nuclide T1/2 Decay (%) E (kev) oxidatietoestand coordination chelator production purification labeling chem conditions

99m-Tc 6.02h IT 141 7 4,5,6,8,9 99MoO42- absorded to alunina colum

99m tc is formed decay 99Mo99mTCo4

- eluted with saline

3 manieren:* direct labeling -schwartz methode -iminothiolane methode* BFC labeling - S-MAG3 (RT nodig) - S-HYNIC (coligand nodig)* integrated methode(P829-->incubate peptide with TcO4- glucoheptone0.9% NaCL, 20min RT)

3 componenten:1) pertechnetate ( TcO4

-)2) reducing agent (Sn(||), Fe(||), Cu(|), NaS2O3)3) ligand

67Ga 78.3h EC (100)-->67ZN 93, 185, 296 3 (aq) 3,4,5,6 Dota cyclotron production--> 68Zn( p,2n) 67Ga *111In 67.9h EC (100) 245, 172 3 (aq) 3,4,5,6,7,8 cyclotron production--> 111Cd( p,n) 111In

67Cu 62h β- 1 of2(aq) Dota/Tetacu(2)Nitrogen& sulfur ligandencu(1)thioether, phosphine, isonitrile

64Cu 12.8h β-(39.6) 573 1 of2(aq) Dota/Teta

123I 13.2h EC (100) - - - Nucleofiele subsitutie Electrofiele subsitutie

N: Cu+ reductor (CuSO4), leaving group is Br/Ioplosmidd(alcohol)E: oxidant (chloramine,( leavinggroup: SnMe3/Bu3, Ti(OCOCf, HgCl, SiMe3)--> Ch3COOH & H2O2

- - -64Cu 12.8h β+(19) EC(41) 1 of 2 (aq) Dota/Teta62Cu 9.79min β+(97) EC(2) 1 of 2 (aq) Dota/Teta61Cu 3.32h β+(60) 1 of 2 (aq) Dota/Teta60Cu 23.4min β+ 1 of 2 (aq) Dota/Teta

89Zr 78.4h β+ Desferal cyclytron prod-->89 Y (p,n) 89Zrdissolve in 6M HCl,affinity chromatography

68Ga 68 min Β+ (89) → 68Zn 3 (aq) 3,4,5,6 Dota Generator production-->68Ge/68Ga

18F 110min β+ -1 - - 18O(p,n)18F in h2o(aq)/O2(g)--(Nu-)h.SA20Ne(d,α)18F ---(E+) low SA

Nu: *aliphatic nucleophilicsubstitution, (substitution nucleophilic bimolecular (SN2) *aromatic nucleophilic substitutionElectrofiel:*[18F]CH3COOF (acetylhypofl uorite)

Nu-reaction(alkali metal halides) *KryptofixNu-reaction(nBu4N18F), 80°*dipolar aprotic solvent (ACN,DMSO, DMF)Electrofiel-reactionkamertemp, chloroform

11C 20.4min β+

14N(p, α)11C -->Nitrogen gas is irradiated with highenergy protons (16-18 MeV)[11C]CO2 is obtained by irradiating N2/O2 gas mixture with protons.[11C]CH4 by irradiating N2/H2 gas mixture.

reacties met Co2, enkatalyst (PD)met THfreacties met CH3I met DMSO, DMF

15O 2 min β+124I

13N 10min

In-target chemistry: 16O(p,α)13N in natural wateradd ethanol: [13N]NH3 is obtained

177Lu 6,7d β- --> 177Hf 3 7,8 ,9,10 dota/(dtpa)

fission-->produced by neutron bombardment of enriched 176Lu in a reactor

90Y 2.7 d β- ---> 90Zr 3 7,8 ,9,10 dota/(dtpa) generator production-->90Sr/90Y

opmerking; 90Y decays without any concomitant y-rays, and thus imaging must be done with another nuclide

nuclear reaction, generator or spallation

3 approaches to couple chelate to biomolecule:a) Via carbon backbone of chelateb) Via one of the chelating arms, with integrity of acidc) Via one of the acid groups (amide bond formed)

metaalTherapie

nonmetaal

SPECT

metaal

Pet

metaal

nonmetaal