SIBUR-NEFTEKHIM JSC SAFETY DATA SHEET METHYL …Keep people away. Isolate fire and deny unnecessary entry. Stay upwind. Keep out of low areas where gases (fumes) can accumulate. Water

VERSION: 1.2

DATE CREATED: 16/11/2018

Page 1 of 120

SIBUR-NEFTEKHIM JSC

SAFETY DATA SHEET According to Regulations (EC) 1907/2006 (REACH), (EC) 1272/2008 (CLP) & (EU) 2015/830

METHYL ACRYLATE

VERSION: 1.2


SECTION 1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND

COMPANY/UNDERTAKING

1.1 Product identifier

NAME OF SUBSTANCE: Methyl acrylate

SYNONYMS: methyl propenoate; methyl prop-2-enoate; 2-propenoic acid, methyl

ester; acrylic acid methyl ester

TRADE NAMES: Methyl acrylate; acrylic acid methyl ester

CAS #: 96-33-3

EC #: 202-500-6

Index No (CLP): 607-034-00-0

REGISTRATION #: 01-2119459302-44-0011

1.2 Relevant identified uses of the substance Most common technical function of substance:

- Intermediates

- Laboratory chemicals

For the detailed identified uses of the product see Annex 1.

The use of the substance should be limited to those specified in Annex 1.

1.3 Details of the safety data sheet supplier

SUPPLIER:

Company name: SIBUR-NEFTEKHIM JSC

Address: Building 390, Eastern Industrial Zone, Dzerzhinsk,

Nizhniy Novgorod region, 606000, Russian Federation

Contact phone: +7 8313 27-59-09

Fax: +7 8313 27-59-99

Email Address: [email protected]

Emergency Telephone: +7 8313 27-52-98 (office hours only, GMT+3)

Emergency phone in

the country of delivery:

112 (Please note that emergency numbers may vary depending upon the

country of delivery though 112 remains valid as universal number)

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Page 2 of 120

ONLY REPRESENTATIVE:

Company name: Gazprom Marketing and Trading France

Address: 68 avenue des Champs-Elysées, Paris, 75008, France

Contact phone: +33 1 42 99 73 50

Fax: +33 1 42 99 73 99

Email address: [email protected]

SECTION 2. HAZARDS IDENTIFICATION

2.1 Classification and labelling according to EC/1272/2008 Annex VI (CLP (GHS)):

Physical/Chemical Hazards:

Flam. Liquid 2 (Hazard statement: H225: Highly flammable liquid and vapour.)

Health Hazards:

Acute Tox. 4 (Hazard statement: H302: Harmful if swallowed)

Acute Tox. 4 (Hazard statement: H312: Harmful in contact with skin)

Acute Tox. 3 (Hazard statement: H331: Toxic if inhaled)

Skin Irrit. 2 (Hazard statement: H315: Causes skin irritation)

Eye Irrit. 2 (Hazard statement: H319: Causes serious eye irritation)

Skin Sens. 1 (Hazard statement: H317: May cause an allergic skin reaction)

Specific target organ toxicity - single: STOT Single Exp. 3 (Hazard statement: H335: May cause

respiratory irritation). Route of exposure: Inhalation.

Environmental hazards:

Aquatic Chronic 3. (H412: Harmful to aquatic life with long lasting effects.)

2.1.1 CLP LABELLING:

Signal word: Danger

Hazard pictogram:

GHS02: flame GHS06: skull and crossbones

2.1.2 Precautionary statements:

P210 Keep away from heat/sparks/open flames/hot surfaces. – No smoking.

P271 Use only outdoors or in a well-ventilated area.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P280: Wear protective gloves/protective clothing/eye protection/face protection.

P264 Wash hands thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P241 Use explosion-proof electrical/ventilating/lighting/equipment.

P233 Keep container tightly closed.

P273 Avoid release to the environment.

Precautionary Statements (Response):

P301+P310: IF SWALLOWED: Immediately call a POISON CENTER

P302+P352 IF ON SKIN: Wash with plenty of soap and water

P332+ P313 If skin irritation occurs: Get medical advice/ attention.

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P303 + P361 + P353 If on skin (or hair): Remove/Take off immediately all contaminated clothing.

Rinse skin with water/shower.

P304+P340 IF INHALED: Remove to fresh air and keep at rest in a position comfortable for

breathing.

P337 + P313 If eye irritation persists: Get medical advice/attention.

P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing.

P370 + P378 In case of fire: Use water spray, dry powder, foam or carbon dioxide for extinction.

Precautionary Statements (Disposal):

P501 Dispose of contents/container to hazardous or special waste collection point.

Precautionary Statements (Storage):

P405 Store locked up.

P410+P403: Protect from sunlight. Store in a well-ventilated place.

P235 +P410 Keep cool. Protect from sunlight.

P403+P233: Store in a well-ventilated place. Keep container tightly closed.

2.2 Other hazards:

Assessment PBT / vPvB:

According to Annex XIII of Regulation (EC) No.1907/2006 concerning the Registration,

Evaluation, Authorisation and Restriction of Chemicals (REACH):

- not fulfilling PBT (persistent/bioaccumulative/toxic) criteria;

- not fulfilling vPvB (very persistent/very bioaccummulative) criteria.

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS

Name/EC No EC No CAS No Content

(w/w) %

Classification Regulation (EC) No

1272/2008 (CLP)

Methyl acrylate

Index No(CLP):

607-034-00-0

202-500-6 96-33-3 99.7 – 99.95

H225; H302; H312; H315; H317;

H319; H331; H335

The product does not contain impurities or additives that could affect product labelling and

classification according to Regulation (EC) No 67/548/ЕЕС and Regulation (EC) No

1272/2008 (CLP) in the concentration ranges specified (none classification):

Impurities

acrylic acid

Index No(CLP):

607-061-00-8

201-177-9 79-10-7 ≤0.005 none

methyl

propionate

Index No(CLP):

607-027-00-2

209-060-4 554-12-1 ≤0.05 none

Methanol

Index No(CLP):

603-001-00-X

200-659-6 67-56-1 ≤0.05 none

methyl acetate

Index No(CLP):

607-021-00-X

201-185-2 79-20-9 ≤0.04 none

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Name/EC No EC No CAS No Content

(w/w) %

Classification Regulation (EC) No

1272/2008 (CLP)

ethyl acrylate

Index No(CLP):

607-032-00-X

205-438-8 140-88-5 ≤0.03 none

n-butyl acetate

Index No(CLP):

607-025-00-1

204-658-1 123-86-4 ≤0.01 none

isobutyl acrylate

Index No(CLP):

607-115-00-0

203-417-8 106-63-8 ≤0.005 none

butan-2-ol

Index No(CLP):

603-127-00-5

201-158-5 78-92-2 ≤0.005 none

butan-1-ol

Index No(CLP):

603-004-00-6

200-751-6 71-36-3 ≤0.001 none

Additives (this stabilizer inhibit the polymerization of butyl acrylate)

Mequinol

Index No(CLP):

604-044-00-7)

205-769-8 150-76-5 10-20 ppm none

Specific Conc. Limits (СLP): none.

M-factor: none.

SECTION 4. FIRST-AID MEASURES

4.1 Description of first aid measures

If inhaled:

Take the victim outside. If he/she is not breathing, give artificial respiration; if mouth to mouth use

rescuer protection (pocket mask, etc). If breathing is difficult, oxygen should be administered by

qualified personnel. Call a physician or transport to a medical facility.

Skin contact:

Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated

clothing. Seek medical attention if symptoms occur or irritation persists. Wash clothing before

reuse. Discard items which cannot be decontaminated, including leather articles such as shoes, belts

and watchbands. Safety shower should be located in immediate work area.

Contact with eyes:

Immediately flush eyes with water; remove contact lenses, if symptoms are present after the first 5

minutes, then continue flushing eyes for at least 15 minutes. Obtain medical attention without delay,

preferably from an ophthalmologist. Eye wash fountain should be located at immediate work area.

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Ingestion:

Immediately rinse mouth and then drink plenty of water, do not induce vomiting, seek medical

attention. Give one cup (8 ounces or 240 ml) of water or milk if available and transport to a medical

facility.

4.2 Note to physician:

Maintain adequate ventilation and oxygenation of the patient. If burn is present, treat as any thermal

burn, after decontamination. Due to irritant properties, swallowing may result in burns/ulceration of

mouth, stomach and lower gastrointestinal tract with subsequent stricture. Aspiration of vomitus

may cause lung injury. Suggest endotracheal/esophageal control if lavage is done. No specific

antidote. Treatment of exposure should be directed at the control of symptoms and the clinical

condition of the patient.

4.3 Emergency Personnel Protection: First Aid responders should pay attention to self-protection and use the recommended protective

clothing (chemical resistant gloves, splash protection).

SECTION 5. FIRE-FIGHTING MEASURES

5.1 Extinguishing Media: Water fog or fine spray. Dry chemical fire extinguishers. Carbon dioxide fire extinguishers. Foam.

Do not use direct water stream. Straight or direct water streams may not be effective to extinguish

fire. Alcohol resistant foams (ATC type) are preferred.

General purpose synthetic foams (including AFFF) or protein foams may function, but will be less

effective.

5.2 Fire Fighting Procedures: Keep people away. Isolate fire and deny unnecessary entry. Stay upwind. Keep out of low areas

where gases (fumes) can accumulate. Water may not be effective in extinguishing fire. Use water

spray to cool fire exposed containers and fire affected zone until fire is out and danger of reignition

has passed. Fight fire from protected location or safe distance. Consider the use of unmanned hose

holders or monitor nozzles. Do not use direct water stream. This may cause spreading fire.

Eliminate ignition sources. Move container from fire area if this is possible without hazard.

Burning liquids may be moved by flushing with water to protect personnel and minimize property

damage.

5.3 Special Protective Equipment for Firefighters:

Wear positive-pressure self-contained breathing apparatus (SCBA) and protective fire fighting

clothing (includes fire fighting helmet, coat, trousers, boots, and gloves). Avoid contact with this

material during fire fighting operations. If contact is likely, change to full chemical resistant fire

fighting clothing with self-contained breathing apparatus. If this is not available, wear full chemical

resistant clothing with self-contained breathing apparatus and fight fire from a remote location.

5.4 Unusual Fire and Explosion Hazards: Container may vent and/or rupture due to fire. Electrically ground and bond all equipment.

Flammable mixtures of this product are readily ignited even by static discharge. Vapors are heavier

than air and may travel a long distance and accumulate in low lying areas. Ignition and/or flash back

may occur. Flammable mixtures may exist within the vapor space of containers at room

temperature.

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5.5 Special hazards:

Risk of spontaneous and violent self-polymerization if inhibitor is lost or product is exposed to

excessive heat. Polymerization is accompanied with heat emissions, during which the temperature

and gas pressure grow rapidly. In case of uncontrolled polymerization there might occur rapid

release of energy with risk of explosion in closed, non ventilated containers.

Methylacrylate vapors and air produce explosive mixture. Open fire, smoking, local overheating

may cause fire or explosion.

5.6 Hazardous Combustion Products: During a fire, smoke may contain the original material in addition to combustion products of

varying composition which may be toxic and /or irritating. Combustion products may include and

are not limited to: сarbon monoxide, carbon dioxide.

5.7 Further information: In case of a fire in the vicinity a restabilization system should be used if the temperature in the

storage container reaches 45°C. Evacuate area of all unnecessary personnel. In case of a fire in the

vicinity evacuate all personnel in a greater area if the temperature in the storage container reaches

60°C.

5.8 Fire safety measures: Provide possibility to quickly pump out the product in case of emergency from vessels used for storage and processing. Inspect work areas regularly, especially storage vessels, loading and discharge lines checking for combustion gas. Immediately clean product spillages. Provide efficient means of fire fighting for cleaning the accidental spillages. Do not use tools which are not intrinsikally safe for maintenance and repairing at areas, where combastible gases accumulation is possbile. Do not add dry inhibitor to the product by loading it via steam discharge pipes due to the risk of static ignition.

SECTION 6. ACCIDENTAL RELEASE MEASURES

6.1 Personal Precautions: Evacuate personnel in the area. Keep unnecessary and unprotected personnel from entering the area.

Keep personnel out of low areas. Keep upwind of spill. Ventilate area of leak or spill. Eliminate all

sources of ignition in vicinity of spill or released vapor to avoid fire or explosion. Vapor explosion

hazard. Keep out of sewers. For large spills, warn public of downwind explosion hazard. Check

area with combustible gas detector before reentering area. Ground and bond all containers and

handling equipment. Use appropriate safety equipment.

6.2 Methods and material for containment and cleaning up:

Small spills: Absorb with materials such as: sand, sawdust.

Large spills: Dike area to contain spill. Contain spilled material if possible. Pump with explosion-

proof equipment.

If available, use foam to smother or suppress. Collect in suitable and properly labeled containers.

6.3 Environmental precautions:

Prevent from entering into soil, ditches, sewers, waterways and/or groundwater.

6.4 Reference to other sections:

Information regarding exposure controls/personal protection and disposal considerations can be

found in section 8 and 13.

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SECTION 7. HANDLING AND STORAGE

7.1 General Handling: Handle in accordance with good industrial hygiene and safety practice. The product may be handled

only by appropriately trained personnel. Facility parts must be checked for polymer residues and

cleaned on regular basis in order to avoid hazardous reactions.

Keep away from heat, sparks and flame. Protect from direct sunlight.

Do not get on skin or clothing. Do not swallow. Avoid contact with eyes. Avoid prolonged or

repeated contact with skin. Avoid breathing vapor.

Keep container closed. Use only with adequate ventilation. Wash thoroughly after handling.

Never use air pressure for transferring product.

Protection against fire and explosion:

No smoking, open flames or sources of ignition in handling and storage area.

Vapors are heavier than air and may travel a long distance and accumulate in low lying areas.

Ignition and/or flash back may occur. Electrically bond and ground all containers and equipment

before transfer or use of material. Containers, even those that have been emptied, can contain

vapors. Do not cut, drill, grind, weld, or perform similar operations on or near empty containers.

Use of non-sparking or explosion-proof equipment may be necessary, depending upon the type of

operation.

Heated containers should be cooled to prevent polymerization. If exposed to fire, keep containers

cool by spraying with water. Emergency cooling must be provided for the eventuality of a fire in the

vicinity.

Sealed containers should be protected against heat as these results in pressure build-up. Avoid

influence of heat.

7.2 Storage:

Minimize sources of ignition, such as static build-up, heat, spark or flame.

Containers should be properly sealed. Store in a dry place. Avoid moisture.

Do not store with less than 10 % headspace above liquid.

Do not store or transfer the product by pressure under inert gases.

The product should be stored with gas containing 6-7% of oxygen (vol.).

This product contains an inhibitor for stabilization during transportation and storage.

Ensure adequate inhibitor and dissolved oxygen level.

Recommended inhibitor level is: 10 to 20 ppm. If storage is prolonged, the inhibitor concentration

should be tested at least every 60 days.

Flammable mixtures may exist within the vapor space of containers at room temperature.

Uninhibited monomer vapors can polymerize and plug relief devices.

Store away from incompatible materials (see STABILITY AND REACTIVITY section).

Storage temperature: <30°C.

Shelf life: use within 12 Months. Avoid prolonged storage

7.3 Storage stability: Storage stability is based upon ambient temperatures and conditions described.

Storage temperature: 45 °C:

A restabilization system should be used if the temperature in the storage container reaches the

indicated value.

All personnel should be evacuated if the temperature in the storage container reaches 60 °C.

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Avoiding polymerization: see STABILITY AND REACTIVITY section

7.4 Suitable materials for containers:

Opaque HDPE plastic container, stainless steel, aluminium, carbon steel, glass-lined container Do

not store in: translucent container aluminum.

Further information on storage conditions:

Vessels should be well protected from penetration of other materials/substances. Provide

designated lines for product loading and discharge.

