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General Histology Power Point
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2. The Cell -- Begins
3. Nucleolus
4.
5. Mitochondria cell organelle
6. Rough ER
7. Smooth ER
8. Golgi Complex
9. Microvilli
10. Centrioles and the centrosome
11. Desmosomes
12. Secretory granules, condensing granules, zymogen granules (not 2) 13. Blood -- begins
14. Eosinophils
15. Basophils
16. PMN Neutrophils
17. Monocytes
18. Bone Marrow smear
19. Epithelial Cells -- begins
20. Simple Cuboidal Epithelia
21. Simple Columnar Epithelia
22. Pseudostratified Columnar Epithelia
23. Stratified Squamous Epithelia
THIN SKIN Thick Skin 24. Stratified Squamous non-keratinized epithelium
25. Stratified Cuboidal Epithelium
Note the eccrine sweat gland at (a) 26. Transitional Epithelium
Relaxed State 27. Zonula Occludens
Left picture -- #2 Right Picture - #1 Tight junction at #3 28. Connective tissue -- Begin
29. Dense Irregular Connective Tissue
Seen at (d) Note the stratified squamous epithelia at (A) (a) And (b) showing different fiber orientation 30. Dense Irregular 31. Areolar (loose) Connective Tissue
Esophagus Small Intestine 32. Some cells found in the connective tissue
Note the clock-face nucleus of the plasma cells 33. Glands -- begins
Mucous gland seen at (a) 34. Serous Gland
35. Mixed Gland
36. Serous Acinus
37. Mucous Acinus
38. Serous Demilunes
39. Intralobular Duct
The red arrow is pointing to the intralobular duct 40. Intercalated Duct
Intercalated duct seen at (c) and a striated duct at (d) 41. Interlobular Duct
42. Integumentary System -- begin
Note the hair follicle at (c) into the hypodermis and a sebaceous gland at (d) 43. Thick Skin
Arrow pointing to stratum Lucidum 44. Epidermal Layers
Corneum (A), Basale (B) Corneum (A), Lucidum (B clear), Granulosum (C), and the Basale and Spinosum at (D) 45. Dermis
Dermis seen at (b) Dermis is seen at (c)layer of dermis right underneath the epidermis the papillary layer 46. Hypodermis
Seen at (f) 47. Cartilage -- begins
Chondrocytes seen at (A) and they arise via appositional growth from the perichondrium (B) 48. Chondroblasts
Chondroblasts seen at (C) which arise from mesenchymal cells 49. Hyaline Cartilgage
Perichondrium at (A), Chondroblasts at (B), and Chondrocytes at (C) 50. Elastic Cartilage
51. Fibrocartilage
52. Bone -- begins
53. Compact Bone
Note the central Haversian Canals and the corresponding canaliculis 54. Osteoblast
Note the periosteum at (A), the Osteoblasts at (B) which lays down Osteoid or bone matrix Note the osteoblast lining and the secreted Osteoid in green The Osteoblasts secrete Osteoid (a) compact bone is seen in (b) osteocyte 55. Osteocytes
Osteocyte seen at (c) Also seen deep to the osteoid Arrows show osteocytes 56. Osteoclasts
Seen at arrow 57. Muscle -- Begin
Skeletal muscle cross-section Both X-section and L-section shown XS note the nuclei at the periphery 58. Smooth Muscle
Shown here is smooth muscle around a blood vessel 59. Cardiac Muscle
. Note the intercalated disc at the dot 60. Perimysium
Perimysium seen at the arrow 61. Endomysium
62. Epimysium
63. Motor End Plate 64. Nervous System -- begins
Motor neurons in the ventral horn seen at (a) nucleolus of the nucleus at (b) the axon shown at (c)the latter is actually the axon hillock You can see lots of RER (nissl substances) at (a), and a dark nucleolus at (b) Motor neuron seen in the ventral horn with dendrites coming off of cell bodymultipolar found in ventral horn 65. Multipolar Neuron 66. Purkinje cells
. Dot shows the location of the purkinje cells cell body Note the purkinje cells lying b/w the inner and outer cortical layers 67. Sensory Ganglion (dorsal ganglion)
The cell body or perikaryon is found at (a) note the light stained nucleus also note the small surrounding cells called satellite cells at (b) Notice again the satellite cells 68. Dorsal Root ganglion 69. White Matter and Gray Matter
Spinal Cord Arrow pointing to the tracts (black) making up the white matter 70. Nerve Longitudinal section in which the arrows point to nodes of ranvier Nerve X-section axis cylinders seen at (a) surrounded by myelin the entire nerve trunk is surrounded by epineurium seen at (b) This is at higher power axons can be seen at (a) and the endoneurium can be seen at (b) These are both myelin stains note in the latter the myelin sheath appears to be blackthe nerve also is divided into fascicles 71. Node of Ranvier
