RESEARCH PROJECT :Exploring the dynamics of

biosafety research using relational data analysis

Christophe Bonneuil (Centre Koyré d’Histoire des Sciences, Cnrs, Paris) Andrei Mogoutov (Aguidel Consulting)Etienne Klein (INRA, Avignon) Fabien Moll-François (Centre Koyré)

Exploring the history of GM crops biosafety research using relational

data analysis A. Analytical Tools for Strategic

Management of Innovation

B. Analysing the dynamics of biosafety research in the EU and the USA

A. Analytical Tools for Strategic A. Analytical Tools for Strategic Management of InnovationManagement of Innovation

Data collection, data warehousing, analytical design and data analysis

Andrei Mogoutov, AGUIDEL CONSULTING68 Bld Port Royal, 75005, Paris, France

www.aguidel.com

ObjectivesObjectives• Research/Industry Network Dynamics• Scientific productivity, Competitiveness,

Benchmarking, Early warning• Strategic Management of Innovation• National/Sectoral Systems of Innovation• Sociology and Economics of Science• Project management and decision support

Using• Systematic Data Collection• Analytical tools

Design of Analytical SolutionDesign of Analytical Solution

Back Office- data tables- matching tools- tools for textual analysis- tools for data update and control

Front Office

Middle Office

- a layer of analytical queries - pre-defined queries for multilevel data aggregationand synthetic analysis and indicators […]

- graphical/analytical interfaces (GIS, Relational Mappings, Statistical Charts, Financial Charts)- statistical tables, indicators and textual synthesis- integrated querying tools

ON-LINEOFF-LINE

DATA UPDATE FEED-BACK

Back OfficeBack Office

Patents

Actors

Literature

Relations

ProductsProjects

FinancialInfo

ActorLocation

ActorIdentity

ContentsClassification

Schema

MATCHING SYSTEM

Johnson & J ohnson

Glaxo SmithKline plc

Aventis

Wyeth

Merck & Co. Inc.

Roche

Bristol-Myers Squibb Co.

Schering-Plough Corp.

Pfizer

Novartis

Pharmacia

Eli Lilly and Co.

Bayer AG

AstraZeneca

Abbott

NETWORK ORIENTED DATABASE

Front OfficeFront Office

Relational Mapping of EUROLABS Data Base:Relational Mapping of EUROLABS Data Base:

EUROLABS is a database of public non-university research centers of the 15 EUROLABS is a database of public non-university research centers of the 15 European countries. It contained beginning of 2002 some 770 entries with over European countries. It contained beginning of 2002 some 770 entries with over 100 items per institution (including country, staff number, sectors addressed, 100 items per institution (including country, staff number, sectors addressed,

domains of activities and main disciplinary competences).domains of activities and main disciplinary competences).

Relational Mapping of EUROLABS Data Base:Relational Mapping of EUROLABS Data Base:Countries vs. SectorsCountries vs. Sectors