Pipelines desing should avoid product stagation. Regularly control the combustible gas concentration in work areas.

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1 Control parameters 8.1.1 Occupational Exposure Limits

International Limit values1)

SUBSTANCE

Methyl acrylate

CAS #96-33-3

LTEL

8 hr

TWA ppm

LTEL

8 hr

TWA mg/m3

STEL

ppm

STEL

mg/m3

Note

Austria 5 18 10 26

Belgium 2 7.2

Denmark 2 7 4 14

European Union 5 18 10 (1) 36 (1) Occupational Exposure Limit

Values

(1) 15 minutes average value

France 5 18 10 36

Germany (AGS) 5 18 5 (1) 18 (1) (1) 15 minutes average value

Germany (DFG) 5 18 5 18 STV 15 minutes average

value

Hungary 18 18

Italy 2 7 10 35

Latvia 20 35(1) (1) 15 minutes average value

Poland 14 28

Spain 2 7.2 skin, sen.

Sweden 10 35 15(1) 50(1) (1) 15 minutes average value

Switzerland 5 18 5 18

The Netherlands - 18 - 36

USA - NIOSH 10 35

USA - OSHA 10 35

1) GESTIS International Limit values:

http://limitvalue.ifa.dguv.de/WebForm_ueliste.aspx

http://www.dguv.de/ifa/en/gestis/limit_values/pdf/au.pdf

http://www.dguv.de/ifa/en/gestis/limit_values/pdf/be.pdf

http://www.dguv.de/ifa/en/gestis/limit_values/pdf/scoel.pdf

http://www.dguv.de/ifa/en/gestis/limit_values/pdf/fr.pdf

http://www.dguv.de/ifa/en/gestis/limit_values/pdf/ags.pdf

http://www.dguv.de/ifa/en/gestis/limit_values/pdf/mak.pdf

http://www.dguv.de/ifa/en/gestis/limit_values/pdf/hu.pdf

http://www.dguv.de/ifa/en/gestis/limit_values/pdf/es.pdf

http://www.dguv.de/ifa/en/gestis/limit_values/pdf/mak_ch.pdf

http://www.dguv.de/ifa/en/gestis/limit_values/pdf/nl.pdf

http://www.dguv.de/ifa/en/gestis/limit_values/pdf/usa_osha.pdf

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8.1.2 DNEL/ PNEC values

DN(M)ELs for workers

Exposure

pattern

Route Descriptor DNEL /DMEL Most sensitive

endpoint

Justification/

Remarks

Acute -systemic

effects

Dermal

Acute - systemic

effects

Inhalation

Acute - local

effects

Dermal DNEL 0.49 mg/cm²

Corrected Dose

descriptor: 4.90 mg/cm² (based

on AF of 10)

sensitisation

(skin)

Acute - local

effects

Inhalation

Long-term -

systemic effects

Dermal

Long-term -

systemic effects

Inhalation

Long-term - local

effects

Dermal

Long-term - local

effects

Inhalation DNEL 18 mg/m³ irritation

(respiratory tract)

DN(M)ELs for the general population

Exposure

pattern

Route Descriptor DNEL / DMEL Most sensitive

endpoint

Justification/

Remarks

Acute - systemic

effects

Dermal

Acute - systemic

effects

Inhalation

Acute - systemic

effects

Oral

Acute - local

effects

Dermal DNEL 0.49 mg/cm²

Corrected Dose

descriptor: 4.90 mg/cm² (based

on AF of 10)

sensitisation

(skin)

Acute - local

effects

Inhalation

Long-term -

systemic effects

Dermal

Long-term -

systemic effects

Inhalation

Long-term -

systemic effects

Oral

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Long-term -

local effects

Dermal

Long-term -

local effects

Inhalation DNEL 2.1 mg/m³ irritation

(respiratory tract)

PNEC water

PNEC Assessment

factor

Remarks/Justification

PNEC aqua

(freshwater):

0.00272 mg/L

50 Extrapolation method: assessment factor

The aquatic toxicity of the six acrylic esters (methyl, 2-ethylhexyl, ethyl,

n-butyl, isobutyl, and tert-butyl acrylate) was evaluated as a category. Due

to the moderate volatility and ready biodegradability of most of the

acrylic esters only effect values based on analytically measured

concentrations were used for the derivation of the PNEC. An assessment

factor of 50 was applied to the lowest NOEC value available (0.136

mg/L).

PNEC aqua

(marine water):

0.00027 mg/L



n-butyl, isobutyl, and tert-butyl acrylate) was evaluated as a category. Due

to the moderate volatility and ready biodegradability of most of the

acrylic esters only effect values based on analytically measured

concentrations were used for the derivation of the PNEC. Such data are

available from a robust data set of acute studies in three trophic levels

(marine and freshwater species) and long-term results from two trophic

levels (freshwater species) (see PNEC aqua (freshwater) for details). An

assessment factor of 500 was applied to the lowest NOEC value available,

derived from a 21-day chronic life-cycle study with Daphnia magna

(0.136 mg/L).

PNEC aqua

(intermittent

releases): 0.011

mg/L



n-butyl, isobutyl, and tert-butyl acrylate) was evaluated as a category. A

robust data set of acute studies in three trophic levels (marine and

freshwater species) is available. Taking all available short-term tests with

freshwater and saltwater species into consideration, the most sensitive

species is Cyprinodon variegatus with an LC50 of 1.1 mg/L. The

recommended assessment factor for the derivation of a PNEC aqua

(intermittent releases) is 100 (ECHA, May 2008).

PNEC sediment

PNEC Assessment

factor


PNEC sediment

(freshwater):

0.0115 mg/kg

sediment dw

Extrapolation method: partition coefficient

Since no experimental data were available for sediment dwelling

organisms, the PNEC sed was estimated using the equilibrium

partitioning method as recommended by the Technical Guidance

Document for Risk Assessment (ECB, 2003) and Guidance on

information requirements and chemical safety assessment, Chapter R.10

(ECHA, May 2008). PNEC sediment in mg/kg sediment ww = 0.00251

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PNEC soil

PNEC Assessment

factor


PNEC soil:

1 mg/kg soil dw


For the derivation of the PNEC soil an OECD TG 217 study with an EC50

greater than 1000 mg/kg soil dw based on soil micro-flora (carbon-cycle)

is available. An assessment factor of 1000 is proposed by the Guidance on

information requirements and chemical safety assessment, Chapter R.10

(ECHA, May 2008) for such data. The resulting PNEC soil is 1 mg/kg soil

dw.

This assessment is supported by data from the structural analogue acrylic

acid for which a PNEC soil of 1 mg/kg soil dw was derived based on a

short-term test in Eisenia fetida with an LC50 > 1000 mg/kg dw and a

long-term toxicity test with a NOEC of 100 mg/kg soil dw based on soil

micro-flora (carbon-cycle).

PNEC sewage treatment plant

Value Assessment

factor


PNEC STP: 10

mg/L


For the derivation of the PNEC STP an activated sludge inhibition test

(BODm test) has to be taken into account. The 72-h NOEC for domestic

activated sludge was 100 mg/L. An assessment factor of 10 was applied to

this value leading to a PNEC STP of 10 mg/L. This value is supported by

the assumption that the test substance was not inhibitory to

microorganisms in a positive ready biodegradability test.

PNEC oral (secondary poisoning)

PNEC Assessment

factor


PNEC oral:

0.0011 g/kg food

90 Based on a log Kow value of 0.74, no bioaccumulation of Methyl acrylate

in organisms is expected. Hence, secondary poisoning will not be an

important factor in the hazard assessment. Nevertheless, a PNEC oral was

determined. Since no data on acute or chronic toxicity towards birds are

available, the PNEC oral for secondary poisoning was derived from a

subchronic drinking water study with rats (Dow 1981). The NOAEL

(systemic) was 5 mg/kg bw corresponding to a NOEC (food) = 0.1E-03

kg/kgfood. The assessment factor for a 90-day study in mammals is 90

resulting in a PNEC oral (mammal) = 1.1E-06 kg/kg food.

8.2 Exposure Controls

Personal protective equipment

Eye protection/Face Protection:

Use chemical goggles. Chemical goggles should be consistent with EN 166 or equivalent. Eye wash

fountain should be located in immediate work area. If exposure causes eye discomfort, use a full-

face respirator.

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Skin Protection:

Use protective clothing chemically resistant to this material. Selection of specific items such as face

shield, boots, apron, or full body suit will depend on the task. Safety shower should be located in

immediate work area. Remove contaminated clothing immediately, wash skin area with soap and

water, and launder clothing before reuse or dispose of properly. Items which cannot be

decontaminated, such as shoes, belts and watchbands, should be removed and disposed of properly.

Respiratory protection:

Respiratory protection should be worn when there is a potential to exceed the exposure limit

requirements or guidelines. If there are no applicable exposure limit requirements or guidelines, use

an approved respirator. When respiratory protection is required, use an approved positive-pressure

self-contained breathing apparatus or positive-pressure airline with auxiliary self-contained air

supply. For emergency conditions, use an approved positive-pressure self-contained breathing

apparatus. In confined or poorly ventilated areas, use an approved self-contained breathing

apparatus or positive pressure air line with auxiliary self-contained air supply.

Hand protection:

Use chemical resistant gloves classified under Standard EN374: Protective gloves against chemicals

and micro-organisms.

Examples of preferred glove barrier materials include: Polyethylene, Chlorinated polyethylene,

Styrene/butadiene rubber, Polyvinyl alcohol ("PVA"), Ethyl vinyl alcohol laminate ("EVAL").

Examples of acceptable glove barrier materials include: Viton, Butyl rubber, Natural rubber

("latex"), Polyvinyl chloride ("PVC" or "vinyl"), Nitrile/butadiene rubber ("nitrile" or "NBR").

When prolonged or frequently repeated contact may occur, a glove with a protection class of 5 or

higher (breakthrough time greater than 240 minutes according to EN 374) is recommended.

When only brief contact is expected, a glove with a protection class of 3 or higher (breakthrough

time greater than 60 minutes according to EN 374) is recommended.

NOTICE: The selection of a specific glove for a particular application and duration of use in a

workplace should also take into account all relevant workplace factors such as, but not limited to:

Other chemicals which may be handled, physical requirements (cut/puncture protection, dexterity,

thermal protection), potential body reactions to glove materials, as well as the

instructions/specifications provided by the glove supplier.

Ingestion:

Avoid ingestion of even very small amounts; do not consume or store food or tobacco in the work

area; wash hands and face before smoking or eating.

Engineering controls: Ventilation: Use engineering controls to maintain airborne level below exposure limit requirements

or guidelines. If there are no applicable exposure limit requirements or guidelines, use only in

enclosed systems or with local exhaust ventilation. Exhaust systems should be designed to move

the air away from the source of vapor/aerosol generation and people working at this point. Lethal

concentrations may exist in areas with poor ventilation.

For more information please see the relevant exposure scenario in Appendix II of this SDS.

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES

Property Value Remarks

Physical state at 20°C liquid

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Page 13 of 120


and 1013 hPa

Colour

Odour

Form: volatile

Colourless

Pungent, acrid odor

Melting / freezing point -76.5 °C at 1013.25 hP

Measured

(The Merck Index - An Encyclopedia

of Chemicals, Drugs, and

Biologicals.)

Boiling point 80.1 °C at 1013.25 hPa Measured

(BASF AG Dampfdruck von

Methylacrylat, Ethylacrylat und

Butylacrylat, 1983)

Relative density 0.95 g/cm3 at 20 °C Measured

(CRC Handbook of Chemistry and

Physics. 76th ed./ Lide, D.R. (ed.))

Vapour pressure 90 hPa at 20°C Measured

(BASF AG Dampfdruck von

Methylacrylat, 1983)

Water solubility 60 g/l at 20°C

(60000 mg/L at 20°C)

Measured

The Merck Index, 14th Edition ver.

14.4. /Smyth, Carpenter, 2006;

Documentation of the Threshold

Limit Values and Biological

Exposure Indices, 6th ed, 1992

Partition coefficient

n-octanol/water

(log value)

0.739 at 25 °C OECD Guideline 107 (Partition

Coefficient (n-octanol / water), Shake

Flask Method), BASF AG

Viscosity 0.472 mPas at 25 °C Measured

(Design Institute for Physical

Properties, Sponsored by AIChE,

2005)

Flash point closed cup

-2.8 °C

(270.4 K at 1013 hPa)

Measured

American Conference of

Governmental Industrial Hygienists,

Inc. (1991)

Flammability

Highly flammable.

The substance has no pyrophoric

properties and does not liberate

flammable gases on contact with

water.

Flammability derived from flash

point and boiling point.

Based on chemical structure

pyrophoric properties and

flammability in contact with water

are not predicted.

Lower explosion limit:

Upper explosion limit:

2.4(%)

18.6 (%)

Literature data.

GESTIS Substance database (2008)

Explosive properties non explosive There are no chemical groups

associated with explosive properties

present in the molecule.

In accordance with column 2 of

REACH Annex VII, the

VERSION: 1.2


Page 14 of 120


explosiveness of the substance does

not need to be tested, because there

are no chemical groups associated

with explosive properties in the

molecule

Self-ignition temperature 468 °C

Oxidising properties no oxidising properties The Substance is incapable of

reacting exothermically with

combustible materials.


REACH Annex VII, the oxidising

properties do not need to be tested,

because the substance is incapable of

reacting exothermically with

combustible materials on the basis of

the chemical structure.

Granulometry not applicable Substance is marketed or used in a

non solid or granular form. In

accordance with column 2 of

REACH Annex VII, the particle size

distribution (Granulometrie) study

does not need to be performed as the

substance is marketed or used in a

non solid or granular form

Stability in organic

solvents and identity of

relevant degradation

products

The stability of the substance is not

considered as critical.


REACH Annex IX, the test does not

need to be conducted because the

stability of the substance is not

considered as critical

Dissociation constant not applicable The substance does not contain any

ionic structure.

In accordance with section 1 of

REACH Annex XI, the dissociation

constant study does not need to be

performed because the substance

does not contain any ionic structure.

Surface tension not surface active In accordance with column 2 of

REACH Annex VII, the surface

tension of the substance does not

need to be tested because due to its

chemical structure, no surface

activity is predicted.

9.2 Other information

Self-accelerating

polymerisation

temperature (SAPT)

> 50 °C at the inhibitor level not less than 15 ppm

VERSION: 1.2


Page 15 of 120

SECTION 10. STABILITY AND REACTIVITY

10.1 Chemical stability:

Stable under recommended storage conditions. Unstable at elevated temperatures. Hygroscopic.

10.2 Reactivity:

The product undergoes the following reactions: polymerization, hydrolyzation, oxidation,

hydration, interesterification, halogenation.

10.3 Possibility of hazardous reactions:

Risk of spontaneous and violent self-polymerization if inhibitor is lost or product is exposed to

excessive heat.

Polymerization can be catalyzed by: аbsence of air, free radical initiators, oxidizing agents, high

temperature, peroxides. Presence of water can accelerate rate of polymerization. Uninhibited

monomer vapors can polymerize and plug relief devices.

Under uncontrolled polymerization there might occur rapid release of energy with risk of explosion

in closed, non ventilated containers.

10.4 Conditions to avoid:

Avoid temperatures above 30°C. Avoid direct sunlight. Avoid prolonged storage. Avoid inhibitor

loss. Exposure to elevated temperatures can cause product to decompose. Avoid static discharge.

Avoid moisture. Do not blanket or purge with an inert gas to avoid depleting the oxygen

concentration.

10.5 Incompatible materials:

Avoid contact with oxidizing materials.

Avoid contact with: alcohols, аldehydes, amines, free radical initiators, halides, mineral acids,

peroxides, strong inorganic bases.

Avoid contact with metals such as: brass, copper.

Avoid unintended contact with: activated carbon, aluminum oxide, silica gel.