72. Endoneurium
73. Perineurium
74. Epineurium
75. Auerbachs Plexus
76. Myenteric Plexus continued 77. Meissners plexus
78. Ganglion Cells . The ganglionic cell layer where the dot is Dorsal Root Ganglion 79. Esophagus
Epithelium at (a) lamina propria at (b) smooth muscled muscularis mucosae at (c) the submucosa composed of areolar connective tissue at (D) and the inner and outer layer of the muscularis externa at (E) and (F) Picture of the esophageal wall duct of a gland is seen at (a), mucous acini at (b), and the thick mescularis externa at (c) 80. Esophagus Continued High power of esophageal epithelium basal layer of stratum germanitvum at (a), papillae of the lamina propria projecting at (b) Seen here is the gastroesophageal junction esophageal epithelium at (a), the simple columnar junction of the stomach at (B), and the cardiac glands at (C) in the lamina propria 81. Stomach Tall simple columnar cells at (A) the gastric or fundus glands at (B),(C) shows the circular layer of the muscularis externa, while (D) shows the longitudinal layer A picture of the gastric mucosa lining epithelium at (a) gastric pit at (b) gastric gland (c) Picture of the base of a gastric gland chief cells at (a) parietal cell at (b) muscularis mucosae at (c) 82. Stomach continued Another gastric mucosa picture parietal cells at (a) b/w chief cells mucous neck cells at (b) Epithelial cells at (A) gastric gland at (B) connective tissue of the mucosa at (C) Zoom of a gastric gland parietal cells at (a) chief cells at (b) connective tissue at (c) b/w the glands 83. Stomach Note the (reddish) or lighter parietal cells in between the darker chief cells in a close up of the gastric gland 84. Stomach 85. The small intestine
Intestinal villi at (a) in the lamina propria the the crypts of Liberkuhn (b) Brunner Glands at (c) along with the nerves and BVs at (d) make up the submucosa Muscularis externa at (e) Simple Columnar Epithlium covering the villi at (A) (B) shows the core of each villus the intestinal glands (crypts of lieberkuhn) is at (C) and submucosal glands (Brunners) are seen at (D) Picture of the duodenum submucosa base of crypts of lieberkuhn at (A) (B) shows the Brunners glands a muscular artery at (D) 86. 87. Duodenum continued Picture of Brunners Glands note the basal nuclei location Auerbachs plexus inner circular layer at (A) soma of the autonomic nuclei at (B) outer longitudinal muscle layer at (C) a venule at (D) 88. Jejunum Note the tall villi and the short intestinal glands the left shows the lacteal at (a) the columnar cells at (b) and the intestinal glands at (c) 89. Crypts of Lieberkuhn The muscularis mucosae (a), the submucosa collagen tissue of the submucosa (b) lumen of the crypts at (c) Goblet cells at (a) lamina propria connective tissue at (b) and intestinal gland cells at (c) Paneth cells occupying the basal region of the gland at (A) 90. Ileum Accumulation of lymphoid tissue called Peyers patches seen at (A) mesentery cut at (B) Germinal center of a lymph nodule of a peyers patch at (a) the muscularis at (b) intestinal gland at (c) Long villi with many goblet cells seen 91. Peyers Patches found in the submucosa of the ileum Villi at (a) intestinal gland at (b) the peyers patch at (c) the connective tissue of the submucosa at (d) -- circular and longitudinal muscle layers at (e) and (f) the serosa at (g) Peyers patches 92. The Large Intestine (Colon) Note the mucosa (A) has crypts of lieberkuhn, but no villi submucosa (B) is loose connective tissue muscularis externa at (C), and Adventia at (D) Close up of the colon mucosa lumen of the colon at (a) (b) is the opening of the crypts (d) is the lamina propria Again, the colon mucosa goblet cells in the epithelium (b), and crypts at (a) 93. Colon 94. Liver The connective tissue at (B) separates the lobes of the liver into lobules the center of a lobule is the central vein shown at (A) which, in this case, is branched Arrows depict the parenchyma of the liver the central vein shown at (A) which drains the sinusoids and connective tissue shown at (B) 95. Liver continued The central vein at (A) The hepatic portal vein at (A) the hepatic artery at (B) and the bile duct at (C) The sinusoids are shown with arrows the hapatic portal vein at (A) the bile duct at (C) The central