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So what is the problem?
Michael Savvas
Assisted Conception Unit
King’s College Hospital
Chance of conception Natural
Woman < 40 years
•More than 80% of couples will conceive within 1 year
•Of remaining 20% half will conceive in second year
•2 year cumulative pregnancy 90%.
Chance of conception
Pregnancy Rate (%)
Age
When to investigate
• After one year of unprotected SI
• Earlier referral where:
The woman is > 36 years
There is a known clinical cause
There is a history of predisposing factors
Assessment
• A specific enquiry about lifestyle and sexual history should be made.
NICE 2013
Lifestyle
• Frequency and timing of SI• Alcohol• Smoking• Caffeine• Body weight• Exercise• Diet• Psychological stress
Frequency and timing
• Timing not helpful
• SI 2-3 times a week
• Most pregnancies result from SI occurring in window 5 days before and day of ovulation
Alcohol
• Women who are pregnant or trying to conceive should consume <1-2 units per week
• Excess alcohol (more than 3-4 units per day) is detrimental to sperm
Smoking
• Reduced fertility in women
• Effect on pregnancy
• Effect on male fertility unclear but does effect semen quality
Caffeine
• In combination with alcohol can effect semen quality
Obesity
• BMI >30 assoc with reduced fertility in men and women
• Women with BMI<19 Amenorrhoea, infertility and pregnancy complications
Diet and exercise can improve fertility
Recreational Drugs
Marijuana and Cocaine
• Can effect ovulation and tubal function
• Can effect Semen quality
Anabolic steroids
• Can effect semen quality
Stress
• Effects male and female fertility
• Fertility treatment stressful
Vitamins and Anti-oxidants
• Selenium
• Vitamin C , E
• Zinc
• Selenium
• Folate
Shown to improve sperm motility
Conclusion
Healthy lifestyle improves
•Natural fertility
•Treatment outcomes