France

Germany

Sector Natural Resources, Energy, Environment

Sector Health

Sector Industry

UK

Sector Government/Public Services

Sector Agriculture

Sector Services, Infrastructure

Spain

Holland

Sector Defence

Italy

Finland

Denmark

Portugal Belgium

Greece

Austria

Sw eden

Ireland

Luxembourg

Sector Industry Sector Natural Resources, Energy, Environment

Sector Agriculture

Sector Health

Sector Government/Public ServicesSector Services, Infrastructure

Sector Defence

CEREQADIT

BNM

INRA

AFNOR

CNES

ANVAR

LNE

CEA

AFD

TECHNACOL

CTCPA

CEMAGREF

ADEME

INRETS

AFSSA

CSTB

BBV

INRIA

CIRAD

IPSN

CTBA

GEVES

ITERG

ANACT

AGROTEC

ITP

OST

CERFISE

ADRIA-NORMANDIE

FRS

ONERA

ASGA

CTP

ITV

CNS

CREID

CRITT 2ABI

SHOM

UNGDA

CTSCCV

IFRI

IRFRH

IGR

IRD ITPF

CEDRE

IFREMER

AFOCEL

CRITT IAA IDFCVG

BNIC

AGPH

BRGM

CERIB

CNG

CETIOM

CETIM

CETIAT

ASTREDHOR

AFSSAPS

INRS

SFC

LRCCP

LCPC

ITL

ITFF

ITEIPMAI

ITCF

ITAVI

IS

Institut Pasteur

INSERM

INRPINERIS

INED

GENETHON

IDF

CTTN/IREN

GEMCEA

CTTB

CTIF

GIP Ultrasons

CTICM

ACTA

CTIFL

ANITTALRPV

ITB

CIRTES

SETRA

AGPM

UNIP

Institut Curie

ANIFELTITAB

CETIH

Institut de l'ElevageFNPC

CTC

C.T.DEC

CETEHOR

CEE

GIP-MI

ANDRA

Relational Mapping of EUROLABS Data Base:Relational Mapping of EUROLABS Data Base:France - Institutes vs. SectorsFrance - Institutes vs. Sectors

Relational Mapping of EUROLABS Data Base:Relational Mapping of EUROLABS Data Base:Single Institution Profile (INED)Single Institution Profile (INED)

INED

Basic Research Function

Certif ication/Standards

Development

Diffusion/Extension

Applied Research Function

public sector contracts

private sector contracts

government grant/core funding

Medical Sciences

Social Sciences

Other Social Sciences

Sector Government/Public Services

Sector Health

Health Sciences

National Authorities Links

BIRABEN

TOULEMON

MESLE

DESESQUELLES

THERE

CHASTELAND

BROUARD

LEFEVRE

VALLIN

LOCOH

ROHRBASSER

BONVALET

PAILHE

KATEB

SIMON

PENNEC

FESTY

GUERIN-PACE

GAYMU

HERTRICH

COURBAGE

ATTANE

LEBUGLE

VERON

BLUM

HERAN

COURGEAU

LELIEVRE

LERIDON

MERON

GRIBAUDI

FARGUES

ARDUIN

VICHNEVSKAIA

HECHT

SOLAZ

PARANT

KHLAT

BEDIDI

BRIAN

CHESNAIS

TAMOUZA

GOUSSEFF

MARPSAT-COMPAIN

GUYAVARCH

GABADINHO

FIRDION

Lantoine

EKERT-JAFFE

CAMBOIS

BARBIERI

ENEL

RIANDEY

MONNIER

PISON

LEVY

FILHON

MUNOZ-PEREZ

MAZUY

LE COEUR-LALLEMANT

NIZARD

CHARLES

BELLIS

Lièvre

THIERRY

PERROT

PRIOUX

ARBONVILLE

COLLOMB

ANDRO

ROUSSEL

DEGUY

CAZES

TRIBALAT

BOZON

RABHI

DE BRAEKELEER

SARDON

LESCLINGAND

SERMET

GROSBRAS

VIVIER

Basse

WALTISPERGER

PAUGAM

AIILET

HEILBORN

MOUGIN

PALOMARES

BOMMIER

MOUVAGHA

PONTONE

CONDON

SEBILLE

TOURNYOL-DU-CLOS

DE MIRAS

HAUDIDIER

DIGOIX

GUIBERT-LANTOINE

ECKHARDT

CLEMENT

SEGUY

KANTOROVA

FRECHON

RALLU

BACCAINI TODD

VILLENEUVE

BONNEUIL

BOURCIER

BRACHET

VALETAS

Relational Mapping of Collaboration Networks: INEDRelational Mapping of Collaboration Networks: INED

Decision Support for Management of International Collaboration Decision Support for Management of International Collaboration Projects – EC INTAS ProgramProjects – EC INTAS Program