vein at (A) parenchyma cell at (C) endothelial cells at (D) separated from the parenchymal cells via the space of disse kupffer cells at (C) lining the endothelium 96. Liver continued Parenchymal cells are involved in carbohydrate metabolism seen see glycogen depoits at (A) sinusoids seen at (B) Parenchymal cells are the source of livers bile intercellular spaces b/w parenchymal cells form bile canaliculi seen at (A) longitudinally and at (B) in X-section sinusoids with blood cells at (C) Liver bile is gather from bile canaliculi in the lobule by small ducts shown at arrows the small ducts empty into the bile duct at the triad shown at (A) 97. Liver Arrow pointing to hepatic portal vein 98. Gall Bladder Mucosa at (A) muscularis externa at (B) adventia at (C) At (B) shows the mucosa w/simple columnar epithelia and underlying lamina propria folds and sinuses seen at (A) the muscularis at (C) is composed of three types of smooth muscles that empty the gall bladder vianerves (arrow) serosa at (D) 99. Lymphatic System -- begins Lymphatic nodules found in the lamina propria of GI system and respiratory system formed in response to specific antigens Picture of the iliem portion of the SI lymph nodules at (A) note the lighter staining center at (A) where cell proliferation of B-cells occurs Picture of a lymph nodule lighter staining center at (a) and the dark periphery at (b) which is composed of lymphocytes 100. Diffuse Lymphatic Tissue 101. Tonsils
Center of crypts at (d) tonsils have lymph nodules with lymph nodules seen at (a) and surrounding lymphocytes at (b) A lymph nodule is seen at (a) and the epithelium is seen at (b) note the free lymphocytes at the surface of the epithelium 102. Tonsil 103. Lymph Nodes
The is the cortex of a lymph node connective tissue capsule at (a) and trabeculae (connective tissue extensions) at (b) the subcapsular sinus at (c) which allows lymph vessels to pass through and into the trabecular sinus (d) the cortex has many lymph nodules at (e) This is the medullary central region composed of trabecular (a) trabecular sinus at (b) leading into the medullary sinus (c) medullary cords are seen at (d) which are composed of small plasma cells and lymphocytes The medullary sinuses are the clearer areas such as in (a) while the darker areas shown at (b) are medullary cords 104. Lymph node continued Lymph node medulla 105. Lymph node Subcapsular space of the lymph node at arrow 106. Spleen An outer connective tissue capsule projects trabeculae seen at (c) the white pulp seen at (a) contains mainly lympcytes and the surrounding red pulp seen at (b) The white pulp (a) is a collection of lymph nodules with lymphocytes surrounding the central artery (b)Periarterial Lymphatic Sheath blood from these central arteries flows to the sinusoids of the red pulp seen at (c) 107. Spleen High power sinuoids seen at (a) and the surrounding cords of Billroth Silver stain of the same area as the left one 108. Spleen 109. Thymus Thymus composed of lobules outer cortex seen at (a) composed of T-lymphocytes and an inner medulla at (b) composed of epithelial cells forming the blood-thymus barrier The edge of the cortex is seen at (a) and the medulla is seen at (b) within the medulla are Hassalls corpuscles seen at (c) Close up of the medulla at (b) and a sliced onion shaped Hassall's corpuscle at (a) 110. Thymus Arrow pointing to a epithelial reticular cell of the thymus 111. Thymus general structure 112. Arteriole A smaller artery and a larger arteriole 113. Venule Note the round arteriole and the squashed venule Arrow pointing to a venule Picture of a venule and an arteriole 114. Vein 115. Elastic artery 116. Renal System -- begins
The arrows point to arcuate arteries and veins the cortex can be seen on the left side while the medulla is seen on the right the capsule is seen at the far left collecting tububles seen at (A) little yellow arrow shows a glomerulus in the cortex . The Same as the slide to the left, but a closer focus on the medulla 117. The Nephron
