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Reversing (skin) aging
Dr. Carolina OliveiraCEO & Co-Founder
From the academy to the marketFrom Minas Gerais to Silicon Valley and beyond
From building skin models in the lab to developing products able to rejuvenate tissues
Our (dream) team
Carolina Oliveira, PhDChief Executive Officer
Alessandra Zonari, PhDChief Scientific Officer
Andres Ochoa, PhDChief Technology Officer
Juliana Carvalho, PhD Head of Innovation
Mariana Boroni, PhDHead of Bioinformatics
How do you see yourself aging?
The longevity revolution
The longevity revolution
“to just have a healthy life and then turn out the lights.”
“I decided that I was just not going to die.”
Longevity investor and “biohacker” Dave Asprey
Cynthia Kenyon, the vice president for aging research at Calico
Impact in the healthcare system
- Aging drives chronic diseases
- The main risk factor: 2/3rd die from cancer, heart disease, diabetes, Alzheimer's etc
3
The complexity of the aging pathways and process
Kumar S and Lombard DB. F1000Research 2016,
Why now?Why us?
- Aging is a malleable process
- There is a “code” that controls this process and helps us to measure aging
- We can manipulate this “code”
Decoding aging
The code of aging
Age (years)
DNA
SKIN CELL (YOUNG)STEM CELL SKIN CELL (OLD)
Epigenetic modifications accumulated during aging
Resetting the aging clock
Age (years)
DNA
SKIN CELL (YOUNG)STEM CELL SKIN CELL (OLD)
Epigenetic modifications accumulated during aging
Total cell reprogramming
Aging is a malleable process
Age (years)
DNA
SKIN CELL (YOUNG)STEM CELL SKIN CELL (OLD)
Epigenetic modifications accumulated during aging
Partial reprogramming or rejuvenation
Biological markers x
chronological aging
How can we measure aging?
Epigenetic markers
Molecular clock
34Y
54Y
30Y0Y
Yamanaka Reprogramming
46Y
44Y
46Y
cerebellum
breast
liver
skin
cartilageSkin cellStem cell
Horvath Genome Biology 2013, 14:R115
Senescence: cell division has a limit
Inflammation
STOP
Cells live, die or become senescent
50 divisions
Senescent cell
Clearing senescent cells: a new path to aging reversal
Mayo Clinic, 2015
9
Senescent cells
depletedFull of
senescent cells
OneSkin strategy to to promote rejuvenation
SKIN CELL (YOUNG) SKIN CELL (OLD)STEM CELL
Age (years)
Reversing the aging clock
Growing HUMAN skins in the lab
11
Human skin OneSkin 3D skin model
Replicating skin aging in the lab
Young skin (~30y) Aged skin (~60y)Baby skin (0y)
Decoding the skin aging
Creating a skin specific clock
mDNA AGEA
GE
R2 is 0.8015
mDNA AGE
AG
E
| algorithm
Horvath’s Molecular Clock
We are the first company able to quantify the rejuvenation effect of novel compounds using DNA age.
Scaling up our platform to find molecules able to promote skin rejuvenation
Where are we now?
Senescent cells Senescent cells + compound treatment (1.25 uM)
Our data: Age reversal at the cellular level
Compounds validation and product development
Young skin Aged skinAged skin + anti-aging compound treatment
Age measurement
30Y 60Y <60 Years
OUR CLAIM
X YEARS OF AGE
REVERSE
=
Products in the market
From skin rejuvenation to
Human longevity
Our vision
Care Health
Help Humanity to Age Better
Thank you!
Join us on this mission to reverse aging!