Decision Support for Management of International Collaboration Projects Decision Support for Management of International Collaboration Projects – EC INTAS Program Life Sciences– EC INTAS Program Life Sciences

Physical Chemical Biology

RU

Biotechnology

General Biology

UK

Physiology, Fundamental Medical Science

DE

FR

UA

Pharmacology

NL

IT

DK

BE

PT

BYES

CH

UZ

FI

GR

AM

KZ

SE

AT GE

IE

TM

MD

LVLT

Decision Support for Management of International Collaboration Projects Decision Support for Management of International Collaboration Projects – EC INTAS Program – Biotechnology Subfield– EC INTAS Program – Biotechnology Subfield

Universidade de Coimbra,

Engelhardt Institute of Molecular Biology, Institute of Cytology,

St. Petersburg State University,

Moscow State University M.V. Lomonosov,

Institute of Gene Biology,

Biotechnological Company Bioservis

National Research Center GNII Genetica,

National Research Centre of Medical Genetics,Institute of Protein Research,

Institute of Experimental Cardiology,

Centre National de la Recherche Scientifique,

Cancer Research Centre,

Institute of Immunology,

Institute of Rheumatology,

N.I. Vavilov Institute of General Genetics,

Ivanovsky Institute for Virology,

Institute of Molecular Genetics,

Ludwig-Maximilians-Universität München,Centre National de la Recherche

Université des Sciences et Techniques

Imperial Cancer Research Fund,

Rijksuniversiteit Groningen,

Russian Medical Academy,

Institute of Agricultural Biotechnology,

Karolinska Institute,

Medical Research Council,

Århus Universitet,

Wageningen Agricultural University,

Deutsches Krebsforschungszentrum,

Universidad Complutense de Madrid,

University of Sussex,

University of Sheffield,

University of Portsmouth,

King’s College School of Medicine and Dentistry,

Instituto Nacional de Engenharia eJ ohn Innes Centre,

Danish Cancer Society,

Erasmus University Rotterdam,

Universidade Nova de Lisboa,

Le Biopole Végétal,

Forschungszentrum Karlsruhe GmbH,

Hospital for Infectious Diseases,

Aristotelian University of Thessaloniki,

Eberhard-Karls-Universität Tübingen,

European Molecular Biology Laboratory,

Centre for Hygiene and Epidemiology,

Rijksuniversiteit Leiden,

Vrije Universiteit Amsterdam,

University Medical Center Leiden,

Universiteit Gent,

Universitätsklinikum Essen,

Universität Köln,

Universität Bern,

Università di Roma II Tor Vergata, Katholieke Universiteit Leuven,

Universidad Politecnica etsi Agronomos,

Institute of Genetics,

National University Hospital,

National Kiev Taras Shevchenko University,

Max-Delbrück-Centre for Molecular Medicine,

Lund University,

Kongelige Veterinær og Landbohøjskol,

Albert-Ludwigs-Universität Freiburg im Breisgau,

International Centre for Genetic

Early Warning: Strategic Diagrams of Research Community Evolution: Early Warning: Strategic Diagrams of Research Community Evolution: biosafety research biosafety research

