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Reticular fibers. Overview. Cytotoxic T cells. B Cells. Antigen Presenting Cells. Helper T cells. Activate. Help Activate. Help Activate. Cell mediateted immunity. antibody mediateted immunity. - PowerPoint PPT Presentation
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Reticular fibers
Fig. 14.1
Activate
Helper
T cells
B CellsCytotoxic
T cells
Help Activate
Help Activate
Cell mediatete
d immunity
antibody mediatete
d immunity
Figure 2. Activation of naive T-cells requires two independent signals. The binding of the peptide:MHC complex by the T-cell receptor and, in this example, the CD4 co-receptor transmits a signal (signal 1 indicated by arrow 1) to the T-cell that antigen has been recognized. Activation of naive T-cells requires a second signal (signal 2 indicated by arrow), the co-stimulatory signal, which is delivered by the same antigen-presenting cell (APC). From Janeway CA, Jr., and Travers P. Immunobiology. 2nd edition, 1996, pp. 7:8, with permission from the publisher, Current Biology, Ltd, London.
Cellular interactions involved in induction of immune responses. Activation and proliferation of TH cells. (a) is required for generation of humoral response (b) and cell-mediated response to altered self-cells (c). APC = antigen-presenting cell; Ag =
antigen.
http://highered.mcgraw-hill.com/sites/0072507470/student_view0/chapter22/animation__t-cell_dependent_antigens__quiz_2_.html
http://highered.mcgraw-hill.com/sites/0072507470/student_view0/chapter22/animation__cytotoxic_t-cell_activity_against_target_cells__quiz_2_.html
Helpful animations
Helper T cells 1 & Helper T cells 2
T independent imm unity T dependent imm unit yH elper T cells no t invo lved
A ntigens are usually lip ids o r carbohydrates
No m em ory cells m ade
D evelops after age 2
H elper T cells invo lved
A ntigens are usually pro teins
Mem ory cells m ade
C an occur at b irth