I will represent with arrows the Bowmans capsule is shown with the little yellow arrow on the right and is lined by parietal epithelium the blue arrow represents the glomerulus at (A) is the distal convoluted tubule with increased epithelial nucleation lining it (macula densa cells) (B) juxtaglomerular cells (C) shows Mesangial cells The Proximal Convoluted Tubule can be seen here at (A) note its smaller lumen, brush border and darker pink stain (B) shows the distal convoluted tubule note it has a lighter pink stain and a larger lumen the red arrow is pointing to macula densa cells 118. Nephron continued Proximal convoluted tubule Note the Brush border on the proximal tubule 119. The Medulla The tubules of the medulla include the collecting tubules (A) and the loop of Henle at (B) The collecting tubules have a large lumen and are comprised of simple cuboidal epithelia and these cells have distinct lateral borders The loops of henle are comprised of simple squamous epithelia and have indistinct lateral borders This is the inner section of the medulla which contains the main collecting ducts that carries the urine to the minor calyx (A) The calyx is lined with trasitional epithelium (arrow) 120. Collecting Duct 121. Ureter Urine is carried from the minor calyx to the major calyx then to the pelvis and to the ureter The lumen of the ureter is at (A) which is star-shaped and is lined with transitional epithelium Inner Circularis muscles are seen at (B) and longitudinal muscles at (C) Another Ureter Picture note the transitional epithelium 122. Endocrine System -- begins
(A) and (B) represent the adenohypophysis while (C) represents the neurohypophysis (A) is actually a section of the adenohypophysis called the Pars Distalis while (B) is the Pars Intermedia (C) represents the Pars Nervosa This is a pic of the capsule of the pituitary gland the fibrous capsule is seen at (B) while the Pars Distalis is seen at (A) 123. Hypophysis Top left arrow is a acidophil bottom left arrow is a chromophobe top right arrow is a basophil 124. Pars Distalis Note the irreular cords of epithelial cells composing the pars distalis Acidophils are seen at (a) with a reddish cytoplasm. Acidophils produce GH or Prolactin smaller basophils are seen at (b) with a blue cytoplasm chromophobes are seen at (c) and can differentiate into either acidophils or basophils they are separated by conn tissue fibers seen at (d) 125. Pars Distalis continued The acidophils are seen at (a) again note their pink cytoplasm basophils are seen at (b), and a few chromophobes (light staining cytoplasm) can be seen at (c) the (s) represents the sinusoids that are present 126. Pars Intermedia
Contains high levels of basophils (producing MSH and ACTH) and follicles containing colloid (A) 127. Pars Nervosa
Axon tracts can be seen at (a) and the accumulated neural secretions called Herring bodies can be seen at (B) in the Pars Nervosa Pituicytes can be seen at (a) Herring bodies can be seen at (b) in the pars nervosa, while the axon fiber can be seen at (c) 128. Thyroid Gland Made up of follicles surround by simple cuboidal epithelium the follicles are filled with colloid (A) colloid can be globular as seen in (B) or dark staining seen at (C) Follicles can vary in sizes as seen in (A) and (B) 129. Thyroid gland continued (A) Shows the colloid within the follicle follicular cells can be seen at (B) which produce Thyroglobulin and release T4 into the capillaries (seen at C) (D) shows clumping of follicular cells At (a) is a follicular cell and at (b) is a parafollicular cell (light stained) which are clear cells the latter cell produces calcitonin 130. Random Thyroid Gland pix 131. Parathyroid Gland Picture of thyroid [(C) and (B)] and parathyroid glands (A) note the parathyroid gland is composed of cords of cells and is separated from the thyroid by a capsule Note the cells are lined up along capillaries chief cells are seen at (a) and comprise most of the cells some chief cells are large and contain lots of glycogen (b) note they are more clear these chief cells release PTH chief cells are also seen at (c) and are in contact with capillaries 132. Parathyroid continued
133. Adrenal Glands
Another picture of the adrenal gland 134. Adrenal Gland G F R Medulla 135. Adrenal Cortex Zona glomerulosa at (A) the zona fasciculata at (B) which are paler in color the reticularis is seen at (C) and has darker cells The adrenal capsule is seen at (a) zona glomerulosa at (b) the Zona fasciculata at (c) the large amounts of SER in the cytoplasm of cells in the glomerulosa and fasciculata make the pale staining This is a pic of the zona fasciculata note the pale staing cytoplasm and the dark nuclei of (a) note large amount of fatty acids make the cytoplasm pale a sinusoid is seen at (b) 136. Adrenal Medulla