MALONE LA - 35

LEFOL E - 35

MICHAUD D - 36

J EFFERSON RA - 36

WILLIAMSON M - 37

RIESEBERG LH - 37

MACINTOSH SC - 37

HILDER VA - 37

CAPRIO MA - 37

LINDER CR - 40

SNOW AA - 41

SCHUBBERT R - 41

ONSTAD DW - 41

MEYER R - 42

SHELTON AM - 43PADGETTE SR - 43

DEBLOCK M - 43

ANDOW DA - 44

ALSTAD DN - 44TAYLOR SL - 45

J OHNSON MT - 45

BARTSCH D - 45

TANG J D - 47

SAXENA D - 47

CHEVRE AM - 48

STEWART CN - 49

PILCHER CD - 49

LIU YB - 49

J ORGENSEN RB - 49

SCHEFFLER J A - 50

NIELSEN KM - 50

MIKKELSEN TR - 54KLINGER T - 54

RAYBOULD AF - 57

SIMS SR - 59

LOSEY J E - 59SCHULER TH - 64

GATEHOUSE AMR - 71

KOZIEL MG - 72CRAWLEY MJ - 76

DALE PJ - 85

DANIELL H - 89

HILBECK A - 92

ROUSH RT - 96

PERLAK FJ - 98MCGAUGHEY WH - 98

ELLSTRAND NC - 114

TABASHNIK BE - 250

GOULD F - 258

0,001

0,01

0,10,0001 0,001 0,01 0,1

1984-1999

2000

-200

3

Analytical Tools for Strategic Analytical Tools for Strategic Management of InnovationManagement of Innovation

Data collection, data warehousing, analytical design and data analysis

Andrei Mogoutov, AGUIDEL68 Boulevard Port Royal, 75005, Paris, France

www.aguidel.com

Financial Analysis (I)Financial Analysis (I)Historical Volatility and Network CentralityHistorical Volatility and Network Centrality

R&D Collaboration and Historical Volatility 2002

MGI Pharma

CurisSepracor

TriposAVANT ImmunotherapeuticsRepligen

GENSET Protein DesignAntigenics Genelabs

Oxford GlycoSciences

NabiMylan LaboratoriesAlliance

Discovery Partners InterNational Targeted Genetics

Exelixis

InvitrogenGilead Sciences

Celgene

SuperGenQuintiles TransNational

Enzon

Sicor

Gene Logic

Scios

EvotecOrchid BioSciencesImClone Systems

Qiagen

NPS PharmaceuticalsMyriad GeneticsSerono

Valentis

ArQule

Xenova Genome Therapeutics

King

SkyePharmaOSI

XomaDyax

ICN Pharmaceuticals

Cephalon

Lexicon Genetics

DegussaTeva

Cardinal Health

Acambis

Allergan

Abgenix

Cytogen

Lion Bioscience

Bio Technology General

Ligand

ISIS Pharmaceuticals

IndevusSequenom

Vertex Pharmaceuticals

Medtronic

Mds

Biovail

Corixa

Biogen

Solvay

MedImmune

AffymetrixMedarex

Akzo Nobel

BASF

PharmacopeiaShire Pharmaceuticals

Novo Nordisk

Sanofi Synthelabo

Amgen

Incyte

Genentech

Celltech Group

Schering PloughSchering

Baxter

Merck KGaA

Amersham

Bayer

Chiron

Applera

ElanMerck & Co

AstraZeneca

Eli Lilly

Wyeth

Pharmacia

Abbott

Bristol Myers Squibb

Novartis

Pf izer

Roche

Johnson & Johnson

Glaxo SmithKline

Aventis

0%

1%

2%

3%

4%

5%

6%

7%

8%

0,0 1,0 2,0 3,0 4,0 5,0 6,0 7,0 8,0 9,0 10,0

Historical Volatility 2002

Cen

tral

ity

Amersham

Bayer

Chiron

Applera

Merck & CoAstraZeneca

Eli Lilly

Wyeth

Pharmacia

Abbott

Bristol Myers Squibb

Novartis

Pf izer

Roche

Johnson & Johnson

Glaxo SmithKline

Aventis

0%

1%

2%

3%

4%

5%

6%

7%

8%

0,0 1,0 2,0 3,0 4,0 5,0 6,0 7,0 8,0 9,0 10,0

Heterogeneous NetworksHeterogeneous NetworksCompanies & TechnologiesCompanies & Technologies

