sciences

SBUMS

10Research Centers

Research

Laboratories

Tehran Lipid and

Glucose Study

Endocrine

Clinics

Department Of

Endocrinology

Research Centers of Research Institute for Endocrine Science

1. The Endocrine and Metabolism Research Center2. The Research Center for the Prevention of Metabolic Disorders3. The Research Center for Prevention and Treatment of Obesity4. The Research Center for Reproductive Endocrinology5. The Research Center of Nutrition and Endocrine6. The Research Center of Cellular and Molecular Endocrinenology7. The Research Center of Endocrine Physiology8. The Research Center for Determinants of Health

9. Research Development Center for Endocrinology

10. Medical Laws and Ethics Research Center

WHO Collaborating Center for Research and Training on Endocrine Science (2003)

The Terms of References:

1. To attain, upgrade and expand new knowledge in various aspects of

endocrine sciences.

2. To compile, upgrade and classify latest information related to

endocrinology in particular IDD and DM.

3. To train qualified personnel for education and research in endocrinology.

4. To collaborate with national, regional and international health

organizations and scientific centers in research and training in

endocrinology.

TOR 1

To attain, upgrade and expand new

knowledge in various aspects of endocrine

sciences.

Scientific Achievements of ERC Published Articles (Total): 1128

Published in International English Journals 568

Published in Scientific Farsi Journals 560

Guidelines and country programs 12

Books Published in English 6

Books Published in Farsi 25

Research Proposals (ongoing) 115

Research Proposals (accomplished) 600

International Research collaboration 30

TOR 2

To compile, upgrade and classify latest

information related to endocrinology in

particular IDD and DM.

The RIES SBMU Research laboratories

The RIES Research Lab is divided into three labs:

1) Biochemistry Lab: Routine and specialized bio-

chemistry tests, including bio-chemical analyses and

enzyme activities

2) Endocrinology Lab: Classic endocrines tests

3) Basic Research Lab : Endocrine receptors, cytokines,

metal ions etc.

Research Institute for Endocrine Sciences

Shahid Beheshti University of Medical Seciences

National Endocrine Laboratory

• Acting as:

• Reference laboratory for national programs of IDD &

DM

• Designing and preparation of endocrine diagnostic kits

• Training of endocrine laboratory personnel both

nationally and regionally

Total goiter rate in 4 national surveys in the I.R. Iran

1989 1996 2001 20070

50

100

150

200

250

Med

ian

urin

ary

iodi

ne (µ

g/L

)

Before After iodine supplementation

Median urinary iodine excretion in 4 national surveys in the I.R.Iran

Azizi F. Thyroid International 2009;4:1

Tehran Lipid

and

Glucose Study

TLGS Cohort

1380-1377 1384-1380 1387-1384

Phase 1 Phase 2 Phase 3

15005 57.9 % 71.9 %

15005

9474 63.2 %

1390-1387

Phase 4

71.0 %

Continuous NCD outcomes follow-up

1390 -….

Phase 5

?

Fat and sweet group6.4 ± 3.0

(Not recommended)

Milk and Dairy products1.1 ± 0.8

(2-3 servings)

Vegetable group3.6 ± 2.0

(3-5 servings)

Meat and its alternatives1.2 ± 0.7

(2-3 servings)

Fruits group3.1 ± 3.0

(2-4 servings)

Bread Group

7.8 ± 3.7( 9-11

servings)

Mean servings of intakes of various food groups in TLGS population in comparison with Food Guide Pyramid

Male Female Total0

10

20

30

40

50

60

70

33 32.3 32.6

52.1

41.9

46.4

57.3

38.9

47.1

63.2

51.8

56.7

Frequency of central obesity Waist ≥ 90 dur-ing 12 years of follow up in Tehranian adults:

TLGS

Phase 1Phase 2Phase 3phase 4

(%)

Important in causality Important in public health

Hazard ratio, survival time ratio and population attributable fraction (PAF) for CHD risk factors

Risk factors Hazard Ratio (95% CI)

Time Ratio

(95% CI) Average PAF

(%)

Men

High risk age 3.7 (2.8-5.1) 0.45 (0.37-0.55) 40.1

Family history of cardiovascular diseases

1.4 (1.1-1.9) 0.81 (0.68-0.96) 2.4

Smoking 1.5 (1.2-1.9) 0.78 (0.68-0.89) 9.6

Hypertension 1.7 (1.4-2.2) 0.72 (0.62-0.83) 8.9

Diabetes Mellitus 2.0 (1.6-2.6) 0.66 (0.56-0.77) 6.5

High total cholesterol 1.7 (1.3-2.1) 0.74 (0.64-0.85) 7.3

Low HDL cholesterol 1.2 (1.0-1.5) 0.90 (0.78-1.03) 6.5

Modifiableriskfactors

Changes following

lifestyle modification

18

ResultsThe change in the prevalence of metabolic syndrome componentsOver the time in cases and controls

Cases Controls

0

10

20

30

40

50

60

70

80

90

1st phase 2nd phase

High FBS Low HDL-c Central obesity

High TGs High blood pressure

0

10

20

30

40

50

60

70

80

90

1st phase 2nd phase

Prev

alen

ce (%

)

Harati et al. Am J Prev Med. 2010 Jun;38(6):628-636.e1.

TOR 3

To train qualified personnel for

education and research in

endocrinology

Manpower Training

Subspecialty Training in Endocrinology

Graduate training program offered to 6 specialists in internal medicine for 2 years

PhD in Molecular Medicine

PhD in Research

Continuing Medical Education for:GP's & internists Weakly grand roundsWeakly journal clubsMonthly endocrine conferences

Research Institute for Endocrine Sciences

Shahid Beheshti University of Medical Sciences

Workshops (National and International)

Iodine Deficiency Disorders

Diabetes Mellitus

Obesity

Research methodology

Management of endocrine disorders

Research Institute for Endocrine Sciences

Shahid Beheshti University of Medical Seciences

TOR 4

To collaborate with national, regional

and international health organizations

and scientific centers in research and

training in endocrinology

پژوهشي علمي آمتياز با

Research Institute for Endocrine Sciences (SBUMS)

Main office for scientific and professional societies:

Iran Endocrine Society

Iran Obesity Society

Association of Editors of Iranian Medical

Journals

RIES-SBUMS, has been in close collaboration with WHO EMRO during the last 35 years. The main activities include:

1. Two regional training courses on monitoring and evaluation of IDD elimination program held for 23

representatives from 12 countries of EMR in 2001 and for 39 representatives from 20 countries of EMR, East

Europe and Central Asia in 2002

2. The “Tehran Glucose and Lipid Study” (TLGS) conducted from 1998 to 2001, and initiation of “Interventions for

change of life style’’ in a population sample of Tehran. The findings have been presented at WHO sponsored

meetings in Isfahan 2001 Beirut 2002 and Cairo 2013

3. Participation of the director of the ERC-SBUMS as WHO-EMRO advisor and consultant on multiple occasions to

address IDD, diabetes, NCD and medical education in various countries of the region, EMRO and Geneva

meetings

4. Publication of the book “Assessment, Monitoring and Evaluation of IDD in the Middle East and Eastern

Mediterranean countries” 2002

5. Participation in the Regional Consultation in Diabetes Prevention and Control

6. Participation in NCD control, EMRO

7. Participation in consultations of WHO-Geneva (NCD, childhood obesity, IDD, Nutrition)

8. Training for many countries of the region

Collaboration with WHO

28