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www.hyalofemme.co.uk PURPLE ORCHID PHARMA LTD PO Box 462, Ruislip HA4 4HS [email protected] www.purpleorchidpharma.com 0844 415 2420 KC/012017/A4R1 Restore moisture Regain normality Revive intimacy AVAILABLE ON PRESCRIPTION AND OVER THE COUNTER Purple Orchid is called the women’s self-care company rather than health-care company because we are committed to the idea of looking after ourselves better in order to enjoy good health for longer in life. We focus on two ways of achieving that. Sharing information is at the core of our reason for being. Self-care is about being proactive, making decisions about what’s best for us not just during medical treatment but before we even need it, possibly to avoid it. Because each of us knows our own body well. Purple Orchid specialises in the area of women’s health which is above the knee, below the waist and at the front – that’s the bit people least want to discuss. It’s time to get over that. We created a national awareness day - EveryWoman Day – to acknowledge the extraordinary things that ordinary women manage every day to keep life ticking over despite debilitating conditions. And to raise awareness in order to be able to look after ourselves better. The cause of vaginal dryness is well understood but not well discussed. We go to conferences where speakers appeal to healthcare professionals to ask patients about their sex lives because patients rarely open the conversation. Vaginal dryness is a relatively simple condition with Hyalofemme as a simple solution, yet millions of women suffer in silence because they don’t understand what’s going on “down there” or they think it’s something they have to put up with, maybe just part of getting older. And by choosing this path, their health can deteriorate, and relationships can suffer as pain or discomfort lead to loss of intimacy. The heartache of divorce is too high a price for a problem that can be solved by a moisturiser. So we need to talk – mothers and daughters, doctors and patients, aunties and nieces can all learn from each other. Gynaecological cancers are discussed less than breast cancer because we don’t want to mention “women’s troubles” – a tag which is still guaranteed to shut down questions and conversation. But women’s troubles can be painful, life limiting or life threatening. Conditions such as interstitial cystitis, fibroids, endometriosis and infertility are still not well understood. Women can be stuck with these problems for life. Sharing information can reduce feelings of isolation and quality of life can be improved by talking about what works, what makes things worse and how to cope with the debilitating effects. Just getting through each day of challenges, pain, exhaustion, depression and other difficulties can be a major achievement. Our second area of focus is to find and supply products that support self-care. Our range can be found at our website. Managing DIrector, Purple Orchid Hyalofemme: Feels good. HORMONE FREE, LONG LASTING VAGINAL MOISTURISER THAT’S PROVEN TO BE AS EFFECTIVE AS OESTROGEN CREAM

Restore moisture Regain normality Revive intimacy · Restore moisture Regain normality Revive intimacy ... their shape and elasticity to a pre- ... uronic acid vaginal gel on the

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www.hyalofemme.co.ukPURPLE ORCHID PHARMA LTDPO Box 462, Ruislip HA4 4HS

[email protected]

0844 415 2420KC/012017/A4R1

Restore moistureRegain normalityRevive intimacyAVAILABLE ON PRESCRIPTION

AND OVER THE COUNTER

Purple Orchid is called the women’s self-care company rather than health-care company because we are committed to the idea of looking after ourselves better in order to enjoy good health for longer in life.

We focus on two ways of achieving that. Sharing information is at the core of our reason for being. Self-care is about being proactive, making decisions about what’s best for us not just during medical treatment but before we even need it, possibly to avoid it. Because each of us knows our own body well.

Purple Orchid specialises in the area of women’s health which is above the knee, below the waist and at the front – that’s the bit people least want to discuss. It’s time to get over that. We created a national awareness day - EveryWoman Day – to acknowledge the extraordinary things that ordinary women manage every day to keep life ticking over despite debilitating conditions. And to raise awareness in order to be able to look after ourselves better.

The cause of vaginal dryness is well understood but not well discussed. We go to conferences where speakers appeal to healthcare professionals to ask patients about their sex lives because patients rarely open the conversation.

Vaginal dryness is a relatively simple condition with Hyalofemme as a simple solution, yet millions of women suffer in silence because they don’t understand what’s going on “down there” or they

think it’s something they have to put up with, maybe just part of getting older. And by choosing this path, their health can deteriorate, and relationships can suffer as pain or discomfort lead to loss of intimacy. The heartache of divorce is too high a price for a problem that can be solved by a moisturiser.

So we need to talk – mothers and daughters, doctors and patients, aunties and nieces can all learn from each other. Gynaecological cancers are discussed less than breast cancer because we don’t want to mention “women’s troubles” – a tag which is still guaranteed to shut down questions and conversation. But women’s troubles can be painful,

life limiting or life threatening. Conditions such as interstitial cystitis, fibroids, endometriosis and infertility are still not well understood.

Women can be stuck with these problems for life. Sharing information can reduce feelings of isolation and quality of life can be improved by talking about what works, what makes things worse and how to cope with the debilitating effects. Just getting through each day of challenges, pain, exhaustion, depression and other difficulties can

be a major achievement.Our second area of focus is to find and supply

products that support self-care. Our range can be found at our website.