DEVICES SERVICESDIAGNOSTICS

GENOMICS

DRUG DELIVERY

LARGE MOLECULE

SMALL MOLECULE

PROTEOMICS

RECOMBINANT DNA

ANTIBODY

MOLECULAR DIVERSITYSCREENING

GENE THERAPY

SYNTHESIS

VACCINES

GENE EXPRESSION

GENERICS OTC

CELL THERAPY

AVENTIS

GLAXO

BIOINFORMATICS

JOHNSON

ROCHE

APPLERA

PFIZER

AHP

BMS

NOVARTIS

GENE SEQUENCING

GENZYME

AMERSHAM

ABBOTT

INCYTEG

MERCK_CO

PHMACIA

CHIRON

TRANSGENICS

NIH

ELAN

BAYER

ELILILLY

AFFYMET

NUTRACEUTICALS

ASTRAZEN

GENENTEC

SCHER_AG

CELLTECH

SCHERING

MILL_PHA

PERKIN

BAXTER

NANOTECHNOLOGY

PCOP

AMGEN

MEDAREX

RATIONAL DRUG DESIGN

MERCK

BOEHRING

LEXICON

VERTEX

SEQUENOM

APP_BIOS

UN_CAL

E.I. DU

CORIXA

VALENTIS

BD MONSANTO

ARQULE

NATURAL PRODUCTS

DYAX

ABGENIX

NOVO NOR

HU_GE_SC

LION_BIO

ISIS

GENE_LOG

MDS

OXFGLYCO

CYTOGEN

MEDIMMUN

UNIV_TEX

ORCHID

INDEVUSTREGA

BASF

GENOME

HARV_UNI

TGEN

EXELIXIS

J H_UNIV

AKZO

CARBOHYDRATE

CELL_PAT

BIOGEN

SUSM

MYRIAD

DPI

HMS

EVOTEC

TYCO_INT

SANOF_S

CAMBTECH

SANGAMO

BIOVAIL

QIAGEN

GENSET

BECKMAN

MIT

INVITROG

CHUGAI_B

OSI

MITSUB

IMMUNEX

TRIPOS

LIGAND

IMCLONE

ACAMBIS

P & G

CANC_RC

NEXSTAR

OXFBIOM

AURORA

XOMA

XENOVA

ENZON

AVANT

LYNX_USA

WATSON

E-HEALTH

MEDTRONI

MORPHOSY

THIRD_WA

GILEAD

SCIOS

DOUBLETW

HYSEQ

CURAGEN

SHIRE

SEPRACOR

CRUCELL

AMERNYCO

SKYEPH

MSKC_CEN

ANTIGENI

VICAL

THERMO_E

GENELABS

IVAX

DELTAGEN

GPC_BIOT

TULARIK

DOW_CHEM

GENVEC

PDL

NEORX

STEMCELL

CORNING

EPIMMUNE

HITACHI

BIO_TG

BAY_C_M

ALEXION

YAMANOUC

DUHS

IDEC

CUBIST

NEXELL

CEPHALON

FUJ ISAWA

TAKARALUDWIG_I

LIFE_TEC

GERON

NEOPROBE

PPD

ALLIANCE

SERONO

PROTSYS

TEVA

VARIAGEN

SOLVAY

CHRYSALI

DAIICHIP

DECODE

REPLIGEN

QUIDEL

SCHWARZ

TAKEDA

BIOSITE

YALE_U

UCSF

CELGENE

IMMUNOME

BIOMIRA

ROBERTS

ALLERGAN

PROGENIC

NPS

KIRIN

IMMUNOGE

ONCOR

AMRAD

DIVERSA

SCRIPPS

ICOS

ALKERMES

PITTSB_U

CURIS

POWDERJ

MYLAN

ID_BIOME

NANOGENBTG_PHAR

MEDIGENE

NEUR_BIO

UCSD

J TOBACCOKING

SANKYO

PEREGRIN

SUMITOM

MAXIGEN

IMMUNE

SOMATIX

SICOR

ONCORMED

BIOMERIE

HYBRIDON

UCLA

RIBOZYME

AD_POLY

NABI

AMYLIN

SUPERGEN

ICN_PHAR

IGEN

TAISHOPH

NYU

ACACIA

MGH