Avoid contact with absorbent materials such as: cellulose-based absorbents, clay-based absorbents.

Avoid unintended contact with peroxides.

10.6 Hazardous decomposition products:

Thermal Decomposition. Decomposition products depend upon temperature, air supply and the

presence of other materials.

SECTION 11. TOXICOLOGICAL INFORMATION

Property Results Remarks

Acute toxicity

Oral LD50: ca. 768 mg/kg bw (rat, male) key study, experimental result

OECD TG 401 (Acute Oral Toxicity),

BASF AG (1958)

Inhalation LC50 (4 h): 10.382 mg/L air (rat,

male/female)

key study, experimental result

OECD Guideline 403 (Acute

Inhalation Toxicity), BASF SE (2012)

VERSION: 1.2


Page 16 of 120

Dermal LD50 (dermal): ca. 1250 mg/kg bw

(rabbit, occlusive)


Acute dermal toxicity study in rabbits

conducted according to the method

described by Draize et al. (1944).

Smyth HF and Carpenter CP (1948)

Irritation/Corrosivity:

Skin contact with methyl acrylate causes irritation. Methyl acrylate may be irritating to the

respiratory system, and may cause severe damage to the eyes.

EU classification according to Annex I of Directive 67/548/EEC: Xi, R36/37/38

GHS classification (GHS UN rev.3, 2009):

- Skin corrosion/irritation: Category 2

- Serious eye damage/eye irritation: Category 2

- Specific target organ toxicity, Single exposure: Category 3 (May cause respiratory irritation)

Eye irritant/ corrosive rabbit: irritating

rabbit: corrosive


BASF test (BASF AG 1958);

Draize Test /TNO (1978)

Skin irritant rabbit: irritating key study, experimental result

OECD TG 404 (Acute Dermal

Irritation / Corrosion)

BASF AG test (1982)

Respiratory tract

rats and mice, inhalation, vapour:

irritating effects on the respiratory

system


BASF test (BASF AG 1979)

Sensitisation: After repeated skin contact with Methyl acrylate sensitization is possible

EU classification according to Annex I of Directive 67/548/EEC: Xi, R43

GHS classification (GHS UN rev.3, 2009):

- Skin Sensitization Category 1 B

Skin sensitization

Mouse: sensitizing

Stimulation index: 3.8


OECD Guideline 429 (Skin

Sensitisation: Local Lymph Node

Assay)

Syngenta CTL (2006)

Respiratory system There is no information available on

the potential for MA to produce

respiratory sensitisation in animals.

Repeated dose toxicity

EU classification according to Annex VI of Directive 67/548/EEC: no

classification required

GHS classification (GHS UN rev.3, 2009): Specific Target Organ

Toxicity: Repeated Exposure: no classification required

Oral

NOAEL = 5 mg/kg bw/d

rat, male/female

LOAEL: 20 mg/kg

rat, male/female;

Effects on kidney weight


OECD TG 408 (Repeated Dose 90-Day

Oral Toxicity in Rodents)

Dow Chemical Co. (1981)

Inhalation

NOAEC: 0.082 mg/L air

Rat, male/female


OECD TG 413 (Subchronic Inhalation

Toxicity: 90-Day)

VERSION: 1.2


Page 17 of 120

LOAEC: 0.44 mg/L air

rat, male/female

(body weight change and organ

weight changes (lung and liver))

LOAEC: 58 mg/m3

Rat: nasal and ocular local effects

NOAEC >= 519 mg/m3.

BASF AG (1978)

BASF AG (1980)

Dermal

Not applicable No subacute or subchronic repeated

dose studies with dermal application are

available for Methyl acrylate.

Mutagenicity Genetic toxicity: negative

EU classification according to Annex VI of Directive 67/548/EEC: no

classification required

GHS classification (GHS UN rev.3, 2009): no classification required

Methyl acrylate was negative in bacterial mutation tests. In gene mutation

assays in mammalian cells, i. e. HGPRT and XPRT assays, MA was clearly

negative. MA seems to have some potential for genotoxicity in mammalian

cells, presumably by a clastogenic mechanism. Since this effect is limited to

doses with moderate to strong cytotoxicity, it is highly unlikely that this

potential will be expressed in vivo. Methyl acrylate was negative in several in

vivo mouse micronucleus assays. Thus, taking the negative test results in vivo

for MA into consideration, it can be assumed that MA will not cause any DNA

damage, i. e. genotoxicity in vivo.

In vitro data

negative:

bacterial reverse mutation assay e.g.

Ames test, gene mutation

(S. typhimurium TA)


The study was conducted according to

the method described by Ames BN et al.

(1975). Mut. Res. 31: 347-364

BASF AG (1977);

HGPRT assay / Moore MM et al. (1989;

1991);

XPRT mutation assay performed

according to the procedure described by

Oberly et al. (1987, 1990) with some

modifications.

Methyl acrylate was tested at two

laboratories: Case Western Reserve

University (CWR) and SRI International

(SRI)/ Zeiger E et al. (1987);

Rannug et al (1976). Chem.-Biol.

Interact. 12: 251-263/ Waegemaekers

THJM and Bensink MPM (1984)

In Vivo Data negative:

micronucleus assay (chromosome

aberration)

mouse, inhalation: vapour


Sofuni T, Hayashi M, Matsouka A

(Bull National Institute of Hygiene

VERSION: 1.2


Page 18 of 120

mouse, oral:

Sciences 102: 84-90, 1984 in Japanese)

Hachiya N et al. (1981)

Carcinogenicity No carcinogenic effects

Inhalation Neoplastic effects: no effects

Methyl acrylate showed no evidence

of carcinogenicity in a 2-year

vapour inhalation study in Sprague-

Dawley rats up to the highest tested

dose:

rat (Sprague-Dawley), male/female

inhalation: vapour (whole body)

NOAEC (carcinogenicity):

>=0.519 mg/L air

LOAEC (toxicity): 0.058 mg/L air

(Local effects (nasal and ocular))


OECD TG 453 (Combined Chronic

Toxicity / Carcinogenicity Studies)

Inbifo (1985)Reininghaus W, Koestner

A, and Klimisch H-J (1991)

Dermal This information is not available.

Toxicity for

reproduction:

No effect on reproductive organs

EU classification according to Annex VI of Directive 67/548/EEC:

no classification required

GHS classification (GHS UN rev.3, 2009): no classification required

Effects on fertility In a two-generation study in which

groups of rats were whole-body

exposed to methyl acrylate vapours,

no effects on reproductive function

(i. e. fertility) were observed.

NOEC (reproductive toxicity):=

ca. 0.269 mg/L air = 75 ppm

(rat; male/female)


OECD TG 416

EPA OPPTS 870.3800 (Reproduction

and Fertility Effects)

JMAFF, Guideline 2-1-17,

Reproduction Study (2000)

The Dow Chemical Company (2009)

Developmental toxicity No indications of a developmental

toxic / teratogenic effect were seen

in animal studies:

Inhalation: vapour (whole body),

Rabbit:

NOAEL (maternal toxicity): 15 ppm

NOAEL (developmental toxicity):

45 ppm

inhalation: vapour (whole body)

rat (Sprague-Dawley):

NOAEC (maternal toxicity): ca.

0.089 mg/L air (nominal) (body

weight)

NOAEC (teratogenicity):

>= 0.357 mg/L air (nominal)

LOAEC (fetotoxicity):


OECD TG 414

EPA OPPTS 870.3700 (Prenatal

Developmental Toxicity Study)

BASF SE (2009)

OECD TG 414 (Prenatal Developmental

Toxicity Study)

Saillenfait AM et al. (1999)

VERSION: 1.2


Page 19 of 120

ca. 0.357 mg/L air (nominal) (fetal

body weight)

Toxicokinetics

(absorption,

metabolism,

distribution and

elimination)

Methyl acrylate is readily absorbed by the oral, dermal and inhalation

routes and the major portion is rapidly hydrolyzed by carboxyesterases to

acrylic acid and methanol. Greater than 90 % is excreted within 72 hours,

primarily via the lungs (> 50 %) as CO2, and kidneys (40-50 %) as

products of methyl acrylate-glutathione conjugation. Dermal absorption is

somewhat slower and appears to follow irritation of the skin, possibly

reflecting an initial de-esterification, with subsequent absorption of the

acrylic acid formed.

Other effects None.

SECTION 12. ECOLOGICAL INFORMATION

Property

Value

Remarks

AQUATIC TOXICITY

Fish:

Short-term toxicity

LC50 (96 h): 3.4 mg/L test mat.

Salmo gairdneri (new name:

Oncorhynchus mykiss)/ freshwater

LC50 (96 h, flow through) = 1.1 mg/L

(measured)

Cyprinodon variegates/saltwater


OECD Guideline 203 (Fish, Acute

Toxicity Test)

Basic Acrylic Monomer

Manufacturers (1995)

OECD Guideline 203 (Fish, Acute

Toxicity Test)

Wildlife International Ltd. (1995)

Long-term toxicity to fish: Not applicable

In accordance with section 3 of REACH Annex XI, the study does not need to be conducted. The

use of methyl acrylate as a monomer, almost exclusively in closed systems for the production of

polymers, indicates that environmental exposure would be limited. The volatility of methyl acrylate

provides for volatilization of any releases to the air. Methyl acrylate is slowly photodegradable and

readily biodegradable, and accidental releases to the environment would not result in accumulation

or persistence. The relatively high water solubility and corresponding low log Kow indicate that no

bioaccumulation potential exists.

In order to assess long-term toxicity towards aquatic organisms, a 21-day chronic life-cycle study

with Daphnia magna was conducted with the structurally-related ethyl acrylate. The respective

NOEC was 0.19 mg/L.

Aquatic invertebrates

Short-term toxicity

EC50 (48 h) = 2.6 mg/L (measured),

Daphnia magna/ freshwater/flow-

through

LC50 (96 h) = 1.6 mg/L (measured)

Mysidopsis bahia (new name:

Americamysis bahia) /saltwater/

flow-through


OECD Guideline 202 (Daphnia

sp. Acute Immobilisation Test)


Manufacturers Inc. (1995a)

EPA OTS 797.1930 (Mysid Acute

Toxicity Test)

BASF AG (2001)

VERSION: 1.2


Page 20 of 120

Long-term toxicity

(Daphnia Magna)

NOEC (21 d): 0.136 mg/L test mat.

meas. (TWA) based on: reproduction

LOEC (21 d): 0.457 mg/L test mat.

meas. (TWA) based on: reproduction

NOEC (21 d): 0.19 mg/L test mat.

meas. (arithm. mean) based on:

reproduction

LOEC (21 d): 0.45 mg/L test mat.

meas. (arithm. mean)) based on:

reproduction


Read-across to n-butyl acrylate

(CAS 141-32-2)

OECD Guideline 211 (Daphnia

magna Reproduction Test)

BASF SE (2009c)

Read-across to Ethyl acrylate

(CAS 140-88-5)

EPA OTS 797.1330 (Daphnid

Chronic Toxicity Test)

ABC Laboratories, Inc. (1997)

Algae and aquatic plants

(Selenastrum

capricornutum, new

name: Pseudokirchnerella

subcapitata) (algae)

EC50 (72 h): 3.55 mg/L test mat.

based on: growth rate/ freshwater/ static


OECD Guideline 201 (Alga,

Growth Inhibition Test)


Manufacturers Inc. (1995b)

Toxicity to aquatic micro-

organisms

EC10 (72 h): > 100 mg/L test mat.

(nominal) based on: respiration rate

key study, experimental result ASTM Microbial Inhibition

Testing Procedure


Manufacturers Inc. (1996)

Sediment organisms: Not applicable In Annex IX of Regulation (EC) No 1907/2006, it is laid down that long-term toxicity testing shall be

proposed by the registrant if the chemical safety assessment indicates the need to investigate further the

effects on sediment organisms.

According to Annex I of this regulation, the chemical safety assessment triggers further action when the

substance or the preparation meets the criteria for classification as dangerous according to Directive

67/548/EEC or Directive 1999/45/EC or is assessed to be a PBT or vPvB.

The hazard assessment of nBA reveals neither a need to classify the substance as dangerous for the

environment, nor is it a PBT or vPvB substance. Furthermore, due to the physico-chemical properties of the

substance and its ready biodegradability, a considerable exposure of the sediment compartment is unlikely.

Therefore, a long-term toxicity study in sediment organisms is not provided. The PNEC sediment can be

estimated based on the equilibrium partitioning method.

Toxicity to soil macro-organisms: Not applicable In accordance with section 3 of REACH Annex XI, the study does not need to be conducted. Since n-butyl

acrylate is readily biodegradable and no direct releases to soil from point sources are known, no significant

exposure of the terrestrial compartment is expected.

Toxicity to soil micro-

organisms

EC50 (28 d): > 1000 mg/kg soil dw test

mat.

(nominal) based on: respiration rate


OECD Guideline 217 (Soil

Microorganisms: Carbon

Transformation Test)

BASF SE (2010)

Toxicity to terrestrial plants: Not applicable In accordance with section 3 of REACH Annex XI, the study does not need to be conducted. Since n-butyl

acrylate is readily biodegradable and no direct releases to soil from point sources are known, no significant

exposure of the terrestrial compartment is expected

Toxicity to birds: Not applicable.

In accordance with section 1 and 3 of REACH Annex XI, the study does not need to be conducted.

Since no exposure of birds is expected, testing of birds is not required.

VERSION: 1.2


Page 21 of 120

DEGRADATION

Abiotic degradation: Methyl acrylate does not absorb UV radiation at wavelengths > 290 nm, i. e.

methyl acrylate does not directly photolyse. However, it is susceptible to photo-oxidation via vapour

phase reaction with photochemically-produced hydroxyl radicals and ozon. The substance will

hydrolyse slowly in contact with water under environmental conditions.

Hydrolysis In contact with water Methyl

acrylate will hydrolyse slowly:

Half-life (DT50):

t1/2 (pH 7): > 28 d at 25 °C

t1/2 (pH 11): 1.8 h at 25 °C


EPA OTS 796.3500

(Hydrolysis as a Function of pH at

25°C)

BASF AG (1998)

Phototransformation in air After evaporation or exposure to

the air, Methyl acrylate will be

slowly degraded by

photochemical processes:

Half-life (DT50):

40.9 h (24-h day)

Concentration of OH radicals:

0.5E+06 OH/cm3

Degradation rate constant:

9.423 E-12 cm3/molecule*sec

key study, calculated

(Q)SAR

Computer programme: SRC AOP

v1.92 BASF SE (2008)

Biodegradation: Methyl acrylate is readily biodegradable according to OECD criteria.

Biodegradation in water readily biodegradable:

% Degradation of test substance:

90 — 100 after 28 d

inherently biodegradable:

% Degradation of test substance:

50 — 60 after 28 d

(O2 consumption)

experimental result

OECD OECD TG 310 (Ready

Biodegradability - CO2 in Sealed

Vessels (Headspace Test)

BASF AG (2005)

OECD Guideline 301 D (Ready

Biodegradability: Closed Bottle

Test)


Manufacturers, Inc. (1996)

Biodegradation in soil study scientifically unjustified In accordance with column 2 of

REACH Annex IX, no simulation

tests in soil are required, since

Methyl acrylate is readily

biodegradable according to OECD

criteria.

ENVIRONMENTAL DISTRIBUTION

Adsorption/desorption Adsorption of Methyl acrylate to

solid soil phase is not expected

Adsorption coefficient:

Koc at 20°C = 6.4

log Koc = 0.81

Study type: adsorption (soil)

Calculated, QSAR

PCKOCWIN v1.66

BASF SE, 2008b

Volatilization From the water surface, Methyl

acrylate will slowly evaporate

into the atmosphere.

