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Table S3 % of patients with vasopressors 1 day after randomization HFO group: 78% Control group: 58%
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 ≥4Number of extrapulmonary organ failures
Mor
talit
y, %
p<0.00001
N=2
N=14
N=26
N=27
N=40
95%CI 1.7-15.7
95%CI 12.9-28.3
95%CI 32.0-52.3
95%CI 45.5-68.7
95%CI 87.4-98.6
• Diminution du shunt pulmonaire: Sous-estimation de l’atteinte pulmonaire
• Effet basse PvO2: Surestimation de l’atteinte pulmonaire
• Foramen ovale perméable: Surestimation de
l’atteinte pulmonaire
INTERPRETATION ERRONEE DES GAZ DU SANG
Intensive Care Med 2003
• 401 ARDS
– 53% had associated circulatory failure
– 26% in a context of severe sepsis or septic shock
Day 1 420 x 25
Pplat 29 cmH2O NE 1.5 mg/heure
Day 3 350 x 28
Pplat 25 cmH2O NE 0.25 mg/heure
Intensive Care Med 2013
D1, 7 p.m PaCO2: 88 mmHg
BD 12 mmol/l
D2, 7 a.m PaCO2: 55 mmHg
BD 2.3 mmol/l
Control hypercapnia (Avoid intrinsic PEEP)
• H, 41 y • Obese, BMI 59.2 kg/m2 (P 169 kg) • Sleeve/gastrectomy • ARF related to aspiration • Temperature 39°C, NE 1 mg/hour