Managing DIrector, Purple Orchid

Hyalofemme: Feels good.HORMONE FREE, LONG LASTING VAGINAL MOISTURISER THAT’S PROVEN TO BE AS EFFECTIVE AS OESTROGEN CREAM

Statistics about vaginal dryness are disturbing...millions of women suffer in silence because they don’t want to ask for help, are embarrassed, or perhaps don’t know that they don’t have to just shut up and put up with it. But there is a simple solution – and it’s different to any other product.

Whether the dryness is brought about by natural or medical menopause, childbirth or any other hormonal disturbance, Hyalofemme can make it better. It is hormone free but has been proven to be as effective as oestrogen cream in relieving symptoms such as itching, burning, soreness or pain during sex4. And 88% of women said in a survey that Hyalofemme improved their symptoms3. Hyalofemme doesn’t just put moisture into the vagina like other products, it puts it right into

the cells. It is uniquely formulated with patented Hydeal-D, a Low Molecular Weight version of hyaluronic acid. Its LMW allows it to cross the cell membrane then attract and bind water. This plumps up the cells, restoring their shape and elasticity to a pre-menopausal condition. It also helps to repair microlesions caused by friction, and improve the body’s innate ability to fend off infections caused by changing pH and microflora.

In a survey5, 88% of perimenopausal and menopausal women had experienced vaginal dryness, 18% admitted to it affecting self-image, 33% affecting confidence, 56% felt relationships had been affected, and 34%

felt that it affected general wellbeing.

That’s a lot of concerns that

could be solved.

1 Non-hormonal but as effective as oestrogen creamMany women can’t or don’t want to use treatments with hormones - after cancer, for instance. Hyalofemme has been proven to be as effective as 0.1% oestrogen cream in relieving symptoms of vaginal dryness such as itching, burning, pain and odour4. Applied once every three days, women can often return to a spontaneous sex life without the need for lubricants.

Well tolerated and paraben freeHyalofemme is made with an optimised version of hyaluronic acid. HA is found naturally around the body – in the skin, around the joints and in the vagina. That’s why women say Hyalofemme feels like natural moisture in the vagina, and why side effects such as discharge are extremely rare. Since some people have concerns about paraben preservatives and prefer to avoid them, Hyalofemme gel is paraben free.

Fast acting, long lasting – may reverse atrophy by entering cellsThe hyaluronic acid in Hyalofemme is optimised into a patented Low Molecular Weight version called Hydeal-D. It has superior muco-adhesive properties, helping its effects to last longer. In one study, the amount of Hydeal-D still adhering to the mucosa after the last cycle of washing (saline solution) was 30% more than unmodified hyaluronic acid6.Unlike standard HA which is a salt which just sits in the vaginal cavity. Hydeal-D molecules are esters, small enough to cross the cell membrane. Once there, Hydeal-D hydrolisis to release the initial HA and hydrolyses into HA to attract water – 1g of HA can bind 3 litres of water. This plumps up the cells themselves and restores their turgor. Data suggests that Hyalofemme may actually be effective in the reversal of vaginal atrophy7.

Helps heal microlesions and prevent infection/inflammationHyalofemme induces vaginal epithelial cells to release antimicrobial peptides via activation of Toll-like Receptors (TLR2 and 4), helping the repair of micro lesions caused by friction and helping prevent infection7. Hyaluronic acid binding to the cells yields several effects, including proliferation, motility and angiogenesis7. Menopause brings an increased risk of infections because vaginal flora and pH are disrupted by loss of oestrogen. As well as Hyalofemme being beneficial for improving the postmenopausal microecosystem8, it acts as a free radical scavenger, protecting against cell damage.

Cost effectiveA 30g tube of Hyalofemme is enough for one month if used once every three days as recommended. This makes it an extremely competitive and cost-effective hormone free option for the relief of the symptoms of vaginal dryness.

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1. The REVIVE (REal Women’s VIews of Treatment Options for Menopausal Vaginal ChangEs) survey in Europe. Nappi et al, Maturitas, Sep 2016; 2. Bachmann GA, Nevadunsky NS Diagnosis and treatment of atrophic vaginitis. Am Fam Physician 2000; 3. HyaloGYN Marketing and Efficacy, 2011, data on file at Fidia Pharma USA inc.; 4. Evaluation of the efficacy and safety of hyaluronic acid vaginal gel to ease vaginal dryness: a multicenter, randomized, controlled, open-l bel, parallel-group, clinical trial. Chen, J, et al, J Sex Med, Jun 2013; 5. www.menopausematters.co.uk; 6. Campoccia et al. Biomaterials. Vol 19, 2101-2127; 1998; 7. 6. The effects of hyal-uronic acid vaginal gel on the vaginal epithelium of ovariectomized rats, Shuai-Bin Liu et al. 2014; 8. Dusio et al, Immunology and cell Biology (2011) 89, 630-639

53% 88%

20% 96%

of menopausal women have vaginal drynesss1

of women who were using Hyalofemme said it improved their symptoms3

of sufferers ask for help2

would recommend it to a friend3