BIOCHEMP

U_WASH

SEQUUS

CAM_BIO

CELL_GEN

CYTRX

INHALE

RECORDAT

WASH_U

ANADYS

KYOWA

INSITE

BIO_RAD

3M

DEGUSSA

AASTROM

MAR_UN

GENTA

PROTHER

MCGILL_U

ALBANYMR

BBIOTECH

SYNCOR

AVANIR

ANTARES THERATEC

DSM_GIST

EISAI

CARDINAL

AMARINPHARMASC

PENEDERM

ALTANA

BIOGLAN

BOSTON_S

CENES

UNIV_COL

COLUMBIA

MAYO_FOU

MARTEK

COLLAGEN

LIPOSOME

IBM

MAX_PLAN

DUPONT_M

CORTECS

ADVMAG

DAINIPP

CYGNUS

MILLENN

ABSC

GENENCOR

ATRIX

UNIV_TR

BERLEX

UCB_GROU

BAUSCH

ENTREMED

OXFORD_U

CONNETIC

MGI

FISHER_S

MAYNE

ILEX

TRIANGLE

DRAXIS

VIRAGEN

TEIJ IN

MERI_BIO

ACCESS

DADEBEGEN_EL

FOREST

TANABESE

MEDICIS

Pasteur

PHOTOTHERAPY

FRESENIU

ONO_PHAR

STERL_DR

PH_RES

QUESTCOR

AJ INOMO

MUNDIPHA

MICHIG_U

MEIJ I

DYNAGEN

SYNBIOTI

SENETEK

QUINTILE

MASS_GEN

PIERRE

NRC_CAN

NESTLE

COLLAGEX

CHIESI

AMERISB

XENOGEN

HESKA

CHEMTRAK

PHARMASBARR_LAB

OTSUKA

BENTLEY

PROVALIS

BTG

ASAHI

NYCOMED

SUNY

MERCKLE

GUILFORD

BEAUFOUR

ELF_AQUI

INTEG_LS

AD_TS

US_BIOSC

LUNDBECK

HSC

EPITOPE

WELLCOME

COCENSYS

SYNSORBALPHARMA

MEDCO_R

ORION

SMITH

KISSEI

AXCAN

AMARILLO

UNITED_T

SHIONOGI

SPECTRAL

CORNELLU

SUNTORY

AMBI

BCU

MYCOGEN

GELTEX

NCI

FERRER

BOOTS CO

PAREXELGENOMICS

PROTEOMICS

GENE EXPRESSION

BIOINFORMATICS

INCYTEG

MERCK_CO

AFFYMET

NANOTECHNOLOGY

LEXICON

SEQUENOM

APP_BIOS

HU_GE_SC

GENE_LOG

OXFGLYCO

ORCHIDGENOME

EXELIXIS

MYRIAD

GENSET

INVITROG

LYNX_USA

THIRD_WA

HYSEQ

CURAGEN

GPC_BIOTCORNINGHITACHI

VARIAGEN

DECODE

NANOGEN

WASH_U

MCGILL_U

IBM

MAX_PLAN

MILLENNUNIV_TR

SUNY

Actor/NetworksActor/NetworksAventis

Glaxo SmithKline plc

Johnson & Johnson

Roche

Pfizer

Novartis

Bristol-Myers Squibb Co.

Abbott

Pharmacia

Wyeth

National Institutes of Health

Eli Lilly and Co.

Genzyme Corp.

AstraZenecaMerck & Co. Inc.

Elan Corporation plc.

Applera Corporation

Chiron Corp.

Bayer AG

Amersham Pharmacia Biotech

Monsanto

Merck KGaABaxter International inc.

Schering AG Schering-Plough Corp.

Celltech Group plc

Genentech Inc.

Incyte Genomics

Boehringer Ingelheim EI DuPont de Nemours & Co. Inc.

Perkin Elmer

Amgen

Sanofi-SynthelaboBecton Dickinson and Co.