Henry's Law constant H:

9.37 Pa m³/mol at 25 °C

key study, estimated by

calculation, (Q)SAR

SRC HENRYWIN v3.10

BASF SE (2008c)

VERSION: 1.2


Page 22 of 120

Environmental distribution

Percent distribution in media:

Air (%): 81.9

Water (%): 18

Soil (%): 0.01

Sediment (%): 0.01

Susp. sediment (%): 0

Biota (%): 0

Aerosol (%): 0


calculation

Calculation according to Mackay,

Level I

BASF SE (2008d)

BIOACCUMULATION: Methyl acrylate does not accumulate in organisms

Aquatic bioaccumulation BCF: 3.162 (log Pow)

log BCF: 0.5

The BCF was calculated based on

the log Pow = 0.74


calculation

SRC BCFBAF v3.00

BASF SE (2009a)

SECONDARY POISONING PNEC oral = 0.0011 g/kg food

No bioaccumulation of Methyl

acrylate in organisms is expected.

Secondary poisoning will not be an

important factor in the hazard

assessment. Nevertheless, a PNEC

oral was determined.

The PNEC oral for secondary

poisoning was derived from a

subchronic drinking water study

with rats, based on

NOAEL (systemic) =5 mg/kg bw

or NOEC(food) = 0.1E-03 kg/kg

food. PNEC oral (mammal) =

1.1E-06 kg/kg food.

logKow = 0.74

PBT/vPvB Properties Methyl acrylate does not have PBT or vPvB Properties

SECTION 13. DISPOSAL CONSIDERATIONS

13.1 General information:

Do not allow spilled product and waste water to enter the sewage and open surface water. Avoid

groundwater pollution.

This product, when being disposed of in its unused and uncontaminated state should be treated as a

hazardous waste according to EC Directive 91/689/EEC. Any disposal practices must be in

compliance with all national and provincial laws and any municipal or local by-laws governing

hazardous waste. For used, contaminated and residual materials additional evaluations may be

required. Do not dump into any sewers, on the ground, or into any body of water.

13.2 Waste treatment methods: Must be sent to a suitable incineration plant (thermal neutralization), observing local regulations.

13.3 Contaminated packaging: Uncleaned empties should be disposed of in the same manner as the contents.

For more information please see the relevant exposure scenario in Appendix II of this SDS

SECTION 14. TRANSPORT INFORMATION

Land transport:

ADR/ RID

ID number: UN 1919

Proper shipping name: METHYL ACRYLATE, STABILIZED

VERSION: 1.2


Page 23 of 120

Chemical name Methyl acrylate

Hazard class: 3

Classification code F1

Packing group: PG II

Hazard label: Class 3 (flammable)

Inland waterway transport:

ADN

ID number: UN 1919


Chemical name Methyl acrylate

Hazard class: 3

Classification code F1



Marine transport:

IMDG

ID number: UN 1919


Chemical name Methyl acrylate / 2-Propenoic Acid, methyl ester

Hazard class: 3


EMS Number: F-E, S-D


Marine pollutant: NO

Air transport:

IATA/ICAO

ID number: UN 1919


Chemical name Methyl acrylate / 2-Propenoic Acid, methyl ester

Hazard class: 3



Cargo Packing Instruction: 307

Passenger Packing Instruction: 305

SECTION 15. REGULATORY INFORMATION

REGULATORY

Chemical Safety Report has been performed for Methyl acrylate.

APPENDIX II to the e-SDS: Exposure scenarios.

KEY LITERATURE REFERENCES AND SOURCES

DOCUMENTS, PROVIDED BY ACRYLATE REACH TASK FORCE CONSORTIUM CHEMICAL SAFETY REPORT to Methyl acrylate (CAS 96-33-3).

VERSION: 1.2


Page 24 of 120

EU DIRECTIVES

REGULATION (EC) No 1907/2006 OF THE EUROPEAN PARLIAMENT AND OF THE

COUNCIL of 18 December 2006 concerning the Registration, Evaluation, Authorisation and

Restriction of Chemicals (REACH), establishing the European Chemicals Agency, amending

Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission

Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives

91/155/EEC, 93/67/EEC 93/105/EC and 2000/21/EC

Regulation (EC) No 1272/2008 REGULATION (EC) No 1272/2008 OF THE EUROPEAN

PARLIAMENT AND OF THE COUNCIL of 16 December 2008 on classification, labelling and

packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and

1999/45/EC, and amending Regulation (EC) No 1907/2006

Regulations: Commission regulation (EU) no 453/2010 of 20 May 2010 amending Regulation (EC)

No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation,

Authorization and Restriction of Chemicals (REACH)

DIRECTIVE 1999/45/EC OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 31

May 1999 concerning the approximation of the laws, regulations and administrative provisions of

the Member States relating to the classification, packaging and labelling of dangerous preparations

Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions

relating to the classification, packaging and labeling of dangerous substances.

COMMISSION DECISION of 16 January 2001 amending Decision 2000/532/EC as regards the list

of wastes (notified under document number (2001/118/EC)

UK REGULATORY REFERENCES

Chemicals (Hazard Information & Packaging) Regulations. The Control of Substances Hazardous

to Health Regulations 1988. Health and Safety at Work Act 1974.

ENVIRONMENTAL LISTING

Control of Pollution Act 1974.

STATUTORY INSTRUMENTS

Notification of New Substances Regulations (NONS) 1993. The Export and Import of Dangerous

Chemicals Regulations 2005 number 928.

APPROVED CODE OF PRACTICE

Classification and Labelling of Substances and Preparations Dangerous for Supply (EU

2001/59/EC). Safety Data Sheets for Substances and Preparations (REACH)

GUIDANCE NOTES

Workplace Exposure Limits EH40. Introduction to Local Exhaust Ventilation HS(G)37. CHIP for

everyone HSG(108).

NATIONAL REGULATIONS

The Chemicals (Hazard Information and Packaging for Supply) Regulations 2002. No. 1689.

Workplace Exposure Limits 2005 (EH40).

The Carriage of Dangerous Goods and use of transportable pressure equipment regulations 2004.

Control of Substances hazardous to health regulations 2002 (as amended).

NATIONAL REGULATIONS (GERMANY)

Major Accident Hazard Legislation 82/501/EWG.

VERSION: 1.2


Page 25 of 120

SECTION 16. OTHER INFORMATION

16.1 Indication of changes

VERSION Date of change Section Description of changes

Version: 1.0 10/10/2011 All Initial SDS.

Version: 1.1 25/07/2014 3; 10 The dossier was updated by the Lead Registrant

1. Section 3. The substance was classified

additional as: Aquatic Chronic 3 (H412: Harmful

to aquatic life with long lasting effects).

2. Section 10. Acute toxicity after inhalation

exposure: LD50 was corrected.

Version: 1.2 16/11/2018 9 Physical and chemical properties were updated.

16.2 Abbreviations and acronyms

ADR

European Agreement concerning the International Carriage of Dangerous Goods by

Road

AGS The German Committee on Hazardous Substances (Ausschuss für Gefahrstoffe –

AGS)

BCF Bioconcentration factor

DFG Germany Research Foundation

DNEL Derived No Effect Level

IMDG International Maritime Dangerous Goods

ICAO-TI Technical Instructions for the Safe Transport of Dangerous Goods by Air

Koc Adsorption coefficient

Kow octanol-water partition coefficient

LC50 Lethal Concentration to 50 % of a test population

LD50 Lethal Dose to 50% of a test population (Median Lethal Dose)

LOAEC Lowest Observable Adverse Effect Concentration

LTEL Long Term Exposure Limit

NIOSH National Institute for Occupational Safety and Health (USА CDC)

NOEC No Observed Effect Concentration

NOAEL No Observed Adverse Effect Level

OECD Organization for Economic Co-operation and Development

OSHA Occupational Safety & Health Administration (USА)

PNEC Predicted No Effect Concentration

PBT Persistent, bioaccumulative, toxic chemical

vPvB Very Persistent, Very Bioaccumulative

RID Regulations concerning the International Carriage of Dangerous Goods by Rail

STEL Short Term Exposure Limit

STOT Specific Target Organ Toxicity

(STOT) RE Repeated Exposure

(STOT) SE Single Exposure

TWA Time Weighted Average

UN United Nations

WGK Wassergefährdungsklasse (German: Water Hazard Class)

16.3 List of ES (exposure scenario) given in Appendix I to the extended SDS:

ES1 Manufacture and distribution

ES2 Polymerization at production sites (IU1)

http://encyclopedia.thefreedictionary.com/Persistent+organic+pollutant

VERSION: 1.2


Page 26 of 120

ES3 Manufacture of intermediates at production sites (IU2)

ES4 Polymerization at downstream user sites (IU3)

ES5 Manufacture of intermediates at downstream user sites (IU4)

ES6 Use as laboratory reagent (IU5)

IU1: polymerization at production sites

IU2: manufacture of intermediates at production sites

IU3: polymerization at downstream user sites

IU4: manufacture of intermediates at downstream user sites

IU5: use as laboratory reagent

DISCLAIMER

This information is based on our current level of knowledge. This information may be subject to

revision as new knowledge and experience becomes available, and SIBUR makes no warranties and

assumes no liability in connection with any use of this information. Since SIBUR cannot be aware

of all aspects of your business and the impact the REACH Regulation has for your company, SIBUR

strongly encourages you to get familiar with the REACH Regulation in order to comply with its

requirements and timelines.

VERSION: 1.2


Page 27 of 120

Annex I

Relevant identified uses of the substance

Table 1. Uses by workers in industrial settings

Confidential IU number Identified

Use (IU)

name

Substance

supplied to

that use

Use descriptors

Manufacture

and

distribution

as such

(substance

itself)

Process category (PROC):

PROC 1: Use in closed process, no likelihood of exposure

PROC 2: Use in closed, continuous process with occasional controlled exposure

PROC 3: Use in closed batch process (synthesis or formulation)

PROC 8a: Transfer of substance or preparation (charging/discharging) from/to

vessels/large containers at non-dedicated facilities

PROC 8b: Transfer of substance or preparation (charging/discharging) from/to

vessels/large containers at dedicated facilities

PROC 9: Transfer of substance or preparation into small containers (dedicated

filling line, including weighing)

Market sector by type of chemical product: PC 19: Intermediate

Environmental release category (ERC): ERC 1: Manufacture of substances

Sector of end use (SU): SU 8: Manufacture of bulk, large scale chemicals (including petroleum products)

SU 9: Manufacture of fine chemicals

Subsequent service life relevant for that use?: no

Article category related to subsequent service life (AC):

AC 0: Other: No articles

VERSION: 1.2


Page 28 of 120


Use (IU)

name

Substance

supplied to

that use

Use descriptors

1 Polymerizati

on at

production

sites (IU1)

as such

(substance

itself)





PROC 4: Use in batch and other process (synthesis) where opportunity for exposure

arises

PROC 5: Mixing or blending in batch processes for formulation of preparations and

articles (multistage and/or significant contact)







Market sector by type of chemical product:

PC 19: Intermediate

PC 32: Polymer preparations and compounds

Environmental release category (ERC):

ERC 6c: Industrial use of monomers for manufacture of thermo-plastics

ERC 6d: Industrial use of process regulators for polymerisation processes in

production of resins, rubbers, polymers

Sector of end use (SU):

SU 8: Manufacture of bulk, large scale chemicals (including petroleum products)


SU 12: Manufacture of plastics products, including compounding and conversion

VERSION: 1.2


Page 29 of 120


Use (IU)

name

Substance

supplied to

that use

Use descriptors



AC 0: Other: No articles

2 Manufacture

of

intermediates

at production

sites

as such

(substance

itself)






arises









Market sector by type of chemical product:

PC 19: Intermediate

Environmental release category (ERC):

ERC 6a: Industrial use resulting in manufacture of another substance (use of

intermediates)



VERSION: 1.2


Page 30 of 120


Use (IU)

name

Substance

supplied to

that use

Use descriptors




AC 0: Other: No article

3 Polymerizati

on at

downstream

user sites

as such

(substance

itself)

Process category (PROC): PROC 1: Use in closed process, no likelihood of exposure




arises










PC 32: Polymer preparations and compounds

Environmental release category (ERC): ERC 6c: Industrial use of monomers for manufacture of thermo-plastics

ERC 6d: Industrial use of process regulators for polymerisation processes in

production of resins, rubbers, polymers


VERSION: 1.2


Page 31 of 120


Use (IU)

name

Substance

supplied to

that use

Use descriptors



SU 12: Manufacture of plastics products, including compounding and conversion


Article category related to subsequent service life (AC): AC 0: Other: No article

4 Manufacture

of

intermediates

at

downstream

user sites

as such

(substance

itself)

Process category (PROC): PROC 1: Use in closed process, no likelihood of exposure




arises










Environmental release category (ERC): ERC 6a: Industrial use resulting in manufacture of another substance (use of

intermediates)




VERSION: 1.2


Page 32 of 120


Use (IU)

name

Substance

supplied to

that use

Use descriptors

Article category related to subsequent service life (AC): AC 0: Other: No article

5 Use as

laboratory

reagent

as such

(substance

itself)

Process category (PROC): PROC 15: Use as laboratory reagent


PC 21: Laboratory chemicals

Environmental release category (ERC): ERC 1: Manufacture of substances



SU 24: Scientific research and development


Most common technical function of substance (what it does):

- Intermediates

- Laboratory chemicals

VERSION: 1.2


Страница 33 из 120

Annex II

1. EXPOSURE ASSESSMENT

General remarks

Introduction and uses

Methyl acrylate (MA) is a chemical intermediate, manufactured and processed almost entirely within

closed systems. Its major use is the production of homo- and co-polymers with other monomers (i.e.,

acrylic acid and its salts, esters, amides, etc.) to produce emulsion polymers. The three major uses of

acrylate esters are: surface coatings, adhesives/sealants and textiles.

The most likely route of human exposure (workers) to methyl acrylate is through inhalation and/or

dermal contact. In industrial settings, ingestion is not an anticipated route of exposure. Worker

exposure can occur in manufacturing facilities, in industrial facilities where the substance is used as

an intermediate, and in industrial facilities where polymerization is conducted.

The ECETOC Targeted Risk Assessment Tool (TRA) version 2.0 was used for the occupational

exposure assessment. Details of the TRA may be found in the ECETOC Technical Report No. 93

(2004), and the accompanying Addendum Technical Report No. 107 (2009), or at

https://www.ecetoc-tra.org/. The assessment of environmental exposure was carried out using

EUSES v2.1. Documentation for EUSES 2.1 may be found at http://ecb.jrc.ec.europa.eu/euses.

The registrant has conducted a mapping of uses within the supply chain. Based on the results of this

mapping and using the Generic Exposure Scenarios as a basis (as developed within the solvent sector,

ESIG/ESVOC), the following uses (as stated in chapter 2) have been identified:

IU1: polymerization at production sites

IU2: manufacture of intermediates at production sites

IU3: polymerization at downstream user sites

IU4: manufacture of intermediates at downstream user sites

IU5: use as laboratory reagent

For these identified uses a number of exposure scenarios have been derived which are

summarized in the table below.

For the occupational scenarios, it is possible that individual manufacturers and/or downstream

users may use and handle methyl acrylate under differing operational conditions, such as indoors

or outdoors and in the presence or absence of local exhaust ventilation. To cover these potential

conditions, 3 scenarios and appropriate risk management measures (when necessary) were

developed for certain TRA Process Categories (PROCs):

1) indoor process without local exhaust ventilation (LEV);

2) indoor process with LEV present; and 3) outdoors (with general dilution ventilation).