The Medulla cell seen at (A) which contains granules containing epi and norepi note the small arteries at (B) 137. Pancreatic Islets Islets are composed of 4 cells types islet cells (a) are pale staining just know this is a picture of the pancreas composed of islets Islets comprise the light staining area of the pancreas 138. Respiratory System -- begins
Note the C-shaped hyaline cartilage composing the wall of the trachea at (A) the opening of the C-shape is composed of smooth muscle that can be seen at (B) Here we see the layers of the trachea (A) shows the the respiratory epithelium (B) shows the connective tissue of the lamina propria (C) shows the submucosa (D) shows the cartilage rings (E) shows the adventia 139. Trachea continued Note the Mixed glands seen at (A), and the Hyaline cartilage at (B) Note here of the respiratory epithelium at the arrow 140. Trachea cont. 141. Respiratory Epithelium pix 142. Bronchus Consists of respiratory epithelium at (A) smooth muscle at (B) Glands at (C) are surrounded by cartilage plate seen at (D) 143. The Lung The bronchi is seen at (A) while the pulmonary arteries and veins are seen at (B) A bronchiole is seen at (A) in which the mucosa is covered with ciliated low columnar epithelia note the increase in smooth muscle as seen at the arrow and noticeably less cartilage 144. The Lung Continued Terminal bronchioles are seen at (A) and are lined with cuboidal epithelium Respiratory bronchioles are seen at (B) while the alveolar duct is seen at (C) Individual Alveoli is seen at (A) lined by simple squamous epithelia numerous capillaries (arrows) are seen here (A) Denotes the visceral pleura covering the lung the septa seen at (B) forms lobules in the lung and is composed of simple squamous epithelia and fibrous conn tissue 145. The Lung Macrophages seen in the alveoli (arrow) and in the interalveolar septa note the black cytoplasm of engulfed material Good picture of an alveolar duct with its lumen being shown 146. Random Pix Bronchiole 147. Vocal Cords Larynx picture -- Elastic Cartilage at (A) the false vocal fold at (E) and the true vocal fold at (F) if the others come up, sue me 148. Vocal cords True vocal fold at arrow covered with simple squamous epithelia conn tissue at (A) and smooth muscle at (B) False vocal fold covered with respiratory epithelium at (A) the duct has mucous (B) and Serous (C) components 149. The Eye -- begins
Sclera 150. Sclera 151. Cornea
Stratified squamous epithelium Stroma Endothelium Iris 152. Cornea Continued 153. Conjunctiva
Conjuntiva on the left, and cornea on the right 154. Conjunctiva Conjunctiva skin 155. Lens
capsule Zonule fibers 156. Lens 157. Anterior and posterior chambers of the eye
Lens Posterior Chamber Anterior Chamber Iris 158. Vitreous body
159. Ciliary Body
160. Ciliary body 161. Iris This is a continuation of the ciliary process towardthe pupil containing smooth muscle 162. Pupil
------------------ Pupil 163. Choroid
Choroid 164. Choroid Pigmented Epithelium 165. Ora Serrata
166. Optic Nerve Collection point for axons from the ganglion cells 167. Retina
168. Retina cont
169. Retina Rod cone 170. Macula Lutea
171. Male Reproductive system begins
172. Seminiferous Tubules
Numerous seminiferous tubules Note that the arrow is pointing to a spermatogonia within the seminiferous tubule 173. Seminiferous Tubule Note the arrow pointing to a spermatid within the seminiferous tubule Upper arrow is a spermatogonia while the bottom arrow is a primary spermatocyte 174. Seminiferous Spermatocytesspermatidsspermatozoa (in lumen) 175. Sertoli Cells
Arrow pointing to Sertoli cell Sertoli Cells 176. Leydig Cells
177. Leydig cells 178. Rete Testis
epididymis Rete Testis Epididymis Rete Testis 179. Rete Testis 180. Epididymis
Note the stereocilia 181. Epididymis 182. Female Reproductive systembegins
183. Ovary 184. Ovary Primordial Follicles
Arrow pointing to a primordial follicle Note the flattened cells around the primordial follicles 185. Ovary Primary Follicles
Primary oocyte 186. Primary oocyte Primary oocyte 187. Ovary -- Secondary Follicle
A secondary follicle is seen at (3) 188. Mature (Graafian) Follicles
Oocyte Corona radiata Cumulus Oophorus Granulosa cells 189. Graafian Follicle 190. Corpus Luteum
191. Corpus Albicans