Novo NordiskShire Pharmaceuticals Group plc

Pharmacopeia Inc.

BASF

IVAX Corporation

Mitsubishi Group

Millennium Pharmaceuticals Inc.

University of California

Akzo Nobel NV

Medarex Inc.

Tyco International Ltd.

Affymetrix Inc.

Procter & Gamble Co.

Harvard University

MedImmune Inc.

Massachusetts Institute of Technology

Solvay Pharmaceuticals incChugai Biopharmaceuticals Inc.

Biogen Inc.

Mds Inc.

Johns Hopkins University

Biovail Corporation

Corixa Corp.

Stanford University School of MedicineMedtronic Inc.

Vertex Pharmaceuticals Incorporated

Watson Pharmaceuticals Inc

Harvard Medical School

Sequenom Inc.

University of Texas Interneuron

Fujisaw a Healthcare INCLigand Pharmaceuticals

ISIS Pharmaceuticals Inc.

Bio-Technology General Corp.

Lion Bioscience AG

Cytogen Corp.Schw arz Pharma AG

QUIDEL Corp.

Allergan INC.

Abgenix Inc.

Cardinal Health Inc.

Acambis plc

Teva Pharmaceutical Industries Ltd

Yamanouchi Pharmaceutical Co. Ltd.Lexicon Genetics Incorporated

Degussa AG

Cell Pathw ays Inc.

Corning Inc

Applied Biosystems Group

SankyoCephalon Inc.Takeda Chemical Industries Ltd

ICN Pharmaceuticals Inc.

Duke University Health SystemDyax Corporation

Xoma ltd.

SkyePharmaOSI Pharmaceuticals Inc.

Nycomed Amersham plc.King Pharmaceuticals Inc

Xenova Group plc

ArQule Inc.

Genome Therapeutics Corp.

Aurora Biosciences Corp.

Valentis Inc.

0%

1%

2%

3%

4%

5%

6%

7%

8%

0% 2% 4% 6% 8% 10% Density

Cen

tral

ity Pharma Group ICentral, Star-like hierarchical networks

Pharma Group IILess central, Less hierarchical

Platform Tech. CompaniesClique-like, complex networks

Content AnalysisContent AnalysisDiversification PatternsDiversification Patterns

J 6F

N2B M1A

R5D

N6A

N5B

C3A

C7A

R5C

N5A

N5C

A6A

C4A

G3A

C8A

R6A

M2A

N2A

A2B

A2A

R1B

R1A

S1G

N4A

A11A

D7A

R2A

A10B

N3A

H2A

J 1D

R5A

S1E

C1E

D2A

S1A

G4B

D1A

A12A

C1B

C2A

M3B

D3A

S1L

J 1C

C9A

B3A

D10

C10A

C5C

N2C

D6A

J 1F

C7B

D11

D8A

J1A

D7B

C1C

J7A

A5A

S1K

R3AL2B

J1H

G3C

A4A

A1A

A9A

S1X

R3B

N1B J 5B

A3F

S1C

A12C

J7B

C5B

M4A

A11H

A3A

A7E

C9B

A11B

J2A

A13A

C5A

J 1G

A11E

A7H

L1X

A11C

G3D

L4AG3F

L1B

R5F

N1A

D4A

S1F

L1D

C1D

A12B

J1K

L1C

D6D

M5X

D5A

J 1E

R3D

H3A

A11G

J4A

B1B

L2A

A5B

S1B

B3X

C1A

J5C

G1B

C6A

A8A

A10C

G3GG3B

L1A

A11D

N7X

M5B

M1C

G2X

A7F

S1S

P1D

J 1X

R3G

R4A

S2D

H4A

S2C

B2D

C9C

G3H

M3A

C1X

A11F

R5B

S1N

A2C

C10B

G2D

G2A

S1R

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J 7C

H4C

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H4D

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J8B

A14A

S1H

C2B

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B1D

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J4B

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