Methyl acrylate completely reacts (less than 0.1 wt% remains) during use; therefore, development of

exposure scenarios covering downstream uses (i.e., professional use, consumer use, service life, waste

treatment) are not required and have not been conducted for this assessment.

https://www.ecetoc-tra.org/

VERSION: 1.2



ES

no

Linked to

Identified Use

Sector

of Use

(SU)

Life

Cycle

Stage*

Product

Category

(PC)

Process

Category

(PROC)

Article

Category

(AC)

Environmental

Release

Category

(ERC)

Tonnage

(ktonnes)

ES1 Manufacture

and distribution

8, 9 MA 19 1, 2, 3,

8a, 8b, 9

NA ERC1 ES1-E1

3.12E04

ES1-E2

3.12E04

ES1-E3

6.25E04

Total ES1

1.25E05

ES2 Polymerization

at production

sites (IU1)

8, 9, 12 EU 19, 32 1, 2, 3, 4,

5, 8a, 8b,

9

NA ERC6C,

ERC6D

1.24E04

ES3 Manufacture of

intermediates

at production sites (IU2)

8, 9 EU 19 1, 2, 3, 4,

5, 8a, 8b, 9

NA ERC6A 6.22E03

ES4 Polymerization

at downstream

user sites (IU3)

8, 9, 12 EU 19, 32 1, 2, 3, 4,

5, 8a, 8b,

9

NA ERC6C,

ERC6D

7.0E04

ES5 Manufacture of

intermediates

at downstream

user sites (IU4)

8, 9 EU 19 1, 2, 3, 4,

5, 8a, 8b, 9

NA ERC6A 2.33E04

ES6 Use as

laboratory reagent (IU5)

8, 9, 24 EU 19, 21 15 NA ERC1 NA

(included

in ERC1 ES1)

*Life cycle stage: MA = manufacture; FO = formulation; EU = end use; CU = consumer use; SL=

service life; WS = waste stage

For methyl acrylate [MA] a total of four facilities were assumed. In order to facilitate the

parameterization of EUSES to reflect operations in the production facilities analytical samples were

taken for each site with regard to concentration of MA in STP influent and effluent. Samples of the

STP influent and effluent were taken. [Analytical sampling protocol and method attached.] Sampling

in this manner will encompass production and [internal] down stream uses including wet

polymerization and transesterification. Wet polymerization and transesterification down stream uses

external to the three specific production plants were also parameterized within EUSES employing the

measured effluent concentrations. These concentrations assume that risk mitigation measures will be

in place at each external DU production site. These external DUs represent customer use.

Based on the analytical measurements, a value of 0.01 mg.L-1 [10 µg.L-1] was input into EUSES as

the STP effluent concentration for the three production sites and the internal and external DU process

sites. This assumes that the analytical method limit of detection [LOD] was 10 µg.L-1. If MA

concentrations were below the LOD, one-half the LOD concentration could be assumed yielding 5

µg.L-1. Thus the assumption of 10 µg.L-1 would be considered conservative if measured values were

below the LOD.

VERSION: 1.2



METHYL ACRYLATE

μg/l Site 1 Site 2 Site 3 Site 4

Industrial Use Influent Effluent Influent Effluent Influent Effluent Influent Effluent

Manufacture

and Distribution

of Substance

38.6 <1 81 < 1

<1 <1

Polymerization

at Production

Site

30.5 < 1

Polymerization

at Downstream

User Sites

Manufacture of

Intermediates at

Production and

Downstream

User Sites

30.5 < 1

Use as

Laboratory

Reagent

81 < 1

Use of

Preparations

Containing Up

to 21%

Monomer

Other Uses of

Substance as

Intermediate

The following information has been used for the exposure assessments:

Substance Methyl acrylate

CAS no 96-33-3

Substance Volatility (hPa at 20 °C) 90

TRA Volatility Range Medium

Biodegradability Readily biodegradable

Molecular Weight (g/mol) 86.0892

Melting Point (° C) -76.5

Boiling Point (° C) 80.1

Solubility (g/l at 20 °C) 6.0E01

Kow 0.739

Chemical class for Koc-QSAR Esters

Koc L/kg 6.423

VERSION: 1.2



1.1. Exposure scenario 1: Manufacture and distribution

This scenario covers the manufacture and distribution of the bulk substance. Included within this

scenario are material receipt, preparation, reaction, bulk transfer and storage, as well as equipment

cleaning, and associated maintenance activities.

1.1.1. Exposure scenario

Section 1 Exposure Scenario Title

Title Manufacture and distribution

Sector of Use SU8, SU9

Process Category PROC1, PROC2, PROC3, PROC8a, PROC8b, PROC9

Product Category PC19

Article Category n/a

Environmental release

Category

ERC1

Specific environmental

release category

n/a

Processes, tasks, activities

covered

Covers the manufacture and distribution of the substance in the Process Categories

listed above.

Section 2 Operational conditions and risk management measures

Section 2.1 Control of worker exposure

Product characteristics

Physical form of product Liquid

Volatility Medium volatility

Concentration of

substance in product

Up to 100%

Operational conditions

Amounts used Not relevant for this scenario

Frequency and duration of

use

Covers daily exposures up to 8 hours (unless stated differently) [G2].

Human factors not

influenced by risk

management

None identified for this scenario.

Other Operational

Conditions affecting

worker exposure

Assumes activities are at ambient temperature (unless stated differently) [G17].

Assumes a good basic standard of occupational hygiene is implemented [G1].

Since methyl acrylate is a potential skin sensitizer, the use of chemically resistant gloves (tested to

EN374) in combination with ‘basic’ employee training is required when handling methyl acrylate and

where indicated under the Risk Management Measures (RMMs) for a given scenario. Butyl rubber

gloves with a minimum thickness of 0.7 mm and a chemical specific breakthrough time of >480

minutes are required for these scenarios.

VERSION: 1.2



Risk Management Measures Detailed information on this Exposure Scenario can be found in

appendix A.

Identifier* Contributing Scenarios Process

Categories

Risk Management Measures

ES1-W1 General exposures (closed

systems); Indoors, No LEV

present.

1 Handle substance within a closed system [E47].


systems); With sample

collection; Indoors, No

LEV present.

2 Handle substance within a closed system [E47]. Avoid

carrying out operation for more than 1 hour [OC11]

or: Wear a respirator conforming to EN140 with Type

A/P2 filter or better {PPE29]



collection; Indoors, with

LEV present.


Provide extract ventilation to points where emissions

occur [E54].



collection; Outdoors.


Ensure operation is undertaken outdoors [E69]. Avoid

carrying out operation for more than 4 hours [OC12]



ES1-W5 Use in contained batch

processes;

With sample collection;

Indoors, No LEV present.






processes;


Indoors, with LEV present.

3 Handle substance within a predominantly closed

system provided with extract ventilation [E49].


processes;


Outdoors






ES1-W8 Drum/batch transfers; Non-

dedicated facility; Indoors,

No LEV present.

8a Transfer via enclosed lines [E52].; Clear transfer lines

prior to de-coupling [E39].Avoid carrying out

operation for more than 15 minutes [OC10] or: Wear a

respirator conforming to EN140 with Type A/P2 filter

or better {PPE29]; Wear chemically resistant gloves

(tested to EN374) in combination with ‘basic’

employee training [PPE16].



with LEV present.


prior to de-coupling [E39].Provide extract ventilation

to material transfer points and other openings

[E82].Wear chemically resistant gloves (tested to

EN374) in combination with ‘basic’ employee training

[PPE16].


dedicated facility;

Outdoors.


prior to de-coupling [E39].Ensure operation is

undertaken outdoors [E69]. Avoid carrying out


VERSION: 1.2







ES1-W11 Drum/batch transfers;

Dedicated facility; Indoors,

No LEV present.

8b Transfer via enclosed lines [E52]; Clear transfer lines









with LEV present.


prior to de-coupling [E39]. Provide extract ventilation




[PPE16].


Dedicated facility;

Outdoors.


prior to de-coupling [E39]. Ensure operation is







ES1-W14 Drum and small package

filling;


9 Use in semi-automated and predominantly enclosed

filling lines [E41]. Avoid carrying out operation for

more than 15 minutes [OC10] or: Wear a respirator

conforming to EN140 with Type A/P2 filter or better

{PPE29]; Wear chemically resistant gloves (tested to


[PPE16].


filling; Indoors, with LEV

present.

9 Fill containers/cans at dedicated fill points supplied

with local extract ventilation [E51]. Wear chemically

resistant gloves (tested to EN374) in combination with

‘basic’ employee training [PPE16].


filling; Outdoors.


filling lines [E41]. Ensure operation is undertaken

outdoors [E69]. Avoid carrying out operation for more

than 15 minutes [OC10] or: Wear a respirator


{PPE29];

Wear chemically resistant gloves (tested to EN374) in

combination with ‘basic’ employee training [PPE16].

*Identifier: each contributing scenario of the ES has been assigned a unique identifier which

facilitates tracking all the information (exposure estimation, risk characterization in chapter 1 and 2

and appendices) related to this contributing scenario of the ES

VERSION: 1.2




Section 2.2 Control of environmental exposure

Identifier*: Manufacturing Site #1 ES1-E1

Contributing scenario Manufacturing

Environmental Release Category ERC1

Specific ERC -

Assessment scenario IC=3, UC=33

Operational Conditions

Amounts used

Amounts used in the EU (tonnes/year) 3.12E04

Fraction of EU tonnage used in region 1.0

Fraction of main source to local

environment 1

Fraction of substance in end-use products 1

Frequency and duration of use

Type of release Continuous

Emission days (days/year) 300

Environmental factors not influenced by

risk management

Local freshwater dilution factor 10 (default)

Local marine water dilution factor 100 (default)

Other given operational conditions

affecting environmental exposure Not applicable


Conditions and measures related to

municipal sewage treatment plant

E13.20 - Biological treatment – Anaerobic – For soluble

biodegradable contaminants

E13.21 - Biological treatment – Aerobic – For soluble


E13.23 - Biological treatment - Central Biological Waste

Water Treatment - For soluble biodegradable

contaminants

Estimated substance removal from

wastewater via domestic sewage treatment

(%) 95 %


external treatment of waste for disposal No application of sludge to soil


external recovery of waste

Other environmental control measures

additional to above

Dispose of waste cans and containers according to local

regulations.




VERSION: 1.2



1.1.2. Exposure estimation

1.1.2.1. Workers exposure

The worker exposure estimates for the activities associated with this use of methyl acrylate have been assessed using ECETOC TRA v2, unless stated differently (see appendix B). Assessment parameter default values: Fugacity: moderate Type of Use; industrial Concentration: > 25 % Local Exhaust Ventilation: indoor scenarios assessed both with, and without LEV Duration of Exposure: > 4 hours/day unless indicated under RMMs Respiratory Protection Equipment: none required unless indicated under RMMs The ECETOC TRA v2 estimates task based exposure. The exposure estimates shown are representative for activities lasting up to 8 hours. Due to the activity based character of this estimation tool, these exposure estimates are thereby also representative for short term activities (e.g., 15 minutes to 1 hour). Therefore no short term inhalatory exposure estimates are calculated nor shown in the table below (indicated by n.a.), since long term (8 hour) estimates already cover short term exposure.

VERSION: 1.2



Identifier Contributing

scenarios

PROC Risk Management Measures Inhalatory exposure

(mg/m3)

Dermal exposure (mg/kg/day) Dermal exposure

(µg/cm2)

Long

term

Acute Long term Acute systemic Acute local

ES1-W1 General exposures

(closed systems);

Indoors, No LEV

present.

1 Handle substance within a closed system

[E47].

0.04 n.a. n.a. n.a. 100


(closed systems);

With sample

collection; Indoors,

No LEV present.


[E47]. Avoid carrying out operation for

more than 1 hour [OC11] or: Wear a

respirator conforming to EN140 with

Type A/P2 filter or better {PPE29]

7.18 n.a. n.a. n.a. 200


(closed systems);

With sample


with LEV present.


[E47]. Provide extract ventilation to

points where emissions occur [E54].

3.59 n.a. n.a. n.a. 200


(closed systems);

With sample

collection;

Outdoors.


[E47]. Ensure operation is undertaken

outdoors [E69]. Avoid carrying out

operation for more than 4 hours [OC12]

or] or: Wear a respirator conforming to

EN140 with Type A/P2 filter or better

{PPE29]

15.07 n.a. n.a. n.a. 200

ES1-W5 Use in contained

batch processes;

With sample


No LEV present.



more than 1 hour [OC11] or] or: Wear a

respirator conforming to EN140 with

Type A/P2 filter or better {PPE29]

17.94 n.a. n.a. n.a. 100


batch processes;

3 Handle substance within a

predominantly closed system provided

8.97 n.a. n.a. n.a. 100

VERSION: 1.2



With sample


with LEV present.

with extract ventilation [E49].


batch processes;

With sample

collection;

Outdoors




operation for more than 1 hour [OC11]

or: Wear a respirator conforming to


{PPE29]

12.56 n.a. n.a. n.a. 100

ES1-W8 Drum/batch

transfers; Non-

dedicated facility;

Indoors, No LEV

present.

8a Transfer via enclosed lines [E52].; Clear

transfer lines prior to de-coupling

[E39].Avoid carrying out operation for

more than 15 minutes [OC10] or: Wear

a respirator conforming to EN140 with

Type A/P2 filter or better {PPE29];

Wear chemically resistant gloves (tested

to EN374) in combination with ‘basic’


17.94 n.a. n.a. n.a. 100

ES1-W9 Drum/batch

transfers; Non-

dedicated facility;

Indoors, with LEV

present.



[E39].Provide extract ventilation to

material transfer points and other

openings [E82].Wear chemically

resistant gloves (tested to EN374) in

combination with ‘basic’ employee

training [PPE16].

17.94 n.a. n.a. n.a. 100

ES1-W10 Drum/batch

transfers; Non-

dedicated facility;

Outdoors.

8a Transfer via enclosed lines [E52]; Clear


[E39].Ensure operation is undertaken


operation for more than 15 minutes

[OC10] or: Wear a respirator

12.56 n.a. n.a. n.a. 100

VERSION: 1.2



conforming to EN140 with Type A/P2

filter or better {PPE29]; Wear

chemically resistant gloves (tested to

EN374) in combination with ‘basic’


ES1-W11 Drum/batch

transfers;

Dedicated facility;

Indoors, No LEV

present.

8b Transfer via enclosed lines [E52].; Clear









17.94 n.a. n.a. n.a. 100

ES1-W12 Drum/batch

transfers;

Dedicated facility;

Indoors, with LEV

present.

8b Transfer via enclosed lines [E52]; Clear

transfer lines prior to de-coupling [E39].

Provide extract ventilation to material

transfer points and other openings

[E82].Wear chemically resistant gloves

(tested to EN374) in combination with


5.38 n.a. n.a. n.a. 100

ES1-W13 Drum/batch

transfers;

Dedicated facility;

Outdoors.



Ensure operation is undertaken outdoors








12.56 n.a. n.a. n.a. 100

ES1-W14 Drum and small 9 Use in semi-automated and 17.94 n.a. n.a. n.a. 100

VERSION: 1.2



package filling;

Indoors, No LEV

present.

predominantly enclosed filling lines








ES1-W15 Drum and small

package filling;

Indoors, with LEV

present.

9 Fill containers/cans at dedicated fill

points supplied with local extract

ventilation [E51]. Wear chemically



training [PPE16].

17.94 n.a. n.a. n.a. 100


package filling;

Outdoors.

9 Use in semi-automated and

predominantly enclosed filling lines




[OC10] or: Wear a respirator

conforming to EN140 with Type

A/P2 filter or better {PPE29];




12.56 n.a. n.a. n.a. 100

VERSION: 1.2



1.1.2.2. Consumer exposure

Not applicable.

1.1.2.3. Indirect exposure of humans via the environment (oral)

The bioaccumulation potential of this substance is very low, therefore secondary poisoning can be

considered negligible as reflected by the values below.

LOCAL ES1-E1 ES1-E2 ES1-E3

local Concentration in wet fish kg/kgwwt 3.18E-09 3.18E-09 1.23E-09

local concentration in drinking water kg/m3 8.13E-05 8.13E-05 9.55E-06

local concentration in meat (wet weight) kg/kgwwt 3.34E-11 3.34E-11 3.59E-12

local concentration in milk (wet weight) kg/kgwwt 3.34E-10 3.34E-10 3.59E-11

1.1.2.4. Environmental exposure

Identifier ES1-E1

Manufacture Site #1 The exposure scenario is based A&B tables

IC= 3 and UC= 33

Release fraction to air from process 1.0E-02

Release fraction to wastewater from

process 3.0E-03

Release fraction to soil from process

(regional only) 0

Local release to air (kg/d) 1.04E03

Local release to sewage (kg/d) 3.65E02

Local release to soil (kg/d) 0

Fraction remaining in water after STP

treatment (Fwater) 3.25E-02

Removal in STP (fraction) 9.50E-01

VERSION: 1.2



1.1.2.4.1 Predicted exposure concentrations in aquatic the STP and in aquatic compartments

(freshwater, seawater and sediment)

Local Concentration, Compartment: STP and

aquatic unit ES1-E1

Local PEC in surface water during emission

episode (dissolved) mg/L 1.18E-03

Annual average local PEC in surface water

(dissolved) mg/L 1.01E-03

Local PEC in fresh water sediment during

emission episode

mg/kg

dwt 5.03E-03

Local PEC in sea water during emission episode mg/L 1.22E-04

Annual average local PEC in sea water (dissolved) mg/L 1.04E-04

Local PEC in marine sediment during emission

episode

mg/kg

dwt 5.17E-04

PEC for microorganisms in STP mg/L 1.00E-02

Comments

1.1.2.4.2 Predicted exposure concentration in soils

Local Concentration, Compartment: soil unit ES1-E1

Local PEC in agricultural soil, averaged over 30

days

mg/kg

dwt 2.13E-02

Local PEC agricultural soil, averaged over 180

days

mg/kg

dwt 2.13E-02

Local PEC in grass land, averaged over 180 days

mg.kg

dwt 3.93E-02

Comments

1.1.2.4.3 Predicted exposure concentration in the atmospheric compartment

Local Concentration,

Compartment: air unit ES1-E1

Annual average local PEC in air

(total) kg/m

3 2.38E-07

Comments

VERSION: 1.2



1.1.2.4.4 Predicted exposure concentration in food for secondary poisoning


considered negligible. The table below illustrates the negligible PECs as a function of secondary

poisoning.

Secondary poisoning unit ES1-E1

Conc. in fish for secondary poisoning in freshwater

environment mg/kgwwt 1.88E-03

Conc. in fish for secondary poisoning in marine


Conc. in fish-eating predator for marine top predators mg/kgwwt 9.52E-05

Conc. in earthworms for secondary poisoning mg/kgwwt 3.41E-02

Comments

Manufacturing Site #2

Section 2

Operational conditions and risk management

measures


Identifier*: Manufacture Site #2 ES1-E2



Specific ERC -



Amounts used




environment 1






risk management








E13.20 - Biological treatment – Anaerobic – For

soluble biodegradable contaminants

E13.21 - Biological treatment – Aerobic – For

soluble biodegradable contaminants

E13.23 - Biological treatment - Central Biological

Waste Water Treatment - For soluble




(%) 95 %

VERSION: 1.2








additional to above

Dispose of waste cans and containers according to

local regulations.





Identifier ES1-E2

Manufacture Site #2

The exposure scenario is based A&B tables

IC= 3 and UC= 33



process 3.0E-03


(regional only) 0





treatement (Fwater) 3.25E-02


1.1.2.5.1 Predicted exposure concentrations in aquatic the STP and in the aquatic compartments

(freshwater, seawater and sediments)

Local Concentration, Compartment: STP and aquatic unit ES1-E2

Local PEC in surface water during emission episode


Annual average local PEC in surface water (dissolved) mg/L 1.01E-03

Local PEC in fresh water sediment during emission episode mg/kg dwt 5.03E-03



Local PEC in marine sediment during emission episode mg/kg dwt 5.17E-04


Comments



Local PEC in agricultural soil, averaged over 30 days mg/kg dwt 2.13E-02

Local PEC agricultural soil, averaged over 180 days mg/kg dwt 2.13E-02

Local PEC in grass land, averaged over 180 days mg.kg dwt 3.93E-02

VERSION: 1.2







(total) kg/m

3 2.38E-07

Comments




poisoning.






Conc. in fish-eating predator for marine top predators mg/kgwwt 9.52E-05


Comments

Manufacturing Site #3



Identifier*: Manufacture Site #3 ES1-E3



Specific ERC -



Amounts used




environment

1






risk management




affecting environmental exposure

Not applicable

VERSION: 1.2












contaminants



(%)

95 %


external treatment of waste for disposal

No application of sludge to soil




additional to above


regulations.





Identifier ES1-E3

Manufacture Site #3 The exposure scenario is based A&B tables

IC= 3 and UC= 33


Release fraction to wastewater from process 3.0E-03

Release fraction to soil from process (regional

only) 0




Fraction remaining in water after STP treatement

(Fwater) 3.25E-02


VERSION: 1.2









Local PEC in fresh water sediment during emission

episode mg/kg dwt 1.84E-03





Comments






Comments





(total) kg/m

3 2.53E-08

Comments




poisoning.






Conc. in fish-eating predator for marine toppredators mg/kgwwt 9.52E-05


Comments

VERSION: 1.2



1.2. Exposure scenario 2: Polymerization at production sites

This scenario covers the use of methyl acrylate as an intermediate or monomer in the production of

polymers and resins at production sites (including material receipt, preparation, mixing and reaction,

bulk transfer and storage, as well as equipment cleaning and maintenance. This scenario covers both

wet and dry polymerization processes.



Title Polymerization at production sites

Sector of Use SU8, SU9, SU12

Process Category PROC1, PROC2, PROC3, PROC4, PROC5, PROC8a, PROC8b, PROC9

Product Category PC19, PC32



Category

ERC6C, ERC6D


release category

n/a


covered

Covers the polymerization at production sites for the Process Categories listed

above.






Concentration of


Up to 100%




use


Human factors not

influenced by risk

management


Other Operational


worker exposure

Assumes activities are at ambient temperature (unless stated differently) [G17];







VERSION: 1.2




appendix A.


Categories




present.





LEV present.








LEV present.



occur [E54].










processes;








processes;






processes;


Outdoors







processes; Drum/batch

transfers; With sample


LEV present.

4 Avoid carrying out operation for more than 1 hour

[OC11] or: Wear a respirator conforming to EN140

with Type A/P2 filter or better {PPE29]; Wear

chemically resistant gloves (tested to EN374) in






LEV present.

4 Provide extract ventilation to material transfer points

and other openings [E82].Wear chemically resistant

gloves (tested to EN374) in combination with ‘basic’





collection; Outdoors

4 Ensure operation is undertaken outdoors [E69]. Avoid



A/P2 filter or better {PPE29]; Wear chemically



ES2-W11 General exposures; Batch 5 Avoid carrying out operation for more than 15

VERSION: 1.2



process; Indoors, No LEV

present.

minutes [OC10] or: Wear a respirator conforming to

EN140 with Type A/P2 filter or better {PPE29]; Wear



ES2-W12 General exposures; Batch

process; Indoors, with LEV

present.

5 Provide extract ventilation to points where emissions

occur [E54]. Wear chemically resistant gloves (tested

to EN374) in combination with ‘basic’ employee

training [PPE16].


process; Outdoors


carrying out operation for more than 15 minutes







No LEV present.

8a Transfer via enclosed lines [E52]; Clear transfer lines









with LEV present.






[PPE16].


dedicated facility;

Outdoors.











No LEV present.

8b Transfer via enclosed lines [E52].; Clear transfer lines









with LEV present.






[PPE16].


Dedicated facility;

Outdoors.

8b Transfer via enclosed lines [E52].; Clear transfer lines



VERSION: 1.2









filling; Indoors, No LEV

present.







[PPE16].



present.






filling; Outdoors.






{PPE29];








Identifier*: Polymerization at Production

Sites ES2-E1

Contributing scenario Industrial Use

Environmental Release Category ERC 6C, ERC 6D

Specific ERC -



Amounts used




environment 0.33






risk management



VERSION: 1.2















contaminants



(%) 95 %






additional to above


regulations.






The worker exposure estimates for the activities associated with this use of methyl acrylate have been assessed using ECETOC TRA v2, unless stated differently (see appendix B). Assessment parameter default values: Fugacity: moderate Type of Use; industrial Concentration: > 25 % Local Exhaust Ventilation: indoor scenarios assessed both with and without LEV Duration of Exposure: > 4 hours/day unless indicated under RMMs Respiratory Protection Equipment: none required unless indicated under RMMs The ECETOC TRA v2 estimates task based exposure. The exposure estimates shown are representative for activities lasting up to 8 hours. Due to the activity based character of this estimation tool, these exposure estimates are thereby also representative for short term activities (e.g., 15 minutes to 1 hour). Therefore no short term inhalatory exposure estimates are calculated nor shown in the table below (indicated by n.a.), since long term (8 hour) estimates already cover short term exposure.

VERSION: 1.2



Identifier Contributing scenarios PROC Risk Management Measures Inhalatory

exposure

(mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)

Long

term

Acute Long

term

Acute

systemic Acute local



present.


[E47].

0.04 n.a. n.a. n.a. 100



collection; Indoors, No LEV

present.




respirator conforming to EN140 with Type


7.18 n.a. n.a. n.a. 200




LEV present.


[E47]. Provide extract ventilation to points

where emissions occur [E54].

3.59 n.a. n.a. n.a. 200







operation for more than 4 hours [OC12] or:

Wear a respirator conforming to EN140

with Type A/P2 filter or better {PPE29]

15.07 n.a. n.a. n.a. 200


processes;








17.94 n.a. n.a. n.a. 100


processes;


3 Handle substance within a predominantly

closed system provided with extract

ventilation [E49].

8.97 n.a. n.a. n.a. 100

VERSION: 1.2




exposure

(mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)

Long

term

Acute Long

term

Acute




processes;


Outdoors




operation for more than 1 hour [OC11] or:



12.56 n.a. n.a. n.a. 100





present.

4 Avoid carrying out operation for more than

1 hour [OC11] or: Wear a respirator


filter or better {PPE29]; Wear chemically



training [PPE16].

14.35 n.a. n.a. n.a. 100





LEV present.

4 Provide extract ventilation to material





7.18 n.a. n.a. n.a. 100





4 Ensure operation is undertaken outdoors




A/P2 filter or better {PPE29]; Wear




10.05 n.a. n.a. n.a. 100

ES2-W11 General exposures; Batch 5 Avoid carrying out operation for more than 17.94 n.a. n.a. n.a. 200

VERSION: 1.2




exposure

(mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)

Long

term

Acute Long

term

Acute



present.

15 minutes [OC10] or: Wear a respirator





training [PPE16].



present.

5 Provide extract ventilation to points where

emissions occur [E54]. Wear chemically



training [PPE16].

17.94 n.a. n.a. n.a. 200


process; Outdoors



more than 15 minutes [OC10] or: Wear a






12.56 n.a. n.a. n.a. 200



No LEV present.










17.94 n.a. n.a. n.a. 100

VERSION: 1.2




exposure

(mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)

Long

term

Acute Long

term

Acute




with LEV present.




material transfer points and other openings




17.94 n.a. n.a. n.a. 100


dedicated facility; Outdoors.





operation for more than 15 minutes [OC10]

or: Wear a respirator conforming to EN140

with Type A/P2 filter or better {PPE29];

Wear chemically resistant gloves (tested to



12.56 n.a. n.a. n.a. 100



No LEV present.










17.94 n.a. n.a. n.a. 100





5.38 n.a. n.a. n.a. 100

VERSION: 1.2




exposure

(mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)

Long

term

Acute Long

term

Acute


with LEV present.







Dedicated facility; Outdoors.











12.56 n.a. n.a. n.a. 100



present.

9 Use in semi-automated and predominantly

enclosed filling lines [E41]. Avoid carrying

out operation for more than 15 minutes

[OC10] or: Wear a respirator conforming

to EN140 with Type A/P2 filter or better

{PPE29]; Wear chemically resistant gloves



17.94 n.a. n.a. n.a. 100



present.

9 Fill containers/cans at dedicated fill points

supplied with local extract ventilation

[E51]. Wear chemically resistant gloves



17.94 n.a. n.a. n.a. 100

VERSION: 1.2




exposure

(mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)

Long

term

Acute Long

term

Acute



filling; Outdoors.


enclosed filling lines [E41]. Ensure

operation is undertaken outdoors [E69].

Avoid carrying out operation for more than



A/P2 filter or better {PPE29];




12.56 n.a. n.a. n.a. 100

VERSION: 1.2




Not applicable.




LOCAL ES2-E1

local Concentration in wet fish kg/kgwwt 3.18E-09

local concentration in drinking water kg/m3 1.13E-06

local concentration in meat (wet weight) kg/kgwwt 4.64E-13

local concentration in milk (wet weight) kg/kgwwt 4.64E-12


Identifier ES2-E1

Polymerization at Production Sites The exposure scenario is based A&B tables

IC= 3 and UC= 33



process 5.0E-04


(regional only) 0

Local release to air (kg/d) 13.7

Local release to sewage (kg/d) 6.84





VERSION: 1.2















Comments






Comments





(total) kg/m

3 3.30E-09

Comments

VERSION: 1.2






poisoning.








Comments

VERSION: 1.2



1.3. Exposure scenario 3: Manufacture of intermediates at production

sites

This scenario covers the use of methyl acrylate as a chemical intermediate in monomer synthesis

(transesterification or functionalisation) at production sites.



Title Manufacture of intermediates at production sites






Category

ERC6A


release category

n/a


covered

Covers the manufacture of intermediates at production sites for the Process

Categories listed above.






Concentration of


Up to 100%




use


Human factors not

influenced by risk

management


Other Operational


worker exposure

Assumes activities are at ambient temperature (unless stated differently) [G17].;







VERSION: 1.2




appendix A.


Categories



systems); Indoors, No

LEV present.





LEV present.


carrying out operation for more than 1 hour [OC11] or:

Wear a respirator conforming to EN140 with Type





LEV present.



occur [E54].










processes;








processes;






processes;


Outdoors










LEV present.










LEV present.















ES3-W11 General exposures; Batch 5 Avoid carrying out operation for more than 15 minutes

VERSION: 1.2




present.






process; Indoors, with

LEV present.




training [PPE16].


process; Outdoors








Non-dedicated facility;

















[PPE16].



Outdoors.










Dedicated facility;










Dedicated facility;







[PPE16].


Dedicated facility;

Outdoors.




VERSION: 1.2










present.







[PPE16].



present.






filling; Outdoors.






{PPE29];








Identifier*: Manufacture of Intermediates

at Production Sites ES3-E1


Environmental Release Category ERC 6A

Specific ERC -



Amounts used




environment 0.33






risk management


VERSION: 1.2
















contaminants



(%) 95 %






additional to above


regulations.







VERSION: 1.2



Identifier Contributing scenarios PROC Risk Management Measures Inhalatory exposure

(mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)

Long term Acute Long term Acute

systemic

Acute local


(closed systems);

Indoors, No LEV

present.


[E47].

0.04 n.a. n.a. n.a. 100


(closed systems); With

sample collection;

Indoors, No LEV

present.


[E47]. Avoid carrying out operation for more

than 1 hour [OC11] or: Wear a respirator

conforming to EN140 with Type A/P2 filter

or better {PPE29]

7.18 n.a. n.a. n.a. 200



sample collection;

Indoors, with LEV

present.




3.59 n.a. n.a. n.a. 200



sample collection;

Outdoors.



outdoors [E69]. Avoid carrying out operation

for more than 4 hours [OC12] or: Wear a



15.07 n.a. n.a. n.a. 200


processes;

With sample


LEV present.





or better {PPE29]

17.94 n.a. n.a. n.a. 100


processes;

With sample



8.97 n.a. n.a. n.a. 100

VERSION: 1.2




(mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)


systemic

Acute local


with LEV present.

ventilation [E49].


processes;

With sample




outdoors [E69]. Avoid carrying out operation

for more than 1 hour [OC11] or: Wear a



12.56 n.a. n.a. n.a. 100





LEV present.

4 Avoid carrying out operation for more than 1

hour [OC11] or: Wear a respirator conforming





14.35 n.a. n.a. n.a. 100





with LEV present.

4 Provide extract ventilation to material transfer

points and other openings [E82].Wear

chemically resistant gloves (tested to EN374)

in combination with ‘basic’ employee training

[PPE16].

7.18 n.a. n.a. n.a. 100








conforming to EN140 with Type A/P2 filter or

better {PPE29]; Wear chemically resistant

gloves (tested to EN374) in combination with


10.05 n.a. n.a. n.a. 100

ES3-W11 General exposures;

Batch process; Indoors,


minutes [OC10] or: Wear a respirator

17.94 n.a. n.a. n.a. 200

VERSION: 1.2




(mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)


systemic

Acute local

No LEV present. conforming to EN140 with Type A/P2 filter or





Batch process; Indoors,

with LEV present.




combination with ‘basic’ employee training

[PPE16].

17.94 n.a. n.a. n.a. 200


Batch process;

Outdoors








12.56 n.a. n.a. n.a. 200



Indoors, No LEV

present.


transfer lines prior to de-coupling [E39].Avoid

carrying out operation for more than 15



or better {PPE29]; Wear chemically resistant



17.94 n.a. n.a. n.a. 100



Indoors, with LEV

present.



[E39].Provide extract ventilation to material

transfer points and other openings [E82].Wear

17.94 n.a. n.a. n.a. 100

VERSION: 1.2




(mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)


systemic

Acute local



[PPE16].



Outdoors.



[E39].Ensure operation is undertaken outdoors







12.56 n.a. n.a. n.a. 100


Dedicated facility;

Indoors, No LEV

present.


transfer lines prior to de-coupling [E39].Avoid




or better {PPE29]; Wear chemically resistant



17.94 n.a. n.a. n.a. 100


Dedicated facility;

Indoors, with LEV

present.



Provide extract ventilation to material transfer




[PPE16].

5.38 n.a. n.a. n.a. 100

ES3-W19 Drum/batch transfers; 8b Transfer via enclosed lines [E52]; Clear 12.56 n.a. n.a. n.a. 100

VERSION: 1.2




(mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)


systemic

Acute local

Dedicated facility;

Outdoors.










package filling;

Indoors, No LEV

present.


enclosed filling lines [E41]. Avoid carrying


[OC10] or: Wear a respirator conforming to





17.94 n.a. n.a. n.a. 100


package filling;

Indoors, with LEV

present.


supplied with local extract ventilation [E51].


EN374) in combination with ‘basic’ employee

training [PPE16].

17.94 n.a. n.a. n.a. 100


package filling;

Outdoors.


enclosed filling lines [E41]. Ensure operation

is undertaken outdoors [E69]. Avoid carrying




{PPE29];


12.56 n.a. n.a. n.a. 100

VERSION: 1.2




(mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)


systemic

Acute local


training [PPE16].

VERSION: 1.2




Not applicable.




LOCAL ES3-E1






Identifier ES3-E1

Manufacture of Intermediates at Production

Sites


IC= 3 and UC= 33


Release fraction to wastewater from process 5.0E-04

Release fraction to soil from process (regional

only) 0



















Comments

VERSION: 1.2








Comments





(total) kg/m

3 1.74E-09

Comments




poisoning.








Comments

VERSION: 1.2



1.4. Exposure scenario 4: Polymerization at downstream user sites

This scenario covers the use of methyl acrylate as an intermediate or monomer in the production of

polymers and resins at downstream user sites (including material receipt, preparation, mixing and

reaction, bulk transfer and storage, as well as equipment cleaning and maintenance. This scenario

covers both wet and dry polymerization processes.



Title Polymerization at downstream user sites






Category

ERC6C, ERC6D


release category

n/a


covered

Covers the polymerization at downstream user sites for the Process Categories

listed above.






Concentration of


Up to 100%




use


Human factors not

influenced by risk

management


Other Operational


worker exposure








VERSION: 1.2




appendix A.


Categories




LEV present.





LEV present.








LEV present.



occur [E54].










processes; With sample


LEV present.






processes;






processes;


Outdoors










LEV present.










LEV present.















VERSION: 1.2





present.

5 Avoid carrying out operation for more than 15 minutes







LEV present.




training [PPE16].


process; Outdoors

























[PPE16].



Outdoors.










Dedicated facility;



prior to de-coupling [E39]. Avoid carrying out







Dedicated facility;







[PPE16].

VERSION: 1.2




Dedicated facility;

Outdoors.











present.







[PPE16].



present.






filling; Outdoors.






{PPE29];








Identifier*: Polymerization at Downstream

User Sites ES4-E1


Environmental Release Category ERC 6C, ERC 6D

Specific ERC -



Amounts used




environment 0.05





VERSION: 1.2





risk management














contaminants



(%) 95 %






additional to above


regulations.







VERSION: 1.2




scenarios

PROC Risk Management Measures Inhalatory

exposure (mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)

Long

term

Acute Long

term

Acute

systemic

Acute

local


(closed systems);

Indoors, No LEV

present.

1 Handle substance within a closed system [E47]. 0.04 n.a. n.a. n.a. 100


(closed systems);

With sample


No LEV present.


Avoid carrying out operation for more than 1



{PPE29]

7.18 n.a. n.a. n.a. 200


(closed systems);

With sample


with LEV present.


Provide extract ventilation to points where

emissions occur [E54].

3.59 n.a. n.a. n.a. 200


(closed systems);

With sample



Ensure operation is undertaken outdoors [E69].


hours [OC12] or: Wear a respirator conforming


{PPE29]

15.07 n.a. n.a. n.a. 200


batch processes; With

sample collection;

Indoors, No LEV

present.





{PPE29]

17.94 n.a. n.a. n.a. 100



sample collection;



8.97 n.a. n.a. n.a. 100

VERSION: 1.2




scenarios


exposure (mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)

Long

term

Acute Long

term

Acute

systemic

Acute

local

Indoors, with LEV

present.



sample collection;

Outdoors


Ensure operation is undertaken outdoors [E69].




{PPE29]

12.56 n.a. n.a. n.a. 100


batch processes;

Drum/batch transfers;

With sample


No LEV present.







14.35 n.a. n.a. n.a. 100


batch processes;


With sample


with LEV present.

4 Provide extract ventilation to material transfer




[PPE16].

7.18 n.a. n.a. n.a. 100


batch processes;


With sample


4 Ensure operation is undertaken outdoors [E69].







10.05 n.a. n.a. n.a. 100

ES4-W11 General exposures; 5 Avoid carrying out operation for more than 15 17.94 n.a. n.a. n.a. 200

VERSION: 1.2




scenarios


exposure (mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)

Long

term

Acute Long

term

Acute

systemic

Acute

local

Batch process;

Indoors, No LEV

present.







Batch process;

Indoors, with LEV

present.





[PPE16].

17.94 n.a. n.a. n.a. 200


Batch process;

Outdoors

5 Ensure operation is undertaken outdoors [E69].







12.56 n.a. n.a. n.a. 200


Non-dedicated

facility; Indoors, No

LEV present.

8a Transfer via enclosed lines [E52]; Clear transfer

lines prior to de-coupling [E39].Avoid carrying

out operation for more than 15 minutes [OC10]

or: Wear a respirator conforming to EN140 with

Type A/P2 filter or better {PPE29]; Wear



[PPE16].

17.94 n.a. n.a. n.a. 100


Non-dedicated

facility; Indoors, with


lines prior to de-coupling [E39].Provide extract

ventilation to material transfer points and other

17.94 n.a. n.a. n.a. 100

VERSION: 1.2




scenarios


exposure (mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)

Long

term

Acute Long

term

Acute

systemic

Acute

local

LEV present. openings [E82].Wear chemically resistant




Non-dedicated

facility; Outdoors.


lines prior to de-coupling [E39].Ensure

operation is undertaken outdoors [E69]. Avoid



EN140 with Type A/P2 filter or better {PPE29];



training [PPE16].

12.56 n.a. n.a. n.a. 100


Dedicated facility;

Indoors, No LEV

present.

8b Transfer via enclosed lines [E52]; Clear transfer

lines prior to de-coupling [E39].Avoid carrying

out operation for more than 15 minutes [OC10]

or: Wear a respirator conforming to EN140 with




[PPE16].

17.94 n.a. n.a. n.a. 100


Dedicated facility;

Indoors, with LEV

present.


lines prior to de-coupling [E39]. Provide extract

ventilation to material transfer points and other

openings [E82].Wear chemically resistant



5.38 n.a. n.a. n.a. 100


Dedicated facility;


lines prior to de-coupling [E39]. Ensure

12.56 n.a. n.a. n.a. 100

VERSION: 1.2




scenarios


exposure (mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)

Long

term

Acute Long

term

Acute

systemic

Acute

local

Outdoors. operation is undertaken outdoors [E69]. Avoid



EN140 with Type A/P2 filter or better {PPE29];



training [PPE16].


package filling;

Indoors, No LEV

present.


enclosed filling lines [E41]. Avoid carrying out

operation for more than 15 minutes [OC10] or:

Wear a respirator conforming to EN140 with




[PPE16].

17.94 n.a. n.a. n.a. 100


package filling;

Indoors, with LEV

present.


supplied with local extract ventilation [E51].



training [PPE16].

17.94 n.a. n.a. n.a. 100


package filling;

Outdoors.


enclosed filling lines [E41]. Ensure operation is


operation for more than 15 minutes [OC10] or:

Wear a respirator conforming to EN140 with




12.56 n.a. n.a. n.a. 100

VERSION: 1.2




scenarios


exposure (mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)

Long

term

Acute Long

term

Acute

systemic

Acute

local

[PPE16].

VERSION: 1.2




Not applicable.




LOCAL ES4-E1






Identifier ES4-E1

Polymerization at Downstream User

Sites


IC= 11 and UC= 33



process 1.00E-02


(regional only) 0

Local release to air (kg/d) 583

Local release to sewage (kg/d) 117

















Comments

VERSION: 1.2





Local PEC in agricultural soil, averaged over 30

days mg/kg dwt 1.19E-02

Local PEC agricultural soil, averaged over 180

days mg/kg dwt 1.19E-02


Comments





(total) kg/m

3 1.33E-07

Comments




poisoning.








Comments

VERSION: 1.2



1.5. Exposure scenario 5: Manufacture of intermediates at

downstream user sites

This scenario covers the use of methyl acrylate as a chemical intermediate in monomer synthesis

(transesterification or functionalisation) at downstream user sites.



Title Manufacture of intermediates at downstream user sites






Category

ERC6A


release category

n/a


covered

Covers the manufacture of intermediates at downstream user sites for the Process

Categories listed above.






Concentration of


Up to 100%




use


Human factors not

influenced by risk

management


Other Operational


worker exposure








VERSION: 1.2




appendix A.


Categories




LEV present.





LEV present.








LEV present.



occur [E54].












LEV present.






processes;






processes;


Outdoors










LEV present.










LEV present.















VERSION: 1.2





present.

5 Avoid carrying out operation for more than 15 minutes







LEV present.




training [PPE16].


process; Outdoors

























[PPE16].



Outdoors.










Dedicated facility;










Dedicated facility;







[PPE16].

VERSION: 1.2




Dedicated facility;

Outdoors.











present.







[PPE16].



present.






filling; Outdoors.






{PPE29];




facilitates tracking all the information (exposure estimation, risk characterization in chapter 1 and

2and appendices) related to this contributing scenario of the ES



Identifier*: Manufacture of Intermediates

at Downstream User Sites. ES5-E1


Environmental Release Category ERC 6A

Specific ERC -



Amounts used




environment 0.25





VERSION: 1.2





risk management














contaminants



(%) 95 %






additional to above


regulations.







VERSION: 1.2



Identifier Contributing scenarios PRO

C

Risk Management Measures Inhalatory

exposure (mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)

Long

term

Acute Long

term

Acute

systemic

Acute

local



LEV present.


[E47].

0.04 n.a. n.a. n.a. 100




LEV present.






7.18 n.a. n.a. n.a. 200




LEV present.




3.59 n.a. n.a. n.a. 200







operation for more than 4 hours [OC12] or:



15.07 n.a. n.a. n.a. 200




LEV present.






17.94 n.a. n.a. n.a. 100




LEV present.



ventilation [E49].

8.97 n.a. n.a. n.a. 100

VERSION: 1.2




C


exposure (mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)

Long

term

Acute Long

term

Acute

systemic

Acute

local







operation for more than 1 hour [OC11] or:



12.56 n.a. n.a. n.a. 100





LEV present.


1 hour [OC11] or: Wear a respirator





training [PPE16].

14.35 n.a. n.a. n.a. 100





LEV present.

4 Provide extract ventilation to material





7.18 n.a. n.a. n.a. 100













10.05 n.a. n.a. n.a. 100





17.94 n.a. n.a. n.a. 200

VERSION: 1.2




C


exposure (mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)

Long

term

Acute Long

term

Acute

systemic

Acute

local

present. conforming to EN140 with Type A/P2




training [PPE16].



LEV present.





training [PPE16].

17.94 n.a. n.a. n.a. 200


process; Outdoors









12.56 n.a. n.a. n.a. 200













17.94 n.a. n.a. n.a. 100

ES5-W15 Drum/batch transfers; 8a Transfer via enclosed lines [E52]; Clear 17.94 n.a. n.a. n.a. 100

VERSION: 1.2




C


exposure (mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)

Long

term

Acute Long

term

Acute

systemic

Acute

local


Indoors, with LEV

present.



material transfer points and other openings






Outdoors.






[OC10] or: Wear a respirator conforming





12.56 n.a. n.a. n.a. 100


Dedicated facility;










training [PPE16].

17.94 n.a. n.a. n.a. 100


Dedicated facility;

Indoors, with LEV





5.38 n.a. n.a. n.a. 100

VERSION: 1.2




C


exposure (mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)

Long

term

Acute Long

term

Acute

systemic

Acute

local

present. [E82].Wear chemically resistant gloves




Dedicated facility;

Outdoors.











12.56 n.a. n.a. n.a. 100



present.


enclosed filling lines [E41]. Avoid







training [PPE16].

17.94 n.a. n.a. n.a. 100



present.


supplied with local extract ventilation

[E51]. Wear chemically resistant gloves



17.94 n.a. n.a. n.a. 100

ES5-W22 Drum and small package 9 Use in semi-automated and predominantly 12.56 n.a. n.a. n.a. 100

VERSION: 1.2




C


exposure (mg/m3)

Dermal exposure

(mg/kg/day)

Dermal

exposure

(µg/cm2)

Long

term

Acute Long

term

Acute

systemic

Acute

local

filling; Outdoors. enclosed filling lines [E41]. Ensure

operation is undertaken outdoors [E69].








VERSION: 1.2




Not applicable.




LOCAL ES5-E1






Identifier ES5-E1

Manufacture of Intermediates at

Downstream User Sites

The exposure scenario is based A&B

tables

IC= 3 and UC= 33



process 5.0E-04


(regional only) 0









Local Concentration, Compartment: STP and

aquatic unit ES5-E1



Annual average local PEC in surface water






Local PEC in marine sediment during emission


VERSION: 1.2









Comments


Local Concentration, Compartment:

air unit ES5-E1

Annual average local PEC in air (total) kg/m3 4.62E-09

Comments




poisoning.








Comments

VERSION: 1.2



1.6. Exposure scenario 6: Use as laboratory reagent

This scenario covers the use and handling of methyl acrylate in small-scale analytical laboratories

associated with production sites and in small research and development facilities.



Title Use as laboratory reagent


Process Category PROC15




Category

ERC1


release category

n/a


covered

Covers the use as a laboratory reagent for the Process Category listed above.






Concentration of


Up to 100%




use


Human factors not

influenced by risk

management


Other Operational


worker exposure



VERSION: 1.2




appendix A.


Categories


ES6-W1 Laboratory activities;


15 Handle in a fume cupboard or under extract ventilation

[E83].




The residues following use in small scale analytical laboratories are incinerated together with residues

from manufacturing at production sites. Thus, this use (PROC15) is linked with ERC1 (manufacture

and distribution) and therefore no further environmental assessment is required.



The worker exposure estimates for the activities associated with this use of methyl acrylate have been assessed using ECETOC TRA v2, unless stated differently (see appendix B). Assessment parameter default values: Fugacity: moderate Type of Use; industrial Concentration: > 25 % Local Exhaust Ventilation: with LEV Duration of Exposure: > 4 hours/day Respiratory Protection Equipment: none The ECETOC TRA v2 estimates task based exposure. The exposure estimates shown are representative for activities lasting up to 8 hours. Due to the activity based character of this estimation tool, these exposure estimates are thereby also representative for short term activities (e.g., 15 minutes to 1 hour). Therefore no short term inhalatory exposure estimates are calculated nor shown in the table below (indicated by n.a.), since long term (8 hour) estimates already cover short term exposure.


scenarios

PRO

C

Risk Management

Measures

Inhalatory

exposure

(mg/m3)

Dermal

exposure

(mg/kg/day)

Dermal

exposur

e

(µg/cm2

)

Long

term

Acut

e

Long

term

Acute

systemic

Acute

local

ES6-W1 Laboratory

activities; Indoors,

with LEV present.

15 Handle in a fume

cupboard or under

extract ventilation

[E83].

3.59 n.a. n.a. n.a. 100


VERSION: 1.2



Not applicable.









1.7. Regional exposure concentrations

Regional concentrations unit value

Regional PEC in surface water (total) mg/L 1.85E-04

Regional PEC in sea water (total) mg/L 2.19E-05

Regional PEC in air (total) kg/m3 1.78E-10

Regional PEC in agricultural soil (total) mg/kg dwt 1.55E-05

Regional PEC in natural soil (total) mg/kg dwt 1.56E-05

Regional PEC in industrial soil (total) mg/kg dwt 1.56E-05

Regional PEC in sediment (total) mg/kg dwt 6.77E-04

Regional PEC in sea water sediment (total) mg/kg dwt 8.13E-05

Comments

VERSION: 1.2



2. RISK CHARACTERISATION

The risk characterisation of substance methyl acrylate has been conducted based on the PNECs and

DNELs in the following tables.

Table 2.1 PNECs

Compartments PNEC

STP 10.0 mg L-1

Freshwater 2.72E-03 mg L-1

Freshwater sediment 1.15E-02 mg kgdwt-1

Marine water 2.72E-04 mg L-1

Marine water

sediment 1.15E-03 mg kgdwt-1

Soil 1.13 mg kgdwt-1

Table 2.2 DN(M)ELs for workers

Acute –

systemic effects

Acute –

local effects

Long-term –

systemic effects

Long-term –

local effects

dermal (mg/kg

bw /day)

Inhalation

(mg/m3)

Dermal

(µg/cm2)

Inhalation

(mg/m3)

Dermal

(mg/kg bw

/day)

Inhalation

(mg/m3)

Dermal

(µg/cm2)

Inhalation

(mg/m3)

n.a. n.a. 490 n.a. n.a. n.a. n.a. 18

n.a. = not applicable

Table 2.3 DN(M)ELs for General Population

Acute –

systemic effects

Acute –

local effects

Long-term –

systemic effects

Long-term – local

effects

Dermal

(mg/kg

bw /day)

Inhalation

(mg/m3/day)

Oral

(mg/kg

bw/day)

Dermal

(µg/cm2)

Inhalatio

n

(mg/m3)

Dermal

(mg/kg

bw /day)

Inhalation

(mg/kg

bw/day)

Oral

(mg/kg

bw /day)

Dermal

(µg/cm2)

Inhalatio

n

(mg/m3)

n.a. n.a. n.a. n.a. n.a. n.a. n.a. n.a. n.a. n.a.

n.a. = not applicable

VERSION: 1.2



2.1. Exposure scenario 1: Manufacture and distribution

2.1.1. Human health

2.1.1.1. Workers

Identifier Contributing scenarios Risk Characterization Ratio

Long term (local effects)

Risk Characterization Ratio

Acute (local effects)

Inhalation Dermal Combined

routes


routes



present.

0.0020 n.a. n.a. n.a. 0.2041 n.a.

ES1-W2

General exposures (closed



present.

0.3986 n.a. n.a. n.a. 0.4082 n.a.

ES1-W3



collection; Indoors, with LEV

present.

0.1993 n.a. n.a. n.a. 0.4082 n.a.




0.8371 n.a. n.a. n.a. 0.4082 n.a.

ES1-W5

Use in contained batch



present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.

ES1-W6




present.

0.4983 n.a. n.a. n.a. 0.2041 n.a.




0.6976 n.a. n.a. n.a. 0.2041 n.a.

ES1-W8

Drum/batch transfers; Non-


No LEV present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.



with LEV present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.


dedicated facility; Outdoors. 0.6976 n.a. n.a. n.a. 0.2041 n.a.



No LEV present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.


Dedicated facility; Indoors, 0.2990 n.a. n.a. n.a. 0.2041 n.a.

VERSION: 1.2



with LEV present.


Dedicated facility; Outdoors. 0.6976 n.a. n.a. n.a. 0.2041 n.a.



present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.



present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.


filling; Outdoors. 0.6976 n.a. n.a. n.a. 0.2041 n.a.

2.1.1.2. Consumers

Not applicable.

2.1.1.3. Indirect exposure of humans via the environment


considered negligible.

2.1.2. Environment

Compartments: Risk Characterization

Ratio

ES1-E1: Manufacture

Site 1

STP 1.00E-03

Freshwater 4.34E-01

Freshwater sediment 4.37E-01

Soil 1.88E-02

Marine water 4.49E-01

Marine water sediment 4.50E-01

Compartments: Risk Characterization Ratio

ES1-E2: Manufacture

Site 2

STP 1.00E-03

Freshwater 4.34E-01


Soil 1.88E-02



Compartments: Risk Characterization Ratio

ES1-E3: Manufacture

Site 3

STP 1.00E-03

Freshwater 1.60E-01


Soil 2.21E-03



VERSION: 1.2



2.2. Exposure scenario 2: Polymerization at production sites

2.2.1. Human health

2.2.1.1. Workers






routes


routes

ES2-W1



present.

0.0020 n.a. n.a. n.a. 0.2041 n.a.

ES2-W2




present.

0.3986 n.a. n.a. n.a. 0.4082 n.a.

ES2-W3




present.

0.1993 n.a. n.a. n.a. 0.4082 n.a.

ES2-W4




0.8371 n.a. n.a. n.a. 0.4082 n.a.

ES2-W5




present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.

ES2-W6




present.

0.4983 n.a. n.a. n.a. 0.2041 n.a.

ES2-W7




0.6976 n.a. n.a. n.a. 0.2041 n.a.

ES2-W8





present.

0.7972 n.a. n.a. n.a. 0.2041 n.a.

ES2-W9





present.

0.3986 n.a. n.a. n.a. 0.2041 n.a.

ES2-W10





0.5581 n.a. n.a. n.a. 0.2041 n.a.

VERSION: 1.2



ES2-W11

General exposures; Batch


present.

0.9965 n.a. n.a. n.a. 0.4082 n.a.



present.

0.9965 n.a. n.a. n.a. 0.4082 n.a.


process; Outdoors 0.6976 n.a. n.a. n.a. 0.4082 n.a.


dedicated facility; Indoors, No

LEV present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.



with LEV present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.





No LEV present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.

ES2-W18



with LEV present.

0.2990 n.a. n.a. n.a. 0.2041 n.a.



ES2-W20

Drum and small package


present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.

ES2-W21



present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.



2.2.1.2. Consumers

Not applicable.




2.2.2. Environment

Compartments: Risk Characterization Ratio ES2-E1: Polymerization [Wet] at Production Sites

STP 1.00E-03

Freshwater 4.34E-01


Soil 2.62E-04


VERSION: 1.2




2.3. Exposure scenario 3: Manufacture of intermediates at production

sites

2.3.1. Human health

2.3.1.1. Workers





Inhalati

on

Dermal Combined

routes


routes

ES3-W1



present.

0.0020 n.a. n.a. n.a. 0.2041 n.a.

ES3-W2




LEV present.

0.3986 n.a. n.a. n.a. 0.4082 n.a.

ES3-W3




LEV present.

0.1993 n.a. n.a. n.a. 0.4082 n.a.

ES3-W4




0.8371 n.a. n.a. n.a. 0.4082 n.a.

ES3-W5




LEV present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.

ES3-W6




LEV present.

0.4983 n.a. n.a. n.a. 0.2041 n.a.

ES3-W7




0.6976 n.a. n.a. n.a. 0.2041 n.a.

ES3-W8





LEV present.

0.7972 n.a. n.a. n.a. 0.2041 n.a.

ES3-W9





LEV present.

0.3986 n.a. n.a. n.a. 0.2041 n.a.

ES3-W10





0.5581 n.a. n.a. n.a. 0.2041 n.a.

VERSION: 1.2



ES3-W11



present.

0.9965 n.a. n.a. n.a. 0.4082 n.a.



present.

0.9965 n.a. n.a. n.a. 0.4082 n.a.





No LEV present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.



with LEV present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.





No LEV present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.

ES3-W18



with LEV present.

0.2990 n.a. n.a. n.a. 0.2041 n.a.



ES3-W20



present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.

ES3-W21



present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.



2.3.1.2. Consumers

Not applicable.




2.3.2. Environment

Compartments: Risk Characterization

Ratio

ES3-E1: Manufacture of Intermediates at Production

Sites

STP 1.00E-03

Freshwater 4.34E-01


VERSION: 1.2



Soil 1.38E-04



2.4. Exposure scenario 4: Polymerization at downstream user sites

2.4.1. Human health

2.4.1.1. Workers






routes


routes

ES4-W1



LEV present.

0.0020 n.a. n.a. n.a. 0.2041 n.a.

ES4-W2




LEV present.

0.3986 n.a. n.a. n.a. 0.4082 n.a.

ES4-W3




LEV present.

0.1993 n.a. n.a. n.a. 0.4082 n.a.

ES4-W4




0.8371 n.a. n.a. n.a. 0.4082 n.a.

ES4-W5




LEV present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.

ES4-W6




LEV present.

0.4983 n.a. n.a. n.a. 0.2041 n.a.

ES4-W7




0.6976 n.a. n.a. n.a. 0.2041 n.a.

ES4-W8





LEV present.

0.7972 n.a. n.a. n.a. 0.2041 n.a.

ES4-W9





LEV present.

0.3986 n.a. n.a. n.a. 0.2041 n.a.


processes; Drum/batch 0.5581 n.a. n.a. n.a. 0.2041 n.a.

VERSION: 1.2





ES4-W11



present.

0.9965 n.a. n.a. n.a. 0.4082 n.a.

ES4-W12



LEV present.

0.9965 n.a. n.a. n.a. 0.4082 n.a.



ES4-W14




0.9965 n.a. n.a. n.a. 0.2041 n.a.

ES4-W15




0.9965 n.a. n.a. n.a. 0.2041 n.a.

ES4-W16



Outdoors.

0.6976 n.a. n.a. n.a. 0.2041 n.a.

ES4-W17



No LEV present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.

ES4-W18



with LEV present.

0.2990 n.a. n.a. n.a. 0.2041 n.a.

ES4-W19


Dedicated facility;

Outdoors.

0.6976 n.a. n.a. n.a. 0.2041 n.a.

ES4-W20



present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.

ES4-W21



present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.



2.4.1.2. Consumers

Not applicable.




2.4.2. Environment

Compartments: Risk Characterization Ratio ES4-E1: Polymerization at Downstream User Sites

STP 1.00E-03

Freshwater 1.60E-01


Soil 1.05E-02

VERSION: 1.2





2.5. Exposure scenario 5: Manufacture of intermediates at

downstream user sites

2.5.1. Human health

2.5.1.1. Workers






routes


routes

ES5-W1



present.

0.0020 n.a. n.a. n.a. 0.2041 n.a.

ES5-W2




present.

0.3986 n.a. n.a. n.a. 0.4082 n.a.

ES5-W3




present.

0.1993 n.a. n.a. n.a. 0.4082 n.a.

ES5-W4




0.8371 n.a. n.a. n.a. 0.4082 n.a.

ES5-W5




present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.

ES5-W6




present.

0.4983 n.a. n.a. n.a. 0.2041 n.a.

ES5-W7




0.6976 n.a. n.a. n.a. 0.2041 n.a.

ES5-W8





present.

0.7972 n.a. n.a. n.a. 0.2041 n.a.

ES5-W9





present.

0.3986 n.a. n.a. n.a. 0.2041 n.a.

VERSION: 1.2



ES5-W10





0.5581 n.a. n.a. n.a. 0.2041 n.a.

ES5-W11



present.

0.9965 n.a. n.a. n.a. 0.4082 n.a.

ES5-W12



present.

0.9965 n.a. n.a. n.a. 0.4082 n.a.



ES5-W14



No LEV present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.

ES5-W15



with LEV present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.



ES5-W17



No LEV present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.

ES5-W18



with LEV present.

0.2990 n.a. n.a. n.a. 0.2041 n.a.



ES5-W20



present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.

ES5-W21



present.

0.9965 n.a. n.a. n.a. 0.2041 n.a.



2.5.1.2. Consumers

Not applicable.




2.5.2. Environment

Compartments: Risk

Characterization Ratio

ES5-E1: Manufacture of Intermediates at Downstream User

Sites

STP 1.00E-03

Freshwater 4.34E-01

VERSION: 1.2




Soil 3.66E-04



2.6. Exposure scenario 6: Use as laboratory reagent

2.6.1. Human health

2.6.1.1. Workers






routes


routes

ES6-W1 Laboratory activities; Indoors,

with LEV present. 0.1993 n.a. n.a. n.a. 0.2041 n.a.

2.6.1.2. Consumers

Not applicable.


The residues following use in small scale analytical laboratories are incinerated together with residues from

manufacturing at production sites. Thus, this use (PROC15) is linked with ERC1 (manufacture and

distribution) and therefore no further environmental assessment is required.

2.6.2. Environment

The residues following use in small scale analytical laboratories are incinerated together with residues from

manufacturing at production sites. Thus, this use (PROC15) is linked with ERC1 (manufacture and

distribution) and therefore no further environmental assessment is required.

VERSION: 1.2



2.7. Overall exposure (combined for all relevant emission/release

sources

2.7.1. Human health (combined for all exposure routes)

The critical effects associated with exposure to methyl acrylate are local effects (dermal sensitization and

respiratory irritation) and local effects from different exposure routes are not cumulative. The worker

exposure scenarios presented represent different industrial processes that would typically occur at different

facilities, therefore it is not appropriate to combine these scenarios. Regarding potential exposure in non-

industrial applications, methyl acrylate completely reacts (less than 0.1 wt% remains) during use; therefore,

development of exposure scenarios covering downstream uses (i.e., professional use, consumer use, service

life, waste treatment) are not required and have not been conducted for this assessment.

2.7.2. Environment (combined for all emission sources)

Compartments:

(REGIONAL) RCR

Freshwater 6.80E-02




Soil [Natural Soil (Total)] 1.38E-05

END OF SDS

Documents

SIBUR-NEFTEKHIM JSC SAFETY DATA SHEET METHYL …Keep people away. Isolate fire and deny unnecessary entry. Stay upwind. Keep out of low areas where gases (fumes) can accumulate. Water